Page last updated: 2024-09-27

Hyperlactatemia

Increase in blood LACTATE concentration often associated with SEPTIC SHOCK; LUNG INJURY; SEPSIS; and DRUG TOXICITY. When hyperlactatemia is associated with low body pH (acidosis) it is LACTIC ACIDOSIS.

Synonyms(1)

Synonym
Hyperlactatemia

Research Excerpts

Overview

ExcerptReference
"Hence, hyperlactatemia is closely associated with disease severity but it is an epiphenomenon as the body attempts to protect itself."( Gillespie, Í; Hughes, D; Rosenstein, PG, 2017)
"Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission."( Minton, J; Sidebotham, DA, 2017)
"Hyperlactatemia is common in critically ill patients and has a variety of etiologies."( Blohm, E; Lai, J; Neavyn, M, 2017)
"Hyperlactatemia is a relatively rare but life-threatening toxicity of various medication classes."( Blohm, E; Lai, J; Neavyn, M, 2017)
"Persistent hyperlactatemia is associated with adverse outcome in critically ill patients."( Godinjak, A; Iglica, A; Jusufovic, S; Kukuljac, A; Rama, A; Rozajac, S; Tancica, I; Zvizdic, F, 2017)
"The etiology of hyperlactatemia is complex and multifactorial."( Hughes, D; Rosenstein, PG; Tennent-Brown, BS, 2018)
"Although hyperlactatemia is often developed in critically ill patients, it is unclear whether hyperlactatemia is associated with poor prognosis for surgical ICU (SICU) patients."( Abe, T; Sasabuchi, Y; Takinami, M; Uchino, S, 2018)
"BACKGROUND Hyperlactatemia is a common phenomenon following cardiac surgeries and is associated with prolonged ICU stay and higher morbidity and mortality rates, but such analyses have never focused on patients undergoing heart transplantation (HTX), in whom hyperlactatemia defined with the traditional threshold is observed in nearly every individual."( Drwiła, R; Górkiewicz-Kot, I; Hymczak, H; Kapelak, B; Kędziora, A; Milaniak, I; Piątek, J; Sobczyk, D; Tomsia, P; Wierzbicki, K, 2020)
"Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes."( Hoste, EAJ; Kruse, JM; Van Biesen, W; Van De Ginste, L; Vanommeslaeghe, F; Verbeke, F, 2022)
"Hyperlactatemia is a common metabolic disorder after cardiac surgery with cardiopulmonary bypass."( Ge, YP; Jiang, W; Luo, TG; Pan, YC; Shi, Q; Xiao, ZH; Zhan, YF; Zheng, BS, 2022)
"Hyperlactatemia is a common complication in critically ill patients with high morbidity and mortality."( Bai, M; Li, L; Sun, S; Zhang, Q, 2022)
"Severe hyperlactatemia is not uncommon in this group of patients."( Albers, J; Bodenstein, M; Dohle, DS; Koelm, S; Kriege, M; Oezkur, M; Rissel, R; Schepers, M, 2022)
"Severe hyperlactatemia is not uncommon in this group of patients."( Albers, J; Bodenstein, M; Dohle, DS; Koelm, S; Kriege, M; Oezkur, M; Rissel, R; Schepers, M, 2022)
"Hyperlactatemia is associated with mortality outcomes in patients undergoing CRRT for acute kidney injury."( Han, SS; Joo, KW; Kang, MW; Kim, DK; Kim, SG; Kim, YC; Kim, YS; Lee, J; Oh, KH; Yun, D, 2023)
"Hyperlactatemia is a common finding in critically ill patients and has significant prognostic implications."( Ağın, H; Atakul, G; Ceylan, G; Çolak, M; Karaarslan, ÜU; Sandal, ÖS; Sarı, F; Soydan, E; Topal, S, 2022)

Context

ExcerptReference
"VTE risk and blood hyperlactatemia have been associated with a higher mortality risk in critically ill Covid-19 patients who are hospitalized in the ICU in Saudi Arabia."( Ali Khan, I; AlQarni, HM; Alshammary, AF; Farzan, R; Vennu, V, 2023)

Research

Studies (164)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (0.61)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's100 (60.98)28.8240
2020's63 (38.41)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ethylene glycol0low10
carnitine0low30
citric acid, anhydrous0low30
3-hydroxybutyric acid0low20
lactic acid0medium1226
hydrogen carbonate0low30
propylene glycol0low10
pyruvic acid0low10
thiamine0low60
uric acid0low10
acetaminophen0low10
albuterol0low10
caffeine0low10
carbamazepine0low10
clenbuterol0low10
metformin0low110
omeprazole0low10
propranolol0low10
terbutaline0low10
prednisolone0low10
thymidine0low10
mannitol0low10
pyridostigmine bromide0low10
thiophenes0low10
hematoxylin0low10
helium0low10
magnesium sulfate0low10
amitraz0low10
sufentanil0low10
esmolol0low20
lamivudine0low10
fluorodeoxyglucose f180low10
heliox0low10
telbivudine0low10
glycogen0low10
linezolid0low10
cocaine0low10
sodium bicarbonate0low10
cocaethylene0low10
quinine0low10
bilirubin0low10
coenzyme q100low10
naloxone0low10
dexmedetomidine0low10
azd39650low10
1-phenyl-2-(1-pyrrolidinyl)-1-pentanone0low10
pituitrin0low10
ubiquinone0low10
sodium lactate0low10
raltegravir potassium0low10
ro13-99040low10
dolutegravir0low20
calca protein, human0low10
folic acid0low10
leptin0low10
pyrimidinones0low10

Protein Targets (666)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent serotonin transporter0505
Sodium-dependent dopamine transporter 0404
Protein skinhead-10101
Monocarboxylate transporter 20202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
RAR-related orphan receptor gamma100010
ATAD5 protein, partial1001
GLS protein4004
Microtubule-associated protein tau5005
Smad31001
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor6006
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor5005
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha120012
estrogen nuclear receptor alpha210021
peroxisome proliferator activated receptor gamma5005
aryl hydrocarbon receptor6006
chromobox protein homolog 15005
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 226006
cytochrome P450 3A4 isoform 15005
Gamma-aminobutyric acid receptor subunit pi5117
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014015
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump017017
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10505
Carbonic anhydrase 20606
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20305
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30101
Cytochrome P450 3A40506
Cytochrome P450 2D60708
Cytochrome P450 2C9 09010
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-15117
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta5117
Gamma-aminobutyric acid receptor subunit gamma-25117
UDP-glucuronosyltransferase 1-60102
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-55117
Gamma-aminobutyric acid receptor subunit alpha-35117
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0204
Carbonic anhydrase 40404
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60202
Gamma-aminobutyric acid receptor subunit gamma-15117
Gamma-aminobutyric acid receptor subunit alpha-25117
Gamma-aminobutyric acid receptor subunit alpha-45117
Gamma-aminobutyric acid receptor subunit gamma-35117
Gamma-aminobutyric acid receptor subunit alpha-65117
Carbonic anhydrase 5A, mitochondrial0303
Prostaglandin G/H synthase 20102
Carbonic anhydrase 70101
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20606
Gamma-aminobutyric acid receptor subunit alpha-15117
Gamma-aminobutyric acid receptor subunit beta-35117
Gamma-aminobutyric acid receptor subunit beta-25117
Carbonic anhydrase 90303
GABA theta subunit5117
Canalicular multispecific organic anion transporter 1015015
Carbonic anhydrase 150202
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon5117
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
glp-1 receptor, partial4004
thioredoxin reductase5005
regulator of G-protein signaling 44004
NPYLR7B0011
arylsulfatase A3003
euchromatic histone-lysine N-methyltransferase 28008
thyroid stimulating hormone receptor5005
flap endonuclease 12002
Beta-2 adrenergic receptor06713
Beta-1 adrenergic receptor06511
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor0246
Delta-type opioid receptor0347
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
Beta-2 adrenergic receptor 0039
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Beta-2 adrenergic receptor0348
ATP-dependent phosphofructokinase4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
hypoxia-inducible factor 1 alpha subunit3003
GLI family zinc finger 39009
AR protein110011
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
cytochrome P450 2D65005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d3003
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin9009
lamin isoform A-delta109009
Cellular tumor antigen p539009
Alpha-2A adrenergic receptor05410
Peroxisome proliferator-activated receptor alpha1001
Monocarboxylate transporter 10011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Cruzipain1001
phosphopantetheinyl transferase4004
USP1 protein, partial6006
vitamin D3 receptor isoform VDRA3003
DNA polymerase kappa isoform 14004
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 12002
Solute carrier organic anion transporter family member 1B30304
Solute carrier organic anion transporter family member 1B10304
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0022
Chain A, glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor1001
DNA polymerase beta3003
nuclear receptor ROR-gamma isoform 14004
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Potassium channel subfamily K member 20112
Glycogen phosphorylase, muscle form0101
Renin0101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30213
Replicase polyprotein 1ab0101
Amine oxidase [flavin-containing] A0303
Acetylcholinesterase0202
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0326
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10215
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0102
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Guanine deaminase0202
Chain A, Beta-lactamase2002
acetylcholinesterase4004
TDP1 protein7007
IDH11001
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 12002
Vpr1001
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70102
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Potassium voltage-gated channel subfamily H member 20404
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Beta-lactamase0101
Proto-oncogene tyrosine-protein kinase Src0101
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0001
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0202
Alpha-ketoglutarate-dependent dioxygenase FTO0202
histone acetyltransferase KAT2A isoform 14004
5-hydroxytryptamine receptor 1A0517
5-hydroxytryptamine receptor 1B0505
ATPase family AAA domain-containing protein 52002
Ataxin-23003
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
5-hydroxytryptamine receptor 2C0202
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
D0101
Alpha-2B adrenergic receptor0314
Alpha-2C adrenergic receptor0314
Alpha-2A adrenergic receptor0314
Liver carboxylesterase 10001
Sodium-dependent dopamine transporter0202
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0203
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0101
Sigma non-opioid intracellular receptor 10505
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
Alpha-1B adrenergic receptor 0022
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
Alpha-1B adrenergic receptor0314
Alpha-1A adrenergic receptor0123
Alpha-2C adrenergic receptor0348
Alpha-1D adrenergic receptor0314
Alpha-1D adrenergic receptor0113
Alpha-1A adrenergic receptor0314
Histamine H2 receptor3003
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Fumarate hydratase1001
polyprotein1001
Solute carrier family 22 member 20304
ATP-dependent translocase ABCB10708
Cytochrome P450 2C80202
Cytochrome P450 2A60101
Cytochrome P450 2C190406
Spike glycoprotein3003
Integrase 0011
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10303
Vesicular acetylcholine transporter0101
Reverse transcriptase/RNaseH 0112
Integrase 0213
67.9K protein2002
Beta-1 adrenergic receptor 0124
estrogen receptor 2 (ER beta)4004
peroxisome proliferator-activated receptor delta3003
Chain A, Dihydrofolate reductase0011
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
glucocerebrosidase2002
alpha-galactosidase2002
activating transcription factor 63003
lysosomal alpha-glucosidase preproprotein2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
Thymidylate synthase0202
Thymidylate synthase0102
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain E, Fibrin beta chain0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
Luciferase2002
15-lipoxygenase, partial1001
WRN1001
Mcl-10202
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
PPM1D protein1001
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase1001
apical membrane antigen 1, AMA12002
hypothetical protein, conserved1001
G3003
luciferase1001
bromodomain adjacent to zinc finger domain 2B2002
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
serine/threonine-protein kinase PLK12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Vif0101
Tat0101
survival motor neuron protein isoform d2002
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Rap guanine nucleotide exchange factor 31001
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Integrin beta-32002
Integrin alpha-IIb2002
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Carbonic anhydrase0202
Hsf1 protein0011
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Albumin0033
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Capsid protein 0123
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0404
streptokinase A precursor0011
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Estrogen receptor0011
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Amine oxidase [flavin-containing] B0101
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Estrogen receptor beta0011
Renin0101
TAR DNA-binding protein 431001
Solute carrier family 22 member 1 0607
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10305
Multidrug and toxin extrusion protein 10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Histidine decarboxylase0011
D(3) dopamine receptor0202
Delta-type opioid receptor0214
Kappa-type opioid receptor0102
Mu-type opioid receptor0527
Kappa-type opioid receptor0224
Mu-type opioid receptor0337
Delta-type opioid receptor0326
Kappa-type opioid receptor0213
Kappa-type opioid receptor0337
Mu-type opioid receptor0102
Mu-type opioid receptor0213
UDP-glucuronosyltransferase 1A80001
Sigma non-opioid intracellular receptor 10101
ClpP1001
SMAD family member 21001
SMAD family member 31001
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1A40101
Bombesin receptor subtype-30011
UDP-glucuronosyltransferase 2B10 0101
Fatty acid synthase0202
Sodium/potassium-transporting ATPase subunit alpha-20101
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
WD repeat-containing protein 50101
Glutathione S-transferase omega-10101
Histone-lysine N-methyltransferase 2A0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Cytosolic endo-beta-N-acetylglucosaminidase0101
dopamine D1 receptor1001
NFKB1 protein, partial1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
D(1A) dopamine receptor2002
ras-related protein Rab-9A1001
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor0113
Beta-1 adrenergic receptor0315
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0236
Alpha-1B adrenergic receptor0124
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
luciferase0001
nuclear receptor subfamily 1, group I, member 21001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40202
Muscarinic acetylcholine receptor M20112
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Muscarinic acetylcholine receptor M10112
D(2) dopamine receptor0112
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70202
Beta-2 adrenergic receptor0101
Sodium channel protein type 5 subunit alpha0202
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
endonuclease IV1001
M-phase phosphoprotein 81001
Monocarboxylate transporter 40002
Monocarboxylate transporter 20002
Monocarboxylate transporter 10002
C-terminal-binding protein 20101
Solute carrier organic anion transporter family member 2A10101
Solute carrier family 22 member 10101
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 20101
Histidine-rich protein PFHRP-II0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Solute carrier organic anion transporter family member 1A10101
Cytochrome P450 2D40101
Solute carrier family 22 member 20303
Translocator protein0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
beta-2 adrenergic receptor1001
Beta-adrenergic receptor kinase 10011
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidine phosphorylase0001
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]