melatonin has been researched along with Chronic Pain in 7 studies
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Melatonin (MT) has a good analgesic effect in many diseases, including fibromyalgia, neuropathic pain, chronic headache, and burn pain, with very low acute toxicity and side effects." | 8.12 | Melatonin Abates TMJOA Chronic Pain by MT ( Feng, Y; Hu, S; Jiang, H; Ke, J; Li, H; Liu, W; Liu, X; Long, X, 2022) |
| "Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance." | 6.94 | Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol. ( Adam, R; Columb, M; Galley, H; Kanakarajan, S; Onyeakazi, U, 2020) |
| "In this study, chronic pain was induced by spared nerve injury model (SNI) for 4 weeks." | 5.48 | Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. ( Li, C; Liu, M; Ma, H; Mu, N; Shi, Z; Wang, Y; Yang, J; Yang, Z; Yin, Y; Yu, L, 2018) |
| " Melatonin (MT) has a good analgesic effect in many diseases, including fibromyalgia, neuropathic pain, chronic headache, and burn pain, with very low acute toxicity and side effects." | 4.12 | Melatonin Abates TMJOA Chronic Pain by MT ( Feng, Y; Hu, S; Jiang, H; Ke, J; Li, H; Liu, W; Liu, X; Long, X, 2022) |
| "Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance." | 2.94 | Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol. ( Adam, R; Columb, M; Galley, H; Kanakarajan, S; Onyeakazi, U, 2020) |
| "Chronic orofacial pain can greatly improve following treatment of the underlying insomnia, and therefore, re-evaluation of COFP is advised after 1 month of treatment." | 2.55 | An update of management of insomnia in patients with chronic orofacial pain. ( Almoznino, G; Benoliel, R; Haviv, Y; Sharav, Y, 2017) |
| "Melatonin (MLT) has been implicated in several pathophysiological states, including pain." | 1.72 | Acute and Chronic Pain Preclinical Models to Study the Analgesic Properties of Melatonergic Compounds. ( Comai, S; De Gregorio, D, 2022) |
| "In this study, chronic pain was induced by spared nerve injury model (SNI) for 4 weeks." | 1.48 | Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. ( Li, C; Liu, M; Ma, H; Mu, N; Shi, Z; Wang, Y; Yang, J; Yang, Z; Yin, Y; Yu, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| De Gregorio, D | 1 |
| Comai, S | 1 |
| Adam, R | 1 |
| Kanakarajan, S | 1 |
| Onyeakazi, U | 1 |
| Columb, M | 1 |
| Galley, H | 1 |
| Liu, W | 1 |
| Jiang, H | 1 |
| Liu, X | 1 |
| Hu, S | 1 |
| Li, H | 1 |
| Feng, Y | 1 |
| Ke, J | 1 |
| Long, X | 1 |
| Yang, Z | 1 |
| Li, C | 1 |
| Wang, Y | 1 |
| Yang, J | 1 |
| Yin, Y | 1 |
| Liu, M | 1 |
| Shi, Z | 1 |
| Mu, N | 1 |
| Yu, L | 1 |
| Ma, H | 1 |
| Haack, M | 1 |
| Simpson, N | 1 |
| Sethna, N | 1 |
| Kaur, S | 1 |
| Mullington, J | 1 |
| Learman, LA | 1 |
| Almoznino, G | 1 |
| Haviv, Y | 1 |
| Sharav, Y | 1 |
| Benoliel, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for melatonin and Chronic Pain
| Article | Year |
|---|---|
Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Humans; Hypothalamo-Hypophyseal System; Melatonin; Pain M | 2020 |
What is new in chronic pelvic pain?: best articles from the past year.
Topics: Antioxidants; Chronic Pain; Endometriosis; Female; Humans; Melatonin; Musculoskeletal Diseases; Pelv | 2014 |
An update of management of insomnia in patients with chronic orofacial pain.
Topics: Amines; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Chronic Pain; Cognitive Behavioral | 2017 |
1 trial available for melatonin and Chronic Pain
| Article | Year |
|---|---|
Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Central Nervous System Depressants | 2020 |
3 other studies available for melatonin and Chronic Pain
| Article | Year |
|---|---|
Acute and Chronic Pain Preclinical Models to Study the Analgesic Properties of Melatonergic Compounds.
Topics: Acetamides; Analgesics; Animals; Chronic Pain; Melatonin; Neuralgia | 2022 |
Melatonin Abates TMJOA Chronic Pain by MT
Topics: Animals; Chronic Pain; Humans; Melatonin; Neurons; Osteoarthritis; Rats; Rats, Sprague-Dawley; Temef | 2022 |
Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Pain; Immunohistochemistry; Mal | 2018 |