Page last updated: 2024-11-13

achn 490

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Description

plazomicin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID42613186
CHEMBL ID1650559
SCHEMBL ID11928040
MeSH IDM0548440

Synonyms (38)

Synonym
CHEMBL1650559
plazomicin
achn-490
D10151
plazomicin (usan)
1154757-24-0
SCHEMBL11928040
(2s)-4-amino-n-((1r,2s,3s,4r,5s)-5-amino-4-((2-amino-2,3,4,6-tetradeoxy-6-((2- hydroxyethyl)amino)-alpha-d-glycero-hex-4-enopyranosyl)oxy)-2-((3-deoxy-4-c-methyl-3- (methylamino)-beta-l-arabinopyranosyl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide
d-streptamine, o-2-amino-2,3,4,6-tetradeoxy-6-((2-hydroxyethyl)amino)-alpha-d-glycero- hex-4-enopyranosyl-(1->4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l- arabinopyranosyl-(1->6))-n(sup 1)-((2s)-4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-
lyo9xz250j ,
plazomicin [usan:inn]
unii-lyo9xz250j
achn490
6'-(hydroxylethyl)-1-(haba)-sisomicin
achn 490
plazomicin [inn]
plazomicin [usan]
plazomicin [who-dd]
plazomicin [mi]
(2s)-4-amino-n-((1r,2s,3s,4r,5s)-5-amino-4-(((2s,3r)-3-amino-6-(((2-hydroxyethyl)amino)methyl)-3,4-dihydro-2h-pyran-2-yl)oxy)-2-((3-deoxy-4-c-methyl-3-(methylamino)-.beta.-l-arabinopyranosyl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide
d-streptamine, o-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-a-d-glycero-hex-4-enopyranosyl-(1?4)-o-[3-deoxy-4-c-methyl-3-(methylamino)-b-l-arabinopyranosyl-(1?6)]-n1-[(2s)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
DB12615
(2s)-4-amino-n-[(1r,2s,3s,4r,5s)-5-amino-4-{[(2s,3r)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2h-pyran-2-y
(2s)-4-amino-n-[(1r,2s,3s,4r,5s)-5-amino-4-{[(2s,3r)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2h-pyran-2-yl]oxy}-2-{[3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
l]oxy}-2-{[3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
Q15426988
gtpl10847
(2s)-4-amino-n-[(1r,2s,3s,4r,5s)-5-amino-4-[[(2s,3r)-3-amino-6-[(2-hydroxyethylamino)methyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-[(2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
DTXSID001031303
EN300-20605720
(2s)-4-amino-n-[(1r,2s,3s,4r,5s)-5-amino-4-{[(2s,3r)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2h-pyran-2-yl]oxy}-2-{[(2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
plazomicinum
(2s)-4-amino-n-((1r,2s,3s,4r,5s)-5-amino-4-(((2s,3r)-3-amino-6-(((2-hydroxyethyl)amino)methyl)-3,4-dihydro-2h-pyran-2-yl)oxy)-2-((3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide
zemdri (plazomicin)
plazomicina
plazomicine
j01gb14
AKOS040746239

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Safety was assessed from adverse event (AE) reporting, standard clinical laboratory procedures, and testing for renal, cochlear, and vestibular function."( Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects.
Borin, MT; Brooks, CD; Bruss, JB; Cass, RT; Havrilla, NA; Tack, KJ; Young, D, 2011
)
0.37
" The full repertoire of cellular targets and processes leading to the toxicity of aminoglycosides is not fully resolved, making it challenging to devise rational directions to circumvent their adverse effects."( The relationship between the structure and toxicity of aminoglycoside antibiotics.
Fridman, M; Jospe-Kaufman, M; Siomin, L, 2020
)
0.56

Pharmacokinetics

ExcerptReferenceRelevance
" Model-derived pharmacokinetic parameters and safety findings were generally consistent with previously reported plazomicin studies."( A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics.
Choi, T; Gall, J; Gibbons, JA; Riddle, V; Seroogy, J; Van Wart, S, 2019
)
0.51
" A previous population pharmacokinetic (PK) model was used to evaluate the dosage regimen in cUTI patients with different degrees of renal impairment."( Application of Population Pharmacokinetic Modeling, Exposure-Response Analysis, and Classification and Regression Tree Analysis to Support Dosage Regimen and Therapeutic Drug Monitoring of Plazomicin in Complicated Urinary Tract Infection Patients with Re
Iarikov, D; Jang, SH; Mishra, S; Reynolds, KS; Wu, K; Zhuang, L, 2022
)
0.72

Compound-Compound Interactions

ExcerptReferenceRelevance
" Synergy was observed when plazomicin was combined with meropenem, colistin or fosfomycin against both isolates, whilst the combination with tigecycline resulted in indifference."( In vitro activity of the next-generation aminoglycoside plazomicin alone and in combination with colistin, meropenem, fosfomycin or tigecycline against carbapenemase-producing Enterobacteriaceae strains.
Culebras, E; Pena, I; Picazo, JJ; Rodríguez-Avial, C; Rodríguez-Avial, I, 2015
)
0.42
" To determine synergy with other antibiotics, plazomicin was combined with antibiotics in checkerboard assays against MDR Enterobacteriaceae, including isolates with resistance to aminoglycosides and β-lactams; 10 Escherichia coli isolates, 8 Klebsiella spp."( Activity of plazomicin in combination with other antibiotics against multidrug-resistant Enterobacteriaceae.
Hall, D; Krause, KM; Marra, A; Pillar, C; Serio, AW; Shinabarger, D; Stoneburner, A; Thwaites, M, 2018
)
0.48

Dosage Studied

ExcerptRelevanceReference
" The 15-mg/kg dose did not accumulate with repeated dosing over 5 days."( Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects.
Borin, MT; Brooks, CD; Bruss, JB; Cass, RT; Havrilla, NA; Tack, KJ; Young, D, 2011
)
0.37
" Due to limited efficacy and safety data, plazomicin is indicated for the treatment of cUTIs in adults with limited or no alternative treatment options, using a dosage regimen of 15 mg/kg intravenously every 24 hours for 4-7 days."( Plazomicin: A Next-Generation Aminoglycoside.
Chahine, EB; Cho, JC; Piccicacco, N; Shaeer, KM; Zmarlicka, MT, 2019
)
0.51
" A lack of pediatric-specific comparative effectiveness data, uncertain pediatric dosing regimens for several agents, and a relative lack of new antibiotics with pediatric indications approved by the US Food and Drug Administration (FDA) collectively present unique challenges for children."( Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children.
Chiotos, K; Gerber, JS; Hayes, M; Tamma, PD, 2020
)
0.56
" The objective of this article is to provide the scientific rationales behind the recommended dosage regimen and therapeutic drug monitoring (TDM) of plazomicin in cUTI patients with renal impairment."( Application of Population Pharmacokinetic Modeling, Exposure-Response Analysis, and Classification and Regression Tree Analysis to Support Dosage Regimen and Therapeutic Drug Monitoring of Plazomicin in Complicated Urinary Tract Infection Patients with Re
Iarikov, D; Jang, SH; Mishra, S; Reynolds, KS; Wu, K; Zhuang, L, 2022
)
0.72
" Yet, selecting an appropriate dose and appropriate time to administer the dose with dosing frequency requires extensive understanding of the interplay between drug pharmacokinetics/pharmacodynamics (PK/PD), the host immune system, and bacterial-resistant mechanisms."( Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin.
Luterbach, CL; Rao, GG, 2022
)
0.72
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (291)

Assay IDTitleYearJournalArticle
AID1329644Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 50 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329609Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 16 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329657Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 6.9 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329665Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 7.5 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583264Antibacterial activity against aminoglycoside-resistant Serratia marcescens expressing AAC(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329454Cmax in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329658Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 12 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329573Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in brain at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.92016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329553Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583219Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus expressing ANT(4')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583212Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing ANT(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329560Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in heart at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 2.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329452Cmax in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583265Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus expressing ANT(4',4'')-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329624Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 53 IU/2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329632Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 67 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329493Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329486Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in lung at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329527Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in kidney at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583223Antibacterial activity against aminoglycoside-susceptible Acinetobacter baumannii by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID564685Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae isolates by microdilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
AID583221Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus expressing APH(2'') + AAC(6') by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583228Antibacterial activity against efflux pump deficient Pseudomonas aeruginosa by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329631Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 44 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329482Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.7 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583237Antibacterial activity against Proteus mirabilis by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583250Antibacterial activity against aminoglycoside-resistant Serratia liquefaciens expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329537Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583211Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing ANT(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329579Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583271Antibacterial activity against aminoglycoside-resistant Acinetobacter baumannii expressing APH(3')-6 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329663Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 10 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329554Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583251Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing AAC(3)-4 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583236Antibacterial activity against Klebsiella spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583255Antibacterial activity against aminoglycoside-resistant Enterobacter cloacae expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329574Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in brain at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329498Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329585Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329572Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in brain at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.92016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583235Antibacterial activity against Enterobacter spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329494Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6469 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329481Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.7 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329506Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583225Antibacterial activity against aminoglycoside-resistant Acinetobacter calcoaceticus expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329664Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 6.1 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583262Antibacterial activity against aminoglycoside-resistant Enterobacter cloacae expressing AAC(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329558Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in heart at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2.62016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329592Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in blood at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329634Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 62 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329477Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey assessed as survival of monkey at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329652Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 287 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329507Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329534Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in kidney at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329659Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 6.8 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329580Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329618Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 1 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329656Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 8 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329629Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 44 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329515Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 5.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329484Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.7 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329517Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in liver at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583226Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329650Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 381 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329555Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329596Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as inappetence at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329607Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 15 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583254Antibacterial activity against aminoglycoside-resistant Enterobacter aerogenes expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329551Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329630Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 40 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329623Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 35 IU/2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329522Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329451Cmax in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583230Antibacterial activity against Pseudomonas aeruginosa expressing ANT(4')-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329503Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583261Antibacterial activity against aminoglycoside-resistant Klebsiella pneumoniae expressing AAC(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329514Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 5.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583222Antibacterial activity against aminoglycoside-resistant Acinetobacter spp. expressing APH(3')-6 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583243Antibacterial activity against aminoglycoside-resistant Klebsiella pneumoniae expressing AAC(3)-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329508Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329587Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329565Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329643Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 55 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329541Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329569Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329616Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.8 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329582Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583245Antibacterial activity against aminoglycoside-resistant Enterobacter aerogenes expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID564687Antimicrobial activity against Escherichia coli ATCC 25922 by microdilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
AID1329615Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.8 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329475Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey assessed as survival of monkey at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID564688Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
AID1329594Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as stomach ulcer at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days measured by hematoxylin staining based2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583233Antibacterial activity against Citrobacter spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329649Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 238 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583259Antibacterial activity against aminoglycoside-resistant Serratia marcescens expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329476Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey assessed as survival of monkey at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329466Clearance in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID564689Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 by microdilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
AID1329602Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 22 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583238Antibacterial activity against indole positive Proteae by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583231Antibacterial activity against Pseudomonas aeruginosa expressing AAC(3)-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329581Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329488Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583241Antibacterial activity against Acinetobacter spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583232Antibacterial activity against Pseudomonas aeruginosa expressing AAC(6')-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329511Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in liver at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329548Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in tracheobronchial lymph nodes at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329545Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329655Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 319 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329544Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329619Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.8 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329598Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as elevation of blood urea nitrogen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583234Antibacterial activity against Escherichia coli by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583218Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329566Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329456AUC (0 to 24 hrs) in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329500Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in spleen at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583270Antibacterial activity against aminoglycoside-resistant Acinetobacter baumannii expressing ANT(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583249Antibacterial activity against aminoglycoside-resistant Klebsiella pneumoniae expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583224Antibacterial activity against Acinetobacter baumannii ATCC 19606 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329610Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 15 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329453Cmax in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329588Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583268Antibacterial activity against aminoglycoside-resistant Staphylococcus epidermidis expressing APH(2'') + AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583272Antibacterial activity against aminoglycoside-resistant Pseudomonas aeruginosa expressing AAC(6')-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329529Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329611Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 22 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583242Antibacterial activity against Pseudomonas aeruginosa by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329469Volume of distribution at steady state in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329646Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 249 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583269Antibacterial activity against aminoglycoside-resistant Acinetobacter baumannii expressing AAC(3')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329513Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 5.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329559Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in heart at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2.62016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329458AUC (0 to 24 hrs) in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329491Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583208Antibacterial activity against Klebsiella pneumoniae ATCC 10031 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329457AUC (0 to 24 hrs) in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329540Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329543Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in tracheobronchial lymph nodes at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329459Elimination half life in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329480Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6469 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.7 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329539Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329472Toxicity in African green monkey assessed as effect on serum creatinine level at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329461Elimination half life in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583267Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus expressing APH(2'') + AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329642Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 53 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329613Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.5 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329654Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 310 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329593Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in blood at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329584Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583266Antibacterial activity against aminoglycoside-resistant Staphylococcus epidermidis expressing ANT(4',4'')-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329509Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 5.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329620Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.5 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329519Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329479Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.7 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583210Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583429Antibacterial activity against aminoglycoside-resistant Staphylococcus epidermidis expressing APH(3')-3 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329464Clearance in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329635Toxicity in African green monkey B6408 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 109 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583258Antibacterial activity against aminoglycoside-resistant Klebsiella pneumoniae expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329621Toxicity in African green monkey 7337 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.7 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329530Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 72016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329639Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 30 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329578Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583252Antibacterial activity against aminoglycoside-resistant Klebsiella pneumoniae expressing AAC(3)-4 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329526Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6469 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329627Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 31 IU/2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329570Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583216Antibacterial activity against aminoglycoside-resistant Providencia stuartii expressing ANT(2')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329467Volume of distribution at steady state in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329628Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 46 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329495Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in spleen at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329638Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 83 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329647Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 212 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329518Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in liver at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329504Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329563Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in heart at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329531Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329661Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 6.9 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329564Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in heart at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329520Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329567Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329533Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in kidney at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583273Antibacterial activity against aminoglycoside-resistant Pseudomonas aeruginosa expressing ANT(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329591Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329550Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in tracheobronchial lymph nodes at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583248Antibacterial activity against aminoglycoside-resistant Klebsiella oxytoca expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583244Antibacterial activity against aminoglycoside-resistant Citrobacter freundii expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329474Toxicity in African green monkey assessed as effect on serum creatinine level at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329523Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329465Clearance in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329521Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583240Antibacterial activity against Staphylococcus spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329606Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 13 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329547Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583257Antibacterial activity against aminoglycoside-resistant Klebsiella oxytoca expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329455AUC (0 to 24 hrs) in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329542Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6469 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583214Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing ANT(3)-4a by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1662708Nephrotoxicity in human patients assessed as proportion of patients with higher serum creatinine level2020Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13
The relationship between the structure and toxicity of aminoglycoside antibiotics.
AID1329492Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583209Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing ANT(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583213Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing ANT(3')-1b by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329589Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329608Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 13 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329597Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as dehydration at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583217Antibacterial activity against aminoglycoside-resistant Serratia marcescens expressing ANT(2''), AAC(6') by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329590Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329501Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in spleen at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329525Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID564686Antimicrobial activity against beta lactamase KPC-producing Klebsiella pneumoniae isolates by microdilution method2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.
AID583256Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329571Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329586Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329502Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in spleen at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329636Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 47 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329568Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in heart at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329612Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.6 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583260Antibacterial activity against aminoglycoside-resistant Enterobacter gergoviae expressing AAC(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329528Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in kidney at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329641Toxicity in African green monkey 8067 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 45 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329546Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in tracheobronchial lymph nodes at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusio2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329470Volume of distribution at steady state in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329512Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 5.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329645Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 364 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329496Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329599Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as effect on serum electrolyte abnormality at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329576Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329603Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 24 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583229Antibacterial activity against Pseudomonas aeruginosa expressing mexXY operon by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329473Toxicity in African green monkey assessed as effect on serum creatinine level at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329557Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in heart at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329460Elimination half life in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329625Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 77 IU/2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329660Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 6.2 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329490Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329617Toxicity in African green monkey 7972 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.8 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329651Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 653 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329549Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in tracheobronchial lymph nodes at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329662Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 10.9 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329604Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 24 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329478Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey assessed as improvement in survival of monkey at 6.25 to 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329600Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as tubule damage at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days by hematoxylin staining based assay2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329633Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 37 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329640Toxicity in African green monkey 7929 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 63 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329626Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as serum gamma glutamyl-transferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 55 IU/2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329524Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in liver at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329485Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in lung at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583215Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing armA methylase by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329510Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6469 model assessed as bacterial burden in liver at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 5.22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583247Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329637Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as serum alanine aminotransferase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 180 IU/L2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329552Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infus2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329601Toxicity in African green monkey B5994 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 15 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329449Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in lung at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329535Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583227Antibacterial activity against wild type Pseudomonas aeruginosa expressing efflux pump by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329532Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in kidney at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583239Antibacterial activity against Serratia spp. by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583246Antibacterial activity against aminoglycoside-resistant Enterobacter cloacae expressing AAC(3)-2 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID583253Antibacterial activity against aminoglycoside-resistant Citrobacter freundii expressing AAC(6')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329575Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in brain at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.92016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329471Toxicity in African green monkey assessed as effect on serum creatinine level at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329653Toxicity in African green monkey 7643 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 278 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329648Toxicity in African green monkey B6140 model infected with Yersinia pestis Colorado 92 assessed as serum lactate dehydrogenase level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 290 IU/L)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329622Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.6 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329463Clearance in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 1 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329595Toxicity in African green monkey B6127 model infected with Yersinia pestis Colorado 92 assessed as weight loss at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days measured from day 7 to 14 post dose2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329462Elimination half life in African green monkey blood at 35 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329556Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in tracheobronchial lymph nodes at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusi2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329536Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329499Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329666Toxicity in African green monkey 7653 model infected with Yersinia pestis Colorado 92 assessed as total white blood cell count at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 7.5 10'3/microL)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329562Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in heart at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 22016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329583Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583263Antibacterial activity against aminoglycoside-resistant Escherichia coli expressing AAC(2'')-1 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329468Volume of distribution at steady state in African green monkey blood at 25 mg/kg administered as iv infusion twice daily for 7 consecutive days measured on day 7 by LC-MS/MS analysis2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329605Toxicity in African green monkey B6428 model infected with Yersinia pestis Colorado 92 assessed as blood urea nitrogen level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 16 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329505Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in spleen at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329489Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in lung at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329516Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in liver at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 52016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329538Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in kidney at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329614Toxicity in African green monkey B6291 model infected with Yersinia pestis Colorado 92 assessed as serum creatinine level at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 0.6 mg/dl)2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329483Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in lung at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 7.72016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID583220Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus expressing APH(3')-3 by broth microdilution method2010Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
Synthesis and spectrum of the neoglycoside ACHN-490.
AID1329450Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329577Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 12016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329487Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in lung at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 7.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329561Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6415 model assessed as bacterial burden in heart at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 2.62016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
AID1329497Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in spleen at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Plazomicin is effective in a non-human primate pneumonic plague model.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (80)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (1.25)29.6817
2010's51 (63.75)24.3611
2020's28 (35.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.50 (24.57)
Research Supply Index4.51 (2.92)
Research Growth Index5.83 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials7 (8.43%)5.53%
Reviews17 (20.48%)6.00%
Case Studies1 (1.20%)4.05%
Observational0 (0.00%)0.25%
Other58 (69.88%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]