imipramine has been researched along with Chronic Pain in 4 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this randomized, double blinded, placebo controlled cross-over study, patients with chronic low back pain are randomly assigned to imipramine, oxycodone or clobazam versus active placebo." | 5.20 | Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain. ( Arendt-Nielsen, L; Curatolo, M; Juni, P; Schliessbach, J; Siegenthaler, A; Vuilleumier, PH; Zeilhofer, HU, 2015) |
| "The involvement of serotonin (5-HT) in chronic pain mechanisms is established." | 1.39 | Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. ( Ferjan, I; Lipnik-Štangelj, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schliessbach, J | 2 |
| Siegenthaler, A | 2 |
| Bütikofer, L | 1 |
| Limacher, A | 1 |
| Juni, P | 2 |
| Vuilleumier, PH | 2 |
| Stamer, U | 1 |
| Arendt-Nielsen, L | 2 |
| Curatolo, M | 2 |
| Ferjan, I | 1 |
| Lipnik-Štangelj, M | 1 |
| Yasuda, S | 1 |
| Yoshida, M | 1 |
| Yamagata, H | 1 |
| Iwanaga, Y | 1 |
| Suenaga, H | 1 |
| Ishikawa, K | 1 |
| Nakano, M | 1 |
| Okuyama, S | 1 |
| Furukawa, Y | 1 |
| Furukawa, S | 1 |
| Ishikawa, T | 1 |
| Zeilhofer, HU | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain[NCT01179828] | Phase 3 | 150 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for imipramine and Chronic Pain
| Article | Year |
|---|---|
Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial.
Topics: Adult; Chronic Pain; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Imipramine; Low Back Pain; M | 2018 |
Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain.
Topics: Adolescent; Adult; Aged; Analgesics; Benzodiazepines; Chronic Pain; Clinical Protocols; Clobazam; Cr | 2015 |
2 other studies available for imipramine and Chronic Pain
| Article | Year |
|---|---|
Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biological Transport; Cells, Cultured; Chr | 2013 |
Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic | 2014 |