formaldehyde has been researched along with Chronic Pain in 26 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 5.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Acute pain was determined using the hot plate test (thermal nociception) and the formalin test (inflammatory pain)." | 5.40 | The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. ( Andersen, ML; Carlini, EL; Gama, VS; Molska, GR; Paula-Freire, LI, 2014) |
| "Ipsilateral, but not contralateral, pre-treatment (in μg/paw) with sumatriptan (10-300), methysergide (1-30) or dihydroergotamine (1-30) significantly prevented flinching behavior (at 1h) as well as secondary allodynia and hyperalgesia (at day 6) induced by formalin." | 3.79 | Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats. ( Argüelles, CF; Godínez-Chaparro, B; Granados-Soto, V; López-Santillán, FJ; Villalón, CM, 2013) |
| "Chronic pain is a common disease that severely disrupts the quality of life." | 1.91 | Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice. ( Cao, W; Cheng, Y; Liu, M; Qin, X; Tong, J; Wu, X, 2023) |
| "Heat and mechanical hyperalgesia were evaluated by radiant heat and von Frey filament tests, respectively." | 1.91 | Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin. ( Guo, J; Song, Y; Tang, J; Tang, Z; Yang, Y; Yu, G; Zhu, C, 2023) |
| "Chronic pain is recognized as an important problem in communities." | 1.62 | Formalin-induced inflammatory pain increases excitability in locus coeruleus neurons. ( Azizi, H; Farahani, F; Janahmadi, M; Semnanian, S; Seutin, V, 2021) |
| "The poncirin (30 mg/kg) treatment considerably inhibited the mechanical hyperalgesia and allodynia as well as thermal hyperalgesia and cold allodynia." | 1.51 | Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice. ( Afridi, R; Khalid, S; Khan, AU; Khan, S; Kim, YS; Rasheed, H; Shal, B; Shehzad, O; Ullah, MZ, 2019) |
| "Furthermore, long-lasting bilateral hyperalgesia could be reversed by pharmacological inhibition of over-expressed spinal PKCγ; however, pretreating with intrathecal KIG31-1 showed no antinociceptive effects on short-term spontaneous pain behaviors." | 1.48 | Contribution of Spinal PKCγ Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice. ( Chen, DS; Chen, GZ; Ding, T; Guo, XJ; Liang, JC; Tang, K; Wang, Y; Wu, HH; Yin, JB; Zhao, YQ, 2018) |
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 1.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Insufficient sleep and chronic pain are public health epidemics." | 1.43 | Sleep Deprivation and Recovery Sleep Prior to a Noxious Inflammatory Insult Influence Characteristics and Duration of Pain. ( Vanini, G, 2016) |
| "In vivo, IT LPS evoked tactile allodynia to a greater degree in male than female mice." | 1.43 | Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. ( Beaton, G; Chigbrow, M; Corr, M; Eddinger, KA; Isseroff, RR; Ravula, SB; Soulika, AM; Tucci, FC; Woller, SA; Yaksh, TL, 2016) |
| "Acute pain was determined using the hot plate test (thermal nociception) and the formalin test (inflammatory pain)." | 1.40 | The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. ( Andersen, ML; Carlini, EL; Gama, VS; Molska, GR; Paula-Freire, LI, 2014) |
| "Finally, despite chronic pain perception in control and unstable male subjects was larger than females; the decrease of chronic pain perception in male stressed animals (poverty and inequality experienced subjects) was much more than stressed females." | 1.38 | The effect of social stress on chronic pain perception in female and male mice. ( Aghajani, M; Ghazanfari, T; Khalili Najafabadi, M; Vaez Mahdavi, MR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (73.08) | 24.3611 |
| 2020's | 7 (26.92) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, M | 3 |
| Cao, W | 3 |
| Qin, X | 3 |
| Tong, J | 3 |
| Wu, X | 3 |
| Cheng, Y | 3 |
| Pepino, L | 1 |
| Malapert, P | 1 |
| Saurin, AJ | 1 |
| Moqrich, A | 1 |
| Reynders, A | 1 |
| Zhu, C | 1 |
| Yang, Y | 1 |
| Song, Y | 1 |
| Guo, J | 1 |
| Yu, G | 1 |
| Tang, J | 1 |
| Tang, Z | 1 |
| Afridi, R | 1 |
| Khan, AU | 1 |
| Khalid, S | 1 |
| Shal, B | 1 |
| Rasheed, H | 1 |
| Ullah, MZ | 1 |
| Shehzad, O | 1 |
| Kim, YS | 1 |
| Khan, S | 1 |
| Lee, JY | 1 |
| Lee, GJ | 1 |
| Lee, PR | 1 |
| Won, CH | 1 |
| Kim, D | 1 |
| Kang, Y | 1 |
| Oh, SB | 1 |
| Jiang, ZJ | 1 |
| Li, QY | 1 |
| Zhang, YY | 1 |
| Zeng, MX | 1 |
| Hu, H | 1 |
| Zhang, FM | 1 |
| Bi, LB | 1 |
| Gu, JH | 1 |
| Liu, XJ | 1 |
| Nakamura, Y | 1 |
| Okano, Y | 1 |
| Sato, M | 1 |
| Kobayashi, M | 1 |
| Yamaguchi, T | 1 |
| Sumi, T | 1 |
| Koyama, Y | 1 |
| Kondo, M | 1 |
| Usui, N | 1 |
| Shimada, S | 1 |
| Farahani, F | 1 |
| Azizi, H | 1 |
| Janahmadi, M | 1 |
| Seutin, V | 1 |
| Semnanian, S | 1 |
| Takahara-Yamauchi, R | 1 |
| Ikemoto, H | 1 |
| Okumo, T | 1 |
| Sakhri, FZ | 1 |
| Horikawa, H | 1 |
| Nakamura, A | 1 |
| Sakaue, S | 1 |
| Kato, M | 1 |
| Adachi, N | 1 |
| Sunagawa, M | 1 |
| Sikandar, S | 1 |
| Minett, MS | 1 |
| Millet, Q | 1 |
| Santana-Varela, S | 1 |
| Lau, J | 1 |
| Wood, JN | 1 |
| Zhao, J | 1 |
| Zhao, YQ | 1 |
| Yin, JB | 1 |
| Wu, HH | 1 |
| Ding, T | 1 |
| Wang, Y | 1 |
| Liang, JC | 1 |
| Guo, XJ | 1 |
| Tang, K | 1 |
| Chen, DS | 1 |
| Chen, GZ | 1 |
| Kataoka, K | 1 |
| Hara, K | 1 |
| Haranishi, Y | 1 |
| Terada, T | 1 |
| Sata, T | 1 |
| Godínez-Chaparro, B | 1 |
| López-Santillán, FJ | 1 |
| Argüelles, CF | 1 |
| Villalón, CM | 1 |
| Granados-Soto, V | 1 |
| Paula-Freire, LI | 1 |
| Andersen, ML | 1 |
| Gama, VS | 1 |
| Molska, GR | 1 |
| Carlini, EL | 1 |
| Demeule, M | 1 |
| Beaudet, N | 2 |
| Régina, A | 1 |
| Besserer-Offroy, É | 1 |
| Murza, A | 1 |
| Tétreault, P | 2 |
| Belleville, K | 2 |
| Ché, C | 1 |
| Larocque, A | 1 |
| Thiot, C | 1 |
| Béliveau, R | 1 |
| Longpré, JM | 2 |
| Marsault, É | 1 |
| Leduc, R | 1 |
| Lachowicz, JE | 1 |
| Gonias, SL | 1 |
| Castaigne, JP | 1 |
| Sarret, P | 2 |
| Nishijima, CM | 1 |
| Ganev, EG | 1 |
| Mazzardo-Martins, L | 2 |
| Martins, DF | 2 |
| Rocha, LR | 1 |
| Santos, AR | 2 |
| Hiruma-Lima, CA | 1 |
| Obniska, J | 1 |
| Sałat, K | 1 |
| Librowski, T | 1 |
| Kamiński, K | 1 |
| Lipkowska, A | 1 |
| Wiklik, B | 1 |
| Rybka, S | 1 |
| Rapacz, A | 1 |
| Vanini, G | 1 |
| Parent, AJ | 1 |
| Roux, M | 1 |
| Goffaux, P | 1 |
| Silva, M | 1 |
| Martins, D | 1 |
| Charrua, A | 1 |
| Piscitelli, F | 1 |
| Tavares, I | 1 |
| Morgado, C | 1 |
| Di Marzo, V | 1 |
| Woller, SA | 1 |
| Ravula, SB | 1 |
| Tucci, FC | 1 |
| Beaton, G | 1 |
| Corr, M | 1 |
| Isseroff, RR | 1 |
| Soulika, AM | 1 |
| Chigbrow, M | 1 |
| Eddinger, KA | 1 |
| Yaksh, TL | 1 |
| Kang, DW | 1 |
| Moon, JY | 1 |
| Choi, JG | 1 |
| Kang, SY | 1 |
| Ryu, Y | 1 |
| Park, JB | 1 |
| Lee, JH | 1 |
| Kim, HW | 1 |
| Hashemzaei, M | 1 |
| Abdollahzadeh, M | 1 |
| Iranshahi, M | 1 |
| Golmakani, E | 1 |
| Rezaee, R | 1 |
| Tabrizian, K | 1 |
| Huh, Y | 1 |
| Bhatt, R | 1 |
| Jung, D | 1 |
| Shin, HS | 1 |
| Cho, J | 1 |
| Nucci, C | 1 |
| Stramosk, J | 1 |
| Brethanha, LC | 1 |
| Pizzolatti, MG | 1 |
| Aghajani, M | 1 |
| Vaez Mahdavi, MR | 1 |
| Khalili Najafabadi, M | 1 |
| Ghazanfari, T | 1 |
26 other studies available for formaldehyde and Chronic Pain
| Article | Year |
|---|---|
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice.
Topics: Animals; Chronic Pain; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Hypersensitivity; Inflammation | 2023 |
Formalin-evoked pain triggers sex-specific behavior and spinal immune response.
Topics: Animals; Chronic Pain; Female; Formaldehyde; Humans; Male; Mice; Oncogenes; Pain Perception; Spinal | 2023 |
Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chronic Pain; Formaldehyde; Ga | 2023 |
Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Pain; Disease Mo | 2019 |
The analgesic effect of refeeding on acute and chronic inflammatory pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Eating; Food Deprivat | 2019 |
Deletion of MyD88 adaptor in nociceptor alleviates low-dose formalin-induced acute pain and persistent pain in mice.
Topics: Acute Pain; Animals; Chronic Pain; Formaldehyde; Mice; Mice, Knockout; Myeloid Differentiation Facto | 2021 |
Pain-like behavior in mice can be induced by the environmental context in which the pain stimulus was previously given.
Topics: Animals; Association Learning; Behavior, Animal; Chronic Pain; Conditioning, Classical; Disease Mode | 2021 |
Formalin-induced inflammatory pain increases excitability in locus coeruleus neurons.
Topics: Action Potentials; Animals; Chronic Pain; Formaldehyde; Inflammation; Locus Coeruleus; Male; Neurons | 2021 |
Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Chronic Pain; Disease Mo | 2021 |
Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carrageenan; Chronic Pain; Disease Models, Animal; Femal | 2018 |
Contribution of Spinal PKCγ Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice.
Topics: Animals; Behavior, Animal; China; Chronic Pain; Formaldehyde; Hyperalgesia; Male; Mice; Pain Measure | 2018 |
The antinociceptive effect of SNAP5114, a gamma-aminobutyric acid transporter-3 inhibitor, in rat experimental pain models.
Topics: Acute Pain; Analgesics; Animals; Anisoles; Behavior, Animal; Chronic Pain; Constriction, Pathologic; | 2013 |
Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
Topics: Acute Pain; Animals; Biphenyl Compounds; Chronic Pain; Dihydroergotamine; Disease Models, Animal; Dr | 2013 |
The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice.
Topics: Acute Pain; Administration, Oral; Analgesics; Animals; Cannabis; Chronic Pain; Formaldehyde; Hot Tem | 2014 |
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.
Topics: Analgesics; Animals; Blood-Brain Barrier; Bone Neoplasms; Capillary Permeability; Cell Line; Cell Li | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Aci | 2014 |
Antinociceptive properties of N-Mannich bases derived from 3-substituted pyrrolidine-2,5-dione in the formalin model of persistent pain in mice.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Pain; Foot; Formaldehyde; Injections; Male; Mannich B | 2015 |
Sleep Deprivation and Recovery Sleep Prior to a Noxious Inflammatory Insult Influence Characteristics and Duration of Pain.
Topics: Animals; Chronic Pain; Formaldehyde; Hyperalgesia; Inflammation; Male; Pain Measurement; Rats; Rats, | 2016 |
Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain.
Topics: Animals; Chromatography, Liquid; Chronic Pain; Disease Models, Animal; Formaldehyde; Hyperalgesia; M | 2016 |
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.
Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pa | 2016 |
Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.
Topics: Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Disinfectants; Female; Formaldehyde | 2016 |
Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor.
Topics: Analgesics; Animals; Berberine Alkaloids; Chronic Pain; Ethylenediamines; Formaldehyde; Gene Express | 2016 |
Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice.
Topics: Acute Disease; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Drug Therapy, Combination; | 2017 |
Interactive responses of a thalamic neuron to formalin induced lasting pain in behaving mice.
Topics: Animals; Behavior, Animal; Cell Communication; Chronic Pain; Electrophysiological Phenomena; Formald | 2012 |
Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Chronic Pain; Cold Temperature; Complex R | 2012 |
The effect of social stress on chronic pain perception in female and male mice.
Topics: Animals; Body Weight; Chronic Pain; Cytokines; Female; Food Deprivation; Formaldehyde; Inflammation | 2012 |