Page last updated: 2024-09-27

Ocular Toxicity

Damage to the eye or its function (e.g., VISUAL IMPAIRMENT) due to OPTIC NERVE damage secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.

Synonyms(2)

Synonym
Toxic Optic Neuropathy
Ocular Toxicity

Research Excerpts

Overview

ExcerptReference
"Nutritional and toxic optic neuropathy is a rare and challenging diagnosis because of a lack of biomarkers."( Cervera-Taulet, E; García-Villanueva, C; Mata-Moret, L; Monferrer-Adsuara, C; Ortiz-Salvador, M; Remolí-Sargues, L, 2020)
"Ethambutol ocular toxicity is a major problem during combination chemotherapy for Mycobacterium avium complex (MAC) pulmonary disease (MAC-PD) due to years-long therapy for MAC."( Ando, T; Kage, H; Matsumoto, Y; Nagase, T; Zokumasu, K, 2021)
"Toxic optic neuropathy is a severe optic nerve injury that can compromise the prognosis for vision, justifying early clinical and ancillary diagnosis."( Abdallah, E; Berraho, HA; Hasnaoui, I; Hassina, S; Krichene, MA; Mrad, K; Serghini, L, 2023)
"Ethambutol ocular toxicity is extremely rare in children, and the required action when detected is to discontinue the drug."( Abdallah, E; Berraho, HA; Hasnaoui, I; Hassina, S; Krichene, MA; Mrad, K; Serghini, L, 2023)

Treatment

ExcerptReference
"Ethambutol ocular toxicity is a major problem during combination chemotherapy for Mycobacterium avium complex (MAC) pulmonary disease (MAC-PD) due to years-long therapy for MAC."( Ando, T; Kage, H; Matsumoto, Y; Nagase, T; Zokumasu, K, 2021)
"This case report outlines a case of ocular toxicity following carboplatin chemotherapy used for the management of a neuroendocrine tumour of the bladder."( Mansoor, Q; Ng, J; Sadiq, M, 2023)
"Carboplatin-induced ocular toxicity was suspected and his vision remained stable following cessation of carboplatin chemotherapy."( Mansoor, Q; Ng, J; Sadiq, M, 2023)
"The study was conducted to evaluate the ocular toxicity of ethambutol given in both intensive and continuation phases of treatment in children with drug-sensitive tuberculosis."( Ali, MK; Mandal, A; Mane, SS; Pustake, M; Yadav, N, 2022)

Research

Studies (39)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (2.56)28.8240
2020's38 (97.44)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
methanol0low10
melatonin0low10
thiamine0low10
bithionol0low10
cefuroxime0low10
chloroquine0low10
clioquinol0low10
gentamicin0low10
hydroxychloroquine0low10
isoniazid0low10
proxymetacaine0low10
propidium0low10
vigabatrin0low10
mustard gas0low10
hematoxylin0low10
eosine yellowish-(ys)0low10
ethambutol0medium102
perillaldehyde0low10
etoposide0low10
triclabendazole0low10
voriconazole0low10
cyclopentenyl cytosine0low10
clarithromycin0medium11
docetaxel anhydrous0low10
erlotinib hydrochloride0low10
organophosphonates0low10
bortezomib0low10
carboplatin0low10
linezolid0low10
digoxin0low10
tamoxifen0low10
quinine0low10
everolimus0low10
chlorhexidine0low10
plx40320low10
vitamin b 120low10
folic acid0low10
rifampin0medium11
eye0low80

Protein Targets (1,019)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase3003
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Chain A, Ferritin light chain3003
Chain A, Cruzipain5005
Luciferase5005
interleukin 85005
acetylcholinesterase4004
calpain II, partial0101
glp-1 receptor, partial6006
15-lipoxygenase, partial5005
pregnane X receptor2002
Mcl-10202
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma110011
SMAD family member 26006
USP1 protein, partial100010
SMAD family member 36006
TDP1 protein150015
GLI family zinc finger 3130013
Microtubule-associated protein tau7007
Estrogen receptor 10101
AR protein140014
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor5005
envelope glycoprotein0101
estrogen receptor 2 (ER beta)7007
nuclear receptor subfamily 1, group I, member 3110011
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 4120012
nonstructural protein 12002
glucocorticoid receptor [Homo sapiens]120012
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor8008
pregnane X nuclear receptor120012
estrogen nuclear receptor alpha170017
G6006
cytochrome P450 2D65005
bromodomain adjacent to zinc finger domain 2B5005
peroxisome proliferator-activated receptor delta8008
peroxisome proliferator activated receptor gamma110011
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
euchromatic histone-lysine N-methyltransferase 2130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
thyroid stimulating hormone receptor7007
activating transcription factor 67007
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x6006
Bloom syndrome protein isoform 14004
polyunsaturated fatty acid lipoxygenase ALOX122002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
vitamin D3 receptor isoform VDRA7007
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d6006
thyroid hormone receptor beta isoform 2140014
estrogen receptor beta isoform 10101
heat shock protein beta-16006
huntingtin isoform 23003
DNA polymerase beta3003
mitogen-activated protein kinase 16006
nuclear factor NF-kappa-B p105 subunit isoform 13003
nuclear factor erythroid 2-related factor 2 isoform 1120012
nuclear receptor ROR-gamma isoform 1100010
geminin130013
DNA polymerase kappa isoform 15005
peripheral myelin protein 225005
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 19009
histone acetyltransferase KAT2A isoform 15005
caspase-1 isoform alpha precursor2002
lethal factor (plasmid)5005
lamin isoform A-delta107007
Gamma-aminobutyric acid receptor subunit pi9009
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0506
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
5-hydroxytryptamine receptor 40404
Nuclear receptor subfamily 1 group I member 20022
Solute carrier family 22 member 30202
Voltage-dependent calcium channel gamma-2 subunit7007
Epidermal growth factor receptor0426
Interferon beta110011
HLA class I histocompatibility antigen, B alpha chain 6006
Transthyretin0213
Receptor tyrosine-protein kinase erbB-20303
Cellular tumor antigen p53120012
Tyrosine-protein kinase Lck0224
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0606
60 kDa chaperonin0101
Replicase polyprotein 1a0235
Adenosine receptor A30404
60 kDa heat shock protein, mitochondrial0202
Muscarinic acetylcholine receptor M20101
Gamma-aminobutyric acid receptor subunit beta-19009
Alpha-1B adrenergic receptor0415
Alpha-2B adrenergic receptor0606
Gamma-aminobutyric acid receptor subunit delta9009
Gamma-aminobutyric acid receptor subunit gamma-29009
Alpha-2C adrenergic receptor0404
5-hydroxytryptamine receptor 1A0404
Glutamate receptor 27007
Gamma-aminobutyric acid receptor subunit alpha-59009
Gamma-aminobutyric acid receptor subunit alpha-39009
Substance-K receptor0404
Gamma-aminobutyric acid receptor subunit gamma-19009
Gamma-aminobutyric acid receptor subunit alpha-29009
Sodium-dependent noradrenaline transporter 0404
Thromboxane-A synthase 0202
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit alpha-49009
Gamma-aminobutyric acid receptor subunit gamma-39009
Mitogen-activated protein kinase 10123
5-hydroxytryptamine receptor 1B0404
Adenosine receptor A2a0404
Gamma-aminobutyric acid receptor subunit alpha-69009
Mu-type opioid receptor0404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0516
Histamine H2 receptor6006
Nuclear receptor ROR-gamma5117
Caspase-72002
Spike glycoprotein4138
10 kDa heat shock protein, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-19009
Gamma-aminobutyric acid receptor subunit beta-39009
Gamma-aminobutyric acid receptor subunit beta-29009
Pup--protein ligase0101
Sodium-dependent dopamine transporter 0404
Peroxisome proliferator-activated receptor alpha1001
Mitogen-activated protein kinase 140123
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Multidrug and toxin extrusion protein 20202
GABA theta subunit9009
Inositol hexakisphosphate kinase 16006
Multidrug and toxin extrusion protein 10202
ATPase family AAA domain-containing protein 5100010
Ataxin-2110011
Gamma-aminobutyric acid receptor subunit epsilon9009
cytochrome P450 2C9, partial6006
M1-family alanyl aminopeptidase0101
large T antigen0202
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
Fumarate hydratase3003
PPM1D protein6006
caspase 7, apoptosis-related cysteine protease6006
EWS/FLI fusion protein7007
polyprotein3003
caspase-36006
nuclear receptor subfamily 1, group I, member 22002
Caspase-72002
caspase-32002
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30202
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015016
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120102
Bile salt export pump017017
Prothrombin0102
Chymotrypsinogen A0101
Carbonic anhydrase 10203
Carbonic anhydrase 20203
Carbonic anhydrase 30102
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40102
Carbonic anhydrase 60203
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0102
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70102
26S proteasome regulatory subunit 6B0123
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10202
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90102
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20202
Canalicular multispecific organic anion transporter 1016017
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150202
Histone deacetylase 80202
Histone deacetylase 60202
Carbonic anhydrase 140102
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
phosphopantetheinyl transferase9009
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
ATP-dependent phosphofructokinase4004
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, BCL-2-RELATED PROTEIN A10011
acid sphingomyelinase2002
PAX80002
PINK12002
67.9K protein7007
glucocerebrosidase4004
Parkin2002
heat shock protein 900011
IDH16006
calcineurin A1, putative0011
aryl hydrocarbon receptor6006
cytochrome P450 2D6 isoform 16006
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a5005
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor2002
perilipin-50101
perilipin-10101
nuclear factor erythroid 2-related factor 2 isoform 27007
transcriptional regulator ERG isoform 33003
importin subunit beta-1 isoform 12002
ubiquitin-conjugating enzyme E2 N0202
flap endonuclease 14004
protein AF-9 isoform a0001
snurportin-12002
melanocortin receptor 40101
CAAX prenyl protease0001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor4004
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
Synaptojanin-20101
Synaptojanin-10101
Glutathione reductase, mitochondrial0102
Integrin beta-35005
72 kDa type IV collagenase0101
Integrin alpha-IIb5005
Matrix metalloproteinase-90101
Trypanothione reductase0101
Alpha-synuclein5106
TAR DNA-binding protein 433003
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Rap guanine nucleotide exchange factor 42002
Spermine oxidase0101
thioredoxin reductase5005
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0202
Spike glycoprotein0134
Replicase polyprotein 1ab0134
glucose-6-phosphate 1-dehydrogenase isoform b0202
Transmembrane protease serine 20134
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0202
Histidine-rich protein PFHRP-II0203
Procathepsin L0134
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40404
Cytochrome P450 3A40809
Muscarinic acetylcholine receptor M50404
Replicase polyprotein 1ab0134
Replicase polyprotein 1ab0235
Spike glycoprotein0202
Replicase polyprotein 1ab0336
Muscarinic acetylcholine receptor M10404
Ribosyldihydronicotinamide dehydrogenase [quinone]0325
DNA ligase 10101
Muscarinic acetylcholine receptor M30404
Serine/threonine-protein kinase mTOR0213
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20808
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10606
Angiotensin-converting enzyme 2 0134
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
GTP-binding nuclear protein Ran isoform 11001
streptokinase A precursor0044
ATP-dependent translocase ABCB108112
Solute carrier organic anion transporter family member 1B30607
Solute carrier organic anion transporter family member 1B10405
mu opioid receptor, partial0011
90-kda heat shock protein beta HSP90 beta, partial0101
ATAD5 protein, partial3003
thioredoxin glutathione reductase3003
Smad33003
regulator of G-protein signaling 45005
LAP40011
MEP20011
delta-type opioid receptor0112
kappa-type opioid receptor isoform 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
heat shock protein HSP 90-alpha isoform 20103
DNA polymerase iota isoform a (long)3003
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Botulinum neurotoxin type A 0101
Catechol O-methyltransferase0101
Alpha-1D adrenergic receptor0011
Histone deacetylase 40101
Disintegrin and metalloproteinase domain-containing protein 171001
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Beta-galactosidase0011
Histone deacetylase 70101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Carbonic anhydrase 130001
Histone deacetylase 90101
Histone deacetylase 50101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
heat shock protein 90, putative0002
Uridine-cytidine kinase 10101
Deoxycytidine kinase0001
STAT3, partial0101
alpha-galactosidase3003
NPC intracellular cholesterol transporter 1 precursor2002
tumor necrosis factor1001
ras-related protein Rab-9A3003
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40304
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit beta-1 0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
Serum paraoxonase/arylesterase 10202
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20101
Serine/threonine-protein kinase B-raf 0202
Enoyl-[acyl-carrier-protein] reductase [NADH]0204
Pantothenate synthetase0202
LMP1 [Human herpesvirus 4]0001
chromobox protein homolog 15005
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Regulatory protein E20011
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0139
Cytochrome P450 2C9 0304
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0001
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta01310
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Glutamate receptor ionotropic, NMDA 3A0001
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30123
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10022
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20022
Protein kinase C beta type0123
Insulin receptor0022
Tyrosine-protein kinase Fyn0123
Cyclin-dependent kinase 10022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0123
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0135
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0033
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20022
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20123
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0123
Exosome RNA helicase MTR40022
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30022
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10123
Protein kinase C theta type0123
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0123
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Sodium channel protein type 5 subunit alpha0101
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420022
Mitogen-activated protein kinase kinase kinase kinase 30022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Regulatory-associated protein of mTOR0101
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70022
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20022
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200123
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10022
Septin-90022
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Chain A, Dihydrofolate reductase0011
lysosomal alpha-glucosidase preproprotein2002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain E, Fibrin beta chain0101
Chain A, RNA-directed RNA polymerase NS50101
WRN1001
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
alkaline phosphatase, intestinal0011
apical membrane antigen 1, AMA12002
hypothetical protein, conserved1001
luciferase1001
pyruvate kinase1001
CDK50001
serine-protein kinase ATM isoform a1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
intestinal alkaline phosphatase precursor0011
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
Rap guanine nucleotide exchange factor 31001
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Inositol monophosphatase 12002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
Genome polyprotein 0101
Alpha-1D adrenergic receptor0404
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
GLS protein2002
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20101
Bile salt export pump0303
Myeloperoxidase0202
Cytochrome P450 1A20304
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0202
DNA gyrase subunit B0202
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190304
Endonuclease III-like protein 10101
DNA gyrase subunit B0202
DNA gyrase subunit A0202
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Estrogen receptor0034
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Cytochrome P450 2D60405
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0303
Prostaglandin G/H synthase 10202
Amine oxidase [flavin-containing] B0101
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
50S ribosomal protein L36 20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Estrogen receptor beta0034
Renin0101
ClpP1001
peripheral myelin protein 22 isoform 11001
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M11001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Cholinesterase0303
Cytochrome P450 2C11 0101
Aromatase0101
Acetylcholinesterase0303
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0202
Mu-type opioid receptor0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
Transient receptor potential cation channel subfamily A member 10011
Transient receptor potential cation channel subfamily A member 10011
Chain A, AKAP9-BRAF fusion protein0101
tyrosine-protein kinase Yes1001
Membrane-associated progesterone receptor component 10011
Pirin0101
Tyrosine-protein kinase JAK20011
GTPase KRas0101
RAF proto-oncogene serine/threonine-protein kinase0113
Vascular endothelial growth factor receptor 20101
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 40011
Heat shock factor protein 10101
Aspartyl/asparaginyl beta-hydroxylase0101
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase ATR0011
Cyclin-dependent kinase 100011
Uncharacterized aarF domain-containing protein kinase 50011
Rab-like protein 30011
MAP kinase-activated protein kinase 50011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase ICK0011
Serine/threonine-protein kinase 38-like0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Acetylcholinesterase0101
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Potassium channel subfamily K member 20101
Albumin0022
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Solute carrier organic anion transporter family member 1A10202
5-hydroxytryptamine receptor 70101
Solute carrier family 22 member 10304
Cytochrome P450 2D40101
Solute carrier family 22 member 20303
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
Cytochrome P450 2B60213
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Lanosterol 14-alpha demethylase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
arylsulfatase A2002
interferon gamma precursor0001
D(1A) dopamine receptor2002
serine/threonine-protein kinase mTOR isoform 11001
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Progesterone receptor0101
Beta-1 adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Androgen receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Protein kinase C eta type0101
Histamine H2 receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Melanocortin receptor 30202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
hepatitis C virus polyprotein1001
Vpr1001
neuropeptide S receptor isoform A1001
Cruzipain0101
Guanine nucleotide-binding protein G1001
endonuclease IV1001
Gamma-aminobutyric acid type B receptor subunit 20101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
Gamma-aminobutyric acid type B receptor subunit 10101
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Lanosterol 14-alpha demethylase0011
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]