Compounds > rubrolide a
Page last updated: 2024-12-11

rubrolide a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rubrolide A: from Synoicum prunum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6055630
CHEMBL ID511842
SCHEMBL ID12402314
MeSH IDM0495631

Synonyms (7)

Synonym
CHEMBL511842
rubrolide a
bdbm50064292
nsc701303
nsc-701303
(5z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2-one
SCHEMBL12402314
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cystathionine beta-synthaseHomo sapiens (human)IC50 (µMol)108.00001.00005.15718.9000AID1192860
Isocitrate lyaseCandida albicansIC50 (µMol)216.00006.00007.50009.0000AID1647644
Class A sortase SrtA Staphylococcus aureusIC50 (µMol)216.00000.30002.86005.9000AID1647643
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
endochondral ossificationCystathionine beta-synthaseHomo sapiens (human)
blood vessel remodelingCystathionine beta-synthaseHomo sapiens (human)
L-serine metabolic processCystathionine beta-synthaseHomo sapiens (human)
L-serine catabolic processCystathionine beta-synthaseHomo sapiens (human)
superoxide metabolic processCystathionine beta-synthaseHomo sapiens (human)
regulation of nitric oxide mediated signal transductionCystathionine beta-synthaseHomo sapiens (human)
cysteine biosynthetic process via cystathionineCystathionine beta-synthaseHomo sapiens (human)
cysteine biosynthetic processCystathionine beta-synthaseHomo sapiens (human)
transsulfurationCystathionine beta-synthaseHomo sapiens (human)
L-cysteine catabolic processCystathionine beta-synthaseHomo sapiens (human)
cerebellum morphogenesisCystathionine beta-synthaseHomo sapiens (human)
DNA protectionCystathionine beta-synthaseHomo sapiens (human)
negative regulation of apoptotic processCystathionine beta-synthaseHomo sapiens (human)
homocysteine catabolic processCystathionine beta-synthaseHomo sapiens (human)
homocysteine metabolic processCystathionine beta-synthaseHomo sapiens (human)
response to folic acidCystathionine beta-synthaseHomo sapiens (human)
maternal process involved in female pregnancyCystathionine beta-synthaseHomo sapiens (human)
cartilage development involved in endochondral bone morphogenesisCystathionine beta-synthaseHomo sapiens (human)
hydrogen sulfide biosynthetic processCystathionine beta-synthaseHomo sapiens (human)
cellular response to hypoxiaCystathionine beta-synthaseHomo sapiens (human)
blood vessel diameter maintenanceCystathionine beta-synthaseHomo sapiens (human)
cysteine biosynthetic process from serineCystathionine beta-synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
cystathionine beta-synthase activityCystathionine beta-synthaseHomo sapiens (human)
protein bindingCystathionine beta-synthaseHomo sapiens (human)
oxygen bindingCystathionine beta-synthaseHomo sapiens (human)
enzyme bindingCystathionine beta-synthaseHomo sapiens (human)
heme bindingCystathionine beta-synthaseHomo sapiens (human)
pyridoxal phosphate bindingCystathionine beta-synthaseHomo sapiens (human)
ubiquitin protein ligase bindingCystathionine beta-synthaseHomo sapiens (human)
identical protein bindingCystathionine beta-synthaseHomo sapiens (human)
protein homodimerization activityCystathionine beta-synthaseHomo sapiens (human)
metal ion bindingCystathionine beta-synthaseHomo sapiens (human)
nitrite reductase (NO-forming) activityCystathionine beta-synthaseHomo sapiens (human)
carbon monoxide bindingCystathionine beta-synthaseHomo sapiens (human)
nitric oxide bindingCystathionine beta-synthaseHomo sapiens (human)
modified amino acid bindingCystathionine beta-synthaseHomo sapiens (human)
S-adenosyl-L-methionine bindingCystathionine beta-synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
nucleusCystathionine beta-synthaseHomo sapiens (human)
cytoplasmCystathionine beta-synthaseHomo sapiens (human)
cytosolCystathionine beta-synthaseHomo sapiens (human)
cytoplasmCystathionine beta-synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID717202Antimicrobial activity against Salmonella typhimurium ATCC 14028 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID1647642Antibacterial activity against Klebsiella pneumoniae ATCC 10031 assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID1192860Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in presence of S-adenosylmethionine2015Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
Marine natural products as inhibitors of cystathionine beta-synthase activity.
AID717210Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0205 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717212Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3089 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID1756236Antibacterial activity against Bacillus subtilis 168 assessed as bacterial growth inhibition measured after 16 hrs by serial dilution method2021Journal of natural products, 02-26, Volume: 84, Issue:2
Hydrated Rubrolides from the New Zealand Tunicate
AID1647644Inhibition of Candida albicans ICL assessed as reduction in glyoxylate phenylhydrazone formation using M threo-DL(+)isocitrate as substrate incubated for 30 mins by spectrophotometric method2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID1647641Antibacterial activity against Proteus hauseri NBRC 3851 assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID1647643Inhibition of Staphylococcus aureus sortase A2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID1756238Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth at 0.06 to 30 uM measured after 48 hrs by MTS assay2021Journal of natural products, 02-26, Volume: 84, Issue:2
Hydrated Rubrolides from the New Zealand Tunicate
AID1647640Antibacterial activity against Salmonella enterica ATCC 14028 assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID379162Inhibition of human recombinant ALR22006Journal of natural products, Oct, Volume: 69, Issue:10
Phenolic marine natural products as aldose reductase inhibitors.
AID1756237Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as bacterial growth inhibition measured after 16 hrs by serial dilution method2021Journal of natural products, 02-26, Volume: 84, Issue:2
Hydrated Rubrolides from the New Zealand Tunicate
AID717208Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0027 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717211Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 3640 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717214Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3634 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717205Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717206Antimicrobial activity against Kocuria rhizophila ATCC 9341 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717204Antimicrobial activity against Staphylococcus aureus ATCC 6538 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID1756235Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition measured after 16 hrs by serial dilution method2021Journal of natural products, 02-26, Volume: 84, Issue:2
Hydrated Rubrolides from the New Zealand Tunicate
AID717207Antimicrobial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717213Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3090 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717215Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3635 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID1647638Antibacterial activity against Enterococcus faecalis ATCC 19433 assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID1647637Antibacterial activity against Staphylococcus aureus ATCC 6538P assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID717201Antimicrobial activity against Klebsiella pneumoniae ATCC 4352 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID717209Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0204 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
AID1647639Antibacterial activity against Enterococcus faecium ATCC 19434 assessed as reduction in microbial growth2020Journal of natural products, 02-28, Volume: 83, Issue:2
Isocadiolides A-H: Polybrominated Aromatics from a
AID717203Antimicrobial activity against Escherichia coli ATCC 11775 incubated for 24 hrs by microtiter broth dilution method2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.78 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-nitropropionic acid
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.		2.2510C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.2510beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
Berberine chloride (TN)
[no description available]		2.2510organic molecular entity
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0710glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		2.0210chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
sorbinil
sorbinil: aldose reductase inhibitor. sorbinil : An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.		2.0310azaspiro compound;
chromanes;
imidazolidinone;
organofluorine compound;
oxaspiro compound		antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor
linezolid
[no description available]		2.0710acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
gentamicin sulfate
[no description available]		2.0710
ly-146032
[no description available]		2.0710heterodetic cyclic peptide;
lipopeptide antibiotic;
lipopeptide;
macrocycle;
macrolide		antibacterial drug;
bacterial metabolite;
calcium-dependent antibiotics
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.6920
ConditionIndicatedRelationship StrengthStudiesTrials