| ID Source | ID |
|---|---|
| PubMed CID | 9561005 |
| CHEMBL ID | 223505 |
| MeSH ID | M0453807 |
| Synonym |
|---|
| [(e)-1-(4-methoxyphenyl)ethylideneamino]thiourea |
| sri-224 |
| AKOS000506378 |
| CHEMBL223505 , |
| p-methoxyphenyl(methyl)thiosemicarbazone |
| bdbm50302754 |
| 9P-047 |
| [(e)-[1-(4-methoxyphenyl)ethylidene]amino]thiourea |
| 150059-53-3 |
| 2-[(e)-1-(4-methoxyphenyl)ethylidene]-1-hydrazinecarbothioamide |
| sr-01000310617 |
| SR-01000310617-1 |
| (1e)-1-(4-methoxyphenyl)ethanone thiosemicarbazone |
| mfcd00808617 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 0.1100 | AID444073 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID178190 | Effective dose for protection against seizures induced in the maximal electroshock anticonvulsant screen test 1 hr after oral dosing in rat | 1993 | Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16 ISSN: 0022-2623 | Anticonvulsant activities of some arylsemicarbazones displaying potent oral activity in the maximal electroshock screen in rats accompanied by high protection indices. |
| AID190125 | Neurotoxicity was determined, 1 hr after oral dosing in rat. | 1993 | Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16 ISSN: 0022-2623 | Anticonvulsant activities of some arylsemicarbazones displaying potent oral activity in the maximal electroshock screen in rats accompanied by high protection indices. |
| AID598528 | Inhibition of alpha-MSH-induced melanin production in mouse B16 cells at 10 uM after 3 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 ISSN: 1464-3405 | Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition. |
| AID283663 | Antimycobacterial activity against Mycobacterium bovis BCG NCTC 5692 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| AID598529 | Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 ISSN: 1464-3405 | Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition. |
| AID283671 | Antimycobacterial activity against Mycobacterium bovis BCG str. Pasteur 1173P2 overexpressing ethA gene | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| AID444073 | Inhibition of mushroom tyrosinase | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21 ISSN: 1464-3405 | Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. |
| AID283664 | Antimycobacterial activity against Mycobacterium bovis BCG NCTC 5692 with ethR-knockout mutant | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| AID1659814 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as reduction in mycolic acids synthesis after 8 hrs in presence of [1, 2-14C]-acetate by TLC analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 ISSN: 1520-4804 | Molecule Property Analyses of Active Compounds for |
| AID283670 | Antimycobacterial activity against Mycobacterium bovis BCG str. Pasteur 1173P2 overexpressing ethR gene | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| AID283662 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| AID283669 | Antimycobacterial activity against Mycobacterium bovis BCG Pasteur with pMV261 vector | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 ISSN: 0066-4804 | EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Absence Seizure | 0 | 1993 | 1993 | 31.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 | |
| B16 Melanoma | 0 | 2011 | 2011 | 13.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Koch's Disease | 0 | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Seizures | 0 | 1993 | 1993 | 31.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 | |
| Tuberculosis | 0 | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |