palmidrol has been researched along with Chronic Pain in 22 studies
palmidrol: a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection
palmitoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic pain is a major source of morbidity for which there are limited effective treatments." | 3.01 | Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. ( Bornemann-Cimenti, H; Brenna, CTA; Klivinyi, C; Lang-Illievich, K; Lasser, C; Szilagyi, IS, 2023) |
| " PEA (600 mg) was administered twice daily for 3 weeks followed by single daily dosing for 4 weeks, in addition to standard analgesic therapies or as single therapy." | 2.77 | Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogenesis. ( Di Paolo, A; Gatti, A; Gianfelice, V; Lazzari, M; Sabato, AF; Sabato, E, 2012) |
| "The population will be patients who have chronic pain, the intervention will be the administration of PEA alone or in combination with other drugs for the pain management; the comparison will be the standard therapy in accordance with the current guidelines for the treatment of pain." | 2.61 | Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review. ( Alfieri, A; Aurilio, C; Barbarisi, M; Fiore, M; Pace, MC; Passavanti, MB; Piccinno, G; Pota, V; Sansone, P, 2019) |
| "The terms chronic pain, neuropathic pain, and micronized and ultra-micronized PEA were used for the search." | 2.53 | Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis. ( Cenacchi, T; Fusco, M; Paladini, A; Piroli, A; Schievano, C; Varrassi, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (81.82) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Indraccolo, U | 1 |
| Favilli, A | 1 |
| Dell'Anna, A | 1 |
| Di Francesco, A | 1 |
| Dionisi, B | 1 |
| Giugliano, E | 2 |
| Murina, F | 1 |
| Stocco, E | 1 |
| Lang-Illievich, K | 1 |
| Klivinyi, C | 1 |
| Lasser, C | 1 |
| Brenna, CTA | 1 |
| Szilagyi, IS | 1 |
| Bornemann-Cimenti, H | 1 |
| Cervigni, M | 1 |
| Nasta, L | 1 |
| Schievano, C | 2 |
| Lampropoulou, N | 1 |
| Ostardo, E | 1 |
| Kiso, T | 1 |
| Watabiki, T | 1 |
| Sekizawa, T | 1 |
| Mabou Tagne, A | 1 |
| Fotio, Y | 1 |
| Lin, L | 1 |
| Squire, E | 1 |
| Ahmed, F | 1 |
| Rashid, TI | 1 |
| Karimian Azari, E | 1 |
| Piomelli, D | 1 |
| Giammusso, B | 1 |
| Di Mauro, R | 1 |
| Bernardini, R | 1 |
| Stensson, N | 2 |
| Ghafouri, B | 4 |
| Gerdle, B | 4 |
| Ghafouri, N | 4 |
| Artukoglu, BB | 1 |
| Beyer, C | 1 |
| Zuloff-Shani, A | 1 |
| Brener, E | 1 |
| Bloch, MH | 1 |
| Germini, F | 2 |
| Coerezza, A | 2 |
| Andreinetti, L | 2 |
| Nobili, A | 2 |
| Rossi, PD | 2 |
| Mari, D | 2 |
| Guyatt, G | 1 |
| Marcucci, M | 2 |
| Passavanti, MB | 1 |
| Alfieri, A | 1 |
| Pace, MC | 1 |
| Pota, V | 1 |
| Sansone, P | 1 |
| Piccinno, G | 1 |
| Barbarisi, M | 1 |
| Aurilio, C | 1 |
| Fiore, M | 1 |
| De Leo, V | 1 |
| Cagnacci, A | 1 |
| Cappelli, V | 1 |
| Biasioli, A | 1 |
| Leonardi, D | 1 |
| Seracchioli, R | 1 |
| Cagnazzo, E | 1 |
| Soave, I | 2 |
| Lo Monte, G | 2 |
| Wenger, JM | 1 |
| Marci, R | 2 |
| Larsson, B | 3 |
| Fowler, CJ | 3 |
| Turkina, MV | 2 |
| Karlsson, L | 2 |
| Di Cesare Mannelli, L | 1 |
| Corti, F | 1 |
| Micheli, L | 1 |
| Zanardelli, M | 1 |
| Ghelardini, C | 1 |
| Caruso, S | 1 |
| Iraci Sareri, M | 1 |
| Casella, E | 1 |
| Ventura, B | 1 |
| Fava, V | 1 |
| Cianci, A | 1 |
| Paladini, A | 1 |
| Fusco, M | 1 |
| Cenacchi, T | 1 |
| Piroli, A | 1 |
| Varrassi, G | 1 |
| Silva, M | 1 |
| Martins, D | 1 |
| Charrua, A | 1 |
| Piscitelli, F | 1 |
| Tavares, I | 1 |
| Morgado, C | 1 |
| Di Marzo, V | 1 |
| Bellintani, L | 1 |
| Gatti, A | 1 |
| Lazzari, M | 1 |
| Gianfelice, V | 1 |
| Di Paolo, A | 1 |
| Sabato, E | 1 |
| Sabato, AF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Postoperative Pain and Inflammation Following Below Knee Fracture Fixation: A Pilot Study.[NCT05317676] | Phase 2 | 0 participants (Actual) | Interventional | 2023-05-31 | Withdrawn (stopped due to Sponsor suspending temporarily.) | ||
| N-of-1 Randomised Trials to Assess the Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain[NCT02699281] | Phase 4 | 11 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| The Effects (Pain, Function, Biochemistry and Psychological Factors) of Two Different Home-exercise Programmes on Women Suffering Long Term Nack/Shoulder Muscle Pain[NCT01876680] | Phase 2 | 57 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| The Effect of Palmitylethanolamide on Central and Peripheral Sensitization After Heat-induced Hyperalgesia[NCT04662827] | 14 participants (Actual) | Interventional | 2020-02-09 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for palmidrol and Chronic Pain
| Article | Year |
|---|---|
Looking for Responders among Women with Chronic Pelvic Pain Treated with a Comicronized Formulation of Micronized Palmitoylethanolamide and Polydatin.
Topics: Amides; Chronic Pain; Dysmenorrhea; Endometriosis; Ethanolamines; Female; Glucosides; Humans; Palmit | 2022 |
Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.
Topics: Amides; Analgesics; Chronic Pain; Humans; Quality of Life; Randomized Controlled Trials as Topic | 2023 |
Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis.
Topics: Acute Pain; Amides; Analgesics; Chronic Pain; Ethanolamines; Humans; Outcome Assessment, Health Care | 2017 |
Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review.
Topics: Amides; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Ethanolamines; Humans; Pain Managemen | 2019 |
Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis.
Topics: Adult; Amides; Analgesics; Chemistry, Pharmaceutical; Chronic Pain; Clinical Trials as Topic; Ethano | 2016 |
7 trials available for palmidrol and Chronic Pain
| Article | Year |
|---|---|
The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trial.
Topics: Adult; Amides; Chronic Disease; Chronic Pain; Ethanolamines; Humans; Male; Middle Aged; Palmitic Aci | 2017 |
N-of-1 Randomized Trials of Ultra-Micronized Palmitoylethanolamide in Older Patients with Chronic Pain.
Topics: Aged; Aged, 80 and over; Amides; Analgesics; Chronic Pain; Ethanolamines; Female; Geriatric Assessme | 2017 |
[Administration of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: preliminary results].
Topics: Adult; Amides; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Drug Combinations; Dysmenorrhe | 2013 |
Effects of two different specific neck exercise interventions on palmitoylethanolamide and stearoylethanolamide concentrations in the interstitium of the trapezius muscle in women with chronic neck shoulder pain.
Topics: Adult; Amides; Chronic Pain; Ethanolamines; Exercise Therapy; Female; Humans; Mass Spectrometry; Mic | 2014 |
Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and α-lipoic acid.
Topics: Adolescent; Adult; Amides; Chronic Pain; Drug Therapy, Combination; Endometriosis; Ethanolamines; Fe | 2015 |
Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials.
Topics: Aged; Amides; Analgesics; Bayes Theorem; Chronic Pain; Clinical Protocols; Cross-Over Studies; Ethan | 2016 |
Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogenesis.
Topics: Adult; Aged; Aged, 80 and over; Amides; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Endoc | 2012 |
10 other studies available for palmidrol and Chronic Pain
| Article | Year |
|---|---|
Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis/Bladder Pain Syndrome.
Topics: Administration, Oral; Adult; Aged; Amides; Chronic Pain; Cystitis, Interstitial; Ethanolamines; Fema | 2019 |
ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.
Topics: Amides; Amidohydrolases; Analgesics; Animals; Behavior, Animal; Brain; Chronic Pain; Disease Models, | 2020 |
Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.
Topics: Acute Pain; Amides; Analgesics; Animals; Cannabis; Chronic Pain; Disease Models, Animal; Drug Synerg | 2021 |
Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain - a case control study.
Topics: Adult; Aged; Amides; Anti-Inflammatory Agents; Chronic Pain; Cytokines; Endocannabinoids; Ethanolami | 2017 |
Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis.
Topics: Adult; Amides; Analgesics; Chronic Pain; Dietary Supplements; Endometriosis; Ethanolamines; Female; | 2019 |
The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain.
Topics: Adult; Amides; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Contraceptives, Oral, Combined | 2013 |
Palmitoylethanolamide and stearoylethanolamide levels in the interstitium of the trapezius muscle of women with chronic widespread pain and chronic neck-shoulder pain correlate with pain intensity and sensitivity.
Topics: Adult; Aged; Amides; Chronic Pain; Endocannabinoids; Ethanolamines; Exercise; Female; Humans; Microd | 2013 |
Delay of morphine tolerance by palmitoylethanolamide.
Topics: Amides; Analgesics; Animals; Astrocytes; Chronic Pain; Drug Resistance; Ethanolamines; Male; Morphin | 2015 |
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.
Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pa | 2016 |
High levels of N-palmitoylethanolamide and N-stearoylethanolamide in microdialysate samples from myalgic trapezius muscle in women.
Topics: Adult; Amides; Chromatography, Liquid; Chronic Pain; Dialysis Solutions; Endocannabinoids; Ethanolam | 2011 |