amitriptyline has been researched along with Pain, Chronic in 32 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized controlled trial is the first to show the effectiveness and tolerance of a medication, low-dose amitriptyline, in managing idiopathic chronic neck pain and its related comorbidities." | 9.27 | Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain. ( Abdel Hay, J; Garcia-Larrea, L; Kobaiter-Maarrawi, S; Maarrawi, J; Peyron, R; Tabet, P, 2018) |
| "This trial suggests that amitriptyline may be an effective treatment for chronic low back pain." | 9.27 | Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial. ( Arnold, C; Cicuttini, FM; Fong, C; Forbes, A; Gibson, SJ; Heritier, S; Sim, MR; Urquhart, DM; van Tulder, M; Wang, Y; Wluka, AE, 2018) |
| "The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms." | 9.17 | Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? ( As, I; Atalay, A; Bagis, S; Erdogan, C; Karabiber, M; Tamer, L, 2013) |
| "The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD)." | 7.77 | Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study. ( Calderon, Pdos S; Camargo, AP; Conti, PC; Oliveira, LC; Ramos Netto, Tde C; Tabaquim, Mde L, 2011) |
| "Low back pain is a major clinical and public health problem, with limited evidence-based treatments." | 6.82 | Is low-dose amitriptyline effective in the management of chronic low back pain? Study protocol for a randomised controlled trial. ( Anthony, SN; Arnold, C; Cicuttini, FM; Fong, C; Forbes, A; Gibson, SJ; Sim, MR; Urquhart, DM; van Tulder, M; Wluka, AE, 2016) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 6.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 6.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| " Antidepressants, such as amitriptyline, have been used to treat chronic pain in other conditions." | 5.41 | Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial. ( Arnold, C; Cicuttini, FM; Forbes, A; Hussain, SM; Teichtahl, AJ; Urquhart, DM; Wang, Y; Wluka, AE, 2021) |
| "This randomized controlled trial is the first to show the effectiveness and tolerance of a medication, low-dose amitriptyline, in managing idiopathic chronic neck pain and its related comorbidities." | 5.27 | Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain. ( Abdel Hay, J; Garcia-Larrea, L; Kobaiter-Maarrawi, S; Maarrawi, J; Peyron, R; Tabet, P, 2018) |
| "This trial suggests that amitriptyline may be an effective treatment for chronic low back pain." | 5.27 | Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial. ( Arnold, C; Cicuttini, FM; Fong, C; Forbes, A; Gibson, SJ; Heritier, S; Sim, MR; Urquhart, DM; van Tulder, M; Wang, Y; Wluka, AE, 2018) |
| "The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms." | 5.17 | Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? ( As, I; Atalay, A; Bagis, S; Erdogan, C; Karabiber, M; Tamer, L, 2013) |
| "We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions." | 4.95 | Antiepileptic drugs for chronic non-cancer pain in children and adolescents. ( Clinch, J; Cooper, TE; Heathcote, LC; Howard, R; Krane, E; Lord, SM; Schechter, N; Sethna, N; Wiffen, PJ; Wood, C, 2017) |
| "The most effective long-term treatments for tension-type mid-facial pain and facial migraine were low-dose amitriptyline and low-dose amitriptyline and triptans, respectively." | 3.80 | Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2014) |
| "The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD)." | 3.77 | Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study. ( Calderon, Pdos S; Camargo, AP; Conti, PC; Oliveira, LC; Ramos Netto, Tde C; Tabaquim, Mde L, 2011) |
| "Low back pain is a major clinical and public health problem, with limited evidence-based treatments." | 2.82 | Is low-dose amitriptyline effective in the management of chronic low back pain? Study protocol for a randomised controlled trial. ( Anthony, SN; Arnold, C; Cicuttini, FM; Fong, C; Forbes, A; Gibson, SJ; Sim, MR; Urquhart, DM; van Tulder, M; Wluka, AE, 2016) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 2.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 2.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors." | 2.50 | Non-surgical interventions for the management of chronic pelvic pain. ( Cheong, YC; Smotra, G; Williams, AC, 2014) |
| "Amitriptyline was prescribed to 223 women with IC/BPS, only 125 of which (56%) had a documented history of depression." | 1.72 | Do medication prescription patterns follow guidelines in a cohort of women with interstitial cystitis/bladder pain syndrome? ( Anger, JT; Barbour, KE; Bresee, C; De Hoedt, AM; Freedland, SJ; Kim, J; Tholemeier, LN, 2022) |
| "We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907." | 1.56 | Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model. ( Aoki, Y; Hattori, M; Horikawa, H; Ito, H; Takemura, Y; Yamazaki, M, 2020) |
| "Cyclobenzaprine specimens were equally likely to be positive whether the dose was oral or topical, although mean levels after topical dosing were approximately 13-21% those after oral dosing." | 1.46 | Urinary Concentrations of Topically Administered Pain Medications. ( Bell, P; Glinn, MA; Harvey, A; Lickteig, AJ; Rappold, B; Recer, S; Salske, M; Stensland, J; Weber, L, 2017) |
| "The involvement of serotonin (5-HT) in chronic pain mechanisms is established." | 1.39 | Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. ( Ferjan, I; Lipnik-Štangelj, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (71.88) | 24.3611 |
| 2020's | 9 (28.13) | 2.80 |
| Authors | Studies |
|---|---|
| Macsari, I | 1 |
| Besidski, Y | 1 |
| Csjernyik, G | 1 |
| Nilsson, LI | 1 |
| Sandberg, L | 1 |
| Yngve, U | 1 |
| Ahlin, K | 1 |
| Bueters, T | 1 |
| Eriksson, AB | 1 |
| Lund, PE | 1 |
| Venyike, E | 1 |
| Oerther, S | 1 |
| Hygge Blakeman, K | 1 |
| Luo, L | 1 |
| Arvidsson, PI | 1 |
| Wluka, AE | 3 |
| Urquhart, DM | 4 |
| Teichtahl, AJ | 1 |
| Hussain, SM | 1 |
| Forbes, A | 3 |
| Arnold, C | 3 |
| Wang, Y | 2 |
| Cicuttini, FM | 3 |
| Schwartz, M | 1 |
| Fischer, LM | 1 |
| Bläute, C | 1 |
| Stork, J | 1 |
| Colloca, L | 1 |
| Zöllner, C | 1 |
| Klinger, R | 1 |
| Tholemeier, LN | 1 |
| Bresee, C | 1 |
| De Hoedt, AM | 1 |
| Barbour, KE | 1 |
| Kim, J | 1 |
| Freedland, SJ | 1 |
| Anger, JT | 1 |
| Anghelescu, DL | 1 |
| Johns, E | 1 |
| Bhatia, S | 1 |
| Frett, MJ | 1 |
| Lu, Z | 1 |
| Dunphy, L | 1 |
| Wood, F | 1 |
| Mubarak, ES | 1 |
| Coughlin, L | 1 |
| Stepanenko, YD | 1 |
| Boikov, SI | 1 |
| Sibarov, DA | 1 |
| Abushik, PA | 1 |
| Vanchakova, NP | 1 |
| Belinskaia, D | 1 |
| Shestakova, NN | 1 |
| Antonov, SM | 1 |
| Khong, TK | 1 |
| Lall, K | 1 |
| Coetzee, R | 1 |
| Johnson, Y | 1 |
| van Niekerk, J | 1 |
| Namane, M | 1 |
| Ito, H | 1 |
| Takemura, Y | 1 |
| Aoki, Y | 1 |
| Hattori, M | 1 |
| Horikawa, H | 1 |
| Yamazaki, M | 1 |
| Mahmoud, AMS | 1 |
| Ragab, SG | 1 |
| Boules, ML | 1 |
| Botros, JM | 1 |
| Glinn, MA | 1 |
| Lickteig, AJ | 1 |
| Weber, L | 1 |
| Recer, S | 1 |
| Salske, M | 1 |
| Harvey, A | 1 |
| Rappold, B | 1 |
| Stensland, J | 1 |
| Bell, P | 1 |
| Cooper, TE | 2 |
| Heathcote, LC | 2 |
| Clinch, J | 2 |
| Gold, JI | 1 |
| Howard, R | 2 |
| Lord, SM | 2 |
| Schechter, N | 2 |
| Wood, C | 2 |
| Wiffen, PJ | 3 |
| Krane, E | 1 |
| Sethna, N | 1 |
| Maarrawi, J | 1 |
| Abdel Hay, J | 1 |
| Kobaiter-Maarrawi, S | 1 |
| Tabet, P | 1 |
| Peyron, R | 1 |
| Garcia-Larrea, L | 1 |
| Biggs, WS | 1 |
| Carey, ET | 1 |
| McIntyre, JM | 1 |
| Hao, D | 1 |
| Olugbodi, A | 1 |
| Udechukwu, N | 1 |
| Donato, AA | 1 |
| van Tulder, M | 2 |
| Heritier, S | 1 |
| Fong, C | 2 |
| Sim, MR | 2 |
| Gibson, SJ | 2 |
| Kalita, J | 1 |
| Misra, UK | 1 |
| Lin, CC | 1 |
| McLachlan, AJ | 1 |
| Maher, CG | 1 |
| Wluka, A | 1 |
| Cicuttini, F | 1 |
| Agius, AM | 3 |
| Jones, NS | 3 |
| Muscat, R | 3 |
| Ferjan, I | 1 |
| Lipnik-Štangelj, M | 1 |
| Cheong, YC | 1 |
| Smotra, G | 1 |
| Williams, AC | 1 |
| Kachko, L | 1 |
| Ben Ami, S | 1 |
| Lieberman, A | 1 |
| Shor, R | 1 |
| Tzeitlin, E | 1 |
| Efrat, R | 1 |
| Hearn, L | 1 |
| Moore, RA | 1 |
| Derry, S | 1 |
| Phillips, T | 1 |
| Anthony, SN | 1 |
| Calderon, Pdos S | 1 |
| Tabaquim, Mde L | 1 |
| Oliveira, LC | 1 |
| Camargo, AP | 1 |
| Ramos Netto, Tde C | 1 |
| Conti, PC | 1 |
| Bagis, S | 1 |
| Karabiber, M | 1 |
| As, I | 1 |
| Tamer, L | 1 |
| Erdogan, C | 1 |
| Atalay, A | 1 |
| Lamberg, JJ | 1 |
| Gordin, VN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Magnesium Supplementation on Anesthesia and Postoperative Analgesia After Surgical Removal of the Lower Third Molars.[NCT03398382] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2017-04-15 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for amitriptyline and Pain, Chronic
| Article | Year |
|---|---|
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Amines; Amitriptyline; Anticonvulsants; Child; Chronic Pain; Complex Regional Pain Syndr | 2017 |
Limited evidence guides empiric Tx of female chronic pelvic pain.
Topics: Adult; Amitriptyline; Analgesics; Chronic Pain; Contraceptive Agents, Female; Contraceptives, Oral, | 2018 |
Non-surgical interventions for the management of chronic pelvic pain.
Topics: Amines; Amitriptyline; Analgesics; Chronic Pain; Clonidine; Contraceptive Agents, Female; Cyclohexan | 2014 |
Desipramine for neuropathic pain in adults.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Pain; Clomipramine; Desip | 2014 |
9 trials available for amitriptyline and Pain, Chronic
| Article | Year |
|---|---|
Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial.
Topics: Amitriptyline; Australia; Benztropine; Chronic Pain; Double-Blind Method; Humans; Osteoarthritis, Kn | 2021 |
Observing treatment outcomes in other patients can elicit augmented placebo effects on pain treatment: a double-blinded randomized clinical trial with patients with chronic low back pain.
Topics: Amitriptyline; Chronic Pain; Humans; Low Back Pain; Male; Pain Measurement; Placebo Effect; Treatmen | 2022 |
Comparison between Two Low Doses of Amitriptyline in the Management of Chronic Neck Pain: A Randomized, Double-Blind, Comparative Study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Chronic Pain; Double-Blind Met | 2021 |
Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Pain; Double-Blind Method; Female; Humans; M | 2018 |
Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Pain; Double-Blind Method; Female; Hum | 2018 |
A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amitriptyline; Analysis of Variance; Antidepre | 2013 |
Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain.
Topics: Adrenergic beta-Antagonists; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tric | 2013 |
Is low-dose amitriptyline effective in the management of chronic low back pain? Study protocol for a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Pain; Clinical Pro | 2016 |
Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?
Topics: Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anxiety; Cathartics; Chronic Pain; Citri | 2013 |
18 other studies available for amitriptyline and Pain, Chronic
| Article | Year |
|---|---|
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
Topics: Amides; Analgesics; Animals; Arthritis, Experimental; Carrageenan; CHO Cells; Chronic Pain; Cricetin | 2012 |
Do medication prescription patterns follow guidelines in a cohort of women with interstitial cystitis/bladder pain syndrome?
Topics: Amitriptyline; Chronic Pain; Cystitis, Interstitial; Drug Prescriptions; Female; Humans; Hydroxyzine | 2022 |
Chronic postsurgical pain in children and young adults with cancer and choice of regional anesthesia for amputation and limb-sparing surgery.
Topics: Amitriptyline; Amputation, Surgical; Anesthesia, Conduction; Child; Chronic Pain; Humans; Neoplasms; | 2023 |
Levator Ani Syndrome Presenting with Vaginal Pain.
Topics: Amitriptyline; Anus Diseases; Chronic Pain; Female; Humans; Pelvic Floor; Pelvic Pain | 2023 |
Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Calcium; Cells, Cultured; Cerebral Cortex; | 2019 |
No benefit from amitriptyline for chronic low back pain?
Topics: Amitriptyline; Chronic Pain; Humans; Low Back Pain; Randomized Controlled Trials as Topic; Treatment | 2020 |
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Chronic Pain; Female; Hospi | 2020 |
Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Pain; Disease Models, Animal; Fluo | 2020 |
Urinary Concentrations of Topically Administered Pain Medications.
Topics: Administration, Oral; Administration, Topical; Amines; Amitriptyline; Analgesics; Chronic Pain; Cycl | 2017 |
Trauma-induced adiposis dolorosa (Dercum's disease).
Topics: Accidents, Traffic; Adipose Tissue; Adiposis Dolorosa; Adult; Amitriptyline; Analgesics, Non-Narcoti | 2018 |
Low-Dose Amitriptyline for Chronic Low Back Pain.
Topics: Amitriptyline; Chronic Pain; Humans; Low Back Pain; Pain Measurement | 2019 |
Low-Dose Amitriptyline for Chronic Low Back Pain.
Topics: Amitriptyline; Chronic Pain; Humans; Low Back Pain; Pain Measurement | 2019 |
Low-Dose Amitriptyline for Chronic Low Back Pain-Reply.
Topics: Amitriptyline; Chronic Pain; Humans; Low Back Pain; Pain Measurement | 2019 |
Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biological Transport; Cells, Cultured; Chr | 2013 |
Neuropathic pain other than CRPS in children and adolescents: incidence, referral, clinical characteristics, management, and clinical outcomes.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Chronic Pain; Female; Humans; In | 2014 |
Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Pain; Facial Pain | 2014 |
Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Pain; Cognitive Behavior | 2011 |
Serotonin syndrome in a patient with chronic pain polypharmacy.
Topics: Adult; Amitriptyline; Anti-Allergic Agents; Antidepressive Agents; Carisoprodol; Cetirizine; Chronic | 2014 |