reserpine has been researched along with Pain, Chronic in 10 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This review highlights the potential therapeutic approaches identified in studies that used reserpine-induced myalgia (RIM) animal model that exhibits nociplastic pain-associated phenotypes." | 9.22 | Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model. ( Nagakura, Y, 2022) |
| "The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model." | 7.96 | Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020) |
| " Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain." | 7.81 | Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015) |
| "The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 7.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 5.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| " This review highlights the potential therapeutic approaches identified in studies that used reserpine-induced myalgia (RIM) animal model that exhibits nociplastic pain-associated phenotypes." | 5.22 | Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model. ( Nagakura, Y, 2022) |
| "The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model." | 3.96 | Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020) |
| " To examine the effects of dysfunction of spinal monoaminergic systems on pain sensitivity, we established a rat chronic pain model by administering lumbar-intrathecal reserpine to minimize its influence on brain." | 3.83 | Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors. ( Asaki, T; Hasegawa, M; Ishida, M; Shinohara, S; Tamano, R, 2016) |
| " Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain." | 3.81 | Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015) |
| "The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 3.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
| "Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy." | 1.48 | α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences. ( Alves, D; Balaguez, R; Baldinotti, R; Birmann, PT; Brüning, CA; Fronza, MG; Savegnago, L; Sousa, FSS, 2018) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 1.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uta, D | 1 |
| Tsuboshima, K | 1 |
| Nishijo, H | 1 |
| Mizumura, K | 1 |
| Taguchi, T | 1 |
| Nagakura, Y | 3 |
| Álvarez-Pérez, B | 2 |
| Deulofeu, M | 2 |
| Homs, J | 1 |
| Merlos, M | 2 |
| Vela, JM | 2 |
| Verdú, E | 2 |
| Boadas-Vaello, P | 2 |
| Bagó-Mas, A | 1 |
| Gonzalez-Soler, EM | 1 |
| Blasco-Serra, A | 1 |
| Alfosea-Cuadrado, GM | 1 |
| Igual-Lopez, M | 1 |
| Orduna-Valls, J | 1 |
| Tornero-Tornero, C | 1 |
| Valverde-Navarro, AA | 1 |
| Sousa, FSS | 1 |
| Birmann, PT | 1 |
| Baldinotti, R | 1 |
| Fronza, MG | 1 |
| Balaguez, R | 1 |
| Alves, D | 1 |
| Brüning, CA | 1 |
| Savegnago, L | 1 |
| Liu, SB | 1 |
| Zhao, R | 1 |
| Li, XS | 1 |
| Guo, HJ | 1 |
| Tian, Z | 1 |
| Zhang, N | 1 |
| Gao, GD | 1 |
| Zhao, MG | 1 |
| Murai, N | 1 |
| Fushiki, H | 1 |
| Honda, S | 1 |
| Murakami, Y | 1 |
| Iwashita, A | 1 |
| Irie, M | 1 |
| Tamura, S | 1 |
| Aoki, T | 1 |
| Tamano, R | 1 |
| Ishida, M | 1 |
| Asaki, T | 1 |
| Hasegawa, M | 1 |
| Shinohara, S | 1 |
| Takahashi, M | 1 |
| Noto, T | 1 |
| Sekizawa, T | 1 |
| Oe, T | 1 |
| Yoshimi, E | 1 |
| Tamaki, K | 1 |
| Shimizu, Y | 1 |
1 review available for reserpine and Pain, Chronic
| Article | Year |
|---|---|
Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model.
Topics: Animals; Chronic Pain; Disease Models, Animal; Fibromyalgia; Humans; Myalgia; Reserpine | 2022 |
9 other studies available for reserpine and Pain, Chronic
| Article | Year |
|---|---|
Neuronal Sensitization and Synaptic Facilitation in the Superficial Dorsal Horn of a Rat Reserpine-induced Pain Model.
Topics: Animals; Chronic Pain; Humans; Neurons; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Reserpin | 2021 |
Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.
Topics: Animals; Chronic Pain; Disease Models, Animal; Fibromyalgia; Mice; Pregabalin; Reserpine | 2022 |
Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Female; Fibromyalgia; Gliosis; Hyperalges | 2022 |
Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Chronic Pain; Depression; Disease Models, Animal; | 2020 |
α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences.
Topics: Acetophenones; Analgesics; Animals; Antidepressive Agents; Antioxidants; Brain; Chronic Pain; Depres | 2018 |
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression | 2014 |
Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
Topics: Analgesics; Animals; Brain; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors.
Topics: Administration, Cutaneous; Analgesics; Animals; Biogenic Monoamines; Brain; Chronic Pain; Cyclopropa | 2016 |
Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats.
Topics: Animals; Chronic Pain; Constriction; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Neura | 2012 |