Compounds > ach 702
Page last updated: 2024-11-12

ach 702

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Description

ACH 702: an anti-tubercular agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16048804
CHEMBL ID1256993
SCHEMBL ID728226
MeSH IDM0548438

Synonyms (17)

Synonym
7-[(3r)-3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy[1,2]thiazolo[5,4-b]quinoline-3,4(2h,9h)-dione
ach-702
7-[(3r)-3-(1-amino-1-methyl-ethyl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-isothiazolo[5,4-b]quinoline-3,4-dione
bdbm50330327
CHEMBL1256993 ,
(r)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cyclopropyl-6-fluoro-8-methoxyisothiazolo[5,4-b]quinoline-3,4(2h,9h)-dione
(r)-7-[3-(1-amino-1-methyl-ethyl)-pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-9h isothiazolo[5,4-b]quinoline-3,4-dione
SCHEMBL728226
35qf8ge1l1 ,
unii-35qf8ge1l1
922491-46-1
isothiazolo(5,4-b)quinoline-3,4(2h,9h)-dione, 7-((3r)-3-(1-amino-1-methylethyl)-1-pyrrolidinyl)-9-cyclopropyl-6-fluoro-8-methoxy-
ach 702
ach702
Q27256483
7-[(3r)-3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-[1,2]thiazolo[5,4-b]quinoline-3,4-dione
AKOS040745465
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA gyrase subunit BStaphylococcus aureusIC50 (µMol)0.68000.00401.50207.7000AID595856
DNA gyrase subunit AStaphylococcus aureusIC50 (µMol)2.44000.00401.98397.7000AID595856; AID595934
DNA gyrase subunit AMycobacterium tuberculosis H37RvIC50 (µMol)5.13330.01503.477310.0000AID532977; AID532978; AID532979
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID532962Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 62010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532978Inhibition of DNA supercoiling activitysof Mycobacterium tuberculosis DNA gyrase subunit A A90V mutant2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595861Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 24 hrs by microdilution method2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532959Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 32010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532972Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 162010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID523219Antimicrobial activity against Mycobacterium fortuitum clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID523217Antimicrobial activity against isoniazid and rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID595858Antibacterial activity against Escherichia coli ATCC25922 after 24 hrs by microdilution method2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532970Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 142010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595862Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 after 24 hrs by microdilution method2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532957Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 12010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID523220Antimicrobial activity against Mycobacterium chelonae clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID595860Ratio of vancomycin MIC to compound MIC for methicillin-resistant Staphylococcus aureus clinical isolate2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID523223Antimicrobial activity against Mycobacterium gordonae after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID523215Antimicrobial activity against isoniazid and rifampin-susceptible Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID532975Antimicrobial activity against multidrug-resistant Mycobacterium tuberculosis isolate 192010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595934Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID523218Antimicrobial activity against isoniazid or rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID595853Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution method2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532963Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 72010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID523222Antimicrobial activity against Mycobacterium kansasii after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID595854Cytotoxicity against human Hep2 cells after 72 hrs by alamar blue assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID518002Antibacterial activity against Nocardia brasiliensis isolated from actinomycetoma patient by broth dilution method2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of ACH-702, a new isothiazoloquinolone, against Nocardia brasiliensis compared with econazole and the carbapenems imipenem and meropenem alone or in combination with clavulanic acid.
AID523216Antimicrobial activity against Mycobacterium avium complex clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID532976Antimicrobial activity against multidrug drug-resistant Mycobacterium tuberculosis isolate 202010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532973Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 172010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595933Inhibition of Staphylococcus aureus topoisomerase 4 Ser80Phe mutant-mediated decatenation of kDNA after 30 mins by gel electrophoresis assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID595937Ratio of ciprofloxacin IC50 to compound IC50 for Staphylococcus aureus topoisomerase 4 Ser80Phe mutant2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532960Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 42010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595859Ratio of levofloxacin MIC to compound MIC for methicillin-resistant Staphylococcus aureus clinical isolate2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532956Antimicrobial activity against Mycobacterium tuberculosis ATCC 358022010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595935Ratio of ciprofloxacin IC50 to compound IC50 for wild-type Staphylococcus aureus DNA gyrase2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID523224Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 72 hrs by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID532968Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 122010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595856Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532979Inhibition of DNA supercoiling activity of Mycobacterium tuberculosis DNA gyrase subunit A D94G mutant2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595936Ratio of ciprofloxacin IC50 to compound IC50 for Staphylococcus aureus DNA gyrase Ser84Leu mutant2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532971Antimicrobial activity against isoniazid-resistant Mycobacterium tuberculosis isolate 152010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532967Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 112010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532964Antimicrobial activity against streptomycin-resistant Mycobacterium tuberculosis isolate 82010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532974Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 182010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532977Inhibition of DNA supercoiling activity of wild type Mycobacterium tuberculosis DNA gyrase A2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID595855Inhibition of wild-type Staphylococcus aureus topoisomerase 4-mediated decatenation of kDNA after 30 mins by gel electrophoresis assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
AID532958Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 22010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532961Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 52010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532969Antimicrobial activity against Mycobacterium tuberculosis isolate 13 isolated from Beijing2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532966Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 102010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID532965Antimicrobial activity against multidrug-resistant Mycobacterium tuberculosis isolate 92010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
AID523221Antimicrobial activity against Mycobacterium abscessus clinical isolates after 7 days by broth microdilution assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
AID595857Antibacterial activity against methicillin- and quinolone-resistant Staphylococcus aureus ATCC700699 after 24 hrs by microdilution method2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0610aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
econazole
Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.. econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.. 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.		2.0510dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.0510carbohydrazideantitubercular agent;
drug allergen
gatifloxacin
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.		2.0510N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antiinfective agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		3.3260monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
oxacillin
Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.		2.0610penicillinantibacterial agent;
antibacterial drug
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.1101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		3.32601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.4720glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
streptomycin
[no description available]		2.0510antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
oxazolidin-2-one
Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.		2.0710carbamate ester;
oxazolidinone		metabolite
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		2.0510beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		2.46209-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
moxifloxacin
Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.		2.7630aromatic ether;
cyclopropanes;
fluoroquinolone antibiotic;
pyrrolidinopiperidine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		2.0510alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
linezolid
[no description available]		2.4720acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
clavulanic acid
Clavulanic Acid: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.. clavulanate : The conjugate base of clavulanic acid.. clavulanic acid : Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.		2.0510oxapenamantibacterial drug;
anxiolytic drug;
bacterial metabolite;
EC 3.5.2.6 (beta-lactamase) inhibitor
gemifloxacin
Gemifloxacin: A naphthyridine and fluoroquinolone derivative antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used for the treatment of community-acquired pneumonia and acute bacterial infections associated with chronic bronchitis.. gemifloxacin : A 1,4-dihydro-1,8-naphthyridine with a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a substituted pyrrolin-1-yl group at the 7-position.		2.06101,8-naphthyridine derivative;
fluoroquinolone antibiotic;
monocarboxylic acid;
quinolone antibiotic		antibacterial drug;
antimicrobial agent;
topoisomerase IV inhibitor
tedizolid phosphate
tedizolid phosphate: a prodrug of DA-7157; structure in first source. tedizolid phosphate : A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.		2.110carbamate ester;
organofluorine compound;
oxazolidinone;
phosphate monoester;
pyridines;
tetrazoles		antimicrobial agent;
prodrug;
protein synthesis inhibitor
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.4720cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Actinomycetoma
[description not available]		02.0510
Cerebral Nocardiosis
[description not available]		02.0510
Mycetoma
A chronic progressive subcutaneous infection caused by species of fungi (eumycetoma), or actinomycetes (actinomycetoma). It is characterized by tumefaction, abscesses, and tumor-like granules representing microcolonies of pathogens, such as MADURELLA fungi and bacteria ACTINOMYCETES, with different grain colors.		02.0510
Koch's Disease
[description not available]		02.0510
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.0510