diclofenac has been researched along with Chronic Pain in 20 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " diclofenac monotherapy in reducing symptoms of mild to moderate depression among patients with chronic pain." | 9.22 | Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial. ( Afarideh, M; Agah, E; Akhondzadeh, S; Arbabi, M; Ghajar, A; Jafarinia, M; Noorbala, AA; Saravi, MA; Tafakhori, A, 2016) |
| "The aim of this study was to compare the efficacy of diclofenac versus lysine acetylsalicylate-based mesotherapy in relieving pain (primary outcome), and disability (secondary outcome) in patients with nonspecific chronic low back pain." | 7.91 | Efficacy of intradermal administration of diclofenac for the treatment of nonspecific chronic low back pain: results from a retrospective observational study. ( Ferrara, PE; Ferriero, G; Foti, C; Maccauro, G; Nigito, C; Ronconi, G, 2019) |
| "To determine if a topically applied non-steroidal anti-inflammatory drug (diclofenac) can provide short-term pain relief for chronic Achilles tendinopathy (CAT), in order to inform the development of a new rehabilitation protocol." | 5.24 | Randomised controlled trial evaluating the short-term analgesic effect of topical diclofenac on chronic Achilles tendon pain: a pilot study. ( Bovard, J; Bussin, ER; Cairns, B; Scott, A, 2017) |
| " diclofenac monotherapy in reducing symptoms of mild to moderate depression among patients with chronic pain." | 5.22 | Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial. ( Afarideh, M; Agah, E; Akhondzadeh, S; Arbabi, M; Ghajar, A; Jafarinia, M; Noorbala, AA; Saravi, MA; Tafakhori, A, 2016) |
| "In acute musculoskeletal pain (strains and sprains) with assessment at about seven days, therapies were diclofenac Emulgel (78% Emulgel, 20% placebo; 2 studies, 314 participants, NNT 1." | 4.95 | Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. ( Aldington, D; Bell, RF; Derry, S; Gaskell, H; Kalso, EA; Moore, RA; Phillips, T; Wiffen, PJ, 2017) |
| "Diclofenac is a non-steroidal antinflammatory drug (NSAID) that finds indication in the treatment of debilitating pathologies characterized by chronic pain sustained by inflammation, such as in rheumatic disease (rheumatoid arthritis or osteoarthritis) or periarthritis, bursitis, tendonitis, myositis and sciatica." | 4.93 | Spinal antinflammatory action of Diclofenac. ( Sandri, A, 2016) |
| "Topical diclofenac and topical ketoprofen can provide good levels of pain relief beyond carrier in osteoarthritis for a minority of people, but there is no evidence for other chronic painful conditions." | 4.93 | Topical NSAIDs for chronic musculoskeletal pain in adults. ( Conaghan, P; Da Silva, JA; Derry, S; Moore, RA; Wiffen, PJ, 2016) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| "Topical NSAIDs can provide good levels of pain relief; topical diclofenac solution is equivalent to that of oral NSAIDs in knee and hand osteoarthritis, but there is no evidence for other chronic painful conditions." | 4.88 | Topical NSAIDs for chronic musculoskeletal pain in adults. ( Derry, S; Moore, RA; Rabbie, R, 2012) |
| "Quarterly time series analyses measuring diclofenac prescription initiation, discontinuation and switching to other systemic nonsteroidal anti-inflammatory (NSAIDs), topical NSAIDs, paracetamol, opioids, and other chronic pain medication in those who discontinued diclofenac." | 3.96 | Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands. ( Bennie, M; Doney, ASF; Ernst, MT; Flynn, RWV; Hallas, J; Herings, RMC; MacDonald, TM; Mackenzie, IS; Mitchell, L; Morales, DR; Morant, SV; Morris, C; Nicholson, L; Overbeek, JA; Pottegard, A; Robertson, C; Smits, E; Wei, L, 2020) |
| " Herein, we describe the clinical manifestations and imaging features, especially the enthesopathy in bilateral Achilles tendons, of a middle-aged Asian woman with SAPHO syndrome, who improved after diclofenac treatment." | 3.91 | SAPHO syndrome with enthesopathy. ( Liao, HT; Shen, YC; Su, CF; Tsai, CY, 2019) |
| "The aim of this study was to compare the efficacy of diclofenac versus lysine acetylsalicylate-based mesotherapy in relieving pain (primary outcome), and disability (secondary outcome) in patients with nonspecific chronic low back pain." | 3.91 | Efficacy of intradermal administration of diclofenac for the treatment of nonspecific chronic low back pain: results from a retrospective observational study. ( Ferrara, PE; Ferriero, G; Foti, C; Maccauro, G; Nigito, C; Ronconi, G, 2019) |
| "Knee osteoarthritis is a common form of arthritis in elderly patients that is characterised by pain and functional limitation." | 2.84 | Moxibustion versus diclofenac sodium gel for the treatment of knee osteoarthritis: a study protocol for a double-blinded, double-placebo, randomised controlled trial. ( Luo, L; Lv, P; Peng, JX; Tang, Y; Wu, Q; Yin, HY; Yu, SG; Zhang, CS; Zhou, JY; Zhu, LL, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (90.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morales, DR | 1 |
| Morant, SV | 1 |
| MacDonald, TM | 1 |
| Mackenzie, IS | 1 |
| Doney, ASF | 1 |
| Mitchell, L | 1 |
| Bennie, M | 1 |
| Robertson, C | 1 |
| Hallas, J | 1 |
| Pottegard, A | 1 |
| Ernst, MT | 1 |
| Wei, L | 1 |
| Nicholson, L | 1 |
| Morris, C | 1 |
| Herings, RMC | 1 |
| Overbeek, JA | 1 |
| Smits, E | 1 |
| Flynn, RWV | 1 |
| Ronconi, G | 3 |
| Ferriero, G | 3 |
| Mammucari, M | 1 |
| Codazza, S | 1 |
| Maccauro, G | 3 |
| Ferrara, PE | 3 |
| Zhou, JY | 1 |
| Luo, L | 1 |
| Zhu, LL | 1 |
| Yin, HY | 1 |
| Wu, Q | 1 |
| Peng, JX | 1 |
| Zhang, CS | 1 |
| Lv, P | 1 |
| Tang, Y | 1 |
| Yu, SG | 1 |
| Bussin, ER | 1 |
| Cairns, B | 1 |
| Bovard, J | 1 |
| Scott, A | 1 |
| Derry, S | 3 |
| Wiffen, PJ | 2 |
| Kalso, EA | 1 |
| Bell, RF | 1 |
| Aldington, D | 1 |
| Phillips, T | 1 |
| Gaskell, H | 1 |
| Moore, RA | 3 |
| Ohmichi, Y | 1 |
| Ohmichi, M | 1 |
| Murai, N | 1 |
| Yasui, M | 1 |
| Takeshita, N | 1 |
| Oshibuchi, H | 1 |
| Naito, M | 1 |
| Nakano, T | 1 |
| Sato, J | 1 |
| Larsen, IM | 1 |
| Drewes, AM | 1 |
| Olesen, AE | 1 |
| Nigito, C | 2 |
| Foti, C | 2 |
| Su, CF | 1 |
| Shen, YC | 1 |
| Liao, HT | 1 |
| Tsai, CY | 1 |
| Huang, R | 1 |
| Jiang, L | 1 |
| Cao, Y | 1 |
| Liu, H | 1 |
| Ping, M | 1 |
| Li, W | 1 |
| Xu, Y | 1 |
| Ning, J | 1 |
| Chen, Y | 1 |
| Wang, X | 1 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Chin, HY | 1 |
| Changchien, E | 1 |
| Lin, MF | 1 |
| Chiang, CH | 1 |
| Wang, CJ | 1 |
| Kurita Varoli, F | 1 |
| Sucena Pita, M | 1 |
| Sato, S | 1 |
| Issa, JP | 1 |
| do Nascimento, C | 1 |
| Pedrazzi, V | 1 |
| Enthoven, WT | 1 |
| Roelofs, PD | 1 |
| Deyo, RA | 1 |
| van Tulder, MW | 1 |
| Koes, BW | 1 |
| Sandri, A | 1 |
| Conaghan, P | 1 |
| Da Silva, JA | 1 |
| Jafarinia, M | 1 |
| Afarideh, M | 1 |
| Tafakhori, A | 1 |
| Arbabi, M | 1 |
| Ghajar, A | 1 |
| Noorbala, AA | 1 |
| Saravi, MA | 1 |
| Agah, E | 1 |
| Akhondzadeh, S | 1 |
| Metin, SK | 1 |
| Meydan, B | 1 |
| Evman, S | 1 |
| Dogruyol, T | 1 |
| Baysungur, V | 1 |
| Rabbie, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effectiveness of Moxibustion Treatment for Osteoarthritis of the Knee : a Double-blinded, Double-dummy, Randomized Controlled Trial[NCT02769572] | Phase 3 | 144 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for diclofenac and Chronic Pain
| Article | Year |
|---|---|
Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews.
Topics: Acute Pain; Adult; Analgesics; Arthritis, Rheumatoid; Capsaicin; Chronic Pain; Diclofenac; Humans; K | 2017 |
Comparative Efficacy of Therapeutics for Chronic Cancer Pain: A Bayesian Network Meta-Analysis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bayes Theorem; Bridged Bicyclo Compou | 2019 |
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
Non-steroidal anti-inflammatory drugs for chronic low back pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Disability Evaluation; Humans; Ib | 2016 |
Spinal antinflammatory action of Diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Cyclooxygenase 2 Inhibitors; Diclofenac; Huma | 2016 |
Topical NSAIDs for chronic musculoskeletal pain in adults.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; H | 2016 |
Topical NSAIDs for chronic musculoskeletal pain in adults.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; H | 2012 |
6 trials available for diclofenac and Chronic Pain
| Article | Year |
|---|---|
Moxibustion versus diclofenac sodium gel for the treatment of knee osteoarthritis: a study protocol for a double-blinded, double-placebo, randomised controlled trial.
Topics: Acupuncture Points; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; China; Chronic Pain; Diclo | 2017 |
Randomised controlled trial evaluating the short-term analgesic effect of topical diclofenac on chronic Achilles tendon pain: a pilot study.
Topics: Achilles Tendon; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; British Columbia; Chronic Pai | 2017 |
The Effect of a Combination of Diclofenac and Methadone Applied as Gel in a Human Experimental Pain Model - A Randomized, Placebo-controlled Trial.
Topics: Administration, Cutaneous; Adult; Capsaicin; Chronic Pain; Cross-Over Studies; Diclofenac; Dose-Resp | 2018 |
Analgesia evaluation of 2 NSAID drugs as adjuvant in management of chronic temporomandibular disorders.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carisoprod | 2015 |
Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial.
Topics: Administration, Oral; Adult; Antidepressive Agents; Chronic Pain; Depression; Diclofenac; Double-Bli | 2016 |
The Effect of Pregabalin and Methylcobalamin Combination on the Chronic Postthoracotomy Pain Syndrome.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Drug Com | 2017 |
7 other studies available for diclofenac and Chronic Pain
| Article | Year |
|---|---|
Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; C | 2020 |
Authors' reply to: Efficacy of intradermal administration of diclofenac for the treatment of nonspecific chronic low back pain: results from a retrospective observational study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Humans; Low Back Pain; Retrospect | 2020 |
Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
Topics: Animals; Chronic Pain; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Muscle, | 2018 |
Efficacy of diclofenac mesotherapy for the treatment of chronic neck pain in spondylartrosis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Female; Humans; Male; Mesot | 2019 |
SAPHO syndrome with enthesopathy.
Topics: Achilles Tendon; Acquired Hyperostosis Syndrome; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pa | 2019 |
Efficacy of intradermal administration of diclofenac for the treatment of nonspecific chronic low back pain: results from a retrospective observational study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Diclofenac; Female; Humans; Injections, | 2019 |
Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: an experimental comparative rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Chronic Pain; Diclofenac; Female; Melox | 2014 |