Page last updated: 2024-12-07

phenylalanine-beta-naphthylamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Phenylalanine-beta-naphthylamide is a synthetic compound that has been studied for its potential as a substrate for the enzyme chymotrypsin. It is a fluorescent probe that can be used to monitor the activity of chymotrypsin and other proteases. The compound is synthesized by reacting phenylalanine with beta-naphthylamine. Phenylalanine-beta-naphthylamide has been shown to be a good substrate for chymotrypsin and is often used in studies of enzyme kinetics. The compound has also been investigated for its potential therapeutic uses, such as in the treatment of cancer. The compound has been shown to inhibit the growth of cancer cells in vitro and in vivo. Further research is needed to fully understand the mechanism of action of this compound and its potential therapeutic uses.'

phenylalanine-beta-naphthylamide: RN given for (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

L-phenylalanine 2-naphthylamide : An L-phenylalanine derivative that is the amide obtained by formal condensation of the carboxy group of L-phenylalanine with the amino group of 2-naphthylamine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID102477
CHEBI ID90599
SCHEMBL ID1614525
MeSH IDM0213145

Synonyms (34)

Synonym
h-phe-betana
740-57-8
l-phenylalanine-2-naphthylamide
(2s)-2-amino-n-naphthalen-2-yl-3-phenylpropanamide
phe-beta-nap
phenylalanine-beta-naphthylamide
(s)-2-amino-n-(2-naphthyl)-3-phenylpropionamide
einecs 212-009-9
l-phenylalanine beta-naphthylamide
SCHEMBL1614525
AKOS024284616
l-phenylalanine-.beta.-naphthylamide
n-l-phenylalanyl-2-naphthylamide
benzenepropanamide, .alpha.-amino-n-2-naphthalenyl-, (.alpha.s)-
l-.alpha.-phenylalanyl-.beta.-naphthylamide
benzenepropanamide, .alpha.-amino-n-2-naphthalenyl-, (s)-
hydrocinnamamide, .alpha.-amino-n-2-naphthyl-, l-
QUOLUWPVABJBKU-SFHVURJKSA-N
2-amino-n-(2-naphthyl)-3-phenylpropanamide #
n-phenylalanyl-2-aminonaphthalene
CHEBI:90599
n-(2-naphthyl)-l-phenylalaninamide
n-naphthalen-2-yl-l-phenylalaninamide
l-phenylalanine 2-naphthylamide
n-(beta-naphthyl)-l-phenylalaninamide
h-phe-na
(s)-2-amino-n-(naphthalen-2-yl)-3-phenylpropanamide
Q27162617
F11019
AS-46953
DTXSID90995279
2-amino-n-(naphthalen-2-yl)-3-phenylpropanimidic acid
CS-0363192
benzenepropanamide,a-amino-n-2-naphthalenyl-,(as)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
chromogenic compoundColourless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into coloured compounds. They are used in biochemical assays and in diagnosis as indicators, particularly in the form of enzyme substrates.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
N-(2-naphthyl)carboxamideAny carboxamide resulting from the formal condensation of a carboxylic acid with 2-naphthylamine.
amino acid amideAn amide of an amino acid formed formally by conversion of the carboxy group to a carboxamido group.
L-phenylalanine derivativeA proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.20 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]