cefotaxime and Nephritis--Interstitial

Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.

Topics: Acute Disease; Acute Kidney Injury; Anti-Bacterial Agents; Azithromycin; Bacteremia; Cefotaxime; Creatinine; Escherichia coli; Escherichia coli Infections; Female; Humans; Kidney; Methylprednisolone; Middle Aged; Nephritis, Interstitial; Pyelonephritis; Renal Dialysis; Shock, Septic

Acute interstitial nephritis accounts for about 10 % of the cases of acute renal failure. An adverse drug reaction caused by an immunoallergic mechanism is suggested when fever, skin rash, eosinophilia, and eosinophiluria are associated. The outcome is favorable after withdrawal of drug therapy in most cases. We report a case of acute interstitial nephritis induced by immunoallergic drug mechanisms, in a 3-week-old infant who presented with acute renal failure associated with eosinophilia and hepatitis and who had received cefotaxime and gentamicin. The patient's progression was favorable with normalization of renal and liver function 1 week after suspension of antibiotic drugs.

Topics: Acute Disease; Anti-Bacterial Agents; Cefotaxime; Eosinophilia; Gentamicins; Hepatitis; Humans; Infant, Newborn; Male; Nephritis, Interstitial

Topics: Acute Disease; Adult; Cefotaxime; Cephalosporins; Cystitis; Female; Humans; Kidney; Nephritis, Interstitial; Pregnancy; Pregnancy Complications; Recurrence; Risk Factors

Topics: Acute Disease; Adult; Cefotaxime; Cephalosporins; Humans; Kidney; Male; Nephritis, Interstitial; Renal Dialysis

Topics: Acute Disease; Cefazolin; Cefotaxime; Female; Humans; Male; Middle Aged; Nephritis, Interstitial