Hyperlactatemia

Increase in blood LACTATE concentration often associated with SEPTIC SHOCK; LUNG INJURY; SEPSIS; and DRUG TOXICITY. When hyperlactatemia is associated with low body pH (acidosis) it is LACTIC ACIDOSIS.

Synonyms(1)

Synonym
Hyperlactatemia

Research Excerpts

Overview

Excerpt	Reference
"Hence, hyperlactatemia is closely associated with disease severity but it is an epiphenomenon as the body attempts to protect itself."	( Gillespie, Í; Hughes, D; Rosenstein, PG, 2017)
"Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission."	( Minton, J; Sidebotham, DA, 2017)
"Hyperlactatemia is common in critically ill patients and has a variety of etiologies."	( Blohm, E; Lai, J; Neavyn, M, 2017)
"Hyperlactatemia is a relatively rare but life-threatening toxicity of various medication classes."	( Blohm, E; Lai, J; Neavyn, M, 2017)
"Persistent hyperlactatemia is associated with adverse outcome in critically ill patients."	( Godinjak, A; Iglica, A; Jusufovic, S; Kukuljac, A; Rama, A; Rozajac, S; Tancica, I; Zvizdic, F, 2017)
"The etiology of hyperlactatemia is complex and multifactorial."	( Hughes, D; Rosenstein, PG; Tennent-Brown, BS, 2018)
"Although hyperlactatemia is often developed in critically ill patients, it is unclear whether hyperlactatemia is associated with poor prognosis for surgical ICU (SICU) patients."	( Abe, T; Sasabuchi, Y; Takinami, M; Uchino, S, 2018)
"BACKGROUND Hyperlactatemia is a common phenomenon following cardiac surgeries and is associated with prolonged ICU stay and higher morbidity and mortality rates, but such analyses have never focused on patients undergoing heart transplantation (HTX), in whom hyperlactatemia defined with the traditional threshold is observed in nearly every individual."	( Drwiła, R; Górkiewicz-Kot, I; Hymczak, H; Kapelak, B; Kędziora, A; Milaniak, I; Piątek, J; Sobczyk, D; Tomsia, P; Wierzbicki, K, 2020)
"Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes."	( Hoste, EAJ; Kruse, JM; Van Biesen, W; Van De Ginste, L; Vanommeslaeghe, F; Verbeke, F, 2022)
"Hyperlactatemia is a common metabolic disorder after cardiac surgery with cardiopulmonary bypass."	( Ge, YP; Jiang, W; Luo, TG; Pan, YC; Shi, Q; Xiao, ZH; Zhan, YF; Zheng, BS, 2022)
"Hyperlactatemia is a common complication in critically ill patients with high morbidity and mortality."	( Bai, M; Li, L; Sun, S; Zhang, Q, 2022)
"Severe hyperlactatemia is not uncommon in this group of patients."	( Albers, J; Bodenstein, M; Dohle, DS; Koelm, S; Kriege, M; Oezkur, M; Rissel, R; Schepers, M, 2022)
"Severe hyperlactatemia is not uncommon in this group of patients."	( Albers, J; Bodenstein, M; Dohle, DS; Koelm, S; Kriege, M; Oezkur, M; Rissel, R; Schepers, M, 2022)
"Hyperlactatemia is associated with mortality outcomes in patients undergoing CRRT for acute kidney injury."	( Han, SS; Joo, KW; Kang, MW; Kim, DK; Kim, SG; Kim, YC; Kim, YS; Lee, J; Oh, KH; Yun, D, 2023)
"Hyperlactatemia is a common finding in critically ill patients and has significant prognostic implications."	( Ağın, H; Atakul, G; Ceylan, G; Çolak, M; Karaarslan, ÜU; Sandal, ÖS; Sarı, F; Soydan, E; Topal, S, 2022)

Context

Excerpt	Reference
"VTE risk and blood hyperlactatemia have been associated with a higher mortality risk in critically ill Covid-19 patients who are hospitalized in the ICU in Saudi Arabia."	( Ali Khan, I; AlQarni, HM; Alshammary, AF; Farzan, R; Vennu, V, 2023)

Research

Studies (164)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.61)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	100 (60.98)	28.8240
2020's	63 (38.41)	9.53

Drug	Relationship Strength	Studies	Trials
ethylene glycol	low	1	0
carnitine	low	3	0
citric acid, anhydrous	low	3	0
3-hydroxybutyric acid	low	2	0
lactic acid	medium	122	6
hydrogen carbonate	low	3	0
propylene glycol	low	1	0
pyruvic acid	low	1	0
thiamine	low	6	0
uric acid	low	1	0
acetaminophen	low	1	0
albuterol	low	1	0
caffeine	low	1	0
carbamazepine	low	1	0
clenbuterol	low	1	0
metformin	low	11	0
omeprazole	low	1	0
propranolol	low	1	0
terbutaline	low	1	0
prednisolone	low	1	0
thymidine	low	1	0
mannitol	low	1	0
pyridostigmine bromide	low	1	0
thiophenes	low	1	0
hematoxylin	low	1	0
helium	low	1	0
magnesium sulfate	low	1	0
amitraz	low	1	0
sufentanil	low	1	0
esmolol	low	2	0
lamivudine	low	1	0
fluorodeoxyglucose f18	low	1	0
heliox	low	1	0
telbivudine	low	1	0
glycogen	low	1	0
linezolid	low	1	0
cocaine	low	1	0
sodium bicarbonate	low	1	0
cocaethylene	low	1	0
quinine	low	1	0
bilirubin	low	1	0
coenzyme q10	low	1	0
naloxone	low	1	0
dexmedetomidine	low	1	0
azd3965	low	1	0
1-phenyl-2-(1-pyrrolidinyl)-1-pentanone	low	1	0
pituitrin	low	1	0
ubiquinone	low	1	0
sodium lactate	low	1	0
raltegravir potassium	low	1	0
ro13-9904	low	1	0
dolutegravir	low	2	0
calca protein, human	low	1	0
folic acid	low	1	0
leptin	low	1	0
pyrimidinones	low	1	0

Protein Targets (666)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	4	0	4
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
RAR-related orphan receptor gamma	10	0	0	10
ATAD5 protein, partial	1	0	0	1
GLS protein	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
thyroid stimulating hormone receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	21	0	0	21
peroxisome proliferator activated receptor gamma	5	0	0	5
aryl hydrocarbon receptor	6	0	0	6
chromobox protein homolog 1	5	0	0	5
thyroid hormone receptor beta isoform 2	5	0	0	5
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	1	1	7
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	17	0	17
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	6	0	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	3	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	5	0	6
Cytochrome P450 2D6	0	7	0	8
Cytochrome P450 2C9	0	9	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	1	1	7
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	1	7
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	1	7
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	4
Carbonic anhydrase 4	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	1	7
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit beta-3	5	1	1	7
Gamma-aminobutyric acid receptor subunit beta-2	5	1	1	7
Carbonic anhydrase 9	0	3	0	3
GABA theta subunit	5	1	1	7
Canalicular multispecific organic anion transporter 1	0	15	0	15
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	1	1	7
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
glp-1 receptor, partial	4	0	0	4
thioredoxin reductase	5	0	0	5
regulator of G-protein signaling 4	4	0	0	4
NPYLR7B	0	0	1	1
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
thyroid stimulating hormone receptor	5	0	0	5
flap endonuclease 1	2	0	0	2
Beta-2 adrenergic receptor	0	6	7	13
Beta-1 adrenergic receptor	0	6	5	11
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	2	4	6
Delta-type opioid receptor	0	3	4	7
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	0	3	9
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Beta-2 adrenergic receptor	0	3	4	8
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
GLI family zinc finger 3	9	0	0	9
AR protein	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
glucocorticoid receptor [Homo sapiens]	10	0	0	10
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	6	0	0	6
cytochrome P450 2D6	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
thyroid hormone receptor beta isoform a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
geminin	9	0	0	9
lamin isoform A-delta10	9	0	0	9
Cellular tumor antigen p53	9	0	0	9
Alpha-2A adrenergic receptor	0	5	4	10
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Monocarboxylate transporter 1	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Cruzipain	1	0	0	1
phosphopantetheinyl transferase	4	0	0	4
USP1 protein, partial	6	0	0	6
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
DNA polymerase beta	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	2	1	3
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	2	0	2
Adenosine receptor A1	0	2	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	2	1	5
Adenosine receptor A2a	0	2	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Guanine deaminase	0	2	0	2
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	4	0	0	4
TDP1 protein	7	0	0	7
IDH1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
mitogen-activated protein kinase 1	2	0	0	2
Vpr	1	0	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
5-hydroxytryptamine receptor 1A	0	5	1	7
5-hydroxytryptamine receptor 1B	0	5	0	5
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	3	0	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
Alpha-1B adrenergic receptor	0	3	1	4
Alpha-1A adrenergic receptor	0	1	2	3
Alpha-2C adrenergic receptor	0	3	4	8
Alpha-1D adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	1	1	3
Alpha-1A adrenergic receptor	0	3	1	4
Histamine H2 receptor	3	0	0	3
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Solute carrier family 22 member 2	0	3	0	4
ATP-dependent translocase ABCB1	0	7	0	8
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C19	0	4	0	6
Spike glycoprotein	3	0	0	3
Integrase	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Vesicular acetylcholine transporter	0	1	0	1
Reverse transcriptase/RNaseH	0	1	1	2
Integrase	0	2	1	3
67.9K protein	2	0	0	2
Beta-1 adrenergic receptor	0	1	2	4
estrogen receptor 2 (ER beta)	4	0	0	4
peroxisome proliferator-activated receptor delta	3	0	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	2	0	0	2
alpha-galactosidase	2	0	0	2
activating transcription factor 6	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	2
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
Luciferase	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
WRN	1	0	0	1
Mcl-1	0	2	0	2
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	1	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
hypothetical protein, conserved	1	0	0	1
G	3	0	0	3
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
serine/threonine-protein kinase PLK1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Vif	0	1	0	1
Tat	0	1	0	1
survival motor neuron protein isoform d	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Carbonic anhydrase	0	2	0	2
Hsf1 protein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Albumin	0	0	3	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Capsid protein	0	1	2	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
streptokinase A precursor	0	0	1	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Solute carrier family 22 member 1	0	6	0	7
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Solute carrier family 22 member 1	0	3	0	5
Multidrug and toxin extrusion protein 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	5	2	7
Kappa-type opioid receptor	0	2	2	4
Mu-type opioid receptor	0	3	3	7
Delta-type opioid receptor	0	3	2	6
Kappa-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	3	3	7
Mu-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	1	3
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
ClpP	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
dopamine D1 receptor	1	0	0	1
NFKB1 protein, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-2B adrenergic receptor	0	1	1	3
Beta-1 adrenergic receptor	0	3	1	5
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	2	3	6
Alpha-1B adrenergic receptor	0	1	2	4
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	1	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	1	2
D(2) dopamine receptor	0	1	1	2
Muscarinic acetylcholine receptor M3	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
endonuclease IV	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Monocarboxylate transporter 4	0	0	0	2
Monocarboxylate transporter 2	0	0	0	2
Monocarboxylate transporter 1	0	0	0	2
C-terminal-binding protein 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Translocator protein	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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