tyrosyl-1-2-3-4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine and Chronic-Pain

We aimed to perform a systematic review and meta-analysis comparing postoperative outcomes in inguinal hernia repair with TIPP versus Lichtenstein technique.. Cochrane Central, Scopus, and PubMed were systematically searched for studies comparing TIPP and Lichtenstein´s technique for inguinal hernia repair. Outcomes assessed were operative time, bleeding, surgical site events, hospital stay, the Visual Analogue Pain Score, chronic pain, paresthesia rates, and recurrence. Statistical analysis was performed using RevMan 5.4.1. Heterogeneity was assessed with I. 790 studies were screened and 44 were thoroughly reviewed. A total of nine studies, comprising 8428 patients were included, of whom 4185 (49.7%) received TIPP and 4243 (50.3%) received Lichtenstein. We found that TIPP presented less chronic pain (OR 0.43; 95% CI 0.20-0.93 P = 0.03; I. TIPP may be a valuable technique for inguinal hernias. It was associated with lower chronic pain, and paresthesia when compared to Lichtenstein technique. Further long-term randomized studies are necessary to confirm our findings. Study registration A review protocol for this meta-analysis was registered at PROSPERO (CRD42023434909).

Topics: Chronic Pain; Hernia, Inguinal; Herniorrhaphy; Humans; Pain, Postoperative; Paresthesia; Recurrence; Surgical Mesh; Treatment Outcome

Topics: Chronic Pain; Endoscopy; Hernia, Inguinal; Herniorrhaphy; Humans; Laparoscopy; Pain, Postoperative; Surgical Mesh; Treatment Outcome

Topics: Chronic Pain; Double-Blind Method; Hernia, Inguinal; Herniorrhaphy; Humans; Oligopeptides; Pain, Postoperative; Prospective Studies; Surgical Mesh; Tetrahydroisoquinolines