Compounds > lidocaine
Page last updated: 2024-10-28

lidocaine and Pain, Chronic

lidocaine has been researched along with Pain, Chronic in 73 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"To compare the incidence in postsurgical persistent pain following breast cancer surgery in women receiving intravenous lidocaine compared to saline using validated pain instruments in accordance with the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations."9.27The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Cont ( Bialek, JM; De Oliveira, GS; Goodwin, E; Kendall, MC; McCarthy, RJ; Nader, A; Panaro, S, 2018)
"We aimed to compare the effects of intraoperative lidocaine and magnesium on postoperative functional recovery and chronic pain after mastectomy due to breast cancer."9.24Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial. ( Kim, MH; Kim, SI; Lee, KY; Park, HS; Park, S; Yoo, YC, 2017)
"There are few data to support paraspinous lidocaine injection use in patients with nonspecific chronic low back pain."9.22Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial. ( Alfieri, FM; Battistella, LR; da Rocha, ID; Filippo, TR; Fregni, F; Imamura, M; Imamura, ST; Morales-Quezada, L; Neto, RB; Onoda Tomikawa, LC; Onoda Tomikawa, LG; Targino, RA, 2016)
"The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable proportion of patients."9.16Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study. ( Apkarian, AV; Baliki, MN; Chanda, ML; Hashmi, JA; Huang, L; Parks, EL; Schnitzer, T, 2012)
"Local anesthetics, such as the 5% transdermal lidocaine patch (5LP), have been frequently used in the treatment of musculoskeletal pain, especially chronic low back pain (CLBP)."9.05The Efficacy, Effectiveness and Safety of 5% Transdermal Lidocaine Patch for Chronic Low Back Pain: A Narrative Review. ( Felix, ER; Klass, S; Santana, JA, 2020)
"Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain."9.01Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. ( Brandenburger, T; Hermanns, H; Hollmann, MW; Lirk, P; Piegeler, T; Stevens, MF; Werdehausen, R, 2019)
"Eighty-eight articles regarding iv lidocaine were included: 36 in vitro studies evaluating the effect on ion channels and receptors; 31 animal studies concerning acute and chronic pain and inflammatory models; 21 clinical studies concerning acute and chronic pain."8.93The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. ( Radema, SA; Scheffer, GJ; Steegers, MA; van Berkum, BF; van den Heuvel, SA; van der Wal, SE; Vaneker, M; Vissers, KC, 2016)
" With more and more perianesthesia nurses involved with chronic pain management, it is imperative they understand the special nursing care needs of patients receiving intravenous lidocaine infusion therapy."8.12Nursing Care During Lidocaine Infusion Therapy for Chronic Pain. ( Wren, KR, 2022)
"To evaluate the safety of and long-term pain relief due to intravenous lidocaine infusion for the treatment of chronic pain in a tertiary pain management clinic."7.88Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain. ( Bokat, CE; Brogan, S; Donaldson, GW; Hagn, EE; Hare, BD; Iacob, E; Junkins, SR; Kennington, KS; Okifuji, A; Sindt, J; Tadler, SC, 2018)
"Chronic postsurgical pain (CPSP) and sensory disturbances at the surgical sites were evaluated 3 months after surgery."6.84The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double-Blinded, Controlled Study. ( Choi, KW; Chung, WY; Joe, YE; Kang, SW; Lee, JH; Lee, JR; Nam, KH, 2017)
"Chronic pain is currently considered a disease state with biopsychosocial consequences and a negative impact on patients' quality of life (QoL)."6.82Changing the paradigm in postherpetic neuralgia treatment: lidocaine 700 mg medicated plaster. ( Fornasari, D; Magni, A; Pais, P; Palao, T; Polati, E; Sansone, P, 2022)
"Treatment of chronic pain conditions is commonly assessed at specific endpoints at preset times during or after treatment by analysis of the total study population."6.78A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia. ( Dahan, A; Krebs-Brown, A; Martini, CH; Olofsen, E; Passier, P; Stoker, M; Yassen, A, 2013)
"Chronic pain was assessed 3 to 6 months after breast surgery in 51 patients of the lidocaine group and 46 patients of the control group."6.55Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials. ( Chang, YC; Chen, MJ; Cheng, SP; Liu, CL; Liu, TP; Yang, PS, 2017)
"We assigned 44 women diagnosed with chronic myofascial pelvic pain associated with trigger points to either the magnesium-based infiltrate (n = 15), lidocaine infiltrate (n = 17), or waitlist (n = 12) group."5.51Magnesium-Based Trigger Point Infiltrations Versus Local Anaesthetic Infiltrations in Chronic Pelvic Myofascial Pain: A Randomized, Double-Blind, Controlled Study. ( Chamberlain, S; Henry, R; Leitch, J; Nitsch, R; Pudwell, J; Webb, A, 2022)
"To compare the incidence in postsurgical persistent pain following breast cancer surgery in women receiving intravenous lidocaine compared to saline using validated pain instruments in accordance with the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations."5.27The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Cont ( Bialek, JM; De Oliveira, GS; Goodwin, E; Kendall, MC; McCarthy, RJ; Nader, A; Panaro, S, 2018)
"We aimed to compare the effects of intraoperative lidocaine and magnesium on postoperative functional recovery and chronic pain after mastectomy due to breast cancer."5.24Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial. ( Kim, MH; Kim, SI; Lee, KY; Park, HS; Park, S; Yoo, YC, 2017)
"Laser irradiation caused an immediate decrease in low back pain post-procedure similar to pain reduction caused by lidocaine injection."5.22Photobiomodulation of the dorsal root ganglion for the treatment of low back pain: A pilot study. ( Anders, JJ; Chavantes, MC; de Holanda, CV; de Oliveira, JO; Holanda, VM; Silva, DF; Wu, X, 2016)
"This qualitative review found insufficient, heterogenous evidence and therefore no recommendation can be made for lidocaine infusion treatment in patients with chronic neuropathic pain due to spinal cord injury, peripheral nerve injury, diabetic neuropathy, postherpetic neuralgia, or complex regional pain syndrome type II."5.22Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. ( Argoff, CE; Bhullar, RK; Koutalianos, EP; Lee, JH; Leimer, EM, 2022)
"There are few data to support paraspinous lidocaine injection use in patients with nonspecific chronic low back pain."5.22Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial. ( Alfieri, FM; Battistella, LR; da Rocha, ID; Filippo, TR; Fregni, F; Imamura, M; Imamura, ST; Morales-Quezada, L; Neto, RB; Onoda Tomikawa, LC; Onoda Tomikawa, LG; Targino, RA, 2016)
"Lidocaine injection seems to be better for reducing the severity of chronic pelvic pain secondary to abdominal wall trigger points compared to ischemic compression via physical therapy."5.20Anaesthetic injection versus ischemic compression for the pain relief of abdominal wall trigger points in women with chronic pelvic pain. ( Braz, CA; Candido-dos-Reis, FJ; Montenegro, ML; Nogueira, AA; Poli-Neto, OB; Rosa-e-Silva, JC, 2015)
"The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable proportion of patients."5.16Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study. ( Apkarian, AV; Baliki, MN; Chanda, ML; Hashmi, JA; Huang, L; Parks, EL; Schnitzer, T, 2012)
"Local anesthetics, such as the 5% transdermal lidocaine patch (5LP), have been frequently used in the treatment of musculoskeletal pain, especially chronic low back pain (CLBP)."5.05The Efficacy, Effectiveness and Safety of 5% Transdermal Lidocaine Patch for Chronic Low Back Pain: A Narrative Review. ( Felix, ER; Klass, S; Santana, JA, 2020)
"Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain."5.01Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. ( Brandenburger, T; Hermanns, H; Hollmann, MW; Lirk, P; Piegeler, T; Stevens, MF; Werdehausen, R, 2019)
"We evaluate the safety and efficacy of intravenous lidocaine in adult patients with acute and chronic pain who are undergoing pain management in the emergency department (ED)."4.98Safety and Efficacy of Intravenous Lidocaine for Pain Management in the Emergency Department: A Systematic Review. ( Bellolio, MF; Cabrera, D; E Silva, LOJ; Erwin, PJ; Motov, S; Murad, MH; Scherber, K; West, CP, 2018)
"Eighty-eight articles regarding iv lidocaine were included: 36 in vitro studies evaluating the effect on ion channels and receptors; 31 animal studies concerning acute and chronic pain and inflammatory models; 21 clinical studies concerning acute and chronic pain."4.93The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. ( Radema, SA; Scheffer, GJ; Steegers, MA; van Berkum, BF; van den Heuvel, SA; van der Wal, SE; Vaneker, M; Vissers, KC, 2016)
" In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain."4.89Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013)
"What is this study about? This study examined data of patients with chronic pain who received an infusion at our hospital with two drugs, lidocaine and ketamine, in an effort to reduce pain."4.31Simultaneous application of lidocaine and ketamine during ambulatory infusion therapy: a retrospective analysis. ( Ruppen, W; Schneider, T; Striebel, J, 2023)
" LCipsi inactivation with lidocaine increased cold allodynia 2 days after nerve injury but not later."4.12Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus-dorsal reticular nucleus pathway. ( Berrocoso, E; Bravo, L; Camarena-Delgado, C; Garcia-Partida, JA; Llorca-Torralba, M; López-Martín, C; Mico, JA; Suárez-Pereira, I, 2022)
" With more and more perianesthesia nurses involved with chronic pain management, it is imperative they understand the special nursing care needs of patients receiving intravenous lidocaine infusion therapy."4.12Nursing Care During Lidocaine Infusion Therapy for Chronic Pain. ( Wren, KR, 2022)
"We conclude that CSF lavage could be a helpful maneuver to clear lidocaine and betamethasone and avoid potential nerve damage caused by an unintentional intrathecal injection during an epidural injection for the treatment of chronic low back pain."3.91An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report. ( Liu, C; Liu, S; Pan, Y; Sun, J; Sun, X; Xu, J, 2019)
"To evaluate the safety of and long-term pain relief due to intravenous lidocaine infusion for the treatment of chronic pain in a tertiary pain management clinic."3.88Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain. ( Bokat, CE; Brogan, S; Donaldson, GW; Hagn, EE; Hare, BD; Iacob, E; Junkins, SR; Kennington, KS; Okifuji, A; Sindt, J; Tadler, SC, 2018)
" Stratification by diagnosis showed a treatment effect of lidocaine plaster for all underlying conditions with highest treatment effects for diabetic polyneuropathy and postherpetic neuralgia."3.78Patient perceptions associated with the 5% lidocaine medicated plaster in daily practice. ( Müller-Schwefe, GH; Überall, MA, 2012)
" The cumulative dosage of sufentanil in perioperative period was significantly lower (149."3.11Effect of lidocaine perioperative infusion on chronic postsurgical pain in patients undergoing thoracoscopic radical pneumonectomy. ( Ding, H; Lian, C; Lu, Y; Shangguan, W; Shao, C; Shi, J; Wang, N; Wu, J, 2022)
"Chronic postsurgical pain (CPSP) and sensory disturbances at the surgical sites were evaluated 3 months after surgery."2.84The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double-Blinded, Controlled Study. ( Choi, KW; Chung, WY; Joe, YE; Kang, SW; Lee, JH; Lee, JR; Nam, KH, 2017)
"Chronic pain is currently considered a disease state with biopsychosocial consequences and a negative impact on patients' quality of life (QoL)."2.82Changing the paradigm in postherpetic neuralgia treatment: lidocaine 700 mg medicated plaster. ( Fornasari, D; Magni, A; Pais, P; Palao, T; Polati, E; Sansone, P, 2022)
"Provoked vestibulodynia (PVD), a frequent form of chronic genital pain, is associated with decreased sexual function for afflicted women, as well as impoverished sexual satisfaction for women and their partners."2.79A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial. ( Aerts, L; Bergeron, S; Corsini-Munt, S; Delisle, I; Mayrand, MH; McDuff, P; Rosen, NO; Santerre-Baillargeon, M; Steben, M, 2014)
"Treatment of chronic pain conditions is commonly assessed at specific endpoints at preset times during or after treatment by analysis of the total study population."2.78A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia. ( Dahan, A; Krebs-Brown, A; Martini, CH; Olofsen, E; Passier, P; Stoker, M; Yassen, A, 2013)
"Lidocaine is an amino amide with a well-established role as a local anesthetic agent."2.72Lidocaine Infusions for Pain Management in Pediatrics. ( Anghelescu, DL; Davis, MS; Hall, EA; Sauer, HE, 2021)
"Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer."2.58Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable. ( Bhaskar, A; Humble, SR; Jayaweera, A; Varela, N, 2018)
"Chronic pain was assessed 3 to 6 months after breast surgery in 51 patients of the lidocaine group and 46 patients of the control group."2.55Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials. ( Chang, YC; Chen, MJ; Cheng, SP; Liu, CL; Liu, TP; Yang, PS, 2017)
"Management of persistent idiopathic facial pain (PIFP) can be challenging."1.91Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain. ( Akçaboy, EY; Çelik, Ş; Göksu, H; Kaya, SS; Şahin, Ş; Yıldız, G, 2023)
"It has played a role in chronic pain management in recent decades, and continues to be a useful tool for pain specialists."1.72Use of intravenous lignocaine in the perioperative and chronic pain setting. ( Crabtree, S, 2022)
"The chronic cervical facet joint pain was diagnosed with cervical facet joint nerve blocks at a prevalence of 49."1.56Assessment of Prevalence of Cervical Facet Joint Pain with Diagnostic Cervical Medial Branch Blocks: Analysis Based on Chronic Pain Model. ( Cash, KA; Hirsch, JA; Kaye, AD; Kosanovic, R; Manchikanti, L; Pampati, V; Soin, A, 2020)
"In patients with focal nerve injury and neuropathic pain cutting the nerve to obtain permanent pain reduction can be considered."1.48Predictive value of a diagnostic block in focal nerve injury with neuropathic pain when surgery is considered. ( Dahan, A; de Boer, R; Eekhof, JLA; Kliot, M; Malessy, MJA; Muñoz Romero, I; Pondaag, W; van Zwet, EW, 2018)
"Patients with neuropathic pain are highly motivated for pain relief, and as motivational factors such as expectations of reward, as well as pain processing in itself, are related to the dopaminergic system, it can be speculated that dopamine release contributes to placebo effects in neuropathic pain."1.48Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain. ( Baastrup, C; Benedetti, F; Grosen, K; Hall, KT; Jensen, TS; Kaptchuk, TJ; Moslemi, K; Petersen, GL; Price, DD; Skyt, I; Svensson, P; Vase, L, 2018)
"In contrast, CRF i."1.48Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. ( Chen, W; Marvizón, JC; Taché, Y, 2018)
"Myocardial infarction is the leading cause of death worldwide."1.46Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. ( Chang, YT; Chen, CC; Chen, WH; Chen, YH; Cheng, YF; Shih, HC; Shyu, BC, 2017)

Research

Studies (73)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.37)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's54 (73.97)24.3611
2020's18 (24.66)2.80

Authors

AuthorsStudies
Voute, M1
Morel, V1
Pickering, G1
Wren, KR1
Camarena-Delgado, C1
Llorca-Torralba, M1
Suárez-Pereira, I1
Bravo, L1
López-Martín, C1
Garcia-Partida, JA1
Mico, JA1
Berrocoso, E1
Crabtree, S1
Leitch, J1
Webb, A1
Pudwell, J1
Chamberlain, S1
Henry, R1
Nitsch, R1
Fornasari, D1
Magni, A1
Pais, P1
Palao, T1
Polati, E1
Sansone, P1
Lu, Y1
Ding, H1
Shao, C1
Wang, N1
Shi, J1
Lian, C1
Wu, J1
Shangguan, W1
Lee, JH2
Koutalianos, EP1
Leimer, EM1
Bhullar, RK1
Argoff, CE1
Kaya, SS3
Çelik, Ş3
Akçaboy, EY3
Göksu, H3
Yıldız, G3
Şahin, Ş3
Jin, L1
Liang, Y1
Yu, Y1
Miao, P1
Huang, Y1
Xu, L1
Wang, H1
Wang, C1
Huang, J1
Guo, K1
Striebel, J1
Ruppen, W1
Schneider, T1
Hui, J1
Seko, K1
Shrikhande, G1
Ahmed, T1
Hill, C1
Reutter, C1
Shrikhande, A1
Santana, JA1
Klass, S1
Felix, ER1
Manchikanti, L3
Kosanovic, R1
Cash, KA3
Pampati, V3
Soin, A1
Kaye, AD1
Hirsch, JA1
Maloney, J1
Pew, S1
Wie, C1
Gupta, R1
Freeman, J1
Strand, N1
Li, T1
Feng, XY1
Feng, XM1
Lv, JW1
Lv, TT1
Wang, SY1
Hall, EA1
Sauer, HE1
Davis, MS1
Anghelescu, DL1
Boelens, OB1
Maatman, RC1
Scheltinga, MR2
van Laarhoven, K1
Roumen, RM2
Kendall, MC2
McCarthy, RJ1
Panaro, S1
Goodwin, E1
Bialek, JM1
Nader, A1
De Oliveira, GS1
Herndon, CL1
Horodyski, M1
Vincent, HK1
Iacob, E1
Hagn, EE1
Sindt, J1
Brogan, S1
Tadler, SC1
Kennington, KS1
Hare, BD1
Bokat, CE1
Donaldson, GW1
Okifuji, A1
Junkins, SR1
Cheng, YF1
Chang, YT1
Chen, WH1
Shih, HC1
Chen, YH1
Shyu, BC1
Chen, CC1
Skyt, I1
Moslemi, K1
Baastrup, C1
Grosen, K1
Benedetti, F1
Petersen, GL1
Price, DD1
Hall, KT1
Kaptchuk, TJ1
Svensson, P1
Jensen, TS1
Vase, L1
Kopach, O1
Zheng, K1
Dong, L1
Sapelkin, A1
Voitenko, N1
Sukhorukov, GB1
Rusakov, DA1
E Silva, LOJ1
Scherber, K1
Cabrera, D1
Motov, S1
Erwin, PJ1
West, CP1
Murad, MH1
Bellolio, MF1
Poli-Neto, OB2
Campos Martins Chamochumbi, C1
Toscano, P1
Pitanguy Julio, M1
Marques, W1
Rosa-E-Silva, JC2
Candido-Dos-Reis, FJ2
Nogueira, AA2
Soto, G1
Naranjo González, M1
Calero, F1
Humble, SR1
Varela, N1
Jayaweera, A1
Bhaskar, A1
Lam, K1
Vasey, C1
Ji, NN1
Kang, J1
Hua, R1
Zhang, YM1
Bicket, MC1
Cohen, SP1
Chen, W1
Taché, Y1
Marvizón, JC1
Kaluza, L1
Meents, JE1
Hampl, M1
Rösseler, C1
Hautvast, PAI1
Detro-Dassen, S1
Hausmann, R1
Schmalzing, G1
Lampert, A1
Malessy, MJA1
de Boer, R1
Muñoz Romero, I1
Eekhof, JLA1
van Zwet, EW1
Kliot, M1
Dahan, A2
Pondaag, W1
Nissen, MJ1
Brulhart, L1
Faundez, A1
Finckh, A1
Courvoisier, DS1
Genevay, S1
Sun, X1
Liu, S1
Liu, C1
Xu, J1
Sun, J1
Pan, Y1
Bailey, M1
Conger, A1
McCormick, ZL1
Henrie, AM1
Huang, R1
Jiang, L1
Cao, Y1
Liu, H1
Ping, M1
Li, W1
Xu, Y1
Ning, J1
Chen, Y1
Wang, X1
Moulin, DE1
Morley-Forster, PK1
Pirani, Z1
Rohfritsch, C1
Stitt, L1
Lee, JJ1
Nguyen, ET1
Harrison, JR1
Gribbin, CK1
Hurwitz, NR1
Cheng, J1
Boachie-Adjei, K1
Bogner, EA1
Moley, PJ1
Wyss, JF1
Lutz, GE1
Hermanns, H1
Hollmann, MW1
Stevens, MF1
Lirk, P1
Brandenburger, T1
Piegeler, T1
Werdehausen, R1
Sinha, P1
Sarkar, B1
Goswami, S1
Ray Karmakar, P1
Dasgupta, SR1
Basu, S1
Martini, CH1
Yassen, A1
Krebs-Brown, A1
Passier, P1
Stoker, M1
Olofsen, E1
Kim, SH1
Kim, DH1
Yoon, DM1
Yoon, KB1
Mooney, JJ1
Pagel, PS1
Kundu, A1
Stanos, SP1
Galluzzi, KE1
Effendy, I1
Gelber, A1
Lehmann, P1
Huledal, G1
Lillieborg, S1
Corsini-Munt, S1
Bergeron, S1
Rosen, NO1
Steben, M1
Mayrand, MH1
Delisle, I1
McDuff, P1
Aerts, L1
Santerre-Baillargeon, M1
Siawash, M1
de Jager-Kievit, JW1
Ten, WT1
Peirs, C1
Seal, RP1
Geurts, JW1
Kallewaard, JW1
Kessels, A1
Willems, PC1
van Santbrink, H1
Dirksen, C1
van Kleef, M1
Montenegro, ML1
Braz, CA1
van der Wal, SE1
van den Heuvel, SA1
Radema, SA1
van Berkum, BF1
Vaneker, M1
Steegers, MA1
Scheffer, GJ1
Vissers, KC1
Imamura, M1
Imamura, ST1
Targino, RA1
Morales-Quezada, L1
Onoda Tomikawa, LC1
Onoda Tomikawa, LG1
Alfieri, FM1
Filippo, TR1
da Rocha, ID1
Neto, RB1
Fregni, F1
Battistella, LR1
Chang, YC1
Liu, CL1
Liu, TP1
Yang, PS1
Chen, MJ1
Cheng, SP1
Takimoto, K1
Nishijima, K1
Ono, M1
Holanda, VM1
Chavantes, MC1
Silva, DF1
de Holanda, CV1
de Oliveira, JO1
Wu, X1
Anders, JJ1
Eker, HE1
Cok, OY1
Aribogan, A1
Arslan, G1
Choi, KW1
Nam, KH1
Lee, JR1
Chung, WY1
Kang, SW1
Joe, YE1
Ferrara, PE1
Ronconi, G1
Viscito, R1
Pascuzzo, R1
Rosulescu, E1
Ljoka, C1
Maggi, L1
Ferriero, G1
Foti, C1
Kim, MH1
Lee, KY1
Park, S1
Kim, SI1
Park, HS1
Yoo, YC1
Furuta, A1
Suzuki, Y1
Honda, M1
Koike, Y1
Naruoka, T1
Asano, K1
Chancellor, M1
Egawa, S1
Yoshimura, N1
Abbasi, A1
Roque-Dang, CM1
Malhotra, G1
Überall, MA1
Müller-Schwefe, GH1
Hashmi, JA1
Baliki, MN1
Huang, L1
Parks, EL1
Chanda, ML1
Schnitzer, T1
Apkarian, AV1
Gofeld, M1
Restrepo-Garces, CE1
Theodore, BR1
Faclier, G1
Wargo, BW1
Malla, Y1
López Ramírez, E1
Singh, V1
Falco, FJ1
Brenneis, C1
Kistner, K1
Puopolo, M1
Segal, D1
Roberson, D1
Sisignano, M1
Labocha, S1
Ferreirós, N1
Strominger, A1
Cobos, EJ1
Ghasemlou, N1
Geisslinger, G1
Reeh, PW1
Bean, BP1
Woolf, CJ1
RIDING, JE1

Clinical Trials (19)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Control Trial of Magnesium-Based Trigger Point Injections vs. Lidocaine-Only Trigger Point Injections for Relief of Chronic Myofascial Pelvic Pain[NCT02728037]Phase 338 participants (Actual)Interventional2016-04-30Terminated (stopped due to Low Enrollment, Adoption of investigational treatment into standard practice at our center.)
Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome[NCT03671993]50 participants (Actual)Interventional2018-10-05Completed
Lidocaine Infusion for Postthoracotomy Pain Syndrome, A Prospective, Randomized, Double-blind, Placebo-controlled Trial (LIPPS Trial)[NCT03666299]72 participants (Anticipated)Interventional2018-11-06Recruiting
Randomized Trial Evaluating Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis - RELIEF-SCC[NCT04614610]Phase 2100 participants (Anticipated)Interventional2024-01-01Not yet recruiting
The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial[NCT04524130]Phase 487 participants (Anticipated)Interventional2021-04-01Active, not recruiting
Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and Hip Osteoarthritis[NCT05490355]80 participants (Anticipated)Interventional2022-12-20Recruiting
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin[NCT01669967]34 participants (Actual)Interventional2011-09-30Completed
Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880]Phase 2/Phase 366 participants (Anticipated)Interventional2021-06-17Recruiting
Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417]Phase 2/Phase 350 participants (Actual)Interventional2017-05-01Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment)
A Comparison of Cognitive-behavioral Couple Therapy and Lidocaine in the Treatment of Provoked Vestibulodynia: A Randomized Clinical Trial[NCT01935063]108 participants (Actual)Interventional2014-03-06Completed
Local Injection of Lidocaine Versus Ischemic Compression in Treatment of Woman With Chronic Pelvic Pain Caused by Abdominal Myofascial Pain Syndrome: Randomized Clinical Trial.[NCT00628355]Phase 430 participants (Actual)Interventional2008-02-29Terminated (stopped due to Lidocaine injection group showed significant improvement in pain)
Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized[NCT03382925]Phase 416 participants (Actual)Interventional2017-12-20Terminated (stopped due to Not enough cervical interlaminar patients who meet criteria in order to meet recruitment goals.)
Study on the Effects of Paraspinal Lidocaine Injection on Nonspecific Low Back Pain[NCT02387567]Phase 3378 participants (Actual)Interventional2007-01-31Completed
Corticosteriods vs. Saline vs. Air Placebo Intra-articular Injections for Knee Osteoarthritis: A Single Blinded Prospective Randomized Trial[NCT02995083]Early Phase 10 participants (Actual)Interventional2017-06-30Withdrawn (stopped due to Study deemed not feasible)
Minimally Invasive Knee Osteoarthritis Pain Control Via Adductor Canal Block Versus Intra-articular Steroid and Lignocaine Injection : a Single-blinded Controlled Trial[NCT04264481]64 participants (Actual)Interventional2019-07-12Completed
[NCT01907997]90 participants (Actual)Interventional2013-07-31Completed
Mind-body Treatments for Chronic Back Pain[NCT03294148]151 participants (Actual)Interventional2017-08-07Completed
Randomized, Placebo-controlled Crossover Trial Evaluating Topical Lidocaine Patch(es) for Mechanical Neck Pain.[NCT04378959]76 participants (Actual)Interventional2021-02-01Completed
Pulsed Radiofrequency of Suprascapular Nerve and Shoulder Joint for Chronic Shoulder Pain: A Randomized Blind Active -Controlled Study[NCT04737993]150 participants (Anticipated)Interventional2020-12-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Response Rate

We analyzed the clinical response rate considering significative reduction of 50% of visual analogue scale or significative subjective improvement. (NCT00628355)
Timeframe: immediately, 1, 3 months after treatment

,
Interventionpercentage of participants (Number)
immediately after treatment1 month after treatment3 months after treatment
Anesthesia Injection45.360.269.9
TENS Plus Ischemic Compression17.58.87.0

Intensity of Pain

"The pain will measured by using the visual analogue scale, that is represented by a straight line of 100mm starting at absence of pain and ending at point worst pain experienced or imagined." (NCT00628355)
Timeframe: immediately, 1, 3 months after treatment

,
Interventionmillimeters (Mean)
immediately after treatment1 month after treatment3 months after treatment
Anesthesia Injection33.727.120.8
Ischemic Compression52.753.050.8

Brief Pain Inventory-Short Form (BPI-SF)

1-week average pain intensity, 0 - 10 numerical rating scale, where a higher score indicates more pain. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionunits on a scale (Mean)
Pain Reprocessing Therapy (PRT)1.18
Placebo2.84
Usual Care3.13

Negative Affect Scale Short Form (PANAS-SF)

Questionnaire to rate negative affect, scores range from 5 - 25, with a higher score meaning a stronger negative affect (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)8.30
Placebo7.70
Usual Care8.19

Oswestry Disability Index

Back pain disability questionnaire measured on a scale of 0-100. A higher score indicates a higher severity of disability. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)10.14
Placebo19.00
Usual Care20.68

Pain Catastrophizing Questionnaire (PCS)

Questionnaire used to help quantify an individual's pain experience. Measured 0-52. A higher score means a higher level of catastrophizing. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)8.30
Placebo7.70
Usual Care8.19

Patient Global Impression of Change (PGIC)

Post-treatment-only outcome measure depicting a patient's subjective rating of overall improvement. Score ranges from 1-7 with a higher score indicating a higher level of change and improvement (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)6.14
Placebo3.61
Usual Care2.06

Positive Affect Scale Short Form (PANAS-SF)

Questionnaire to rate positive affect, scores range from 5 - 25, a higher score means stronger affect (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)17.89
Placebo15.20
Usual Care14.98

PROMIS Anger

Questionnaire measuring anger (5 items) with a score range of 5-25. Higher scores indicate a higher severity of anger. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)9.52
Placebo9.89
Usual Care10.45

PROMIS Anxiety

Questionnaire measuring anxiety (8 items). Scores range from 8-40 with a higher score meaning more severe levels of fear, anxious misery, hyperarousal, and somatic symptoms related to arousal. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)15.02
Placebo13.89
Usual Care14.11

PROMIS Sleep

Questionnaire measuring sleep disturbance (8 items). Scores range from 8-40. Higher scores indicate higher levels of sleep disturbance (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)17.73
Placebo20.50
Usual Care20.89

PROMIS- Depression

Questionnaire measuring depression (8 items). Scores range from 8-32. A higher score indicates higher levels of depressive symptoms (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)12.23
Placebo11.75
Usual Care11.81

Tampa Scale of Kinesiophobia (TSK)

Questionnaire used to assess the subjective rating of kinesiophobia or fear of movement. Scores range from 11-44 with higher scores indicating greater fear of pain, movement, and injury. (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)16.41
Placebo22.16
Usual Care22.51

Timeline Follow-Back Measure for Alcohol (TLFB)

Questionnaire used to assess daily drinking (number of drinks consumed over past two weeks) (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

InterventionDrinks (Mean)
Pain Reprocessing Therapy (PRT)11.63
Placebo12.88
Usual Care8.02

Timeline Follow-Back Measure for Cannabis (TLFB)

Questionnaire used to assess daily cannabis use (number of grams consumed over past two weeks) (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

InterventionGrams of cannabis (Mean)
Pain Reprocessing Therapy (PRT)6.76
Placebo3.31
Usual Care1.49

Timeline Follow-Back Measure for Opioid Use (TLFB)

Questionnaire used to assess daily opioid use (number of pills consumed over past two weeks) (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

InterventionOpioid pills (Mean)
Pain Reprocessing Therapy (PRT)1.29
Placebo0.36
Usual Care1.77

Treatment Satisfaction Questionnaire

Post-treatment-only outcome measure depicting the patient's satisfaction with the treatment. Measured 0 - 100. A higher score means higher satisfaction with treatment/ (NCT03294148)
Timeframe: At post-treatment fMRI session, approximately 1 month after randomization

Interventionscore on a scale (Mean)
Pain Reprocessing Therapy (PRT)92.40
Placebo57.61
Usual Care36.86

Reviews

15 reviews available for lidocaine and Pain, Chronic

ArticleYear
Topical Lidocaine for Chronic Pain Treatment.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Chronic Pain; Drug Therapy, Combination; Hu

2021
Changing the paradigm in postherpetic neuralgia treatment: lidocaine 700 mg medicated plaster.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:10

    Topics: Anesthetics, Local; Chronic Pain; Humans; Lidocaine; Neuralgia, Postherpetic; Quality of Life

2022
Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review.
    The Clinical journal of pain, 2022, 12-01, Volume: 38, Issue:12

    Topics: Adult; Chronic Pain; Diabetic Neuropathies; Humans; Lidocaine; Neuralgia; Peripheral Nerve Injuries;

2022
The Efficacy, Effectiveness and Safety of 5% Transdermal Lidocaine Patch for Chronic Low Back Pain: A Narrative Review.
    PM & R : the journal of injury, function, and rehabilitation, 2020, Volume: 12, Issue:12

    Topics: Anesthetics, Local; Chronic Pain; Humans; Lidocaine; Low Back Pain; Randomized Controlled Trials as

2020
Comprehensive Review of Topical Analgesics for Chronic Pain.
    Current pain and headache reports, 2021, Feb-03, Volume: 25, Issue:2

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; An

2021
Lidocaine Infusions for Pain Management in Pediatrics.
    Paediatric drugs, 2021, Volume: 23, Issue:4

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Child; Chronic Pain; Female; Humans; Infusions, I

2021
Safety and Efficacy of Intravenous Lidocaine for Pain Management in the Emergency Department: A Systematic Review.
    Annals of emergency medicine, 2018, Volume: 72, Issue:2

    Topics: Acute Pain; Administration, Intravenous; Anesthetics, Local; Chronic Pain; Emergency Service, Hospit

2018
Intravenous lidocaine infusion.
    Revista espanola de anestesiologia y reanimacion, 2018, Volume: 65, Issue:5

    Topics: Anesthesia; Anesthetics, Local; Chronic Pain; Humans; Infusions, Intravenous; Lidocaine; Neoplasm Re

2018
Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable.
    Current opinion in supportive and palliative care, 2018, Volume: 12, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Chronic Pain; Drug Therapy, Combination; Gabapentin; Ge

2018
Comparative Efficacy of Therapeutics for Chronic Cancer Pain: A Bayesian Network Meta-Analysis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019, 07-10, Volume: 37, Issue:20

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bayes Theorem; Bridged Bicyclo Compou

2019
Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review.
    British journal of anaesthesia, 2019, Volume: 123, Issue:3

    Topics: Acute Pain; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; H

2019
Topical therapies in the management of chronic pain.
    Postgraduate medicine, 2013, Volume: 125, Issue:4 Suppl 1

    Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C

2013
The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain.
    European journal of pain (London, England), 2016, Volume: 20, Issue:5

    Topics: Acute Pain; Administration, Intravenous; Anesthetics, Local; Animals; Calcium Channels; Chronic Pain

2016
Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials.
    Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:3

    Topics: Acute Pain; Analgesics; Chronic Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Mastectomy;

2017
Persistent hiccups after interventional pain procedures: a case series and review.
    PM & R : the journal of injury, function, and rehabilitation, 2012, Volume: 4, Issue:2

    Topics: Adult; Back Pain; Betamethasone; Chronic Pain; Dexamethasone; Hiccup; Humans; Injections, Spinal; Li

2012

Trials

23 trials available for lidocaine and Pain, Chronic

ArticleYear
Magnesium-Based Trigger Point Infiltrations Versus Local Anaesthetic Infiltrations in Chronic Pelvic Myofascial Pain: A Randomized, Double-Blind, Controlled Study.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2022, Volume: 44, Issue:8

    Topics: Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magnesium; Myofasc

2022
Effect of lidocaine perioperative infusion on chronic postsurgical pain in patients undergoing thoracoscopic radical pneumonectomy.
    BMC anesthesiology, 2022, 08-09, Volume: 22, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Local; Chronic Pain; Double-Blind Method; Humans; Lidocaine; Pain,

2022
Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study.
    Drug design, development and therapy, 2023, Volume: 17

    Topics: Acetaminophen; Analgesia; Cardiac Surgical Procedures; Chronic Pain; Dexmedetomidine; Gabapentin; Hu

2023
The short-term efficacy of electrical pudendal nerve stimulation versus intravesical instillation for the urethral pain syndrome: a randomized clinical trial.
    World journal of urology, 2021, Volume: 39, Issue:10

    Topics: Administration, Intravesical; Anesthetics, Local; Chronic Pain; Electric Stimulation Therapy; Female

2021
The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Cont
    Pain practice : the official journal of World Institute of Pain, 2018, Volume: 18, Issue:3

    Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Local; Breast Neoplasms; Chroni

2018
Acute effects of anesthetic lumbar spine injections on temporal spatial parameters of gait in individuals with chronic low back pain: A pilot study.
    Gait & posture, 2017, Volume: 58

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Local; Chronic Pain; Female; Fluo

2017
Electromyographic characterisation of abdominal wall trigger points developed after caesarean section and response to local anaesthesia: an observational study.
    BJOG : an international journal of obstetrics and gynaecology, 2018, Volume: 125, Issue:10

    Topics: Abdominal Wall; Adult; Anesthesia, Local; Anesthetics, Local; Brazil; Cesarean Section; Chronic Pain

2018
Glucocorticoid injections for greater trochanteric pain syndrome: a randomised double-blind placebo-controlled (GLUTEAL) trial.
    Clinical rheumatology, 2019, Volume: 38, Issue:3

    Topics: Adult; Aged; Anesthetics, Local; Betamethasone; Chronic Pain; Double-Blind Method; Female; Femur; Gl

2019
Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2019, Volume: 66, Issue:7

    Topics: Aged; Anesthetics, Local; Chronic Pain; Cross-Over Studies; Diabetic Neuropathies; Diphenhydramine;

2019
Effectiveness of Combination of Ultrasonography-Guided Pulsed Radiofrequency Neuromodulation With Steroid at the Suprascapular Nerve in Chronic Shoulder Pain.
    Pain practice : the official journal of World Institute of Pain, 2020, Volume: 20, Issue:1

    Topics: Adult; Anesthetics, Local; Chronic Pain; Female; Humans; Injections, Intra-Articular; Lidocaine; Mal

2020
A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia.
    European journal of pain (London, England), 2013, Volume: 17, Issue:10

    Topics: Aged; Aged, 80 and over; Capsaicin; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Ma

2013
A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial.
    Trials, 2014, Dec-23, Volume: 15

    Topics: Administration, Intravaginal; Adolescent; Adult; Anesthetics, Local; Chronic Pain; Clinical Protocol

2014
Efficacy and cost-effectiveness of intradiscal methylene blue injection for chronic discogenic low back pain: study protocol for a randomized controlled trial.
    Trials, 2015, Nov-21, Volume: 16

    Topics: Analgesics; Anesthetics, Local; Chronic Pain; Clinical Protocols; Cost-Benefit Analysis; Disability

2015
Anaesthetic injection versus ischemic compression for the pain relief of abdominal wall trigger points in women with chronic pelvic pain.
    BMC anesthesiology, 2015, Dec-01, Volume: 15

    Topics: Abdominal Wall; Adult; Anesthetics, Local; Chronic Pain; Female; Humans; Lidocaine; Pain Threshold;

2015
Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial.
    The journal of pain, 2016, Volume: 17, Issue:5

    Topics: Adult; Analysis of Variance; Anesthetics, Local; Chronic Pain; Disability Evaluation; Exercise Thera

2016
Photobiomodulation of the dorsal root ganglion for the treatment of low back pain: A pilot study.
    Lasers in surgery and medicine, 2016, Volume: 48, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Pain; Female; Follow-Up Studies; Ganglia

2016
The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study.
    Anaesthesia, critical care & pain medicine, 2017, Volume: 36, Issue:2

    Topics: Aged; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Injections, Intra-Artic

2017
The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study.
    Anaesthesia, critical care & pain medicine, 2017, Volume: 36, Issue:2

    Topics: Aged; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Injections, Intra-Artic

2017
The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study.
    Anaesthesia, critical care & pain medicine, 2017, Volume: 36, Issue:2

    Topics: Aged; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Injections, Intra-Artic

2017
The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study.
    Anaesthesia, critical care & pain medicine, 2017, Volume: 36, Issue:2

    Topics: Aged; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Injections, Intra-Artic

2017
The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double-Blinded, Controlled Study.
    World journal of surgery, 2017, Volume: 41, Issue:5

    Topics: Adult; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Infusions, Intravenous

2017
Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Adult; Breast Neoplasms; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magnesium; Mi

2017
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study.
    Molecular pain, 2012, Apr-24, Volume: 8

    Topics: Back Pain; Brain; Brain Mapping; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magne

2012
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study.
    Molecular pain, 2012, Apr-24, Volume: 8

    Topics: Back Pain; Brain; Brain Mapping; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magne

2012
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study.
    Molecular pain, 2012, Apr-24, Volume: 8

    Topics: Back Pain; Brain; Brain Mapping; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magne

2012
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study.
    Molecular pain, 2012, Apr-24, Volume: 8

    Topics: Back Pain; Brain; Brain Mapping; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Magne

2012
Pulsed radiofrequency of suprascapular nerve for chronic shoulder pain: a randomized double-blind active placebo-controlled study.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:2

    Topics: Aged; Anesthetics, Local; Chronic Pain; Double-Blind Method; Female; Humans; Lidocaine; Male; Nerve

2013
Management of chronic pain of cervical disc herniation and radiculitis with fluoroscopic cervical interlaminar epidural injections.
    International journal of medical sciences, 2012, Volume: 9, Issue:6

    Topics: Adult; Anesthetics, Local; Betamethasone; Cervical Vertebrae; Chronic Pain; Double-Blind Method; Fem

2012
The role of fluoroscopic interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind trial.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:7

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Betamethasone; Chronic Pain; Double-Blind Metho

2013

Other Studies

35 other studies available for lidocaine and Pain, Chronic

ArticleYear
Nursing Care During Lidocaine Infusion Therapy for Chronic Pain.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2022, Volume: 37, Issue:2

    Topics: Anesthetics, Local; Chronic Pain; Humans; Infusions, Intravenous; Lidocaine; Neuralgia; Pain Measure

2022
Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus-dorsal reticular nucleus pathway.
    Pain, 2022, 05-01, Volume: 163, Issue:5

    Topics: Animals; Chronic Pain; Hyperalgesia; Lidocaine; Locus Coeruleus; Male; Neuralgia; Rats; Rats, Spragu

2022
Use of intravenous lignocaine in the perioperative and chronic pain setting.
    British journal of hospital medicine (London, England : 2005), 2022, Feb-02, Volume: 83, Issue:2

    Topics: Administration, Intravenous; Anesthetics, Local; Chronic Pain; Humans; Infusions, Intravenous; Lidoc

2022
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Effect of neuropathic pain on sphenopalatine ganglion block responses in persistent idiopathic facial pain.
    Neurological research, 2023, Volume: 45, Issue:5

    Topics: Adult; Chronic Pain; Facial Pain; Humans; Lidocaine; Middle Aged; Neuralgia; Sphenopalatine Ganglion

2023
Simultaneous application of lidocaine and ketamine during ambulatory infusion therapy: a retrospective analysis.
    Pain management, 2023, Volume: 13, Issue:9

    Topics: Chronic Pain; Humans; Infusions, Intravenous; Ketamine; Lidocaine; Retrospective Studies; Treatment

2023
A novel, nonopiod-based treatment approach to men with urologic chronic pelvic pain syndrome using ultrasound-guided nerve hydrodissection and pelvic floor musculature trigger point injections.
    Neurourology and urodynamics, 2020, Volume: 39, Issue:2

    Topics: Adult; Chronic Pain; Female; Humans; Lidocaine; Male; Middle Aged; Pain Measurement; Pelvic Floor; P

2020
Assessment of Prevalence of Cervical Facet Joint Pain with Diagnostic Cervical Medial Branch Blocks: Analysis Based on Chronic Pain Model.
    Pain physician, 2020, Volume: 23, Issue:6

    Topics: Adult; Anesthetics, Local; Arthralgia; Bupivacaine; Chronic Pain; Female; Humans; Lidocaine; Male; M

2020
Chronic Localized Back Pain Due to Posterior Cutaneous Nerve Entrapment Syndrome (POCNES): A New Diagnosis.
    Pain physician, 2017, Volume: 20, Issue:3

    Topics: Adult; Back Pain; Chronic Pain; Female; Humans; Intercostal Nerves; Lidocaine; Nerve Compression Syn

2017
Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain.
    Pain medicine (Malden, Mass.), 2018, 06-01, Volume: 19, Issue:6

    Topics: Adult; Aged; Anesthetics, Local; Chronic Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Ma

2018
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus.
    Nature communications, 2017, 10-10, Volume: 8, Issue:1

    Topics: Animals; Butadienes; Chronic Pain; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; H

2017
Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain.
    Pain, 2018, Volume: 159, Issue:2

    Topics: Adult; Aged; Anesthetics, Local; Carbidopa; Chronic Pain; Dopamine; Dopamine Agents; Drug Combinatio

2018
Nano-engineered microcapsules boost the treatment of persistent pain.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Chronic Pain; Drug Delivery Systems;

2018
Diagnostic dilemma: think about anterior cutaneous nerve entrapment syndrome (ACNES) in patients with atypical abdominal pain and Crohn's disease.
    BMJ case reports, 2018, Mar-28, Volume: 2018

    Topics: Abdomen; Abdominal Pain; Amides; Anesthetics, Local; Chronic Pain; Crohn Disease; Diagnosis, Differe

2018
Involvement of dopamine system in the regulation of the brain corticotropin-releasing hormone in paraventricular nucleus in a rat model of chronic visceral pain.
    Neurological research, 2018, Volume: 40, Issue:8

    Topics: Animals; Animals, Newborn; Central Nervous System Agents; Chronic Pain; Corticotropin-Releasing Horm

2018
Lidocaine infusions and preventative analgesia: can the answer to our prayers be hiding right under our noses?
    Pain, 2018, Volume: 159, Issue:9

    Topics: Analgesia; Chronic Pain; Humans; Lidocaine; Pain Management

2018
Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain.
    Neuroscience, 2018, 06-15, Volume: 381

    Topics: Analgesics, Opioid; Animals; Brain; Central Nervous System Sensitization; Chronic Pain; Corticotropi

2018
Loss-of-function of Nav1.8/D1639N linked to human pain can be rescued by lidocaine.
    Pflugers Archiv : European journal of physiology, 2018, Volume: 470, Issue:12

    Topics: Action Potentials; Anesthetics, Local; Animals; Cell Line, Tumor; Cell Membrane; Chronic Pain; Human

2018
Predictive value of a diagnostic block in focal nerve injury with neuropathic pain when surgery is considered.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Adolescent; Adult; Aged; Algorithms; Anesthetics, Local; Chronic Pain; Female; Humans; Lidocaine; Ma

2018
An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report.
    Medicine, 2019, Volume: 98, Issue:6

    Topics: Adrenal Cortex Hormones; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Chronic Pain;

2019
Efficacy of systemic lidocaine to reduce chronic postsurgical pain: case not yet closed….
    Pain, 2019, Volume: 160, Issue:3

    Topics: Anesthetics, Local; Chronic Pain; Humans; Lidocaine

2019
Reply.
    Pain, 2019, Volume: 160, Issue:3

    Topics: Chronic Pain; Humans; Lidocaine

2019
Pes Anserine Tendon Injury Resulting from Cooled Radiofrequency Ablation of the Inferior Medial Genicular Nerve.
    PM & R : the journal of injury, function, and rehabilitation, 2019, Volume: 11, Issue:11

    Topics: Aged; Anesthetics, Local; Catheter Ablation; Chronic Pain; Combined Modality Therapy; Female; Follow

2019
Fluoroscopically guided caudal epidural steroid injections for axial low back pain associated with central disc protrusions: a prospective outcome study.
    International orthopaedics, 2019, Volume: 43, Issue:8

    Topics: Adult; Anesthetics, Local; Chronic Pain; Female; Fluoroscopy; Glucocorticoids; Humans; Injections, E

2019
Clinical effectiveness of the obturator externus muscle injection in chronic pelvic pain patients.
    Pain practice : the official journal of World Institute of Pain, 2015, Volume: 15, Issue:1

    Topics: Adult; Aged; Anesthetics, Local; Chronic Pain; Contrast Media; Female; Fluoroscopy; Humans; Injectio

2015
Safety, tolerability, and short-term efficacy of intravenous lidocaine infusions for the treatment of chronic pain in adolescents and young adults: a preliminary report.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:5

    Topics: Adolescent; Anesthetics, Local; Back Pain; Chest Pain; Child; Chronic Pain; Female; Headache; Humans

2014
Plasma concentrations and analgesic efficacy of lidocaine and prilocaine in leg ulcer-related pain during daily application of lidocaine-prilocaine cream (EMLA™) for 10 days.
    The British journal of dermatology, 2015, Volume: 173, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Chronic Pain; Drug Admini

2015
Prevalence of Anterior Cutaneous Nerve Entrapment Syndrome in a Pediatric Population With Chronic Abdominal Pain.
    Journal of pediatric gastroenterology and nutrition, 2016, Volume: 62, Issue:3

    Topics: Abdominal Pain; Adolescent; Child; Chronic Pain; Cohort Studies; Cross-Sectional Studies; Female; Gl

2016
Targeting Toll-like receptors to treat chronic pain.
    Nature medicine, 2015, Volume: 21, Issue:11

    Topics: Anesthetics, Local; Animals; Chronic Pain; Flagellin; Humans; Hyperalgesia; Lidocaine; Mice; Nerve F

2015
Serratus Plane Block for Persistent Pain after Partial Mastectomy and Axillary Node Dissection.
    Pain physician, 2016, Volume: 19, Issue:3

    Topics: Aged; Anesthetics, Local; Axilla; Chronic Pain; Female; Humans; Lidocaine; Lymph Node Excision; Mast

2016
Efficacy of mesotherapy using drugs versus normal saline solution in chronic spinal pain: a retrospective study.
    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 2017, Volume: 40, Issue:2

    Topics: Analgesics; Anesthetics, Local; Aspirin; Back Pain; Chronic Pain; Female; Follow-Up Studies; Humans;

2017
Time-dependent changes in bladder function and plantar sensitivity in a rat model of fibromyalgia syndrome induced by hydrochloric acid injection into the gluteus.
    BJU international, 2012, Volume: 109, Issue:2

    Topics: Anesthetics, Local; Animals; Case-Control Studies; Chronic Pain; Disease Models, Animal; Female; Fib

2012
Patient perceptions associated with the 5% lidocaine medicated plaster in daily practice.
    Current medical research and opinion, 2012, Volume: 28, Issue:6

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Anesthetics, Local; Bandages, Hydrocolloid; Chro

2012
Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:5

    Topics: Acute Pain; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Pain; Female; Humans; Lidocaine; Ma

2013
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-02, Volume: 33, Issue:1

    Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Behavior, Animal; Capsaicin; Chronic Pain; Di

2013
LOCAL ANAESTHETICS FOR CHRONIC PAIN.
    The Manchester medical gazette, 1964, Volume: 43

    Topics: Anesthesia, Local; Anesthetics; Anesthetics, Local; Autonomic Nerve Block; Chronic Pain; Geriatrics;

1964