Compounds > sm-216601
Page last updated: 2024-11-12

sm-216601

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Description

SM-216601: exhibits potent activity against methicillin-resistant staphylococci (MRS) and vancomycin-resistant enterococci (VRE); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10993211
CHEMBL ID1256722
SCHEMBL ID2894324
MeSH IDM0484246

Synonyms (35)

Synonym
D09658
426253-04-5
razupenem (usan/inn)
smp-601
sm-216601
razupenem
CHEMBL1256722
pz-601
razupenem [usan:inn]
(4r,5s,6s)-6-((1r)-1-hydroxyethyl)-4-methyl-3-((4-((5s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl)thiazol-2-yl)sulfanyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
unii-26020h3q1l
26020h3q1l ,
1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((4-((5s)-2,5-dihydro-5-methyl-1h-pyrrol-3-yl)-2-thiazolyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-, (4r,5s,6s)-
(4r,5s,6s)-3-[[4-[(5s)-2,5-dihydro-5-methyl-1h-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
ptz601
pz601
razupenem [usan]
sm216601
razupenem [who-dd]
ptz-601
smp601
(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-3-({4-[(5s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl]thiazol-2-yl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
razupenem [inn]
SCHEMBL2894324
(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-3-({4-[(5s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl}-1,3-thiazol-2-yl)sulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-3-({4-[(5s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl]-1,3-thiazol-2-yl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
XFGOMLIRJYURLQ-GOKYHWASSA-N
(4r,5s,6s)-6-((r)-1-hydroxyethyl)-4-methyl-3-((4-((s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl)thiazol-2-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(4r,5s,6s)-6-((r)-1-hydroxyethyl)-4-methyl-3-((4-((s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl)thiazol-2-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic a
DB12587
(4r,5s,6s)-3-[[4-[(5s)-2,5-dihydro-5-methyl-1h-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid
Q15410192
(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-3-[[4-[(5s)-5-methyl-2,5-dihydro-1h-pyrrol-3-yl]-1,3-thiazol-2-yl]sulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
gtpl10851
DTXSID801045429

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In order to develop a novel broad-spectrum carbapenem, the structure-activity relationships of a series of 2-(4-tetrahydropyridinylthiazol-2-ylthio)-1beta-methylcarbapenems and 4-dihydropyrrolyl thiazole analogs were investigated with regard to their activity against Gram-positive and especially Gram-negative bacteria and also their convulsant activity, which is a major side effect concern of carbapenems."( SM-216601, a novel parenteral 1beta-methylcarbapenem: structure-activity relationships of antibacterial activity and neurotoxicity in mice.
Itoh, M; Sasaki, A; Sunagawa, M; Ueda, Y, 2005)		1.77
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (178)

Assay IDTitleYearJournalArticle
AID560743Protein binding in mouse serum at 10 ug/ml by ultrafiltration method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID525367Antibacterial activity against methicillin-resistant Staphylococcus aureus NUMR101 infected in ddY mouse assessed as viable bacteria in lungs at 100 mg/kg, ip administered 1 day postinfection (Rvb=8.42 +/- 0.50 log CFU/ml)2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID525378T>MIC in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 10 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558719Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558472Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558526Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558523Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562164Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558512Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558735Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558473Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560211Bactericidal activity against methicillin-resistant Staphylococcus aureus2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
AID558706Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558528Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562166Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525387T>MIC in serum in vancomycin intermediate Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562195Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558492Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558732Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558477Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558480Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558505Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558705Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558703Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525362AUC (0 to infinity) in lung of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562158Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558513Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558510Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558731Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525385fT>MIC in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558484Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560746Antibacterial activity against methicillin-resistant Staphylococcus aureus SP-12249 by broth microdilution method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID560742Protein binding in mouse serum at 30 ug/ml by ultrafiltration method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558504Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562165Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558503Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562194Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558518Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558716Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558507Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560749fT>MIC required for inducing 1-log killing effect in vancomycin-resistant Enterococcus faecium TL-3273-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558495Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562189Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562192Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558712Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560756fT>MIC required for inducing 2-log killing effect in methicillin-resistant Staphylococcus aureus SP-12249-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558494Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558727Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560751fT>MIC required for bacteriostatic effect in vancomycin-resistant Enterococcus faecium TL-3621-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID562186Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 after 50 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558509Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558478Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560748fT>MIC required for bacteriostatic effect in vancomycin-resistant Enterococcus faecium TL-3273-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558499Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560745Antibacterial activity against vancomycin-resistant Enterococcus faecium TL-3621 by broth microdilution method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558488Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558506Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560754fT>MIC required for bacteriostatic effect in methicillin-resistant Staphylococcus aureus SP-12249-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID562174Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 after 18 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560753fT>MIC required for inducing 2-log killing effect in vancomycin-resistant Enterococcus faecium TL-3621-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID525363fAUC (0 to infinity) in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID560744Antibacterial activity against vancomycin-resistant Enterococcus faecium TL-3273 by broth microdilution method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558723Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525359Cmax in lung of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558475Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558500Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558701Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525388fT>MIC in serum in vancomycin intermediate Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558702Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558704Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558525Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560758fT>MIC required for inducing 1-log killing effect in methicillin-resistant Staphylococcus aureus TL-3677-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558471Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562161Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562169Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 after 50 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558717Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558470Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558721Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558508Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558524Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562162Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558527Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558487Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558722Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525380T>MIC in lung of methicillin-resistant Staphylococcus aureus infected ddY mouse at 10 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562187Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 after 50 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525365Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in ddY mouse assessed as survival of the mouse at 100 mg/kg, ip administered 1 day postinfection measured after 10 days2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558501Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558485Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558730Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562181Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 49 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558522Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558734Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560212Ratio of MBC to MIC for methicillin-resistant Staphylococcus aureus2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
AID558491Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558729Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525389T>MIC in lung in vancomycin intermediate Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558726Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558514Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525366Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in ddY mouse assessed as viable bacteria in lungs at 100 mg/kg, ip administered 1 day postinfection measured after 3 days (Rvb=9.64 +/- 0.63 log CFU/ml)2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558483Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558497Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560739Antibacterial activity against vancomycin-resistant Enterococcus faecium TL-3273 at 0.5 to 8 ug/mL by time-kill analysis in presence of 1% carrageenan2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID562167Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562172Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 after 27 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558493Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558474Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558714Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560210Antimicrobial activity against methicillin-resistant Staphylococcus aureus2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
AID562191Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525377Antibacterial activity against vancomycin intermediate Staphylococcus aureus Mu50 by broth microdilution method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558515Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525384T>MIC in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID525360fCmax in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562176Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 28 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562163Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525393Protein binding in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558496Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558498Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562178Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 23 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558521Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558479Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562184Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 50 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562170Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 after 30 passages by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558709Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558720Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558517Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525357Half life of free unbound fraction in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562160Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558490Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558489Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 15 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560741Protein binding in mouse serum at 100 ug/ml by ultrafiltration method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID525376Antibacterial activity against methicillin-resistant Staphylococcus aureus NUMR101 by broth microdilution method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID560759fT>MIC required for inducing 2-log killing effect in methicillin-resistant Staphylococcus aureus TL-3677-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558486Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562193Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558724Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525364AUC (0 to infinity) in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID562190Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525356Half life in lung of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558728Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558708Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525386T>MIC in lung of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558707Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558531Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558711Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525361Cmax in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558520Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525379fT>MIC in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 10 mg/kg, ip BID by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID525358Half life in serum of methicillin-resistant Staphylococcus aureus infected ddY mouse at 100 mg/kg, ip administered 1 day post infection by paper disk bioassay method2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558511Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558725Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558469Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured after 10 antibiotic-free subculturing by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558529Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558502Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 20 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558516Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 25 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560740Antibacterial activity against vancomycin-resistant Enterococcus faecium TL-3273 infected in ICR mouse assessed as reduction in bacterial burden at 2.5 to 640 mg/kg, sc in presence of 1% carrageenan2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558713Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525394Antibacterial activity against vancomycin intermediate Staphylococcus aureus Mu50 infected in ddY mouse assessed as decrease in lung abscesses at 100 mg/kg, ip after 3 days2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID560752fT>MIC required for inducing 1-log killing effect in vancomycin-resistant Enterococcus faecium TL-3621-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID562168Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560757fT>MIC required for bacteriostatic effect in methicillin-resistant Staphylococcus aureus TL-3677-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558530Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560750fT>MIC required for inducing 2-log killing effect in vancomycin-resistant Enterococcus faecium TL-3273-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID560213Antimicrobial activity against methicillin-resistant Staphylococcus aureus in mouse systemic infection model2009Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
AID560747Antibacterial activity against methicillin-resistant Staphylococcus aureus TL-3677 by broth microdilution method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558519Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 30 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558733Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID560755fT>MIC required for inducing 1-log killing effect in methicillin-resistant Staphylococcus aureus SP-12249-infected mouse2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.
AID558736Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 50 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558476Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 5 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID562159Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558481Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID525395Antibacterial activity against vancomycin intermediate Staphylococcus aureus Mu50 infected in ddY mouse assessed as decrease in lung inflammation at 100 mg/kg, ip after 3 days2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
AID558482Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 10 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558532Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 35 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558718Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 45 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
AID558710Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 40 by macrodilution method2009Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.07 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (14.29%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		3.8430glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
carbapenems
[no description available]		4.3541
linezolid
[no description available]		3.5520acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
ceftriaxone
[no description available]		3.14101,2,4-triazines;
1,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 3.5.2.6 (beta-lactamase) inhibitor
ceftazidime
[no description available]		3.1410cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
ppi-0903
ceftaroline : A cephalosporin that is the active metabolite of the prodrug ceftaroline fosamil. Used for the treatment of adults with acute bacterial skin and skin structure infections.		3.14101,3-thiazoles;
cephalosporin;
iminium betaine;
organic phosphoramidate;
oxime O-ether;
thiadiazoles		antibacterial drug;
antimicrobial agent;
prodrug
me1036
ME1036: structure in first source		3.1410
ConditionIndicatedRelationship StrengthStudiesTrials
Bronchial Pneumonia
[description not available]		02.0410
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0410
Staphylococcal Pneumonia
[description not available]		02.0410
Pneumonia, Staphylococcal
Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.		02.0410
Infections, Staphylococcal
[description not available]		02.0510
Bacterial Infections, Gram-Positive
[description not available]		02.0510
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0510
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.		02.0510
Absence Seizure
[description not available]		02.0210
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.0210