Compounds > l 640876
Page last updated: 2024-12-07

l 640876

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

L 640876: semisynthetic antibiotic; structure given in first source; RN given refers to (6R-trans)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132445
CHEMBL ID143129
MeSH IDM0125502

Synonyms (10)

Synonym
7-(1-benzylpyridinium-4-yl)amino-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)ceph-3-em-4-carboxylate
pyridinium, 4-((2-carboxy-3-(((1-methyl-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-7-yl)amino)-1-(phenylmethyl)-, inner salt, (6r-trans)-
l-640,876
l-640876
l 640876
CHEMBL143129
77527-71-0
(6r,7r)-7-[(1-benzylpyridin-1-ium-4-yl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6r,7r)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
AKOS040745978
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID163409Minimum inhibitory concentration against aerobic organism Proteus vulgaris strain 28291982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID162937Minimum inhibitory concentration against aerobic organism Pseudomonas aeruginosa strain 28351982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID162882Minimum inhibitory concentration against aerobic organism Proteus mirabilis strain 28301982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID203156Minimum inhibitory concentration against aerobic organism Serratia marcescens strain 28521982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID207394Minimum inhibitory concentration against aerobic organism Staphylococcus aureus strain 28651982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID125411Minimum inhibitory concentration against aerobic organism Morganella morganii strain 28331982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID203038Minimum inhibitory concentration against aerobic organism Shigella species strain 28801982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID67856Minimum inhibitory concentration against aerobic organism Enterobacter aerogenes strain 28281982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID209245Minimum inhibitory concentration against aerobic organism Streptococcus faecalis strain 28641982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID93879Minimum inhibitory concentration against aerobic organism Klebsiella pneumoniae strain 28821982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID69322MIC against aerobic organism Escherichia coli strain 28911982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID68516Minimum inhibitory concentration against aerobic organism Enterobacter cloacae strain 26461982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID209756Minimum inhibitory concentration against aerobic organism Streptococcus pyogenes strain 31241982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID93880Minimum inhibitory concentration against aerobic organism Klebsiella pneumoniae strain 40051982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID200341Minimum inhibitory concentration against aerobic organism Salmonella strain 38601982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID207836Minimum inhibitory concentration against aerobic organism Staphylococcus aureus strain 28681982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID200525Minimum inhibitory concentration against aerobic organism Salmonella schottmuelleri strain 28371982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
AID67857Minimum inhibitory concentration against aerobic organism Enterobacter aerogenes strain 29061982Journal of medicinal chemistry, Apr, Volume: 25, Issue:4
Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cephaloridine
Cephaloridine: A cephalosporin antibiotic.. cefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.		1.9610beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative		antibacterial drug
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		1.9610penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
cephalothin
Cephalothin: A cephalosporin antibiotic.. cefalotin : A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.		1.9610azabicycloalkene;
beta-lactam antibiotic allergen;
carboxylic acid;
cephalosporin;
semisynthetic derivative;
thiophenes		antibacterial drug;
antimicrobial agent
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		1.9610beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
penicillanic acid
Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.		1.9610penicillanic acids
amdinocillin
Amdinocillin: An amidinopenicillanic acid derivative with broad spectrum antibacterial action.. mecillinam : A penicillin in which the 6beta substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria.		2.6530penicillinantibacterial drug;
antiinfective agent
cephalosporin c
cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.		2.8840cephalosporinfungal metabolite
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		1.9610beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
cefoxitin
Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.		2.3620beta-lactam antibiotic allergen;
cephalosporin;
cephamycin;
semisynthetic derivative		antibacterial drug
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.36201,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Poisoning
[description not available]		01.9610
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		01.9610
Bovine Diseases
[description not available]		01.9610
E coli Infections
[description not available]		01.9610
Swine Diseases
Diseases of domestic swine and of the wild boar of the genus Sus.		01.9610
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.		01.9610
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		01.9610