Page last updated: 2024-08-23

substance p and Chronic Pain

substance p has been researched along with Chronic Pain in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.85)29.6817
2010's19 (73.08)24.3611
2020's6 (23.08)2.80

Authors

AuthorsStudies
Hsieh, YL; Yang, CC; Yang, NP1
Brzozowska, M; Całka, J; Jana, B1
Meng, J; Tang, M; Wang, J1
Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K1
Hsieh, YL; Wu, BT; Yang, CC1
Kim, J; Kim, M1
Guo, N; Hallberg, M; Nyberg, F; Nyman, J; Sandström, A; Yu, L1
Gellatly, D; Heuston, CEM; Janzen, ED; Marti, S; Meléndez, DM; Moya, D; Pajor, EA; Schwartzkopf-Genswein, KS1
Chen, W; Gaveriaux-Ruff, C; Hakimian, JK; Kieffer, BL; Marvizón, JCG; Severino, A; Walwyn, W1
Zieglgänsberger, W1
Chen, CC; Han, DS; Lee, CH; Shieh, YD1
Buch, NS; Karlsson, P; Nikolajsen, L1
Algenstaedt, P; Friedrichs, B; Hansen-Algenstaedt, N; Rüther, W; Schaefer, C; Schroeder, M; Viezens, L; Wiesner, L1
Bäckryd, E; Gerdle, B; Ghafouri, B; Larsson, B1
Camparis, CM; de Avila, ED; de Godoi Gonçalves, DA; de Molon, RS1
Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR1
Chen, CC; Chen, WN1
Andersen, ML; Araujo, P; Frange, C; Hachul, H; Hirotsu, C; Tufik, S1
Frallonardo, P; Lorenzin, MG; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A1
Dai, GH; Deng, WT; Guo, XD; Huang, KB; Luo, GQ; Pan, SY; Peng, KR; Qian, NS; Wu, XN; Xiang, W; Yang, HJ; Zhang, T1
Lisowska, B; Lisowski, A; Siewruk, K1
Arrigoni-Blank, MF; Barreto, PA; Brito, RG; Camargo, ZT; Kolker, SJ; Lucca-Júnior, W; Quintans, JSS; Quintans-Júnior, LJ; Santos, PL; Scotti, L; Scotti, MT; Sluka, KA1
Cohen, M; Lyon, P; Quintner, J1
Chen, CC; Chen, CJ; Chen, WN; Lin, CC; Lin, YW; Zimmer, A1
Clark, JD; Guo, TZ; Hou, S; Kingery, WS; Li, WW; Wei, T1
Gendreau, JF; Kranzler, JD; Rao, SG1

Reviews

6 review(s) available for substance p and Chronic Pain

ArticleYear
Substance P and pain chronicity.
    Cell and tissue research, 2019, Volume: 375, Issue:1

    Topics: Animals; Chronic Pain; Humans; Memory; Models, Biological; Nerve Net; Nociception; Substance P

2019
Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review.
    Journal of investigative and clinical dentistry, 2014, Volume: 5, Issue:2

    Topics: Alveolar Bone Loss; Chronic Pain; Gingival Crevicular Fluid; Humans; Neurogenic Inflammation; Periodontitis; Substance P

2014
Fibromyalgia and sleep in animal models: a current overview and future directions.
    Current pain and headache reports, 2014, Volume: 18, Issue:8

    Topics: Animals; Chronic Pain; Disease Models, Animal; Evidence-Based Medicine; Fatigue; Fibromyalgia; Humans; Pain Threshold; Rats; Serotonin; Severity of Illness Index; Sleep; Sleep Wake Disorders; Substance P

2014
Pain and microcrystalline arthritis.
    Reumatismo, 2014, Jun-06, Volume: 66, Issue:1

    Topics: Animals; Arthritis, Gouty; Calcium Pyrophosphate; Chronic Pain; Crystallization; Dinoprostone; Disease Models, Animal; Humans; Inflammation Mediators; Interleukin-1beta; Kinins; Musculoskeletal Pain; Nociceptors; Osteoarthritis; Quality of Life; Rats; Substance P; TRPV Cation Channels; Uric Acid

2014
An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome).
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:8

    Topics: Animals; Biological Evolution; Central Nervous System Sensitization; Chronic Pain; Fibromyalgia; Humans; Nociception; Receptors, Neurokinin-1; Stress, Psychological; Substance P

2011
Understanding the fibromyalgia syndrome.
    Psychopharmacology bulletin, 2007, Volume: 40, Issue:4

    Topics: Animals; Chronic Pain; Fibromyalgia; Humans; Hypothalamo-Hypophyseal System; Neuroimaging; Pituitary-Adrenal System; Serotonin; Substance P; Syndrome

2007

Trials

1 trial(s) available for substance p and Chronic Pain

ArticleYear
Effects of Acupressure on Pain, Flexibility, and Substance P in Middle-Age Women with Chronic Neck Pain.
    Journal of alternative and complementary medicine (New York, N.Y.), 2021, Volume: 27, Issue:2

    Topics: Acupressure; Adult; Chronic Pain; Female; Humans; Middle Aged; Neck Pain; Pain Measurement; Range of Motion, Articular; Substance P; Treatment Outcome

2021

Other Studies

19 other study(ies) available for substance p and Chronic Pain

ArticleYear
Ultra-Low Frequency Transcutaneous Electrical Nerve Stimulation on Pain Modulation in a Rat Model with Myogenous Temporomandibular Dysfunction.
    International journal of molecular sciences, 2021, Sep-14, Volume: 22, Issue:18

    Topics: Animals; Chronic Pain; Disease Models, Animal; Electromyography; Electrophysiological Phenomena; Masticatory Muscles; Motor Endplate; Myofascial Pain Syndromes; Parabrachial Nucleus; Proto-Oncogene Proteins c-fos; Rats; Receptors, Opioid, mu; Substance P; Temporomandibular Joint Disorders; Transcutaneous Electric Nerve Stimulation

2021
Effect of NSAIDs Supplementation on the PACAP-, SP- and GAL-Immunoreactive Neurons in the Porcine Jejunum.
    International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Enteric Nervous System; Female; Galanin; Jejunum; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Substance P; Swine

2021
New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators.
    International journal of molecular sciences, 2019, Dec-30, Volume: 21, Issue:1

    Topics: Animals; Botulinum Toxins; Cell Survival; Chronic Pain; Cytokines; Macrophages; Mice; Neuropeptides; Peptide Hydrolases; Protein Engineering; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Sensory Receptor Cells; Substance P; Vesicle-Associated Membrane Protein 1; Vesicle-Associated Membrane Protein 3

2019
Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors.
    Behavioural brain research, 2020, 08-05, Volume: 391

    Topics: Animals; Chronic Pain; Corpus Striatum; Hyperalgesia; Male; Neuralgia; Nociception; Pain Measurement; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Neurokinin-1; Sciatic Nerve; Sciatic Neuropathy; Substance P

2020
Increased substance P-like immunoreactivities in parabrachial and amygdaloid nuclei in a rat model with masticatory myofascial pain.
    Experimental brain research, 2020, Volume: 238, Issue:12

    Topics: Amygdala; Animals; Chronic Pain; Myofascial Pain Syndromes; Nociception; Rats; Substance P

2020
The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain.
    European journal of pharmacology, 2021, Feb-05, Volume: 892

    Topics: Amides; Analgesics; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice, Inbred ICR; Neuralgia; Pain Threshold; Peptide Fragments; Receptors, Opioid, mu; Substance P

2021
Effect of band and knife castration of beef calves on welfare indicators of pain at three relevant industry ages: II. Chronic pain.
    Journal of animal science, 2017, Volume: 95, Issue:10

    Topics: Animal Welfare; Animals; Behavior, Animal; Body Weight; Cattle; Chronic Pain; Hair; Haptoglobins; Hydrocortisone; Male; Orchiectomy; Pain Measurement; Random Allocation; Saliva; Stress, Physiological; Substance P

2017
Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.
    Pain, 2018, Volume: 159, Issue:8

    Topics: Animals; Calcitonin Gene-Related Peptide; Chronic Pain; Hyperalgesia; Male; Mice; Mice, Transgenic; Neurons, Afferent; Pain Measurement; Receptors, Opioid, mu; Substance P

2018
Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.
    Pain medicine (Malden, Mass.), 2019, 10-01, Volume: 20, Issue:10

    Topics: Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Fibromyalgia; Laser Therapy; Low-Level Light Therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Musculoskeletal Pain; Protein Precursors; Signal Transduction; Substance P; Tachykinins; TRPV Cation Channels

2019
Possible inflammatory pain biomarkers in postamputation pain.
    Scandinavian journal of pain, 2019, 07-26, Volume: 19, Issue:3

    Topics: Adult; Aged; Amputees; Biomarkers; Calcitonin Gene-Related Peptide; Chronic Pain; Humans; Hyperalgesia; Middle Aged; Pain Measurement; Phantom Limb; Substance P

2019
Chemokine profile of disc degeneration with acute or chronic pain.
    Journal of neurosurgery. Spine, 2013, Volume: 18, Issue:5

    Topics: Acute Pain; Adolescent; Adult; Chemokines; Chronic Pain; Female; Humans; Interleukin-1alpha; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Male; Matrix Metalloproteinase 3; Middle Aged; Substance P; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Young Adult

2013
Do low levels of beta-endorphin in the cerebrospinal fluid indicate defective top-down inhibition in patients with chronic neuropathic pain? A cross-sectional, comparative study.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:1

    Topics: Adult; Analgesics; beta-Endorphin; Biomarkers; Chronic Pain; Clinical Trials as Topic; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Neuralgia; Pain, Intractable; Pain, Postoperative; Substance P

2014
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2014
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
    Molecular pain, 2014, May-21, Volume: 10

    Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels

2014
Antinociceptive effects of endomorphin-2: suppression of substance P release in the inflammatory pain model rat.
    Neurochemistry international, 2015, Volume: 82

    Topics: Animals; Arthritis, Experimental; Chronic Pain; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociception; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Presynaptic; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Mechanical; Substance P; Tryptophan

2015
Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Arthritis, Rheumatoid; Chronic Pain; Connective Tissue; Female; Humans; Inflammation; Male; Middle Aged; Osteoarthritis; Substance P; Synovial Fluid; Synovial Membrane

2015
Nanoemulsion Thermoreversible Pluronic F127-Based Hydrogel Containing Hyptis pectinata (Lamiaceae) Leaf Essential Oil Produced a Lasting Anti-hyperalgesic Effect in Chronic Noninflammatory Widespread Pain in Mice.
    Molecular neurobiology, 2018, Volume: 55, Issue:2

    Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Hydrogel, Polyethylene Glycol Dimethacrylate; Lamiaceae; Male; Mice; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Extracts; Proto-Oncogene Proteins c-fos; Spinal Cord; Substance P

2018
An antinociceptive role for substance P in acid-induced chronic muscle pain.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Jan-10, Volume: 109, Issue:2

    Topics: Acid Sensing Ion Channels; Action Potentials; Analgesics; Animals; Chronic Pain; Electrophysiology; Ganglia, Spinal; Gene Deletion; Mice; Mice, Inbred C57BL; Musculoskeletal Pain; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Patch-Clamp Techniques; Protein Precursors; Receptors, Neurokinin-1; Sodium Channels; Substance P; Tachykinins

2012
Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.
    Journal of neuroinflammation, 2012, Jul-23, Volume: 9

    Topics: Acute Pain; Animals; Chronic Pain; Gene Expression Regulation; Inflammation Mediators; Keratinocytes; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Substance P

2012