isoflurane has been researched along with Chronic Pain in 3 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Chronic Pain: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we used a mouse chronic pain model to test the hypothesis that early exposure to the general anesthetic (GA) Isoflurane causes cellular and molecular alterations in dorsal spinal cord (DSC) and dorsal root ganglion (DRG) that produces a predisposition to neuropathic pain via an upregulation of the mammalian target of the rapamycin (mTOR) signaling pathway." | 8.31 | Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway. ( Dong, X; Guan, Y; Li, F; Li, Q; Mathena, RP; Mintz, CD, 2023) |
| " Here, we used a mouse chronic pain model to test the hypothesis that early exposure to the general anesthetic (GA) Isoflurane causes cellular and molecular alterations in dorsal spinal cord (DSC) and dorsal root ganglion (DRG) that produces a predisposition to neuropathic pain via an upregulation of the mammalian target of the rapamycin (mTOR) signaling pathway." | 4.31 | Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway. ( Dong, X; Guan, Y; Li, F; Li, Q; Mathena, RP; Mintz, CD, 2023) |
| "Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive." | 1.39 | Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. ( Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Q | 2 |
| Mathena, RP | 2 |
| Li, F | 1 |
| Dong, X | 1 |
| Guan, Y | 1 |
| Mintz, CD | 2 |
| Eregha, ON | 1 |
| Corder, G | 1 |
| Doolen, S | 1 |
| Donahue, RR | 1 |
| Winter, MK | 1 |
| Jutras, BL | 1 |
| He, Y | 1 |
| Hu, X | 1 |
| Wieskopf, JS | 1 |
| Mogil, JS | 1 |
| Storm, DR | 1 |
| Wang, ZJ | 1 |
| McCarson, KE | 1 |
| Taylor, BK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury. A Randomized, Placebo-controlled, Double-blind Crossover Study[NCT02684669] | Phase 2 | 80 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperal-gesia in Patients Following Recovery From Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, Double-blind Crossover Study.[NCT02976337] | Phase 2 | 14 participants (Anticipated) | Interventional | 2017-10-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for isoflurane and Chronic Pain
| Article | Year |
|---|---|
Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway.
Topics: Anesthetics, General; Animals; Chronic Pain; Disease Models, Animal; Isoflurane; Mammals; Mice; Neur | 2023 |
Effects of Early Exposure of Isoflurane on Chronic Pain via the Mammalian Target of Rapamycin Signal Pathway.
Topics: Animals; Biomarkers; Cerebral Cortex; Chronic Pain; Immunohistochemistry; Isoflurane; Mice; Neurons; | 2019 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |