Compounds > abt 719
Page last updated: 2024-12-08

abt 719

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Cross-References

ID SourceID
PubMed CID178074
CHEMBL ID16727
SCHEMBL ID1290350
MeSH IDM0246423

Synonyms (15)

Synonym
abt-719 (*hydrochloride*)
8-[(3s)-3-aminopyrrolidin-1-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid
a 86719.1(*hydrochloride*)
162829-90-5
4h-quinolizine-3-carboxylic acid, 8-[(3s)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-
abt-719
CHEMBL16727
8-[(3s)-3-aminopyrrolidin-1-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid
a 86719.1(hydrochloride)
abt-719 (hydrochloride)
4h-quinolizine-3-carboxylic acid, 8-((3s)-3-amino-1-pyrrolidinyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-
SCHEMBL1290350
DTXSID10167476
BCP24183
(s)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4h-quinolizine-3-carboxylic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (70)

Assay IDTitleYearJournalArticle
AID208909Antibacterial activity against Gram-positive Streptococcus bovis A5169 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID600468Thermodynamic aqueous solubility of the compound in phosphate buffer at pH 7.42011Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
AID130528In vivo efficacy against Streptococcus pneumoniae ATCC 6303 after subcutaneous administration1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID206789Inhibitory activity against ciprofloxacin-resistant Staphylococcus aureus1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID163448Inhibitory activity against ciprofloxacin-resistant Pseudomonas aeruginosa1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID71092In vitro antibacterial activity against Escherichia coli KNK 437 a ciprofloxacin less sensitive strain1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID112966Effective dose against Escherichia coli JUHL in mice upon subcutaneous administration1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID66100Inhibitory activity against vancomycin-resistant Enterococcus faecium1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID68063Antibacterial activity against Enterococcus faecium ATCC 8043 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID164082In vivo efficacy against Pseudomonas aeruginosa 5007 after subcutaneous administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID130519In vivo efficacy against Staphylococcus aureus NCTC 10649M in mouse protection test after p.o. administration.1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID206605In vitro antibacterial activity against gram-positive organism Staphylococcus aureus NCTC-10649M1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID112964Compound was tested for its effective dose against Escherichia coli JUHL in mice upon peroral administration1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID165192In vitro antibacterial activity against gram-negative organism Pseudomonas aeruginosa DPHD-28621996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID23806Plasma half-life in rats after an oral dose of 5 mg/kg1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID71097In vitro antibacterial against gram-negative organism Escherichia coli JUHL1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID158490In vitro antibacterial activity against gram negative P. aeruginosa DPHP 52631999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID130523In vivo efficacy against Staphylococcus aureus NCTC 10649M in mouse1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID67547Antibacterial activity against Enterobacter aerogenes ATCC 13048 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID209477In vitro antibacterial activity against gram-positive organism Streptococcus pyogenes EES611996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID163898Antibacterial activity against Gram-negative Providencia Stuartii CMX640 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID41286Inhibitory activity against strain of Bacteroides fragilis1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID158489In vitro antibacterial activity against Gram-negative Pseudomonas aeruginosa 50071999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID71057Concentration which causes 50% of the gyrase (Escherichia coli H560)-mediated maximal DNA cleavage.1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID209128Antibacterial activity against Streptococcus pyogenes EES61 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID18008Oral bioavailability in rat (dose 5 mg/kg)1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID112967Effective dose against Staphylococcus aureus NCTC-10649M in mice upon peroral administration1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID208631Inhibitory activity against penicillin-resistant Streptococcus pneumoniae1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID164083In vivo efficacy against Pseudomonas aeruginosa 5007 following p.o. administration.1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206562In vivo efficacy against Staphylococcus aureus NCTC-10649M after oral administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID112969Effective dose against Staphylococcus aureus NCTC-10649M in mice upon subcutaneous administration1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID165191In vitro antibacterial activity against gram-negative organism Pseudomonas aeruginosa 50071996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID130517In vivo efficacy against Pseudomonas aeruginosa 5007 in mouse protection test after subcutaneous administration by oral gavage1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID206601In vitro antibacterial activity against gram-positive Staphylococcus aureus 17751999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID130515In vivo efficacy against Pseudomonas aeruginosa 5007 in mouse protection test after subcutaneous administration1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID164110In vitro antibacterial activity against gram negative Pseudomonas cepacia 29611999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID78716Compound was tested for bacterial DNA gyrase activity1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID206874Antibacterial activity against Staphylococcus aureus A1775 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID96404In vitro antibacterial activity against gram-negative organism Klebsiella pneumoniae ATCC 80451996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206602In vitro antibacterial activity against gram-positive Staphylococcus aureus NCTC 10649M1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID209874In vivo efficacy against Strep. administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID68388In vitro antibacterial activity against gram-positive organism Enterococcus faecium ATCC 80431996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206604In vitro antibacterial activity against gram-positive organism Staphylococcus aureus ATCC 6538p1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID600463Inhibition of Escherichia coli H560 DNA gyrase mediated DNA cleavage2011Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
AID66731In vitro antibacterial activity against gram-negative organism Enterococcus aerogenes ATCC 130481996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206563In vivo efficacy against Staphylococcus aureus NCTC-10649M after subcutaneous administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID600462Oral bioavailability in rat2011Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
AID130527In vivo efficacy against Streptococcus pneumoniae ATCC 6303 after administration by oral gavage1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID130387In vivo efficacy against Escherichia coli JUHL in mouse protection test after subcutaneous administration1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID95915Antibacterial activity against Klebsiella pneumoniae ATCC 8045 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID132572IIn vivo efficacy against Escherichia coli JUHL in mouse protection test after administration by oral gavage.1999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID209871In vivo efficacy against Strep. administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID68826In vivo efficacy against Escherichia coli JUHL by subcutaneous administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID68386In vitro antibacterial activity against gram-positive Enterococcus faecium ATCC 80431999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID69607Antibacterial activity against Escherichia coli JUHL was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID67572Inhibitory activity against enterococcus faecalis Van B1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206603In vitro antibacterial activity against gram-positive organism Staphylococcus aureus 17751996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID206880Antibacterial activity against Staphylococcus aureus NCTC-10649M was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID71096In vitro antibacterial activity against gram negative Escherichia coli KNK 4371999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID208916In vitro antibacterial activity against gram-positive organism Streptococcus bovis A-51691996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID20906Aqueous solubility in pH 7.4 phosphate buffer (0.05 M) at 37 degree C1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID14244Maximum plasma concentration in rats after an oral dose of 5 mg/kg1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID209476In vitro antibacterial activity against gram positive Streptococcus pyogenes 9301999Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
AID206790Inhibitory activity against strain of Staphylococcus aureus1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID11592Compound was evaluated for maximal plasma concentration in rat upon 5 mg/kg upon oral administration1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID68824In vivo efficacy against Escherichia coli JUHL after oral administration1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID68401Inhibitory activity against enterococcus faecium Van A1996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID164239Antibacterial activity against Pseudomonas aeruginosa A-5007 was determined1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
AID163889In vitro antibacterial activity against gram-negative organism Prov. stuartii CMX-6401996Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
AID13195Oral bioavailability in rat (dose 5 mg/kg)1998Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.71 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (40.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
beta-naphthoflavone
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.		3.1610extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.420aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		3.4920glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
4-chlorobiphenyl
4-chlorobiphenyl : A monochlorobiphenyl carrying a chloro substituent at position 4.		3.1610monochlorobiphenyl
2,4'-dichlorobiphenyl
2,4'-dichlorobiphenyl: RN given refers to unlabeled cpd. 2,4'-dichlorobiphenyl : A dichlorobiphenyl that is chlorobenzene in which the hydrogen at position 2 has been replaced by a 4-chlorophenyl group.		3.1610dichlorobiphenyl;
monochlorobenzenes
clinafloxacin
clinafloxacin: structure given in first source; RN given is for monoHCl		3.0910quinolines
trovafloxacin
trovafloxacin: a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity. trovafloxacin : A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.		3.0910
ciprofloxacin hydrochloride anhydrous
[no description available]		3.5220hydrochlorideantibacterial drug;
antiinfective agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
eperezolid
[no description available]		3.0910
tosufloxacin, 4-toluene sulfonate
tosufloxacin tosylate : A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate.		1.9910racemateantiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
hepatotoxic agent;
topoisomerase IV inhibitor
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		3.0910beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
linezolid
[no description available]		3.0910acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		3.0910macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
sitafloxacin
[no description available]		3.0910fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
magainin 1 peptide, xenopus
magainin I: Antibiotic peptide. Thought to preferentially bind to anionic phosholipids.		3.0910
ge 2270 a
GE 2270 A: from Planobispora rosea; inhibits bacterial protein synthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu; structure given in first source		3.0910
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		3.0910
ConditionIndicatedRelationship StrengthStudiesTrials