Compounds > 7-methoxyrosmanol
Page last updated: 2024-11-13

7-methoxyrosmanol

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Description

7-methoxyrosmanol: from Salvia dorrii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
SalviagenusA genus in the mint family (LAMIACEAE).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID23243692
CHEMBL ID464376
MeSH IDM0498845

Synonyms (14)

Synonym
7-o-methylrosmanol
CHEMBL464376
7-methylrosmanol, >=95% (lc/ms-elsd)
7-methoxyrosmanol
HY-111896
CS-0093546
MS-25705
(4br,8as,9s,10s)-3,4-dihydroxy-2-isopropyl-10-methoxy-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5h-9,4b-(epoxymethano)phenanthren-12-one
(1r,8s,9s,10s)-3,4-dihydroxy-8-methoxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
XM170487
7-methylrosmanol - rosmarinus officinalis (rosemary)
DTXSID801316214
PD158807
AKOS040760247
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (41)

Assay IDTitleYearJournalArticle
AID471603Cytotoxicity against human Hep2 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471600Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471356Antibacterial activity against Bacillus cereus ATCC 21772 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471354Antibacterial activity against Staphylococcus epidermidis ATCC 14990 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756073Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID335102Inhibition of bovine spleen cathepsin D up to 10 ug/ml1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID1756061Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471602Cytotoxicity against human Hep2 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756062Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID335105Inhibition of pig pepsin up to 10 ug/ml1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID471355Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471353Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471599Antibacterial activity against Salmonella CECT 4569 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756084Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 80 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756066Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756063Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471607Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471596Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756074Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID471605Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471358Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471359Antibacterial activity against Mycobacterium smegmatis ATCC 19420 after 48 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471601Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471598Antibacterial activity against Pseudomonas aeruginosa AK958 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756083Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 40 ug/ml measured after 48 hrs by MTT assay relative to control
AID471604Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471609Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756080Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756068Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756075Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756067Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756072Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 80 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471608Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID335101Inhibition of HIV1 recombinant protease expressed in Escherichia coli BL21 (DE3) cells by SDS-PAGE1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID1058388Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1756078Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID471597Antibacterial activity against Proteus mirabilis CECT 170 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471357Antibacterial activity against Candida albicans CECT 170 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756079Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756071Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 40 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471606Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.76 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salvin
salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae)		1.9810abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid		angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite
sugiol
sugiol: diterpene with anti-inflammatory activity from Calocedrus formosana bark; structure in first source. sugiol : An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group.		2.0810abietane diterpenoid;
carbotricyclic compound;
cyclic terpene ketone;
meroterpenoid;
phenols		antineoplastic agent;
antioxidant;
antiviral agent;
plant metabolite;
radical scavenger
carnosol
carnosol: isolated from Lepechinia hastata		2.4120diterpenoid
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		2.0810abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
royleanone
royleanone: from root of Salvia officinalis; structure given in first source		2.0810
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.		2.0510aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
6,7-dehydroroyleanone
6,7-dehydroroyleanone: diterpene abietane quinone isolated from Salvia moorcraftiana or Lepechinia bullata (both Lamiaceae); Rn given from CA Index Guide; RN not in Chemline 12/84; structure given in first source		2.0810
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.05101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
1-oxomiltirone
1-oxomiltirone: from roots of the Iranian medicinal plant Perovskia abrotanoides; structure in first source		2.0810
11-hydroxysugiol
11-hydroxysugiol : An abietane diterpenoid that is sugiol in which the hydrogen ortho to the phenolic hydroxy group has been replaced by a hydroxy group.		2.0810abietane diterpenoid;
carbotricyclic compound;
catechols;
cyclic terpene ketone;
meroterpenoid		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
levomepromazine maleate
6-hydroxysalvinolone: from Salvia chorassanica; structure in first source		2.0810
rosmanol
rosmanol: structure in first source		2.4120
ConditionIndicatedRelationship StrengthStudiesTrials