gabapentin has been researched along with Pain, Chronic in 110 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined whether the effect of true electroacupuncture on pain and functionality in chronic pain participants can be differentiated from that of medication (gabapentin) by analyzing quantitative sensory testing (QST)." | 9.41 | Comparison between acupuncture therapy and gabapentin for chronic pain: a pilot study. ( Ahmed, S; Chen, L; Deng, H; Filatava, EJ; Houle, T; Kim, H; Malarick, C; Mao, J; Opalacz, A; Roth, S; Shen, S; Stabach, K; Sullivan, S; Vo, T; You, Z; Zhang, W; Zhang, Y, 2021) |
| "This study was adequately powered, but treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo." | 9.34 | Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020) |
| "Chronic pelvic pain in women may be treated sufficiently with Gabapentin." | 9.30 | Gabapentin for the management of chronic pelvic pain in women. ( AbdelHafeez, MA; El-Zeneiny, H; Elnaggar, A; Mokhles, JM; Reda, A, 2019) |
| "To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women." | 9.30 | The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study. ( Horne, AW; Murnane, J; Murray, SR; Pernet, C; Seretny, M; Whalley, H; Whitaker, L, 2019) |
| " Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions." | 9.27 | GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018) |
| " Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP." | 9.22 | Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022) |
| "Gabapentin is prescribed for analgesia in chronic low back pain, yet there are no controlled trials supporting this practice." | 9.22 | A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. ( Abramson, IS; Atkinson, JH; Capparelli, EV; Funk, SD; Gamst, A; Garfin, SR; Matthews, SC; Patel, SM; Rutledge, TR; Slater, MA; Wallace, MS; Wetherell, JL; Wolfson, T; Zisook, S, 2016) |
| "The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery." | 8.98 | The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis. ( Huang, Q; Jiang, Y; Li, J; Lin, H; Rong, Z; Wang, T; Xiong, J; Zhang, Q; Zhang, S, 2018) |
| " We included studies enrolling adult patients undergoing breast cancer surgery who were randomly assigned to preoperative gabapentin or pregabalin versus placebo or active control and assessed acute (≤24 h) or chronic (≥2 months) pain." | 8.95 | Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials. ( Busse, JW; Choi, S; Clarke, H; Devereaux, PJ; Dhaliwal, J; Khan, JS; Rai, AS, 2017) |
| "To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain and fibromyalgia." | 8.90 | Gabapentin for chronic neuropathic pain and fibromyalgia in adults. ( Derry, S; Moore, RA; Rice, AS; Toelle, T; Wiffen, PJ, 2014) |
| "In summary, cohort Medicare patients with non-cancer pain beginning treatment with duloxetine had rates of AMI, stroke, and out-of-hospital mortality comparable to those who initiated gabapentin." | 8.31 | Duloxetine, Gabapentin, and the Risk for Acute Myocardial Infarction, Stroke, and Out-of-Hospital Death in Medicare Beneficiaries With Non-Cancer Pain. ( Chung, CP; Corriere, MA; Daniel, LL; Dickson, AL; Dupont, WD; Hall, K; Murray, KT; Nepal, P; Plummer, WD; Ray, WA; Stein, CM, 2023) |
| "Gabapentinoid medications are increasingly being used in chronic pain management, yet very little is known about the experiences of those using them." | 8.31 | "We were all looking for the magic pill": A qualitative study of patient experiences using gabapentinoids for chronic pain. ( Ashton-James, CE; McNeilage, AG; Scholz, B, 2023) |
| "Gabapentin can relieve chronic pain and depression-like behavior in rats with chronic pain and depression, and promote neurogenesis of hippocampal dentate gyrus neurons." | 8.12 | Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression. ( Jiang, X; Tan, Y; Yang, L; Zeng, W, 2022) |
| "The authors will collect RCTs related to the use of gabapentin to prevent chronic pain in adults following surgery." | 8.02 | Evaluation on curative effects of gabapentin for the prevention of chronic pain in adults following surgery: A protocol for systematic review and meta-analysis. ( Chen, Y; Zhang, GZ, 2021) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 7.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| "Gabapentin was superior to PGB, with fewer and less severe adverse events." | 6.90 | Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019) |
| "Gabapentinoid use has increased substantially in the past several years after initial promising data with regard to acute perioperative pain control." | 6.61 | The role of gabapentinoids in acute and chronic pain after surgery. ( Habib, AS; Kumar, AH, 2019) |
| "Neuropathic pain is more severe, with significant disability." | 6.53 | Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials. ( AlAmri, R; Bhandari, M; Devereaux, PJ; Gilron, I; Kamath, S; Rajarathinam, M; Shanthanna, H; Thabane, L, 2016) |
| " We are most familiar with the incremental dosing strategy where a ceiling dose is eventually attained guided by efficacy and patient tolerance, after which a fixed dosing regimen is prescribed." | 5.91 | Comparative Descriptive Analysis of Physician Versus Patient-Directed Gabapentin Usage In Chronic Pain - A Preliminary Report. ( Burns, JC; Gill, JS; Madabhushi, SV; Robinson, CL; Ruan, QZ; Simopoulos, TT, 2023) |
| "Gabapentin was used at 8 mg/kg but produced ataxia and anorexia." | 5.62 | Multimodal analgesia in a Southern White Rhinoceros (Ceratotherium simum) with pentosan polysulfate, gabapentin, amantadine and phenylbutazone to manage chronic pain. ( Gardner, BR; Rourke, NL, 2021) |
| "We examined whether the effect of true electroacupuncture on pain and functionality in chronic pain participants can be differentiated from that of medication (gabapentin) by analyzing quantitative sensory testing (QST)." | 5.41 | Comparison between acupuncture therapy and gabapentin for chronic pain: a pilot study. ( Ahmed, S; Chen, L; Deng, H; Filatava, EJ; Houle, T; Kim, H; Malarick, C; Mao, J; Opalacz, A; Roth, S; Shen, S; Stabach, K; Sullivan, S; Vo, T; You, Z; Zhang, W; Zhang, Y, 2021) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 5.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "This study was adequately powered, but treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo." | 5.34 | Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020) |
| "Chronic pelvic pain in women may be treated sufficiently with Gabapentin." | 5.30 | Gabapentin for the management of chronic pelvic pain in women. ( AbdelHafeez, MA; El-Zeneiny, H; Elnaggar, A; Mokhles, JM; Reda, A, 2019) |
| "To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women." | 5.30 | The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study. ( Horne, AW; Murnane, J; Murray, SR; Pernet, C; Seretny, M; Whalley, H; Whitaker, L, 2019) |
| " Recently, preoperative pain facilitation has been associated with chronic pain after TKA, and gabapentin has been shown to decrease pain facilitation." | 5.27 | The influence of pre- and perioperative administration of gabapentin on pain 3-4 years after total knee arthroplasty. ( Arendt-Nielsen, L; Hansen, LT; Husted, H; Kehlet, H; Kjær Petersen, K; Laursen, MB; Lunn, TH; Simonsen, O, 2018) |
| " Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions." | 5.27 | GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018) |
| " Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP." | 5.22 | Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022) |
| "Gabapentin is prescribed for analgesia in chronic low back pain, yet there are no controlled trials supporting this practice." | 5.22 | A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. ( Abramson, IS; Atkinson, JH; Capparelli, EV; Funk, SD; Gamst, A; Garfin, SR; Matthews, SC; Patel, SM; Rutledge, TR; Slater, MA; Wallace, MS; Wetherell, JL; Wolfson, T; Zisook, S, 2016) |
| "The authors examined the safety and efficacy of intrathecal gabapentin in a randomized, blinded, placebo-controlled, multicenter trial in a heterogeneous cohort of candidates with chronic pain for intrathecal drug therapy." | 5.17 | Intrathecal gabapentin to treat chronic intractable noncancer pain. ( Coffey, RJ; Grigsby, EJ; McCarville, SE; Page, LM; Rauck, R; Schultz, DM; Wallace, MS; Webster, LR, 2013) |
| "The purpose of this study was to evaluate the analgesic effects of perioperative gabapentin on postoperative acute and chronic pain after coronary artery bypass graft (CABG) surgery with median sternotomy and internal mammary artery harvesting." | 5.15 | The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. ( Onan, B; Selcuk, I; Sen, H; Turan, A; Ucak, A; Yilmaz, AT, 2011) |
| "Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain." | 5.01 | Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System. ( Hayashida, KI; Obata, H, 2019) |
| "The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery." | 4.98 | The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis. ( Huang, Q; Jiang, Y; Li, J; Lin, H; Rong, Z; Wang, T; Xiong, J; Zhang, Q; Zhang, S, 2018) |
| " We included studies enrolling adult patients undergoing breast cancer surgery who were randomly assigned to preoperative gabapentin or pregabalin versus placebo or active control and assessed acute (≤24 h) or chronic (≥2 months) pain." | 4.95 | Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials. ( Busse, JW; Choi, S; Clarke, H; Devereaux, PJ; Dhaliwal, J; Khan, JS; Rai, AS, 2017) |
| "We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions." | 4.95 | Antiepileptic drugs for chronic non-cancer pain in children and adolescents. ( Clinch, J; Cooper, TE; Heathcote, LC; Howard, R; Krane, E; Lord, SM; Schechter, N; Sethna, N; Wiffen, PJ; Wood, C, 2017) |
| " Most studies used oral gabapentin or gabapentin encarbil at doses of 1200 mg or more daily in different neuropathic pain conditions, predominantly postherpetic neuralgia and painful diabetic neuropathy." | 4.95 | Gabapentin for chronic neuropathic pain in adults. ( Bell, RF; Derry, S; Moore, RA; Phillips, T; Rice, AS; Tölle, TR; Wiffen, PJ, 2017) |
| "To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain and fibromyalgia." | 4.90 | Gabapentin for chronic neuropathic pain and fibromyalgia in adults. ( Derry, S; Moore, RA; Rice, AS; Toelle, T; Wiffen, PJ, 2014) |
| "Gabapentinoid medications are increasingly being used in chronic pain management, yet very little is known about the experiences of those using them." | 4.31 | "We were all looking for the magic pill": A qualitative study of patient experiences using gabapentinoids for chronic pain. ( Ashton-James, CE; McNeilage, AG; Scholz, B, 2023) |
| "In summary, cohort Medicare patients with non-cancer pain beginning treatment with duloxetine had rates of AMI, stroke, and out-of-hospital mortality comparable to those who initiated gabapentin." | 4.31 | Duloxetine, Gabapentin, and the Risk for Acute Myocardial Infarction, Stroke, and Out-of-Hospital Death in Medicare Beneficiaries With Non-Cancer Pain. ( Chung, CP; Corriere, MA; Daniel, LL; Dickson, AL; Dupont, WD; Hall, K; Murray, KT; Nepal, P; Plummer, WD; Ray, WA; Stein, CM, 2023) |
| "Gabapentin can relieve chronic pain and depression-like behavior in rats with chronic pain and depression, and promote neurogenesis of hippocampal dentate gyrus neurons." | 4.12 | Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression. ( Jiang, X; Tan, Y; Yang, L; Zeng, W, 2022) |
| "This study aims to evaluate the anti-nociceptive effects of ECa 233 and its synergistic effect with gabapentin on chronic neuropathic orofacial pain after 3 weeks infraorbital nerve chronic constriction injury in mice." | 4.12 | Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice. ( Buapratoom, A; Khongsombat, O; Tantisira, MH; Wanasuntronwong, A, 2022) |
| "Gabapentin is commonly prescribed for chronic pain, including to patients with HIV (PWH)." | 4.12 | Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV. ( Barry, DT; Becker, WC; Crystal, S; Edelman, EJ; Gordon, KS; Kerns, RD; Li, Y; Marshall, BDL; Oldfield, BJ; Rentsch, CT; Vickers-Smith, R, 2022) |
| ", gabapentin and pregabalin) are medications approved for epilepsy, chronic pain, or generalized anxiety disorder." | 4.12 | Gabapentinoid use in French most precarious populations: Insight from Lyon Permanent Access to Healthcare (PASS) units, 2016-1Q2021. ( Berthier, M; Chappuy, M; Clerc, B; Fahmi, M; Laloi, L; Misslin, P; Nourredine, M; Rolland, B, 2022) |
| "The authors will collect RCTs related to the use of gabapentin to prevent chronic pain in adults following surgery." | 4.02 | Evaluation on curative effects of gabapentin for the prevention of chronic pain in adults following surgery: A protocol for systematic review and meta-analysis. ( Chen, Y; Zhang, GZ, 2021) |
| "Gabapentinoid use for long-term cancer pain control may be problematic, given unclear mechanisms of action and increased concerns for physical dependence." | 3.96 | Use of gabapentinoid medications among US adults with cancer, 2005-2015. ( Choi, SW; Davis, MA; Fauer, AJ; Friese, CR; Wallner, LP, 2020) |
| "Combination therapy with a gabapentinoid and an opioid improves the quality of life (QOL) of patients with chronic pain." | 3.88 | Comparison of the Efficacy of a Gabapentinoid with an Opioid Versus an Opioid Alone in Patients with Spinal Cord Stimulation. ( Choi, RM; Hwang, SM; Jang, JS; Kim, JH; Kim, YS; Kwon, Y; Lee, JJ; Yun, T, 2018) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 3.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| " For immediate pain relief, intranasal fentanyl worked best and gabapentin was successfully used for chronic pain." | 3.83 | Newborn with severe epidermolysis bullosa: to treat or not to treat? ( Boesen, ML; Bygum, A; Hertz, JM; Zachariassen, G, 2016) |
| "Gabapentin has been widely used in human medicine to control acute and chronic pain." | 3.79 | Long-term use of gabapentin for musculoskeletal disease and trauma in three cats. ( Comerford, EJ; Iff, I; Lorenz, ND, 2013) |
| "The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH." | 3.78 | Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012) |
| "Nummular headache is characterized by continuous or intermittent head pain, which remains circumscribed in a round or oval area of the scalp, typically one to six centimeters in diameter." | 3.01 | Epicranial headaches part 2: Nummular headache and epicrania fugax. ( Cuadrado, ML, 2023) |
| "Gabapentin has shown efficacy in the treatment of chronic neuropathic or mixed pain in adults." | 2.90 | Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled t ( Ceci, A; de Leeuw, TG; de Wildt, SN; Kaguelidou, F; Lundin, R; Mangiarini, L; Pasqua, OD; Tibboel, D; van der Zanden, T, 2019) |
| "Gabapentin is currently used 'off-label' in children and adolescents with chronic neuropathic pain, and reliable evidence of its effects and optimal dosing are lacking." | 2.90 | Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol. ( Alberti, C; Bonifazi, D; Ceci, A; de Leeuw, TG; de Wildt, SN; Della Pasqua, O; Felisi, M; Kaguelidou, F; Le Roux, E; Lundin, R; Mangiarini, L; Tibboel, D, 2019) |
| "Gabapentin was superior to PGB, with fewer and less severe adverse events." | 2.90 | Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. ( Downs, E; Marshman, LAG; Plummer, D; Robertson, K, 2019) |
| "Phantom limb pain is a debilitating condition for which no effective treatment has been found." | 2.82 | Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain. ( Burger, H; Caine-Winterberger, K; Eriksson, K; Guðmundsdóttir, RA; Hermansson, L; Kristoffersen, MB; Kulbacka-Ortiz, K; Ortiz-Catalan, M; Pihlar, Z; Ragnö, C; Stockselius, A; Widehammar, C; Zepeda-Echavarria, A, 2016) |
| "The epidemics of chronic pain and opioid misuse have given rise to the widespread use of non-opioid drugs such as the gabapentinoids for treatment." | 2.72 | The gabapentinoid drugs and their abuse potential. ( Alles, SRA; Goins, A; Patel, K, 2021) |
| "A subtype of chronic pain is neuropathic pain (NP), which is defined as "pain caused by a lesion or disease of the somatosensory system," according to the International Association for the Study of Pain (IASP)." | 2.66 | The use of antineuropathic medications for the treatment of chronic pain. ( Artounian, KA; Bandi, P; Berardino, K; Jung, JW; Kaye, AD; Kaye, AM; Kaye, RJ; Li, N; Manchikanti, L; Simopoulos, T; Torres, M; Urits, I; Viswanath, O, 2020) |
| "Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated." | 2.66 | Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis. ( Bhatia, A; Brull, R; Davidson, A; Kapustin, D; McParland, A; Singh, M; Trivedi, A, 2020) |
| "Gabapentinoid use has increased substantially in the past several years after initial promising data with regard to acute perioperative pain control." | 2.61 | The role of gabapentinoids in acute and chronic pain after surgery. ( Habib, AS; Kumar, AH, 2019) |
| "In patients with renal failure and with decreased physiological renal clearance such as the elderly, GBP or PGB dose initiation and changes should be conservative." | 2.61 | Gabapentin or pregabalin induced myoclonus: A case series and literature review. ( Desai, A; Kherallah, Y; Marawar, R; Szabo, C, 2019) |
| "Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer." | 2.58 | Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable. ( Bhaskar, A; Humble, SR; Jayaweera, A; Varela, N, 2018) |
| "Chronic orofacial pain can greatly improve following treatment of the underlying insomnia, and therefore, re-evaluation of COFP is advised after 1 month of treatment." | 2.55 | An update of management of insomnia in patients with chronic orofacial pain. ( Almoznino, G; Benoliel, R; Haviv, Y; Sharav, Y, 2017) |
| "Chronic postoperative pain is common." | 2.53 | Preventing chronic postoperative pain. ( Reddi, D, 2016) |
| "Neuropathic pain is more severe, with significant disability." | 2.53 | Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials. ( AlAmri, R; Bhandari, M; Devereaux, PJ; Gilron, I; Kamath, S; Rajarathinam, M; Shanthanna, H; Thabane, L, 2016) |
| "Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors." | 2.50 | Non-surgical interventions for the management of chronic pelvic pain. ( Cheong, YC; Smotra, G; Williams, AC, 2014) |
| "Chronic pain affects quality of life and adversely affects functional outcomes." | 2.49 | Management of chronic pain following nerve injuries/CRPS type II. ( Carroll, I; Curtin, CM, 2013) |
| "Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic." | 2.49 | Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013) |
| "Chronic pain is an enormous public health concern, and its treatment is still an unmet medical need." | 1.91 | Ketoprofen, lysine and gabapentin co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: Pre-clinical evidences towards an innovative therapeutic approach for neuroinflammatory pain. ( Allegretti, M; Aramini, A; Bianchini, G; Boccella, S; Bordignon, S; Brandolini, L; Canestrari, D; Castelli, V; Chierotti, MR; Cimini, A; Cocchiaro, P; d'Angelo, M; d'Egidio, F; Dragani, MC; Lillini, S; Luongo, L; Maione, S; Mattioli, S; Novelli, R; Pacchiarotti, N; Palmerio, F; Tomassetti, M, 2023) |
| " We are most familiar with the incremental dosing strategy where a ceiling dose is eventually attained guided by efficacy and patient tolerance, after which a fixed dosing regimen is prescribed." | 1.91 | Comparative Descriptive Analysis of Physician Versus Patient-Directed Gabapentin Usage In Chronic Pain - A Preliminary Report. ( Burns, JC; Gill, JS; Madabhushi, SV; Robinson, CL; Ruan, QZ; Simopoulos, TT, 2023) |
| "In the 182 patients with chronic pain, those receiving combination therapy were more likely to respond than those taking AC alone (35." | 1.72 | Does gabapentin impact response to anticholinergics for overactive bladder? ( Alfahmy, A; Dao, A; Mitchell, D; Roberts, K; Sheyn, D, 2022) |
| "Many patients with chronic pain conditions suffer from depression." | 1.62 | Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain. ( Chao, D; Feng, Y; Hillard, CJ; Hogan, QH; Mecca, CM; Pan, B; Pawela, CP; Rodriguez-Garcia, DM; Segel, I; Yu, G; Zhang, Z, 2021) |
| "Gabapentin was used at 8 mg/kg but produced ataxia and anorexia." | 1.62 | Multimodal analgesia in a Southern White Rhinoceros (Ceratotherium simum) with pentosan polysulfate, gabapentin, amantadine and phenylbutazone to manage chronic pain. ( Gardner, BR; Rourke, NL, 2021) |
| "Approaches used to treat chronic pain outside the eye can be applied to ocular pain that is not responsive to traditional therapies." | 1.56 | Oral Gabapentinoids and Nerve Blocks for the Treatment of Chronic Ocular Pain. ( Felix, ER; Galor, A; Horn, DB; Levitt, RC; Sarantopoulos, CD; Small, LR, 2020) |
| " As this patient population can be more challenging because of comorbidities, the presence of polypharmacy, pharmacokinetic, and pharmacodynamic changes, it is important to evaluate the risk of any relevant adverse effects for opioids and adjuncts that can lead to higher risk of opioid toxicities." | 1.56 | Safety and Efficacy Considerations of Gabapentin as Adjunctive Therapy to Opioids in the Perioperative Setting for Older Adults. ( Garcia, E; Reinert, JP; Veronin, M, 2020) |
| "A frail 85-year-old woman with chronic neuropathic pain after hip surgery, not responding to treatment with acetaminophen and morphine patches." | 1.56 | [Whether or not to use gabapentinoids in adults with chronic neuropathic pain]. ( El Houssein, L; Hollmann, MW; Kallewaard, J; Steegers, MAH; van Poelgeest, EP; Wartenberg, HCH, 2020) |
| "Cases with EoE with a psychiatric diagnosis were more likely to be women, white, and 18 years or older and to have a longer symptom duration before diagnosis." | 1.56 | Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation. ( Corder, SR; Dellon, ES; Eluri, S; Kim, E; Reed, CC; Sanders, E; Tappata, M, 2020) |
| "Chronic pain is the most common non-motor symptom among Parkinson's disease (PD) patients, with 1." | 1.51 | Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats. ( Feustel, P; Kaszuba, BC; Maietta, T; Pilitsis, JG; Shin, DS; Slyer, J; Stapleton, A; Walling, I, 2019) |
| "Gabapentin was administered by a nasogastric tube that quickly resulted in a reversal of his symptoms." | 1.51 | Complex encephalopathy arising from the combination of opioids and gabapentin. ( Handa, R; Kak, V; Singh, H; Wasilewski, A, 2019) |
| "Compared with nociceptive pain, neuropathic pain is a challenging diagnosis to make and successfully treat in children with cancer." | 1.46 | Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer. ( Bruera, E; Madden, K, 2017) |
| "Cyclobenzaprine specimens were equally likely to be positive whether the dose was oral or topical, although mean levels after topical dosing were approximately 13-21% those after oral dosing." | 1.46 | Urinary Concentrations of Topically Administered Pain Medications. ( Bell, P; Glinn, MA; Harvey, A; Lickteig, AJ; Rappold, B; Recer, S; Salske, M; Stensland, J; Weber, L, 2017) |
| " This study underscores our previous findings that eToims is safe and efficacious for long-term use in CRMP." | 1.43 | Chronic refractory myofascial pain and denervation supersensitivity as global public health disease. ( Bruyninckx, F; Chu, J; Neuhauser, DV, 2016) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 1.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "Neuropathic pain is currently an insufficiently treated clinical condition." | 1.40 | Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. ( Hammock, BD; Inceoglu, B; Wagner, K; Yang, J, 2014) |
| "Chronic postsurgical pain (CPSP) is a common problem, with up to a third of patients reporting persistent or intermittent pain 1 year after common operations." | 1.40 | Chronic postsurgical pain: prevention and management. ( Ravindran, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 73 (66.36) | 24.3611 |
| 2020's | 37 (33.64) | 2.80 |
| Authors | Studies |
|---|---|
| Shao, PP | 1 |
| Ye, F | 1 |
| Chakravarty, PK | 1 |
| Varughese, DJ | 1 |
| Herrington, JB | 1 |
| Dai, G | 1 |
| Bugianesi, RM | 1 |
| Haedo, RJ | 1 |
| Swensen, AM | 1 |
| Warren, VA | 1 |
| Smith, MM | 1 |
| Garcia, ML | 1 |
| McManus, OB | 1 |
| Lyons, KA | 1 |
| Li, X | 3 |
| Green, M | 1 |
| Jochnowitz, N | 1 |
| McGowan, E | 1 |
| Mistry, S | 1 |
| Sun, SY | 1 |
| Abbadie, C | 1 |
| Kaczorowski, GJ | 1 |
| Duffy, JL | 1 |
| Wu, YJ | 1 |
| Guernon, J | 1 |
| McClure, A | 1 |
| Luo, G | 1 |
| Rajamani, R | 1 |
| Ng, A | 1 |
| Easton, A | 1 |
| Newton, A | 1 |
| Bourin, C | 1 |
| Parker, D | 1 |
| Mosure, K | 1 |
| Barnaby, O | 1 |
| Soars, MG | 1 |
| Knox, RJ | 1 |
| Matchett, M | 1 |
| Pieschl, R | 1 |
| Herrington, J | 1 |
| Chen, P | 1 |
| Sivarao, DV | 1 |
| Bristow, LJ | 1 |
| Meanwell, NA | 1 |
| Bronson, J | 1 |
| Olson, R | 1 |
| Thompson, LA | 1 |
| Dzierba, C | 1 |
| Cioffi, CL | 1 |
| Liang, J | 1 |
| Tae, HS | 1 |
| Zhao, Z | 1 |
| Zhang, J | 2 |
| Chen, S | 1 |
| Jiang, T | 1 |
| Adams, DJ | 1 |
| Yu, R | 1 |
| Chappuy, M | 1 |
| Nourredine, M | 1 |
| Clerc, B | 1 |
| Fahmi, M | 1 |
| Misslin, P | 1 |
| Berthier, M | 1 |
| Laloi, L | 1 |
| Rolland, B | 1 |
| Buapratoom, A | 1 |
| Wanasuntronwong, A | 1 |
| Khongsombat, O | 1 |
| Tantisira, MH | 1 |
| Chen, Y | 1 |
| Zhang, GZ | 1 |
| He, Y | 1 |
| Zhuang, X | 1 |
| Ma, W | 1 |
| McGregor, RH | 1 |
| Warner, FM | 1 |
| Linde, LD | 1 |
| Cragg, JJ | 1 |
| Osborn, JA | 1 |
| Varshney, VP | 1 |
| Schwarz, SKW | 1 |
| Kramer, JLK | 1 |
| Roberts, K | 1 |
| Dao, A | 1 |
| Alfahmy, A | 1 |
| Mitchell, D | 1 |
| Sheyn, D | 1 |
| Kim, TW | 1 |
| Samet, JH | 1 |
| Lodi, S | 1 |
| Kimmel, SD | 1 |
| Forman, LS | 1 |
| Lira, MC | 1 |
| Liebschutz, JM | 1 |
| Williams, EC | 1 |
| Walley, AY | 1 |
| Zeng, W | 1 |
| Tan, Y | 1 |
| Yang, L | 1 |
| Jiang, X | 1 |
| Chen, SR | 1 |
| Zhou, MH | 1 |
| Jin, D | 1 |
| Chen, H | 1 |
| Wang, L | 1 |
| DePinho, RA | 1 |
| Pan, HL | 1 |
| Guerreiro, SR | 2 |
| Guimarães, MR | 2 |
| Silva, JM | 2 |
| Dioli, C | 2 |
| Vamvaka-Iakovou, A | 2 |
| Sousa, R | 2 |
| Gomes, P | 2 |
| Megalokonomou, A | 2 |
| Campos-Marques, C | 2 |
| Cunha, AM | 2 |
| Almeida, A | 2 |
| Sousa, N | 2 |
| Leite-Almeida, H | 2 |
| Sotiropoulos, I | 2 |
| Cuadrado, ML | 2 |
| Nodera, H | 1 |
| Corriere, MA | 1 |
| Dickson, AL | 1 |
| Daniel, LL | 1 |
| Nepal, P | 1 |
| Hall, K | 1 |
| Plummer, WD | 1 |
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| Murray, KT | 1 |
| Stein, CM | 1 |
| Ray, WA | 1 |
| Chung, CP | 1 |
| Aramini, A | 1 |
| Bianchini, G | 1 |
| Lillini, S | 1 |
| Tomassetti, M | 1 |
| Pacchiarotti, N | 1 |
| Canestrari, D | 1 |
| Cocchiaro, P | 1 |
| Novelli, R | 1 |
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| Palmerio, F | 1 |
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| d'Angelo, M | 1 |
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| d'Egidio, F | 1 |
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| Liang, Y | 1 |
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| Huang, J | 1 |
| Guo, K | 1 |
| McNeilage, AG | 1 |
| Ashton-James, CE | 1 |
| Scholz, B | 1 |
| Healy, P | 1 |
| Verrest, L | 1 |
| Felisi, M | 2 |
| Ceci, A | 3 |
| Della Pasqua, O | 2 |
| Grinshpun, G | 1 |
| Ruan, QZ | 1 |
| Robinson, CL | 1 |
| Simopoulos, TT | 1 |
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| AbdelHafeez, MA | 1 |
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| Mokhles, JM | 1 |
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| Friese, CR | 1 |
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| Moore, J | 1 |
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| van Poelgeest, EP | 1 |
| El Houssein, L | 1 |
| Kallewaard, J | 1 |
| Hollmann, MW | 1 |
| Steegers, MAH | 1 |
| Wartenberg, HCH | 1 |
| Garcia, E | 1 |
| Reinert, JP | 1 |
| Veronin, M | 1 |
| Horne, AW | 5 |
| Vincent, K | 4 |
| Hewitt, CA | 2 |
| Middleton, LJ | 1 |
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| Doust, AM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions (The MSK-PELVIC Study)[NCT05750212] | 208 participants (Anticipated) | Observational | 2023-01-24 | Recruiting | |||
| Oral Gabapentin in Management of Chronic Pelvic Pain in Females: A Randomised Placebo-controlled Study.[NCT02918760] | Phase 3 | 64 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| Effects of Muscle Energy Technique Versus Aerobic Exercises on Pain and Disability in Patients With Chronic Pelvic Pain[NCT05429957] | 40 participants (Actual) | Interventional | 2022-01-20 | Completed | |||
| Effect of Acupuncture and Pain Medication on Radicular Pain Using QST[NCT01678586] | 47 participants (Actual) | Interventional | 2012-12-31 | Completed | |||
| GABA-WHY Study: Deprescription of Gabapentinoids in Medical Inpatients[NCT04855578] | 160 participants (Actual) | Interventional | 2021-05-28 | Completed | |||
| "Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355] | 100 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| Observational Prospective Study on the Presence of Typical Migraine Features in Nummular Headache Patients: The Numamig Study[NCT04299958] | 19 participants (Actual) | Observational [Patient Registry] | 2020-04-01 | Completed | |||
| Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting[NCT05475769] | 98 participants (Anticipated) | Observational | 2022-03-01 | Recruiting | |||
| Randomized, Double-blind, Placebo Controlled, Superiority Phase II Study to Evaluate the Safety, Pharmacokinetic, Efficacy of Gabapentin as add-on to Morphine in Children From 3 Months to Less Than 18 Years[NCT03275012] | Phase 2 | 0 participants (Actual) | Interventional | 2017-04-04 | Withdrawn (stopped due to Study not started) | ||
| Randomized, Double-blind, Double-dummy, Active Controlled, Multicentre, Non-inferiority Phase-III Study to Compare Gabapentin Liquid Formulation to Tramadol in Children Experiencing Moderate to Severe Chronic Neuropathic or Mixed Pain[NCT02722603] | Phase 3 | 2 participants (Actual) | Interventional | 2018-09-12 | Terminated (stopped due to The study was early terminated due to insufficient recruitment) | ||
| Effect of Trigeminal Nerve Stimulation on Subbasal Corneal Nerve Plexus Density and Chronic Ocular Pain in Patients With Dry Eye[NCT04648085] | 7 participants (Actual) | Interventional | 2021-02-03 | Completed | |||
| A Randomized Double Blind, Placebo-controlled, Dose Response Study of Intraspinal Gabapentin (MDT2004) in Subjects With Chronic, Intractable Pain.[NCT00414466] | Phase 2 | 254 participants (Actual) | Interventional | 2006-12-31 | Terminated (stopped due to Study closed and subject follow-up completed following analysis of blinded study data.) | ||
| Effect of Preoperative Gabapentin on Postoperative Pain Associated With Ureteroscopy and Stents Insertion: a Double Blind, Randomized, Placebo Controlled Trial[NCT03151746] | Phase 4 | 20 participants (Actual) | Interventional | 2018-01-14 | Terminated (stopped due to Insufficient enrollment) | ||
| Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine[NCT02285010] | Phase 4 | 125 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Single Dose Preoperative Gabapentin Use in Minimally Invasive Hysterectomy for Acute Pain Management[NCT02703259] | Phase 4 | 137 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty - A Randomized Controlled Trial[NCT05447364] | Phase 4 | 82 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
| Labor Pain and Postpartum Behavioral Health Outcomes Study[NCT02692404] | 199 participants (Actual) | Observational | 2016-01-31 | Completed | |||
| Efficacy of Antidepressants in Chronic Back Pain[NCT00108550] | Phase 2 | 108 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| Phantom Motor Execution Via Myoelectric Pattern Recognition, Virtual and Augmented Reality, and Serious Gaming as a Treatment of Phantom Limb Pain[NCT03112928] | 77 participants (Actual) | Interventional | 2017-05-08 | Completed | |||
| Myoelectrically Controlled Augmented Reality and Gaming for the Treatment of Phantom Limb Pain[NCT02281539] | 14 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| The Effects of Targeted Phantom Motor Execution, Prosthetic Embodiment, and Surgical Closure on Phantom Limb Control, and Physical Function in People With Unilateral (Single) Transtibial (Below-the-knee) Amputation[NCT05247827] | 30 participants (Actual) | Interventional | 2022-06-01 | Completed | |||
| Mindful SensoriMotor Therapy With Brain Modulation for the Treatment of Pain in Individuals With Disarticulation or Nerve Injuries: A Single Arm Clinical Trial[NCT04897425] | 8 participants (Anticipated) | Interventional | 2022-06-01 | Not yet recruiting | |||
| Electromyography-controlled Virtual Reality and Serious Gaming to Improve Upper Extremity Function in Chronic Stroke Patients[NCT04154371] | 6 participants (Actual) | Interventional | 2019-11-11 | Active, not recruiting | |||
| Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy: A Prospective Double-blinded, Placebo Controlled Randomized Study[NCT02359110] | Phase 4 | 112 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
| Intervention | score on 10-point scale (Mean) |
|---|---|
| Standard of Care | 2.26 |
| Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 3.84 |
| Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 5.73 |
| Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 0.36 |
| Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 7.83 |
| Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | days (Mean) |
|---|---|
| Standard of Care | 14.8 |
| Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
| Intervention | morphine equivalents (Mean) |
|---|---|
| Standard of Care | 287.0 |
| Postoperative Gabapentin Regimen | 281.1 |
Average pain score calculated over last 7 days of baseline minus average pain score calculated over last 7 days of follow-up using the Numeric Pain Rating Scale where 0=no pain, 10=worst possible pain. (NCT00414466)
Timeframe: Baseline and Post-randomization Day 22
| Intervention | Scores on a scale (Mean) |
|---|---|
| 1 Placebo | 0.48 |
| 2 Gabapentin Low | 0.40 |
| 3 Gabapentin Medium | 0.10 |
| 4 Gabapentin High | -0.02 |
Evaluation of adverse event profiles between placebo and active treatment groups. (NCT00414466)
Timeframe: Randomization to Post-randomization Day 29 (includes dose reduction)
| Intervention | Participants (Number) |
|---|---|
| 1 Placebo | 40 |
| 2 Gabapentin Low | 32 |
| 3 Gabapentin Medium | 37 |
| 4 Gabapentin High | 36 |
Responders were subjects that reported at least a 30% decrease in average daily pain scores between baseline and Day 22. (NCT00414466)
Timeframe: Baseline to Post-randomization Day 22
| Intervention | Participants (Number) |
|---|---|
| 1 Placebo | 4 |
| 2 Gabapentin Low | 4 |
| 3 Gabapentin Medium | 1 |
| 4 Gabapentin High | 2 |
Pain scores using an 11 point numeric pain rating scale 0=no pain 10 = worst pain imaginable (NCT03151746)
Timeframe: 24 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 4.11 |
| Gabapentin | 3.11 |
Total morphine equivalents in milligrams consumed during the first 48 hours after surgery. (NCT03151746)
Timeframe: Up to 48 hours after surgery
| Intervention | morphine milligrams (Mean) |
|---|---|
| Placebo | 51.87 |
| Gabapentin | 15.71 |
Evaluate quality of recovery using the Quality of Recovery 40 (QoR 40) questionnaire a 40 question survey scored from 40 ( poor recovery) to 200 high (good recovery) 48 hours after the surgical procedure. (NCT03151746)
Timeframe: 48 hours after surgical procedure
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 181.3 |
| Gabapentin | 187.5 |
Time to first analgesia is recorded from IV PCA. (NCT02285010)
Timeframe: 24 hours
| Intervention | hour (Median) |
|---|---|
| Placebo | 4.6 |
| Pregabalin | 7.7 |
"Pain score is evaluated by nurses using Numerical Rating Scale (NRS)~Minimum score 0 (no pain), Maximum score 10 (worst imaginable pain), lower scores mean a better outcome" (NCT02285010)
Timeframe: 24 hours
| Intervention | score on a scale (Median) | |
|---|---|---|
| At rest | At movement | |
| Placebo | 2 | 4 |
| Pregabalin | 2 | 4 |
Cumulative morphine consumption in the first 24 hours is recorded from IV PCA (NCT02285010)
Timeframe: 6, 12, and 24 hours after operation
| Intervention | mg (Median) | ||
|---|---|---|---|
| Morphine consumption 6 hr | Morphine consumption 12 hr | Morphine consumption 24 hr | |
| Placebo | 1 | 1 | 4 |
| Pregabalin | 0 | 1 | 5 |
Measure sedation score by evaluate and observe; measure pruritus, PONV, dizziness, visual disturbance using questionnaire (NCT02285010)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pruritus72177998 | Pruritus72177999 | Nausea72177998 | Nausea72177999 | Vomiting72177998 | Vomiting72177999 | Dizziness72177998 | Dizziness72177999 | Visual disturbance72177998 | Visual disturbance72177999 | |||||||||||||||||||||||||||||||
| No | Mild | Moderate | Severe | |||||||||||||||||||||||||||||||||||||
| Pregabalin | 17 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 35 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 31 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 15 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 10 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 1 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 3 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 18 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 23 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 24 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 21 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 31 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 38 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 10 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 9 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 12 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 8 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 5 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 6 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 14 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 39 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 9 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 1 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 51 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 45 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 0 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 0 | |||||||||||||||||||||||||||||||||||||||
Assessment of the amount of narcotic use postoperatively at 2 weeks. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 2 weeks
| Intervention | morphine milligram equivalents (Mean) |
|---|---|
| Gabapentin | 167.2 |
| Control | 187.3 |
Assessment of the amount of narcotic use postoperatively at 24 hours. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 24 hours
| Intervention | morphine milligram equivalents (Mean) |
|---|---|
| Gabapentin | 158.8 |
| Control | 175.0 |
"Assessment of the subject pain score postoperatively at 2 weeks. will use a numeric analog scale from 0-10.~The pain scale ranging from 0-10 with 0 representing No Pain and 10 representing the Worst Pain Possible" (NCT02703259)
Timeframe: 2 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Gabapentin | 1.3 |
| Control | 1.4 |
Pain score assesses patient subjective pain via patient reported numeric analogue scale, range 0-10 with 0 being no pain and 10 being severe pain. (NCT02703259)
Timeframe: 24 hours
| Intervention | score on a scale (Mean) |
|---|---|
| Gabapentin | 3.4 |
| Control | 3.4 |
Will assess for known symptoms of gabapentin postoperatively at 2 weeks. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Dizziness | Blurred vision | Somnolence | Difficulty walking | Tremulousness | Nausea | Vomiting | |
| Control | 8 | 3 | 21 | 5 | 2 | 7 | 1 |
| Gabapentin | 12 | 4 | 18 | 5 | 4 | 12 | 0 |
Will assess for known symptoms of gabapentin postoperatively at 24 hours. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Dizziness | Blurred Vision | Somnolence | Difficulty walking | Tremulousness | Nausea | Vomiting | |
| Control | 8 | 4 | 23 | 11 | 6 | 25 | 15 |
| Gabapentin | 17 | 7 | 20 | 13 | 11 | 24 | 9 |
"This questionnaire measures disability in everyday function due to back pain. It is a 24-item checklist asking patients to endorse whether or not back pain limits activities they normally do (eg, I stay at home most of the time because of my back). Scores range from 0 to 24, with higher scores indicating greater disability in everyday function due to back pain. The single values reported below represent adjusted means of scores over all time points." (NCT00108550)
Timeframe: Baseline to Week 12 with Interim Measurement at Weeks 1, 2, 3, 4, 5, 7 and 9
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 7.50 |
| Gabapentin | 6.96 |
"Self-report measure of current pain intensity of chronic back pain. Participants rate pain on a 20 point scale as being greater or less intense relative to 12 adjectival descriptor word anchors (eg, greater or less than faint, moderate, strong). Scores range from 0 to 20 with higher scores indicating higher pain intensity. Prior to analysis an order-preserving mean-matching variance-stabilizing transformation was applied to this measure placing it on a continuous 0-1.5 scale. The single values reported below represent adjusted means of transformed pain intensity over all time points." (NCT00108550)
Timeframe: Baseline to Week 12 with Interim Measurement at Weeks 1, 2, 3, 4, 5, 7 and 9
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 0.6683 |
| Gabapentin | 0.6988 |
(NCT02359110)
Timeframe: 12 hours post-operatively
| Intervention | mg (Mean) |
|---|---|
| Gabapentin | 14.3 |
| Placebo | 14.7 |
The NRS is a numerical scale ranging from 0-10 implemented with adults. Having no pain is rated as a 0 and the worst pain the patient could tolerate is rated as a 10. (NCT02359110)
Timeframe: 2-8 hours
| Intervention | units on a scale (Least Squares Mean) | |||
|---|---|---|---|---|
| Hour 2 | Hour 4 | Hour 6 | Hour 8 | |
| Gabapentin | 3.5 | 5.4 | 5.3 | 5.7 |
| Placebo | 3.4 | 5.5 | 5.8 | 5.1 |
"The VAS is scored using a horizontal line 100mm in length. The scale is anchored by no pain (score of 0) and worst pain (score of 100)." (NCT02359110)
Timeframe: 2 -6 hours
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| Hour 2 | Hour 6 | |
| Gabapentin | 37.8 | 38.7 |
| Placebo | 33.9 | 36.9 |
39 reviews available for gabapentin and Pain, Chronic
| Article | Year |
|---|---|
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.
Topics: Analgesics; Animals; Chronic Pain; Glycine; Humans; Nociceptors; Receptors, Glycine; Spinal Cord; Sy | 2018 |
Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri | 2022 |
Quality of meta-analyses of non-opioid, pharmacological, perioperative interventions for chronic postsurgical pain: a systematic review.
Topics: Adult; Chronic Pain; Gabapentin; Humans; Ketamine; Pain, Postoperative; Pregabalin | 2022 |
Epicranial headaches part 2: Nummular headache and epicrania fugax.
Topics: Chronic Pain; Gabapentin; Headache; Headache Disorders; Humans; Lamotrigine | 2023 |
Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis.
Topics: Analgesics; Chronic Pain; Clinical Trials as Topic; Gabapentin; Humans; Neuralgia; Pain Measurement; | 2020 |
Narrative review of acute post-craniotomy pain. Concept and strategies for prevention and treatment of pain.
Topics: Acupuncture Analgesia; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory A | 2020 |
Gabapentin for chronic neuropathic pain in adults.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Chronic Pain; Female; Gabapentin; Humans; Male; Middle A | 2019 |
Can Gabapentin Alleviate Chronic Neuropathic Pain in Adults?: A Cochrane Review Summary With Commentary.
Topics: Analgesics; Chronic Pain; Dose-Response Relationship, Drug; Gabapentin; Humans; Neuralgia | 2020 |
The use of antineuropathic medications for the treatment of chronic pain.
Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Chronic Pain; Gabapentin; Humans; Neuralgia; Pain | 2020 |
The gabapentinoid drugs and their abuse potential.
Topics: Analgesics; Chronic Pain; Gabapentin; Humans; Pregabalin; Substance-Related Disorders | 2021 |
Gabapentin for chronic neuropathic pain in adults.
Topics: Adult; Amines; Analgesics; Chronic Disease; Chronic Pain; Cyclohexanecarboxylic Acids; Diabetic Neur | 2017 |
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2017 |
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2017 |
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2017 |
Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Topics: Amines; Analgesics; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2017 |
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Amines; Amitriptyline; Anticonvulsants; Child; Chronic Pain; Complex Regional Pain Syndr | 2017 |
Nummular headache: an update and future prospects.
Topics: Analgesics; Botulinum Toxins, Type A; Chronic Pain; Gabapentin; Headache; Humans; Injections, Subcut | 2018 |
Nummular headache: an update and future prospects.
Topics: Analgesics; Botulinum Toxins, Type A; Chronic Pain; Gabapentin; Headache; Humans; Injections, Subcut | 2018 |
Nummular headache: an update and future prospects.
Topics: Analgesics; Botulinum Toxins, Type A; Chronic Pain; Gabapentin; Headache; Humans; Injections, Subcut | 2018 |
Nummular headache: an update and future prospects.
Topics: Analgesics; Botulinum Toxins, Type A; Chronic Pain; Gabapentin; Headache; Humans; Injections, Subcut | 2018 |
Limited evidence guides empiric Tx of female chronic pelvic pain.
Topics: Adult; Amitriptyline; Analgesics; Chronic Pain; Contraceptive Agents, Female; Contraceptives, Oral, | 2018 |
Gabapentin and pregabalin: do the benefits outweigh the harms?
Topics: Chronic Pain; Gabapentin; Humans; Inappropriate Prescribing; Off-Label Use; Pregabalin; Prescription | 2017 |
Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Chronic Pain; Drug Therapy, Combination; Gabapentin; Ge | 2018 |
The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis.
Topics: Amines; Breast Neoplasms; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Amino | 2018 |
Gabapentin or pregabalin induced myoclonus: A case series and literature review.
Topics: Adult; Aged; Analgesics; Chronic Pain; Female; Gabapentin; Humans; Male; Middle Aged; Myoclonus; Pre | 2019 |
Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment.
Topics: Antidepressive Agents, Tricyclic; Anxiety; Catastrophization; Chronic Pain; Cognitive Behavioral The | 2019 |
Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Pain; GABA Antagonists; Gabapentin; Humans; Locus | 2019 |
Nummular Headache.
Topics: Botulinum Toxins; Chronic Pain; Female; Gabapentin; Head; Headache; Humans; Male | 2019 |
The role of gabapentinoids in acute and chronic pain after surgery.
Topics: Acute Pain; Analgesia; Analgesics; Chronic Pain; Enhanced Recovery After Surgery; Gabapentin; Humans | 2019 |
Chronic pain after childbirth.
Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea | 2013 |
Pharmacotherapy for the prevention of chronic pain after surgery in adults.
Topics: Adrenal Cortex Hormones; Adult; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Femal | 2013 |
Management of chronic pain following nerve injuries/CRPS type II.
Topics: Amines; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Capsaicin; Causalgia; Chronic Pa | 2013 |
Sensory symptoms in restless legs syndrome: the enigma of pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2013 |
Post-surgical pain syndromes: a review for the non-pain specialist.
Topics: Age Factors; Amines; Analgesics; Anesthesia; Anesthetics; Anesthetics, Local; Animals; Chronic Pain; | 2014 |
Non-surgical interventions for the management of chronic pelvic pain.
Topics: Amines; Amitriptyline; Analgesics; Chronic Pain; Clonidine; Contraceptive Agents, Female; Cyclohexan | 2014 |
Gabapentin for chronic neuropathic pain and fibromyalgia in adults.
Topics: Adult; Amines; Analgesics; Chronic Disease; Chronic Pain; Cyclohexanecarboxylic Acids; Fibromyalgia; | 2014 |
Preventing chronic postoperative pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2016 |
Can Chronic Pain Be Prevented?
Topics: Acute Pain; Amines; Anesthesia, Conduction; Chronic Pain; Cyclohexanecarboxylic Acids; Epigenesis, G | 2016 |
An update of management of insomnia in patients with chronic orofacial pain.
Topics: Amines; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Chronic Pain; Cognitive Behavioral | 2017 |
Neonatal pain management.
Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Barbiturates; Chronic Pain; Cyclohexanecarboxylic A | 2017 |
Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials.
Topics: Amines; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Low | 2016 |
The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic | 2012 |
The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic | 2012 |
The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic | 2012 |
The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic | 2012 |
[Mechanisms of action of therapeutic agents in the treatment of chronic pain in the spinal cord].
Topics: Amines; Antidepressive Agents; Calcium Channel Blockers; Chronic Pain; Cyclohexanecarboxylic Acids; | 2011 |
17 trials available for gabapentin and Pain, Chronic
| Article | Year |
|---|---|
Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study.
Topics: Acetaminophen; Analgesia; Cardiac Surgical Procedures; Chronic Pain; Dexmedetomidine; Gabapentin; Hu | 2023 |
Gabapentin for the management of chronic pelvic pain in women.
Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain | 2019 |
Gabapentin for the management of chronic pelvic pain in women.
Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain | 2019 |
Gabapentin for the management of chronic pelvic pain in women.
Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain | 2019 |
Gabapentin for the management of chronic pelvic pain in women.
Topics: Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Pelvic Pain | 2019 |
A randomized-controlled pilot trial of an online compassionate mind training intervention to help people with chronic pain avoid analgesic misuse.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Arthritis, Rheumatoid; Aspirin; Back Pain; Chr | 2020 |
Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; Gabapentin; Humans; Off-La | 2020 |
Comparison between acupuncture therapy and gabapentin for chronic pain: a pilot study.
Topics: Adult; Aged; Analgesics; Chronic Pain; Electroacupuncture; Female; Gabapentin; Humans; Male; Middle | 2021 |
GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol.
Topics: Adolescent; Adult; Amines; Analgesics; Chronic Disease; Chronic Pain; Cyclohexanecarboxylic Acids; D | 2018 |
The influence of pre- and perioperative administration of gabapentin on pain 3-4 years after total knee arthroplasty.
Topics: Aged; Analgesics; Arthralgia; Arthroplasty, Replacement, Knee; Chronic Pain; Female; Follow-Up Studi | 2018 |
Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial.
Topics: Adult; Aged; Analgesics; Chronic Pain; Cross-Over Studies; Double-Blind Method; Female; Gabapentin; | 2019 |
Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled t
Topics: Administration, Oral; Adolescent; Age Factors; Analgesics; Analgesics, Opioid; Child; Child, Prescho | 2019 |
Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Chronic Pain; Double-Blind Meth | 2019 |
The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study.
Topics: Adolescent; Adult; Analgesics; Brain; Brain Mapping; Chronic Pain; Female; Gabapentin; Humans; Magne | 2019 |
Intrathecal gabapentin to treat chronic intractable noncancer pain.
Topics: Adult; Aged; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm | 2013 |
A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component.
Topics: Adult; Aged; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Disability Evaluation; D | 2016 |
Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial.
Topics: Adolescent; Adult; Amines; Analgesics; Chronic Pain; Cost-Benefit Analysis; Cyclohexanecarboxylic Ac | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Topics: Adult; Aged; Amines; Amputation, Surgical; Chronic Pain; Cyclohexanecarboxylic Acids; Exercise Thera | 2016 |
The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Chronic Disease; Chronic Pain; Coronary | 2011 |
Chronic postthoracotomy pain and health-related quality of life.
Topics: Aged; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Fo | 2012 |
54 other studies available for gabapentin and Pain, Chronic
| Article | Year |
|---|---|
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cells, Cultured; Chronic Pain; Dogs; Hu | 2012 |
Discovery of non-zwitterionic aryl sulfonamides as Na
Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor.
Topics: Analgesics; Animals; Chronic Pain; Conotoxins; Histocompatibility Antigens Class I; Humans; Minor Hi | 2022 |
Gabapentinoid use in French most precarious populations: Insight from Lyon Permanent Access to Healthcare (PASS) units, 2016-1Q2021.
Topics: Analgesics; Analgesics, Opioid; Chronic Pain; Delivery of Health Care; Gabapentin; Humans; Pregabali | 2022 |
Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Chronic Pain; Disease Models, Animal; Dose-Res | 2022 |
Evaluation on curative effects of gabapentin for the prevention of chronic pain in adults following surgery: A protocol for systematic review and meta-analysis.
Topics: Analgesics; Chronic Pain; Gabapentin; Humans; Meta-Analysis as Topic; Pain, Postoperative; Randomize | 2021 |
Does gabapentin impact response to anticholinergics for overactive bladder?
Topics: Cholinergic Antagonists; Chronic Pain; Female; Gabapentin; Humans; Neuralgia; Urinary Bladder, Overa | 2022 |
Functional Impairment and Cognitive Symptoms Among People with HIV Infection on Chronic Opioid Therapy for Pain: The Impact of Gabapentin and Other Sedating Medications.
Topics: Analgesics, Opioid; Chronic Pain; Cognition; Cross-Sectional Studies; Gabapentin; HIV Infections; Hu | 2022 |
Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Chronic Pain; Dentate Gyrus; Depression; Gabapentin; Hip | 2022 |
HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity.
Topics: Acute Pain; Animals; Chronic Pain; Female; Gabapentin; Ganglia, Spinal; Histone Deacetylase 2; Histo | 2022 |
Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.
Topics: Autophagy; Chronic Pain; Gabapentin; Hippocampus; Humans; Neuralgia | 2022 |
Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.
Topics: Autophagy; Chronic Pain; Gabapentin; Hippocampus; Humans; Neuralgia | 2022 |
Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.
Topics: Autophagy; Chronic Pain; Gabapentin; Hippocampus; Humans; Neuralgia | 2022 |
Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.
Topics: Autophagy; Chronic Pain; Gabapentin; Hippocampus; Humans; Neuralgia | 2022 |
[Medical Treatment of Chronic Pain].
Topics: Analgesics; Chronic Pain; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; Humans; Prega | 2023 |
Duloxetine, Gabapentin, and the Risk for Acute Myocardial Infarction, Stroke, and Out-of-Hospital Death in Medicare Beneficiaries With Non-Cancer Pain.
Topics: Aged; Chronic Pain; Duloxetine Hydrochloride; Gabapentin; Hospitals; Humans; Medicare; Myocardial In | 2023 |
Ketoprofen, lysine and gabapentin co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: Pre-clinical evidences towards an innovative therapeutic approach for neuroinflammatory pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Gabapentin; Ketoprofen; Lysine; Neur | 2023 |
"We were all looking for the magic pill": A qualitative study of patient experiences using gabapentinoids for chronic pain.
Topics: Adult; Chronic Pain; Gabapentin; Humans; Patient Outcome Assessment; Pregabalin; Qualitative Researc | 2023 |
Dose rationale for gabapentin and tramadol in pediatric patients with chronic pain.
Topics: Adult; Analgesia; Child; Chronic Pain; Gabapentin; Humans; Infant; Prospective Studies; Tramadol | 2023 |
Chronic Pain Syndromes: Complex Regional Pain Syndrome.
Topics: Chronic Pain; Complex Regional Pain Syndromes; Gabapentin; Humans; Ketamine; Physical Therapy Modali | 2023 |
Comparative Descriptive Analysis of Physician Versus Patient-Directed Gabapentin Usage In Chronic Pain - A Preliminary Report.
Topics: Amines; Analgesics; Chronic Pain; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Gabapentin; | 2023 |
Management of chronic pain in newborn infants.
Topics: Chronic Pain; Gabapentin; Humans; Infant; Infant, Newborn; Movement Disorders; Pain Management | 2020 |
Use of gabapentinoid medications among US adults with cancer, 2005-2015.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Cancer Pain; Chronic Pain; Cross-Sectional S | 2020 |
Gabapentinoids for Pain: Potential Unintended Consequences.
Topics: Analgesics; Chronic Pain; Drug Misuse; Gabapentin; Humans; Pain; Practice Guidelines as Topic; Prega | 2019 |
Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation.
Topics: Adolescent; Adult; Age Distribution; Anxiety Disorders; Benzodiazepines; Chest Pain; Child; Chronic | 2020 |
[Whether or not to use gabapentinoids in adults with chronic neuropathic pain].
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Chronic Pain; Diabetic Neuropathies; Female; Gabapentin; | 2020 |
Safety and Efficacy Considerations of Gabapentin as Adjunctive Therapy to Opioids in the Perioperative Setting for Older Adults.
Topics: Aged; Analgesics; Analgesics, Opioid; Chronic Pain; Gabapentin; Humans; Pain Management | 2020 |
Multimodal analgesia in a Southern White Rhinoceros (Ceratotherium simum) with pentosan polysulfate, gabapentin, amantadine and phenylbutazone to manage chronic pain.
Topics: Amantadine; Analgesia; Animals; Cattle; Chronic Pain; Euthanasia, Animal; Gabapentin; Male; Pentosan | 2021 |
Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV.
Topics: Analgesics, Opioid; Chronic Pain; Cohort Studies; Gabapentin; HIV Infections; Humans; Opioid-Related | 2022 |
Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain.
Topics: Animals; Brain Mapping; Chronic Pain; Depression; Endocannabinoids; Feeding Behavior; Female; GABAer | 2021 |
Urinary Concentrations of Topically Administered Pain Medications.
Topics: Administration, Oral; Administration, Topical; Amines; Amitriptyline; Analgesics; Chronic Pain; Cycl | 2017 |
Use of gabapentin in the treatment of chronic pain in an adolescent with sickle cell disease.
Topics: Administration, Oral; Adolescent; Amines; Analgesics; Anemia, Sickle Cell; Chronic Pain; Cyclohexane | 2017 |
Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer.
Topics: Amines; Analgesics; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Chronic Pain; Cyclohex | 2017 |
Gabapentin and Pregabalin for Pain - Is Increased Prescribing a Cause for Concern?
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Approval; Drug Utilization; Gaba | 2017 |
Is gabapentin effective for women with unexplained chronic pelvic pain?
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri | 2017 |
How should we manage women with unexplained chronic pelvic pain in light of uncertainty about the effectiveness of gabapentin?
Topics: Chronic Pain; Female; Gabapentin; Humans; Pelvic Pain; Uncertainty | 2017 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
Comparison of the Efficacy of a Gabapentinoid with an Opioid Versus an Opioid Alone in Patients with Spinal Cord Stimulation.
Topics: Adult; Analgesics; Analgesics, Opioid; Chronic Pain; Combined Modality Therapy; Female; Gabapentin; | 2018 |
Managing chronic pain: are gabapentinoids being misused?
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Misuse; GABA Agents; Gabapentin; | 2018 |
Clinical Pharmacology Considerations in Pain Management in Patients with Advanced Kidney Failure.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Chronic Pain | 2019 |
Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats.
Topics: Animals; Chronic Pain; Deep Brain Stimulation; Disease Models, Animal; Gabapentin; Male; Morphine; O | 2019 |
Prescribing practice of pregabalin/gabapentin in pain therapy: an evaluation of German claim data.
Topics: Adult; Aged; Analgesics; Chronic Pain; Female; Gabapentin; Germany; Humans; Infant; Insurance Claim | 2019 |
Complex encephalopathy arising from the combination of opioids and gabapentin.
Topics: Analgesics, Opioid; Brain Diseases; Chronic Pain; Gabapentin; Humans; Male; Middle Aged; Morphine; R | 2019 |
Oral Gabapentinoids and Nerve Blocks for the Treatment of Chronic Ocular Pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Local; Bupivacaine; C | 2020 |
Gabapentin alleviates chronic spontaneous pain and acute hypoxia-related pain in a mouse model of sickle cell disease.
Topics: Acute Disease; Anemia, Sickle Cell; Animals; Calcium Channels, L-Type; Chronic Pain; Disease Models, | 2019 |
Chronic postsurgical pain: prevention and management.
Topics: Amines; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Pain | 2014 |
Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Topics: Adrenergic Neurons; Amines; Analgesics; Animals; Attention; Behavior, Animal; Chronic Pain; Cyclohex | 2014 |
Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.
Topics: Amines; Analgesics; Animals; Benzoates; Chronic Pain; Conditioning, Psychological; Cyclohexanecarbox | 2014 |
Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin.
Topics: Aged; Aged, 80 and over; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gaba | 2015 |
Upregulation of α₂δ-1 Calcium Channel Subunit in the Spinal Cord Contributes to Pelvic Organ Cross-Sensitization in a Rat Model of Experimentally-Induced Endometriosis.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Calcium Channels; Calcium Channels, L-Type; Chronic P | 2015 |
Chronic refractory myofascial pain and denervation supersensitivity as global public health disease.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Denervation; Electric Stimulation The | 2016 |
Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain.
Topics: Amines; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Freund's Adjuvan | 2016 |
Analgesic drugs and the gut - a reciprocal relationship.
Topics: Acetaminophen; Administration, Oral; Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agent | 2015 |
Newborn with severe epidermolysis bullosa: to treat or not to treat?
Topics: Amines; Blister; Chronic Pain; Cyclohexanecarboxylic Acids; Epidermolysis Bullosa; Epidermolysis Bul | 2016 |
Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.
Topics: Amines; Analgesics, Opioid; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Tolerance; Fent | 2012 |
Chronic postsurgical pain: are we closer to understanding the puzzle?
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri | 2012 |
Long-term use of gabapentin for musculoskeletal disease and trauma in three cats.
Topics: Amines; Analgesics; Animals; Cat Diseases; Cats; Chronic Pain; Craniocerebral Trauma; Cyclohexanecar | 2013 |