ranbezolid profile

ranbezolid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	496993
CHEMBL ID	251384
SCHEMBL ID	14345154
MeSH ID	M0452711

Synonym
n-[[(5s)-3-[3-fluoro-4-[4-[(5-nitro-2-furyl)methyl]piperazin-1-yl]phenyl]-2-oxo-oxazolidin-5-yl]methyl]acetamide
acetamide, n-[[(5s)-3-[3-fluoro-4-[4-[(5-nitro-2-furanyl)methyl]-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-
ranbezolid
rbx7644 (hydrochloride)
CHEMBL251384
n-[[(5s)-3-[3-fluoro-4-[4-[(5-nitrofuran-2-yl)methyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
SCHEMBL14345154
Q7290748
unii-g3nb6jbl8a
gtpl11007
rbx 7644
n-(((5s)-3-(3-fluoro-4-(4-((5-nitro-2-furyl)methyl)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methyl)acetamide
G3NB6JBL8A ,
acetamide, n-(((5s)-3-(3-fluoro-4-(4-((5-nitro-2-furanyl)methyl)-1-piperazinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-
392659-38-0
n-[[(5s)-3-[3-fluoro-4-[4-[(5-nitro-2-furanyl)methyl]-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide
DTXSID701029733

Bioassays (56)

Assay ID	Title	Year	Journal	Article
AID444262	Antibacterial activity against Enterococcus faecalis ATCC 29212 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID308914	Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581014	Inhibition of protein synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [14C]isoleucine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID581028	Inhibition of lipid synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [14C]acetate at 1 ug/ml after 60 mins by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID1519270	Antibacterial activity agianst linezolid-resistant Enterococcus faecalis	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.
AID444261	Antibacterial activity against methicillin-resistant Staphylococcus aureus 33 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID581038	Induction of bacterial membrane damage in Staphylococcus aureus ATCC 25923 at 4 ug/mL by BacLight assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID444263	Antibacterial activity against vancomycin-resistant Enterococcus faecium 6A by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID308917	Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581024	Inhibition of RNA synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]uridine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID255574	In vitro minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID255571	In vitro minimum inhibitory concentration against Enterococcus faecium ATCC 29212 after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID581044	Induction of bacterial membrane damage in Staphylococcus epidermidis ATCC 23760 at 2 ug/mL by BacLight assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308912	Antibacterial activity against Bacillus subtilis ATCC 6633 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581043	Induction of bacterial membrane damage in Staphylococcus epidermidis ATCC 23760 at 2 to 8 ug/mL by BacLight assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID1519273	Antibacterial activity agianst Staphylococcus aureus ATCC 29213	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.
AID308925	Antibacterial activity against multidrug-resistant Streptococcus pneumoniae ATCC 700904 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581031	Bactericidal activity against Staphylococcus aureus ATCC 25923 at 16 ug/ml by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID444260	Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID581016	Inhibition of protein synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [14C]isoleucine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID581030	Bacteriostatic activity against Staphylococcus aureus ATCC 25923 at 8 times MIC after 30 hrs by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308921	Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581034	Bactericidal activity against Staphylococcus epidermidis ATCC 23760 at 8 ug/ml after 4 hrs by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308924	Antibacterial activity against methicillin-resistant Streptococcus pyogenes ATCC 14289 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID444259	Antibacterial activity against Staphylococcus aureus ATCC 25923 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID581020	Inhibition of DNA synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]thymidine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID581039	Induction of bacterial membrane damage in Staphylococcus epidermidis ATCC 23760 at 4 ug/mL by BacLight assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308915	Antibacterial activity against Enterococcus faecalis ATCC 14506 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581040	Inhibition of ribosomal activity in Escherichia coli S30 by coupled transcription/translation assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID581042	Ratio of IC50 for mammalian ribosomal activity to ribosomal activity in Escherichia coli S30 by coupled transcription/translation assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID255573	In vitro minimum inhibitory concentration against Streptococcus pyogenes ATCC 19615 after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID581018	Inhibition of DNA synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [3H]thymidine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID255578	In vitro minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus 562 after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID1519271	Antibacterial activity agianst methicillin-resistant Staphylococcus aureus	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.
AID581041	Inhibition of mammalian ribosomal activity by coupled transcription/translation assay	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308918	Antibacterial activity against Staphylococcus aureus ATCC 33592 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581022	Inhibition of RNA synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [3H]uridine at 1 ug/ml by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308916	Antibacterial activity against Staphylococcus aureus ATCC 33591 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581045	Induction of bacterial membrane damage in Staphylococcus epidermidis ATCC 23760 at 1 ug/mL by BacLight assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308913	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID581032	Bactericidal activity against Staphylococcus epidermidis ATCC 23760 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308919	Antibacterial activity against multidrug resistant Enterococcus faecalis ATCC 700802 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID1519268	Antibacterial activity agianst vancomycin-resistant Enterococcus faecium	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.
AID308923	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID444265	Antibacterial activity against Streptococcus pneumoniae ATCC 6303 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID255577	In vitro minimum inhibitory concentration against vancomycin-resistant Enterococcus faecium 6A after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID581013	Antimicrobial activity against Staphylococcus epidermidis ATCC 23760 by microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID581035	Bactericidal activity against Staphylococcus epidermidis ATCC 23760 at 4 ug/ml after 6 hrs by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID444264	Antibacterial activity against Streptococcus pyogenes ATCC 19615 by NCCLS method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis and biological activity of novel oxazolidinones.
AID581012	Antimicrobial activity against Staphylococcus aureus ATCC 25923 by microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID1519272	Antibacterial activity agianst methicillin-sensitive Staphylococcus aureus	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.
AID308922	Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS 119 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID308920	Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
AID255572	In vitro minimum inhibitory concentration against Staphylococcus aureus ATCC 25923 after incubation in air at 35 degree C for 24 hr using agar dilution method	2005	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19	Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid.
AID581026	Inhibition of cell wall synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]N-acetylglucosamine at 1 ug/ml after 60 mins by liquid scintillation counter	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
AID308926	Antibacterial activity against Staphylococcus epidermidis ATCC 155 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18	Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (84.62)	29.6817
2010's	2 (15.38)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbonyl cyanide m-chlorophenyl hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.	2.05	1	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	2.02	1	carbohydrazide	antitubercular agent; drug allergen
clorgyline Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.	2.03	1	aromatic ether; dichlorobenzene; terminal acetylenic compound; tertiary amino compound	antidepressant; EC 1.4.3.4 (monoamine oxidase) inhibitor
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	3.82	11	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.44	2	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
eperezolid [no description available]	2.03	1
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	3.42	7	carbamate ester; oxazolidinone	metabolite
linezolid [no description available]	3.55	8	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
valinomycin Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.	2.05	1	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore
virginiamycin Virginiamycin: A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.. virginiamycin : A mixture of cyclic polypeptide streptogramin antibiotics produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. The two major components are virginiamycin M1 (also known as pristinamycin IIA) and virginiamycin S1. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci.	2.04	1
quinupristin-dalfopristin quinupristin-dalfopristin: RP 59500 is a combination of RP 57669 & RP 54476, which are water soluble derivatives of pristinamycin IA & pristinamycin IIB, respectively	2.04	1	organic molecular entity
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.02	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Infections, Staphylococcal [description not available]	2.72	3
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.72	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.04	1
Bacterial Disease [description not available]	2.44	2
Foreign Bodies Inanimate objects that become enclosed in the body.	2.08	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.44	2
Infections, Pneumococcal [description not available]	2.01	1
Pneumococcal Infections Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.	2.01	1

ranbezolid

Description

Cross-References

Synonyms (17)

Research Excerpts

Bioassays (56)

Research

Studies (13)

Study Types

ranbezolid

Description

Cross-References

Synonyms (17)

Research Excerpts

Bioassays (56)

Research

Studies (13)

Study Types

Related Drugs (12)

Related Conditions (8)