Compounds > artocarpin lectin
Page last updated: 2024-12-11

artocarpin lectin

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Description

artocarpin lectin: a mannose-specific lectin; from the seeds of Artocarpus integrifolia; a homotetramic protein distinct from jacalin, another jackfruit lectin; MW 65 kDa; devoid of covalently-attached carbohydrates; consists of 4 isolectins with pI 5 - 6.5; do not confuse with artocarpin flavone [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

artocarpin : A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 2', and 4', a methoxy group at position 7, a prenyl group at position 3 and a (1E)-3-methylbut-1-enyl group at position 6. Isolated from Artocarpus heterophyllus and Artocarpus integrifolia, it exhibits antineoplastic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
ArtocarpusgenusA plant genus of the family MORACEAE. Puag-haad extract, from A. lakoocha, contains STILBENES and related 4-substituted RESORCINOLS.[MeSH]MoraceaeThe mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.[MeSH]
Artocarpus heterophyllusspecies[no description available]MoraceaeThe mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID5458461
CHEMBL ID72617
CHEBI ID65439
SCHEMBL ID374230
MeSH IDM0239598

Synonyms (19)

Synonym
chebi:65439 ,
CHEMBL72617 ,
2-(2,4-dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-((e)-3-methyl-but-1-enyl)-3-(3-methyl-but-2-enyl)-chromen-4-one
bdbm50051348
nsc-241010
NSC241010 ,
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(e)-3-methylbut-1-enyl]-3-(3-methylbut-2-enyl)chromen-4-one
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4h-chromen-4-one
artocarpin
artocarpin lectin
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1e)-3-methylbut-1-en-1-yl]-3-(3-methylbut-2-en-1-yl)-4h-chromen-4-one
5-hydroxy-7-methoxy-3-(3-methyl-2-butenyl)-6-(3-methyl-1-butenyl)-2-(2,4-dihydroxyphenyl)-4h-1-benzopyran-4-one
SCHEMBL374230
7608-44-8
artocaprin
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4h-1-benzopyran-4-one, 9ci
FS-9016
Q27133884
AKOS040760278
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
monomethoxyflavoneAny methoxyflavone with a single methoxy substituent.
trihydroxyflavoneAny hydroxyflavone carrying three hydroxy groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Adenosine receptor A3Homo sapiens (human)Ki4.59000.00000.930610.0000AID34709
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
inflammatory responseAdenosine receptor A3Homo sapiens (human)
signal transductionAdenosine receptor A3Homo sapiens (human)
activation of adenylate cyclase activityAdenosine receptor A3Homo sapiens (human)
regulation of heart contractionAdenosine receptor A3Homo sapiens (human)
negative regulation of cell population proliferationAdenosine receptor A3Homo sapiens (human)
response to woundingAdenosine receptor A3Homo sapiens (human)
regulation of norepinephrine secretionAdenosine receptor A3Homo sapiens (human)
negative regulation of cell migrationAdenosine receptor A3Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activityAdenosine receptor A3Homo sapiens (human)
presynaptic modulation of chemical synaptic transmissionAdenosine receptor A3Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathwayAdenosine receptor A3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
G protein-coupled adenosine receptor activityAdenosine receptor A3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
plasma membraneAdenosine receptor A3Homo sapiens (human)
presynaptic membraneAdenosine receptor A3Homo sapiens (human)
Schaffer collateral - CA1 synapseAdenosine receptor A3Homo sapiens (human)
dendriteAdenosine receptor A3Homo sapiens (human)
plasma membraneAdenosine receptor A3Homo sapiens (human)
synapseAdenosine receptor A3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (92)

Assay IDTitleYearJournalArticle
AID1887548Antibacterial activity against Acinetobacter baumannii BAA 1605 assessed as reduction in bacterial growth incubated for 16 to 18 hrs in presence of PMBN by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401547Cytotoxicity against human KBVIN cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401546Cytotoxicity against human KB cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID354991Antiplatelet activity against rabbit platelets assessed as collagen-induced platelet aggregation at 20 uM by turbidimetric method1996Journal of natural products, Sep, Volume: 59, Issue:9
Novel antiplatelet constituents from formosan moraceous plants.
AID1887589Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 at 1 time MIC after 24 hrs in presence of linezolid by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887544Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887610Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of meropenem by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887577Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of gentamycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID354993Antiplatelet activity against rabbit platelets assessed as thrombin-induced platelet aggregation at 20 uM by turbidimetric method1996Journal of natural products, Sep, Volume: 59, Issue:9
Novel antiplatelet constituents from formosan moraceous plants.
AID376640Selectivity index, ratio of CC50 for mouse RAW264.7 cells to IC50 for nitric oxide production in mouse RAW264.7 cells2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID376638Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID1887590Post antibiotic effect against Staphylococcus aureus ATCC 29213 assessed as time required for 1 log10 increase in CFU at 1 time MIC incubated for 1 hr followed by replacement with drug free medium and measured every 1 hr (Rvb = 2 hrs)2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887595Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as increase in dead bacterial cells at 2.5 times MIC after 30 mins by confocal laser scanning microscopy analysis2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887606Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of linezolid by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887594Induction of resistance in Staphylococcus aureus ATCC 29213 assessed as increase in MIC treated over 35 serial passages by resistant development assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887547Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated for 16 to 18 hrs in presence of PMBN by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887597Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as increase in extracellular ATP level after 1 hr by ATP bioluminescence assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887596Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as visible cell destruction at 2.5 times MIC after 30 mins by scanning electron microscopy analysis2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887593Post antibiotic effect against Staphylococcus aureus ATCC 29213 at 10 times MIC incubated for 1 hr followed by replacement with drug free medium and measured every 1 hr (Rvb = 0 hr)2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887608Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of levofloxacin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887582Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of meropenem by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401542Cytotoxicity against human SK-MEL-2 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887563Antibacterial activity against vancomycin sensitive/methicillin resistant Enterococcus NR 31886 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401537Cytotoxicity against human A549 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887581Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of ceftazidime by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887553Antibacterial activity against methicillin/levoflaxacin/meropenem/erythromycin resistant Staphylococcus aureus NRS 192 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887540Antibacterial activity against Enterococcus NR 31903 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887568Antibacterial activity against vancomycin/methicillin/levoflaxacin/minocycline resistant Enterococcus NR 31912 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887552Antibacterial activity against methicillin/meropenem/levoflaxacin resistant Staphylococcus aureus NRS 198 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401540Cytotoxicity against human HCT8 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887576Antibacterial activity against Staphylococcus aureus ATCC 29213 infected in mouse J774A.1 cells assessed as reduction in intracellular bacterial cells at 5 times MIC incubated for 24 hrs followed by re-plating on TSA plate and measured after 18 to 24 hrs2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401541Cytotoxicity against human Caki1 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887609Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of ceftazidime by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887587Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 at 1 time MIC after 24 hrs in presence of gentamicin by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID354990Antiplatelet activity against rabbit platelets assessed as arachidonic acid-induced platelet aggregation at 20 uM by turbidimetric method1996Journal of natural products, Sep, Volume: 59, Issue:9
Novel antiplatelet constituents from formosan moraceous plants.
AID1887570Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as reduction in log10 CFU at 10 times MIC after 5 mins by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887545Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887566Antibacterial activity against vancomycin/methicillin/levoflaxacin/minocycline resistant Enterococcus NR 31903 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887551Antibacterial activity against chloramphenicol resistant Staphylococcus aureus NRS 129 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887559Antibacterial activity against methicillin/levoflaxacin/vancomycin/meropenem/gentamycin/spectinomycin/teicoplanin resistant Staphylococcus aureus VRS 4 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887567Antibacterial activity against vancomycin/methicillin/levoflaxacin/minocycline resistant Enterococcus NR 31909 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887603Antibacterial activity against Staphylococcus aureus ATCC 29213 infected in Swiss mouse skin infection model assessed as reduction in skin bacterial load at 1 % dose administered twice daily for 4 days2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887574Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial regrowth at 10 time MIC after 24 hrs by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887557Antibacterial activity against methicillin/meropenem resistant Staphylococcus aureus NRS 194 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887561Antibacterial activity against vancomycin sensitive/methicillin resistant Enterococcus NR 31884 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887583Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of minocycline by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401544Cytotoxicity against human PC3 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887569Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as reduction in log10 CFU at 2.5 times MIC after 5 mins by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887555Antibacterial activity against methicillin/levoflaxacin/meropenem resistant Staphylococcus aureus NRS 193 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887542Antibacterial activity against Acinetobacter baumannii BAA 1605 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887560Antibacterial activity against methicillin/levoflaxacin/vancomycin/meropenem/gentamycin/spectinomycin/teicoplanin resistant Staphylococcus aureus VRS 12 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887598Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as decrease in intracellular ATP level after 1 hr by ATP bioluminescence assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887558Antibacterial activity against methicillin/levoflaxacin/vancomycin/meropenem/gentamycin/spectinomycin/teicoplanin resistant Staphylococcus aureus VRS 1 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887601Antibacterial activity against Staphylococcus aureus ATCC 29213 infected in BALB/c mouse neutropenic thigh infection model assessed as reduction in thigh bacterial load at 50 mg/kg, ip pre-infected with bacteria for 3 hrs followed by compound addition twi2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID376639Cytotoxicity against mouse RAW264.7 cells by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID1887546Selectivity index, ratio of CC50 for African green monkey Vero cells to MIC for Staphylococcus aureus ATCC 292132022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887539Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401543Cytotoxicity against human U87MG cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887550Antibacterial activity against gentamycin/linezolid/methicillin/trimeth/sulfa resistant Staphylococcus aureus NRS 119 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887605Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of gentamycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID34709Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand.1996Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
AID401545Cytotoxicity against human MDA-MB-231 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID231110Ratio of binding affinities between rA1 and rA3 of rat striatal membrane.1996Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
AID401539Cytotoxicity against human 1A9 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887584Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of rifampicin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887541Antibacterial activity against Klebsiella pneumoniae BAA 1705 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID32023Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement.1996Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
AID354992Antiplatelet activity against rabbit platelets assessed as platelet-activating facto-induced platelet aggregation at 20 uM by turbidimetric method1996Journal of natural products, Sep, Volume: 59, Issue:9
Novel antiplatelet constituents from formosan moraceous plants.
AID1887592Post antibiotic effect against Staphylococcus aureus ATCC 29213 at 1 time MIC incubated for 1 hr followed by replacement with drug free medium and measured every 1 hr (Rvb = 0 hr)2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887578Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of linezolid by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887565Antibacterial activity against vancomycin sensitive/methicillin resistant Enterococcus NR 31888 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887580Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of levofloxacin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887579Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of daptomycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887556Antibacterial activity against methicillin/levoflaxacin/meropenem resistant Staphylococcus aureus NRS 186 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887571Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as reduction in log10 CFU at 1 time MIC after 1 hr by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887562Antibacterial activity against vancomycin sensitive/methicillin resistant Enterococcus NR 31885 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887549Antibacterial activity against methicillin/tetracycline resistant Staphylococcus aureus NRS 100 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887613Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of vancomycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID401538Cytotoxicity against human MCF7 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1887611Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of minocycline by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887591Post antibiotic effect against Staphylococcus aureus ATCC 29213 assessed as time required for 1 log10 increase in CFU at 10 times MIC incubated for 1 hr followed by replacement with drug free medium and measured every 1 hr (Rvb = 2 hrs)2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887612Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of rifampicin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887543Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID33760Percent displacement at 10e-4 M against Adenosine A2 receptor in rat striatal membranes using [3H]-CGS- 216801996Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
AID1887585Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of vancomycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887564Antibacterial activity against vancomycin sensitive/methicillin resistant Enterococcus NR 31887 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1504876Inhibition of tyrosinase (unknown origin) up to 100 uM using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measured for 7 mins by spectrophotometric analysis2017Journal of natural products, 12-22, Volume: 80, Issue:12
Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities.
AID1887588Antibacterial activity against Staphylococcus aureus ATCC 29213 at 1 time MIC after 24 hrs by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887575Antibiofilm activity against Staphylococcus aureus ATCC 29213 assessed as reduction in preformed bacterial biofilm mass at 1 time MIC incubated for 24 hrs by crystal violet staining based microtiter plate reader assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887554Antibacterial activity against methicillin/levoflaxacin/meropenem resistant Staphylococcus aureus NRS 191 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887607Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of daptomycin by checkerboard method2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
AID1887572Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as reduction in log10 CFU at 10 time MIC after 1 hr by time kill assay2022Journal of natural products, 10-28, Volume: 85, Issue:10
Developing the Natural Prenylflavone Artocarpin from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (43)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (16.28)18.2507
2000's15 (34.88)29.6817
2010's16 (37.21)24.3611
2020's5 (11.63)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.89 (24.57)
Research Supply Index3.85 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other46 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid
4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.		2.1510monohydroxybenzoic acidalgal metabolite;
plant metabolite
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		1.9910benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
1-(5-isoquinolinesulfonyl)piperazine
[no description available]		1.9910isoquinolines
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9910aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
kojic acid
[no description available]		2.46204-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
galactose
galactopyranose : The pyranose form of galactose.		2.4120D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.1310penicillin allergen;
penicillin		antibacterial drug
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.4110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
visnagin
visnagin: from Musineon divaricatum. visnagin : A furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga.		1.9910aromatic ether;
furanochromone;
polyketide		anti-inflammatory agent;
antihypertensive agent;
EC 1.1.1.37 (malate dehydrogenase) inhibitor;
phytotoxin;
plant metabolite;
vasodilator agent
flavanone
flavanone: RN given refers to cpd with unspecified isomeric designation; structure in first source. flavanone : The simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4.		1.9910flavanones
flavone
flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.		1.9910flavonesmetabolite;
nematicide
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.4110glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
2-methoxy-1,4-naphthoquinone
2-methoxy-1,4-naphthoquinone: isolated from Swertia calycina; structure in first source. 2-methoxy-1,4-naphthoquinone : A naphthoquinone that is naphthalene-1,4-dione substituted by a methoxy group at position 2. It has been isolated from the roots of Rubia yunnanensis.		2.41101,4-naphthoquinones;
enol ether		antimicrobial agent;
metabolite;
plant metabolite
mannose
mannopyranose : The pyranose form of mannose.		2.9140D-aldohexose;
D-mannose;
mannopyranose		metabolite
dihydrochalcone
dihydrochalcone : A member of the class of dihydrochalcones that is acetophenone in which one of the hydrogens of the methyl group is replaced by a benzyl group.		2.1510dihydrochalconesplant metabolite
gentamicin c1
[no description available]		2.4110
sakuranetin
sakuranetin: major rice phytoalexin; RN given for ((S)-(-))-isomer; structure in first source. sakuranetin : A flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group.		1.9910(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavonoid phytoalexin;
monomethoxyflavanone		antimycobacterial drug;
plant metabolite
methyl mannoside, (alpha-d)-isomer
methylmannoside: RN given refers to (D)-isomer; see also record for 3-O-methylmannose. methyl alpha-D-mannoside : A methyl mannoside having alpha-configuration at the anomeric centre.		2.0110alpha-D-mannoside;
methyl mannoside
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.0310amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		2.41109-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
4'-hydroxyflavanone
4'-hydroxyflavanone: structure in first source. 4'-hydroxyflavanones : Any hydroxyflavanone having a hydroxy substituent located at position 4'.		1.99104'-hydroxyflavanones;
monohydroxyflavanone
2'-hydroxyflavanone
[no description available]		1.9910
6-chloroflavone
6-chloroflavone: structure in first source		1.9910
mrs 1067
3,6-dichloro-2'-isopropyloxy-4'-methylflavone: structure in first source		1.9910
sakuranetin
[no description available]		1.9910
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		2.0110beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		2.4110alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
linezolid
[no description available]		2.4110acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
kazinol b
kazinol B: a natural isoprenylated flavan		1.9910
8-isopentenylnaringenin
8-isopentenylnaringenin: a non-steroidal phytoestrogen from Anaxagorea luzonensis; structure in first source		2.0310flavanones
glycosides
[no description available]		2.3110
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.1510
fusidic acid
Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.		2.411011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.4110
leukotriene b4
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.		2.0510dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		2.4720chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
galangin
5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source. galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.		1.99107-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
mangostin
mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.		2.4110aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.		1.99107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
cycloheterophyllin
cycloheterophyllin: RN refers to ((+)-)-isomer; structure given in first source		2.4420extended flavonoid
Cudraflavone A
[no description available]		2.0310extended flavonoid
cudraflavone c
cudraflavone C: a tyrosinase inhibitor with antimicrobial activity; isolated from Artocarpus integer; structure in first source. cudraflavone C : A tetrahydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 7, 2' and 4' and prenyl groups at positions 3 and 6. Isolated from Morus nigra, it exhibits antibacterial and cytotoxic activities.		2.4620tetrahydroxyflavoneantibacterial agent;
antineoplastic agent;
plant metabolite
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid: chromogen in glucose oxidase-peroxidase method for determining serum glucose; used in free radical scavenging assays; structure in first source		2.4620
ceftazidime
[no description available]		2.4110cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
artonin e
artonin E: structure given in first source; isolated from the bark of Artocarpus communis Forst.		2.0210
Norartocarpetin
[no description available]		2.1510flavones
broussochalcone a
broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source		1.9910
morachalcone a
morachalcone A: tyrosinase inhibitor from the wood of Artocarpus heterophyllus; structure in first source		2.0310chalcones
Cycloartobiloxanthone
cycloartobiloxanthone: a flavonoid isolated from stem bark of Artocarpus gomezianus; has antineoplastic properties		2.4620pyranoxanthones
polymyxin b(1)
[no description available]		2.4110
artocarpanone
artocarpanone: from Artocarpus heterophyllus; structure in first source		2.4320
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.1510
forapin
Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide		2.4110peptidyl amide;
polypeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.13 (protein kinase C) inhibitor;
hepatoprotective agent;
neuroprotective agent;
venom
chitosan
[no description available]		2.0310
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		2.0510
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		2.4110
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.4110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.4110
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.4110
Colorectal Cancer
[description not available]		02.1510
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.1510
Carcinoma, Non-Small Cell Lung
[description not available]		02.1510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1510
Cancer of Lung
[description not available]		02.1510
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.1510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1510
Bone Cancer
[description not available]		02.2110
Osteogenic Sarcoma
[description not available]		02.2110
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.		02.2110
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)		02.2110
Dermatoses
[description not available]		02.0810
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.0810
Hepatocellular Carcinoma
[description not available]		02.1310
Cancer of Liver
[description not available]		02.1310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.1310
Liver Neoplasms
Tumors or cancer of the LIVER.		02.1310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510
Breast Cancer
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0510