Compounds > ge 2270 a
Page last updated: 2024-11-12

ge 2270 a

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Description

GE 2270 A: from Planobispora rosea; inhibits bacterial protein synthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16186054
CHEMBL ID1766417
MeSH IDM0186473

Synonyms (16)

Synonym
unii-jb4j58l2k1
antibiotic ge 2270a
jb4j58l2k1 ,
134861-34-0
ge-2270a
DB02975
ge 2270 a
ge-2270
ge 2770
CHEMBL1766417
ge-2270 a
antibiotic ge-2270a
mdl-62879
Q27281413
CS-0026827
HY-106882
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID675930Aqueous solubility of the compound at pH 7.4 by RP-HPLC analysis2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID675925Antibacterial activity against Clostridium difficile ATCC 43255 by broth microdilution method2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID592856Antibacterial activity against methicillin-resistant Staphylococcus2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID633456Antibacterial activity against Streptococcus pneumoniae by CLSI M07-A8 method2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID633379Antibacterial activity against Enterococcus faecium 7130724 by CLSI M07-A8 method2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID633378Antibacterial activity against Enterococcus faecalis ATCC 29212 by CLSI M07-A8 method2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID113730Inhibitory activity against Streptococcus pyogenes in mice1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID592939Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M100-S19 method2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID113729Inhibitory activity against Streptococcus pneumoniae in mice1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID592940Antibacterial activity against Streptococcus pyogenes ATCC BAA-595 by CLSI M100-S19 method2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID113728Inhibitory activity against Staphylococcus aureus in mice1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
New directions in antibacterial research.
AID633381Antibacterial activity against Streptococcus pyogenes ATCC BAA-595 by CLSI M07-A8 method2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID597872Antimicrobial activity against Enterococcus faecium 7130724 by CLSI method2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
AID633455Aqueous solubility of the compound2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID675941Inhibition of protein synthesis in Escherichia coli S30 extract after 75 mins by luciferase based luminescence assay relative to GE2270A2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID592858Antibacterial activity against Enterococcus faecalis ATCC 29212 by CLSI M100-S19 method2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID597871Antimicrobial activity against Enterococcus faecalis ATCC 29212 by CLSI method2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
AID592938Antibacterial activity against Enterococcus faecium by CLSI M100-S19 method2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID675924Antibacterial activity against Streptococcus pyogenes ATCC BAA-595 by broth microdilution method2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID592857Antibacterial activity against vancomycin-resistant Enterococcus2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
AID675922Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID633380Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate A4.018 by CLSI M07-A8 method2011Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
AID597874Antimicrobial activity against Streptococcus pyogenes ATCC BAA-595 by CLSI method2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
AID675927Binding affinity to Escherichia coli GDPNP-labelled EF-Tu by surface plasmon resonance analysis2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID675923Antibacterial activity against Staphylococcus aureus A4.018 by broth microdilution method2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID597875Inhibition of protein synthesis in Escherichia coli S30 extract at 2 uM by luciferase assay relative to control2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
AID675921Antibacterial activity against Enterococcus faecium 7130724 by broth microdilution method2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID675926Inhibition of protein synthesis in Escherichia coli S30 extract at 2 uM after 75 mins by luciferase based luminescence assay relative to GE2270A2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
AID597873Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate obtained from pharyngeal smear by CLSI method2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (54)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's22 (40.74)18.2507
2000's17 (31.48)29.6817
2010's14 (25.93)24.3611
2020's1 (1.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (5.45%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other52 (94.55%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetamide
acetimidic acid : A carboximidic acid that is acetic acid in which the carbonyl oxygen is replaced by an imino group.		2.0410acetamides;
carboximidic acid;
monocarboxylic acid amide;
N-acylammonia
adenine
[no description available]		2106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.1310metal allergen;
nickel group element atom		epitope;
micronutrient
pyridine
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.		2.4620azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0210isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.0110aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0410amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.08101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		6.95201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		3.5220glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1710metal allergen;
nickel group element atom;
platinum group metal atom
clinafloxacin
clinafloxacin: structure given in first source; RN given is for monoHCl		3.0910quinolines
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		2.0110adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
trovafloxacin
trovafloxacin: a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity. trovafloxacin : A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.		3.0910
sinefungin
[no description available]		2.0110adenosines;
non-proteinogenic alpha-amino acid		antifungal agent;
antimicrobial agent
eperezolid
[no description available]		3.0910
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		3.0910beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
abt 719
[no description available]		3.0910
amythiamicin a
amythiamicin A: isolated from Amycolatopsis		2.420
linezolid
[no description available]		3.5220acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
clindamycin
Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.		2.4320
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		3.0910macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
sitafloxacin
[no description available]		3.0910fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
enacyloxin iia
enacyloxin IIa: produced by Frateuria sp. W-315; structure given in first source		4.3330
pulvomycin
pulvomycin: isolated from culture MA-2465; structure		5.32100
magainin 1 peptide, xenopus
magainin I: Antibiotic peptide. Thought to preferentially bind to anionic phosholipids.		3.0910
ly-146032
[no description available]		2.0610heterodetic cyclic peptide;
lipopeptide antibiotic;
lipopeptide;
macrocycle;
macrolide		antibacterial drug;
bacterial metabolite;
calcium-dependent antibiotics
lff571
LFF571: an antibacterial agent; structure in first source		2.0710
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		3.0910
thiomuracin a
thiomuracin A: isolated from Nonomurae; structure in first source		2.1510
vitamin b 12
Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.		2.0110
guanosine diphosphate
Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.		3.2460guanosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		4.4970guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
efrotomycin
efrotomycin: from Streptomyces lactamdurans; structure		2.3820
mocimycin
mocimycin: induces GTPase activity of EF-TU; N-demethyl analog of antibiotic X-5108; structure		5.1280C-glycosyl compound
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Poisoning
[description not available]		02.0610
Bacterial Infections, Gram-Positive
[description not available]		02.4120
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.		02.4120
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		02.0610
Antibiotic-Associated Colitis
[description not available]		02.0710
Enterocolitis, Pseudomembranous
An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.		02.0710
Actinomycetales Infections
Infections with bacteria of the order ACTINOMYCETALES.		03.0610
Infections, Staphylococcal
[description not available]		02.6930
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.6930