linezolid and Streptococcal-Infections

linezolid has been researched along with Streptococcal-Infections* in 2 studies

Other Studies

2 other study(ies) available for linezolid and Streptococcal-Infections

Article	Year
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24 Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus possess less potential for the side effects associated with MAO inhibition. The title compound (14) showed reduced in vivo myelotoxicity compared to linezolid in a 14-day safety study in rats, potent in vivo efficacy in murine systemic infection models, and excellent pharmacokinetic properties. Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cyclic S-Oxides; Dogs; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Injections, Intravenous; Linezolid; Male; Mice; Microbial Sensitivity Tests; Monoamine Oxidase Inhibitors; Oxazolidinones; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes; Structure-Activity Relationship	2007
DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9 DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models of peritonitis (methicillin-resistant S. aureus, MRSA) and lung infection (S. pneumoniae). Topics: Amino Acids, Aromatic; Animals; Anti-Bacterial Agents; Disease Models, Animal; DNA; Ligands; Lung Diseases; Mice; Peritonitis; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pneumoniae	2004

Article

Year

Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.

Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus possess less potential for the side effects associated with MAO inhibition. The title compound (14) showed reduced in vivo myelotoxicity compared to linezolid in a 14-day safety study in rats, potent in vivo efficacy in murine systemic infection models, and excellent pharmacokinetic properties.

Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cyclic S-Oxides; Dogs; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Injections, Intravenous; Linezolid; Male; Mice; Microbial Sensitivity Tests; Monoamine Oxidase Inhibitors; Oxazolidinones; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes; Structure-Activity Relationship

2007

DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids.

Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9

DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models of peritonitis (methicillin-resistant S. aureus, MRSA) and lung infection (S. pneumoniae).

Topics: Amino Acids, Aromatic; Animals; Anti-Bacterial Agents; Disease Models, Animal; DNA; Ligands; Lung Diseases; Mice; Peritonitis; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pneumoniae

2004