valproic acid has been researched along with Chronic Pain in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the perioperative administration of valproic acid reduces the incidence of chronic pain three months after amputation or revision surgery." | 5.30 | The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial. ( Buchheit, T; Buckenmaier, CT; Cooter, M; Hsia, HJ; Kent, M; McDuffie, M; Shaw, A; Shortell, C; Van de Ven, T, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holder, SD | 1 |
| Buchheit, T | 1 |
| Hsia, HJ | 1 |
| Cooter, M | 1 |
| Shortell, C | 1 |
| Kent, M | 1 |
| McDuffie, M | 1 |
| Shaw, A | 1 |
| Buckenmaier, CT | 1 |
| Van de Ven, T | 1 |
1 review available for valproic acid and Chronic Pain
| Article | Year |
|---|---|
Psychotic and Bipolar Disorders: Bipolar Disorder.
Topics: Antimanic Agents; Bipolar Disorder; Cardiovascular Diseases; Chronic Pain; Comorbidity; Family Pract | 2017 |
1 trial available for valproic acid and Chronic Pain
| Article | Year |
|---|---|
The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial.
Topics: Adult; Aged; Amputation, Surgical; Chronic Pain; Double-Blind Method; Endpoint Determination; Female | 2019 |