Conditions > Fibrous Dysplasia of Bone
Page last updated: 2024-09-27

Fibrous Dysplasia of Bone

A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).

Synonyms(1)

Synonym
Fibrous Dysplasia of Bone

Research Excerpts

Overview

ExcerptReference
"Fibrous dysplasia of bone is a disease that can involve one or several bones and is characterized by bone deformities, pain and iterative fractures."( Chapurlat, RD; Meunier, PJ, 2000)
"Fibrous dysplasia of bone is a congenital non hereditary benign bone disease, where normal bone is replaced by a fibrous-like tissue with immature osteogenesis."( Chapurlat, R; Orcel, P, 2007)
"Fibrous dysplasia of bone is a genetic, non-inheritable disease, characterized by bone pain, bone deformities and fracture, involving one or several bones."( Chapurlat, RD; Orcel, P, 2008)
"Fibrous dysplasia of bone is characterized by focal replacement of normal bone and marrow with abnormal bone and fibrous tissue."( Antignac, C; Bacchetta, J; Bouvier, R; Chapurlat, R; Cochat, P; Delmas, PD; Dubourg, L; Kohler, R, 2008)

Research

Studies (428)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990236 (55.14)23.3326
1990's59 (13.79)12.5806
2000's62 (14.49)18.1394
2010's60 (14.02)28.8240
2020's11 (2.57)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low10
citric acid, anhydrous0low10
dimethyl sulfoxide0low10
hydrogen carbonate0low10
iodine0low10
melatonin0low10
albendazole0low10
alendronate0medium71
aspirin0low20
azathioprine0low10
celecoxib0low10
pentetic acid0low10
etidronate0low10
gabexate0low10
iohexol0low10
iopromide0low10
nicardipine0low10
oxyphenbutazone0low10
pamidronate0medium173
phenylbutazone0low10
potassium iodide0low10
sodium fluoride0low10
suramin0low10
prednisolone0low10
reserpine0low10
hydroxyproline0medium161
thyroxine0low10
spironolactone0low10
prednisone0low40
estrone0medium51
dehydroepiandrosterone0low10
chloramphenicol0low10
lysine0low20
levodopa0low10
edetic acid0low20
leucine0low10
androstenedione0low10
methionine0low10
histidine0low10
medroxyprogesterone acetate0low10
mestranol0low10
arginine0low40
methylprednisolone0low10
2,3,5-triiodobenzoic acid0low10
triethanolamine0low10
glycidyl methacrylate0low10
quinazolines0low10
betamethasone0low10
cyproterone acetate0low20
limestone0low20
reticulin0low10
medroxyprogesterone0low20
testolactone0low30
durapatite0low30
megestrol0low10
technetium0low170
titanium0low70
gadolinium0low70
calcium phosphate, dibasic, anhydrous0low10
calcium phosphate, monobasic, anhydrous0low10
tricalcium phosphate0medium41
calcium sulfate0low10
fluorine0low40
trolamine salicylate0low40
fluorides0low10
bromocriptine0low20
alovudine0low10
tramadol0low10
gallium citrate0low10
zidovudine0low10
amikacin0low10
propiconazole0low690
buserelin0low10
ibandronic acid0low10
tiludronic acid0low10
methionine methyl ester0low10
fluorodeoxyglucose f180low100
zoledronic acid0low30
foxes0low10
calcium phosphate, dibasic, dihydrate0low10
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate0low10
glucosylgalactosylhydroxylysine0low10
imatinib mesylate0low10
technetium tc 99m hydroxymethylene diphosphonate0low10
galactosylhydroxylysine0low10
methotrexate0low10
beta-lactams0low10
proline0low30
ertapenem0low10
cinacalcet0low10
calcium pyrophosphate0low10
organophosphonates0low30
cortisone0low20
inositol 3-phosphate0low10
retinol0low20
clindamycin0low10
keratan sulfate0low10
bromochloroacetic acid0low50
thiouracil0low10
thiourea0low10
tamoxifen0medium21
hydroxylysine0low10
rtki cpd0low10
ovalbumin0low10
sodium dodecyl sulfate0low10
17-ketosteroids0low30
osteoprotegerin0low10
calcitriol0medium51
vitamin d 20low20
cholecalciferol0low50
phenylephrine hydrochloride0low100
cyproterone0low20
lead0low30
aluminum0low60
strontium0low10
gallium0low10
cysteine0low10
phosphorus0medium201
strontium radioisotopes0low10
cefotaxime0low10
oxalates0low20
maxacalcitol0medium11
gadolinium dtpa0low20
amoxicillin-potassium clavulanate combination0low10
technetium tc 99m diphosphonate0low10
technetium tc 99m exametazime0low10
lhrh, ala(6)-gly(10)-ethylamide-0low10
dihydrotachysterol0low30
acid phosphatase0low60
jaw0low220
calcitonin0low10
technetium tc 99m sestamibi0low20
sodium pertechnetate tc 99m0low10
intrinsic factor0low10
trelstar0low30
epidermal growth factor0low10
clay0low10
transforming growth factor beta0low20
cyclin d10low10
gallium ga 68 dotatate0low10
technetium tc 99m medronate0medium191
chondroitin sulfates0low10
dacarbazine0low10
eye0low50
technetium tc 99m bicisate0low10

Protein Targets (968)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein410041
estrogen-related nuclear receptor alpha380038
estrogen nuclear receptor alpha490049
peroxisome proliferator activated receptor gamma290029
vitamin D (1,25- dihydroxyvitamin D3) receptor270027
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a260026
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a120012
thyroid hormone receptor beta isoform 2270027
nuclear factor erythroid 2-related factor 2 isoform 1340034
Chain A, Beta-lactamase110011
Luciferase9009
glp-1 receptor, partial9009
hypoxia-inducible factor 1 alpha subunit110011
RAR-related orphan receptor gamma300030
ATAD5 protein, partial140014
Fumarate hydratase7007
TDP1 protein360036
GLI family zinc finger 3350035
caspase 7, apoptosis-related cysteine protease7007
nuclear receptor subfamily 1, group I, member 3260026
progesterone receptor240024
glucocorticoid receptor [Homo sapiens]320032
retinoic acid nuclear receptor alpha variant 1340034
retinoid X nuclear receptor alpha270027
farnesoid X nuclear receptor230023
pregnane X nuclear receptor350035
polyprotein7007
67.9K protein7007
caspase-37007
IDH1150015
euchromatic histone-lysine N-methyltransferase 2280028
aryl hydrocarbon receptor160016
v-jun sarcoma virus 17 oncogene homolog (avian)150015
nuclear receptor subfamily 1, group I, member 28008
Histone H2A.x100010
cellular tumor antigen p53 isoform a6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
chromobox protein homolog 1180018
nuclear factor erythroid 2-related factor 2 isoform 2110011
transcriptional regulator ERG isoform 34004
histone deacetylase 9 isoform 33003
heat shock protein beta-1120012
mitogen-activated protein kinase 18008
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin330033
Vif0001
peripheral myelin protein 22180018
survival motor neuron protein isoform d9009
muscleblind-like protein 1 isoform 17007
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
lamin isoform A-delta10240024
neuropeptide S receptor isoform A5005
ATP-binding cassette sub-family C member 3023023
Multidrug resistance-associated protein 4023024
Voltage-dependent calcium channel gamma-2 subunit170017
Bile salt export pump026026
Interferon beta210021
Cellular tumor antigen p53270027
Integrin beta-33104
Integrin alpha-IIb3104
Methionine aminopeptidase0101
Glutamate receptor 2170017
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 15005
Canalicular multispecific organic anion transporter 1023023
ATPase family AAA domain-containing protein 5140014
Ataxin-2140014
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0708
Farnesyl pyrophosphate synthase010010
Acetylcholinesterase0303
Hypoxanthine-guanine phosphoribosyltransferase0202
Farnesyl pyrophosphate synthase 0606
Farnesyl pyrophosphate synthase 0303
cytochrome P450 family 3 subfamily A polypeptide 4200020
Thymidylate kinase0202
Reverse transcriptase/RNaseH 0329
histone acetyltransferase KAT2A isoform 1100010
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase140014
Chain A, HADH2 protein110011
Chain B, HADH2 protein110011
interleukin 8110011
acetylcholinesterase9009
SMAD family member 2160016
SMAD family member 3160016
Smad36006
aldehyde dehydrogenase 1 family, member A1180018
estrogen receptor 2 (ER beta)170017
regulator of G-protein signaling 48008
nonstructural protein 18008
peroxisome proliferator-activated receptor delta220022
Caspase-75005
Bloom syndrome protein isoform 1110011
peripheral myelin protein 22 isoform 17007
potassium voltage-gated channel subfamily H member 2 isoform d8008
caspase-35005
importin subunit beta-1 isoform 15005
nuclear factor NF-kappa-B p105 subunit isoform 12002
snurportin-15005
GTP-binding nuclear protein Ran isoform 13003
DNA polymerase iota isoform a (long)170017
nuclear receptor ROR-gamma isoform 1110011
Sex hormone-binding globulin0055
Beta-glucuronidase0202
Cholinesterase0202
Corticosteroid-binding globulin0505
Aromatase0507
Androgen receptor020021
Gastrin/cholecystokinin type B receptor0001
Testosterone 17-beta-dehydrogenase 30101
Alpha-synuclein3407
Nuclear receptor ROR-gamma130013
TAR DNA-binding protein 438008
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase150015
phosphopantetheinyl transferase130013
NFKB1 protein, partial2002
GLS protein9009
thyroid stimulating hormone receptor100010
alpha-galactosidase3003
cytochrome P450 2C19 precursor2002
flap endonuclease 18008
muscarinic acetylcholine receptor M18008
lethal factor (plasmid)8008
Cytochrome P450 3A408011
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE130013
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase9009
GTP-binding protein (rab7)0022
ras protein, partial0022
hypothetical protein, conserved2002
EWS/FLI fusion protein120012
cytochrome P450 2D6110011
glucocerebrosidase4004
Rac1 protein0022
cell division cycle 42 (GTP binding protein, 25kDa), partial0022
DNA polymerase kappa isoform 17007
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60304
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor0505
Carbonic anhydrase 109012
Carbonic anhydrase 209113
Fatty acid-binding protein, liver0202
Myeloperoxidase0202
Prostaglandin G/H synthase 10303
Seed linoleate 13S-lipoxygenase-10202
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10405
Adenosine receptor A10406
Adenosine receptor A2a0305
Substance-P receptor0101
Prostaglandin G/H synthase 20618
Urotensin-2 receptor0202
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0022
Gamma-aminobutyric acid receptor subunit alpha-1142016
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0303
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain6006
Microtubule-associated protein tau110011
thioredoxin glutathione reductase5005
G170017
P531001
arylsulfatase A5005
thyroid stimulating hormone receptor150015
activating transcription factor 6110011
hemoglobin subunit beta2002
cytochrome P450 3A4 isoform 1140014
M-phase phosphoprotein 8100010
Gamma-aminobutyric acid receptor subunit pi140014
Bile salt export pump0202
HLA class I histocompatibility antigen, B alpha chain 170017
Gamma-aminobutyric acid receptor subunit beta-1140014
Gamma-aminobutyric acid receptor subunit delta140014
Gamma-aminobutyric acid receptor subunit gamma-2140014
Gamma-aminobutyric acid receptor subunit alpha-5140014
Gamma-aminobutyric acid receptor subunit alpha-3140014
Gamma-aminobutyric acid receptor subunit gamma-1140014
Gamma-aminobutyric acid receptor subunit alpha-2140014
Gamma-aminobutyric acid receptor subunit alpha-4140014
Gamma-aminobutyric acid receptor subunit gamma-3140014
Gamma-aminobutyric acid receptor subunit alpha-6140014
Gamma-aminobutyric acid receptor subunit beta-3140014
Gamma-aminobutyric acid receptor subunit beta-2140014
GABA theta subunit140014
Inositol hexakisphosphate kinase 1170017
Gamma-aminobutyric acid receptor subunit epsilon140014
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial170017
pregnane X receptor100010
thyroid hormone receptor beta isoform a100010
galanin receptor type 30101
Glucocorticoid receptor018427
Glycine receptor subunit alpha-1018018
Glycine receptor subunit beta018018
Glycine receptor subunit alpha-2018018
Glycine receptor subunit alpha-3018018
ORF730022
Genome polyprotein 0112
dopamine D1 receptor4004
D(1A) dopamine receptor5005
vitamin D3 receptor isoform VDRA140014
serine/threonine-protein kinase mTOR isoform 15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 18008
5-hydroxytryptamine receptor 40404
ATP-dependent translocase ABCB10505
ATP-dependent translocase ABCB109110
Beta-1 adrenergic receptor0404
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0404
D(2) dopamine receptor0415
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0707
Alpha-2B adrenergic receptor0101
ATP-dependent translocase ABCB10505
D(1A) dopamine receptor0606
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0516
5-hydroxytryptamine receptor 2C0415
5-hydroxytryptamine receptor 1B0505
D(4) dopamine receptor0101
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0606
5-hydroxytryptamine receptor 60404
D(2) dopamine receptor0213
Chain A, Vitamin D Nuclear Receptor0011
Vitamin D3 receptor0011
USP1 protein, partial170017
PPM1D protein5005
Vitamin D-binding protein0011
Cytochrome P450 1A20102
Androgen receptor09312
Cytochrome P450 2D60303
Vitamin D3 receptor02410
Cytochrome P450 2C9 0708
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0033
Cytochrome P450 2C190303
Kappa-type opioid receptor0012
Vitamin D3 receptor0022
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0001
Beta-lactamase 0002
Metallo-beta-lactamase0001
Beta-lactamase 0101
Albumin0033
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase0001
Solute carrier family 15 member 10202
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130102
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Solute carrier family 22 member 60103
Solute carrier family 22 member 70102
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0002
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80204
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0002
Solute carrier family 22 member 110103
Solute carrier family 22 member 80101
Beta-lactamase VIM-1 0102
Solute carrier family 22 member 70102
Chain A, Carbonic anhydrase II0101
Chain A, Cruzipain6006
Carbonic anhydrase 0001
Carbonic anhydrase 0202
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
thyrotropin-releasing hormone receptor2002
interferon gamma precursor0002
prostaglandin E2 receptor EP2 subtype0001
Prostaglandin E synthase0101
Histone deacetylase 30101
3-phosphoinositide-dependent protein kinase 10101
Carbonic anhydrase 120204
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20101
Carbonic anhydrase 30103
Procathepsin L0112
Aldo-keto reductase family 1 member B10606
Neuronal acetylcholine receptor subunit alpha-41203
Polyunsaturated fatty acid 5-lipoxygenase0202
Quinolone resistance protein NorA0304
Adenosine receptor A30505
Neuronal acetylcholine receptor subunit beta-21203
Beta-3 adrenergic receptor0404
Alpha-1B adrenergic receptor0404
Calpain-2 catalytic subunit0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 40406
Carbonic anhydrase 60103
Sodium-dependent noradrenaline transporter 0606
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10101
Sodium-dependent serotonin transporter0808
Sodium-dependent serotonin transporter0112
Delta-type opioid receptor0101
Delta-type opioid receptor0202
Mu-type opioid receptor0415
Bifunctional epoxide hydrolase 20202
Carbonic anhydrase 5A, mitochondrial0204
Prostaglandin G/H synthase 2 0202
Carbonic anhydrase0406
Alpha-1A adrenergic receptor0505
Carbonic anhydrase 70103
Carbonic anhydrase0103
Histone deacetylase 40101
Carbonic anhydrase 0101
Mu-type opioid receptor0213
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0404
Prostaglandin G/H synthase 20101
Histone deacetylase 10101
Mitogen-activated protein kinase 140101
Carbonic anhydrase 90406
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0202
Carbonic anhydrase 0103
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130102
Cyclooxygenase-2 0202
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
Histone deacetylase 20101
Carbonic anhydrase 40203
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Carbonic anhydrase 150305
Histone deacetylase 80101
P2Y purinoceptor 120112
Histone deacetylase 60101
Histone deacetylase 90101
Carbonic anhydrase 140204
Histone deacetylase 50101
Carbonic anhydrase 5B, mitochondrial0103
streptokinase A precursor0033
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
50S ribosomal protein L36 20213
Methionine--tRNA ligase, mitochondrial0011
15-lipoxygenase, partial6006
60 kDa chaperonin0303
60 kDa heat shock protein, mitochondrial0303
Glycine receptor subunit alpha-10022
10 kDa heat shock protein, mitochondrial0303
Thiosulfate sulfurtransferase0303
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10203
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
PINK13003
Parkin5005
huntingtin isoform 21001
Extracellular calcium-sensing receptor0011
Angiotensin-converting enzyme 2 0112
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, JmjC domain-containing histone demethylation protein 3A7007
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Beta-lactamase0101
Proto-oncogene tyrosine-protein kinase Src0101
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0001
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
endonuclease IV4004
atrial natriuretic peptide receptor 1 precursor3003
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10404
parathyroid hormone/parathyroid hormone-related peptide receptor precursor8008
Progesterone receptor08211
Adenosine receptor A2b0101
Mu-type opioid receptor0729
Spike glycoprotein140115
Matrix metalloproteinase-90303
Isocitrate lyase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Protein cereblon0202
Eyes absent homolog 20202
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Amyloid-beta precursor protein0202
Angiotensin-converting enzyme 0202
Histamine H2 receptor6006
Beta-lactamase 0101
Beta-lactamase 0101
Motilin receptor0011
acid sphingomyelinase3003
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK14004
Motilin receptor0112
Rap guanine nucleotide exchange factor 34004
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20303
Cytochrome P450 1B10303
Lanosterol 14-alpha demethylase0101
GALC protein4004
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
Estrogen receptor011417
Steryl-sulfatase0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Solute carrier organic anion transporter family member 1A10101
Estrogen receptor beta07412
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20304
apical membrane antigen 1, AMA14004
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
cytochrome P450 2D6 isoform 13003
Membrane primary amine oxidase 0101
Coagulation factor X0101
Plasminogen0202
Coagulation factor XII0101
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Serine protease hepsin0101
Multidrug and toxin extrusion protein 20101
Chain A, HISTIDINE-BINDING PROTEIN0011
Plasma kallikrein0002
Histidine-binding periplasmic protein0011
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0103
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Large neutral amino acids transporter small subunit 10404
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0002
Glutamate receptor ionotropic, NMDA 3B0002
Carbonic anhydrase 130002
Glutamate receptor ionotropic, NMDA 3A0002
Glutamine synthetase0101
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Proton-coupled amino acid transporter 10304
Amino acid transporter0202
DNA repair protein RAD52 homolog isoform a0001
Tyrosine-protein kinase ABL10123
Cytochrome P450 2C80001
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0011
Platelet-derived growth factor receptor alpha0112
Cytochrome P450 3A50001
Chymotrypsinogen A0202
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Phospholipase A-2-activating protein0101
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
pyruvate kinase1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
DNA polymerase eta isoform 14004
Polyphenol oxidase 20001
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0202
Tyrosinase0101
SLC16A10 protein0001
Monocarboxylate transporter 100001
phosphoglycerate kinase1001
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Mineralocorticoid receptor 0517
Androgen receptor0011
Histamine H2 receptor0404
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G3003
Aldo-keto reductase family 1 member C10101
ClpP2002
ras-related protein Rab-9A4004
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Cytochrome P450 2C11 0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Cannabinoid receptor 10202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta2002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor2002
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0202
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-72002
Solute carrier organic anion transporter family member 1A30003
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
bromodomain adjacent to zinc finger domain 2B3003
Nuclear receptor subfamily 1 group I member 20033
Nuclear receptor subfamily 1 group I member 20011
NPC intracellular cholesterol transporter 1 precursor2002
atrial natriuretic peptide receptor 2 precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Equilibrative nucleoside transporter 10101
B2 bradykinin receptor0101
Beta-lactamase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Adenosine receptor A30101
Malate dehydrogenase, cytoplasmic0101
D(1A) dopamine receptor2002
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Transient receptor potential cation channel subfamily A member 10011
Nrf21001
Microphthalmia-associated transcription factor0001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
caspase recruitment domain family, member 150101
glucose-6-phosphate 1-dehydrogenase isoform b0101
receptor-interacting serine/threonine-protein kinase 2 isoform 10101
Beta lactamase (plasmid)0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Estrogen receptor 10101
cytochrome P450 2C9 precursor1001
fMet-Leu-Phe receptor0101
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr2002
5-hydroxytryptamine receptor 2A0011
luciferase0001
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Glutamate 5-kinase0001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
heat shock protein 90, putative0001
Thrombopoietin1001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
DNA topoisomerase 10101
Chromaffin granule amine transporter0101
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
Butyrophilin subfamily 3 member A10023
4-hydroxy-3-methylbut-2-enyl diphosphate reductase0101
Farnesyl diphosphate synthase0101
H0202
Phosphotransferase 0101
Farnesyl diphosphate synthase0101
Peroxisome proliferator-activated receptor alpha1001
Carbonic anhydrase 0101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
ATP-dependent 6-phosphofructokinase0101
Ectonucleoside triphosphate diphosphohydrolase 20101
Serine/threonine-protein kinase D30202
Protein kinase C gamma type0202
Protein kinase C beta type0303
Cathepsin B0101
Protein kinase C alpha type0202
Tyrosine-protein phosphatase non-receptor type 10101
Protein kinase C eta type0202
Delta-type opioid receptor0314
Kappa-type opioid receptor0314
P2Y purinoceptor 20112
Protein kinase C iota type0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 20112
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2Y purinoceptor 40011
NAD-dependent protein deacetylase HST20101
P2X purinoceptor 30011
DNA-dependent protein kinase catalytic subunit0101
Ectonucleoside triphosphate diphosphohydrolase 10101
DNA primase0101
Protein kinase C epsilon type0303
Protein kinase C theta type0202
Protein kinase C zeta type0202
Protein kinase C delta type0202
P2Y purinoceptor 60101
Serine/threonine-protein kinase D10202
Dual specificity protein phosphatase 50101
Ectonucleoside triphosphate diphosphohydrolase 80101
RmtA0101
Ectonucleoside triphosphate diphosphohydrolase 3 0101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-10101
P2Y purinoceptor 110112
P2X purinoceptor 70011
Protein arginine N-methyltransferase 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
ubiquitin-conjugating enzyme E2 N0101
Transmembrane protease serine 20011
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C alpha type0101
Estrogen receptor0012
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Substance-P receptor0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Melanocortin receptor 30202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Taste receptor type 2 member 380012
isocitrate dehydrogenase 1, partial1001
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease0203
Urease subunit alpha0101
Urease subunit alpha0101
Urease subunit beta0101
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
72 kDa type IV collagenase0202
Neutrophil collagenase0202
Matrix metalloproteinase-140202
eyes absent homolog 2 isoform a1001
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
DNA polymerase beta0101
UDP-glucuronosyltransferase 2B70001
Thymidine kinase, cytosolic 0001
Thymidine kinase 0102
Protease 0112
Thymidine kinase0102
Farnesyl diphosphate synthase0101
Geranylgeranyl pyrophosphate synthase0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]