cefaloram profile

Cefaloram is a broad-spectrum cephalosporin antibiotic. It is active against a wide range of gram-positive and gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and Klebsiella pneumoniae. Cefaloram is typically administered intravenously or intramuscularly. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Cefaloram is a synthetic antibiotic, and its synthesis involves multiple steps. It is studied because it is a promising therapeutic agent for the treatment of bacterial infections. It is also studied because it has a unique pharmacological profile, which may make it a good candidate for future drug development.'

cefaloram: RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cefaloram : A cephalosporin derivative with potent antibacterial activity which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division, inactivation of which interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in the weakening of the bacterial cell wall and causing cell lysis. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	68940
CHEMBL ID	1700858
CHEBI ID	192380
SCHEMBL ID	612836
MeSH ID	M0166681

Synonym
smr001554387
MLS002666834
(6r,7r)-3-(acetoxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
NCGC00160359-01
cefaloram
(6r,7r)-3-(acetyloxymethyl)-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
859-07-4
(6r,7r)-3-[(acetyloxy)methyl]-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
3-(acetoxymethyl)-8-oxo-7-(phenylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
cefaloramo
cephaloram
CHEBI:192380
cefaloramum
dtxsid9046106 ,
dtxcid7026106
tox21_111761
cas-859-07-4
CHEMBL1700858
cefaloramum [inn-latin]
(6r,7r)-3-(acetoxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure
einecs 212-725-1
unii-k3086gqj9z
cefaloramo [inn-spanish]
k3086gqj9z ,
cefaloram [inn:ban]
cefaloram [inn]
SCHEMBL612836
Q27281875
(6r,7r)-3-(acetoxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Role	Description
antibacterial drug	A drug used to treat or prevent bacterial infections.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
cephalosporin	A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	79.4328	0.6310	35.7641	100.0000	AID504339
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	12.5893	0.1000	20.8793	79.4328	AID588453
TDP1 protein	Homo sapiens (human)	Potency	25.9290	0.0008	11.3822	44.6684	AID686979
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	7.0795	0.7079	12.1943	39.8107	AID720542
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	112.2020	3.5481	19.5427	44.6684	AID743266
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	12.5893	0.4256	12.0591	28.1838	AID504891
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	25.1189	0.1000	28.9256	213.3130	AID588591
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	2.5119	0.0501	27.0736	89.1251	AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (38)

Assay ID	Title	Year	Journal	Article
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1117380	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 134/93 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1812374	Stability of the compound assessed as Klebsiella pneumoniae beta-lactamase IMP-28-mediated degradation by measuring appearance of vinyl protons release measured after 120 mins by NMR spectra	2021	Journal of medicinal chemistry, 07-08, Volume: 64, Issue:13	Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases.
AID1117390	Antimicrobial activity against Pseudomonas aeruginosa K799/61 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1538444	Prodrug activation in Escherichia coli CFT073 harboring CTX-M-1 assessed as bacterial CTX-M-1-mediated compound hydrolysis incubated for 1 hr by 1H-NMR analysis	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1117382	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 1528 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1538463	Selectivity ratio of MIC for ciprofloxacin-susceptible Escherichia coli CFT073 harboring pSU18 to MIC for ciprofloxacin-susceptible Escherichia coli DH5[alpha]	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1117369	Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117385	Antimicrobial activity against Micrococcus luteus ATCC 10240 assessed as unclear inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117370	Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117374	Antimicrobial activity against Staphylococcus aureus Efs1 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117377	Antimicrobial activity against Staphylococcus aureus Efs4 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117372	Antimicrobial activity against Staphylococcus aureus SG511 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1538434	Growth inhibition of ciprofloxacin-susceptible Escherichia coli DH5[alpha] incubated for 18 hrs by broth microdilution method	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1117384	Antimicrobial activity against Micrococcus luteus ATCC 10240 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1538443	Growth inhibition of Escherichia coli CFT073 harboring pSU18 and CTX-M-15 incubated for 18 hrs by broth microdilution method	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1538435	Growth inhibition of Escherichia coli DH5[alpha] expressing ESBL TEM-116 incubated for 18 hrs by broth microdilution method	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1538442	Growth inhibition of ciprofloxacin-susceptible Escherichia coli CFT073 harboring pSU18 incubated for 18 hrs by broth microdilution method	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1117398	Antimicrobial activity against Pseudomonas aeruginosa K799/WT assessed as faint inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1117393	Antimicrobial activity against Escherichia coli SG458 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
AID1538436	Substrate activity at recombinant Escherichia coli full-length N-terminal His-tagged AmpC (20 to 377 residues) expressed in Escherichia coli assessed as Kcat to Km ratio measured every 20 secs for 1 hr by UV absorbance	2019	Journal of medicinal chemistry, 05-09, Volume: 62, Issue:9	Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.
AID1117396	Antimicrobial activity against Mycobacterium vaccae IMET assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method	2010	MedChemComm, Aug-01, Volume: 1, Issue:2	Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (14.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (21.43)	29.6817
2010's	5 (35.71)	24.3611
2020's	4 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (7.14%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (92.86%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	3.42	1	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
cefuroxime Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.. cefuroxime : A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.	2.05	1	0	carbamate ester; cephalosporin
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.51	2	0	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.35	2	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
cephalothin Cephalothin: A cephalosporin antibiotic.. cefalotin : A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.	2.21	1	0	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	1.94	1	0	penicillin allergen; penicillin	antibacterial drug
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	1.97	1	0	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
penicillanic acid Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.	1.94	1	0	penicillanic acids
dipicolinic acid dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.	2.31	1	0	pyridinedicarboxylic acid	bacterial metabolite
aminopenicillanic acid aminopenicillanic acid: RN given refers to parent cpd; structure. 6-aminopenicillanic acid : A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics.	1.94	1	0	amino acid zwitterion; penicillanic acids	allergen
cephalexin Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.	1.97	1	0	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	4.28	4	1	cephalosporin	fungal metabolite
phenylacetyl 7-aminodesacetoxycephalosporanic acid [no description available]	2.43	2	0
7-aminocephalosporanic acid 7beta-aminocephalosporanic acid : The alpha,beta-unsaturated monocarboxylic acid that is the active nucleus for the synthesis of cephalosporins and intermediates.	1.94	1	0	alpha,beta-unsaturated monocarboxylic acid; amino acid zwitterion
linezolid [no description available]	2.05	1	0	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
fusidic acid Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.	1.94	1	0	11alpha-hydroxy steroid; 3alpha-hydroxy steroid; alpha,beta-unsaturated monocarboxylic acid; steroid acid; steroid antibiotic; sterol ester	EC 2.7.1.33 (pantothenate kinase) inhibitor; Escherichia coli metabolite; protein synthesis inhibitor
bismuth Bismuth: A metallic element that has the atomic symbol Bi, and atomic number 83. Its principal isotope is Bismuth 209.	3.42	1	1	metal atom; pnictogen
cefotaxime Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.	1.97	1	0	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
ceftiofur ceftiofur: structure in first source	2.05	1	0

Condition	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1	0
Infections, Staphylococcal [description not available]	3.76	2	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	3.76	2	1
Mastitis, Bovine INFLAMMATION of the UDDER in cows.	3.42	1	1
Group A Strep Infection [description not available]	3.42	1	1
Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS.	3.42	1	1

cefaloram

Description

Cross-References

Synonyms (29)

Research Excerpts

Bioavailability

Roles (1)

Drug Classes (1)

Protein Targets (8)

Potency Measurements

Bioassays (38)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.55

Study Types

cefaloram

Description

Cross-References

Synonyms (29)

Research Excerpts

Bioavailability

Roles (1)

Drug Classes (1)

Protein Targets (8)

Potency Measurements

Bioassays (38)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.55

Study Types

Related Drugs (19)

Related Conditions (7)