cefotaxime and Subarachnoid-Hemorrhage

cefotaxime has been researched along with Subarachnoid-Hemorrhage* in 2 studies

Other Studies

2 other study(ies) available for cefotaxime and Subarachnoid-Hemorrhage

Article	Year
[A study on transference of cefmenoxime into the cerebrospinal fluid]. The Japanese journal of antibiotics, 1985, Volume: 38, Issue:1 Two grams of cefmenoxime (CMX) was administered by one-shot intravenous injection to the patients in normal pressure hydrocephalus without meningitis, and the transference of CMX into the cerebrospinal fluid (CSF) from blood was investigated. After the injection of CMX, CSF and serum were serially taken, and the concentrations of CMX were measured by agar-well method using E. coli. The conclusions drawn from this study are summarized as follows: The concentrations of CMX in CSF were more slowly decreased than those in serum. The mean ratio of transference of CMX into CSF from the serum was 1.4%. After the intravenous injection of 2 g CMX, the mean maximum concentration of CMX in CSF was 0.36 microgram/ml, which exceeded 80% MIC (minimal inhibitory concentration) against several Gram-positive cocci and Gram-negative rods, and higher concentrations than the 80% MIC were kept over 4 hours in CSF. The efficacy of CMX may be kept by its injections less than 4 times a day. Topics: Aged; Cefmenoxime; Cefotaxime; Female; Humans; Hydrocephalus, Normal Pressure; Injections, Intravenous; Male; Middle Aged; Subarachnoid Hemorrhage; Time Factors	1985
[Penetration of cefotaxime into human cerebrospinal fluid]. The Japanese journal of antibiotics, 1985, Volume: 38, Issue:6 The penetration of cefotaxime (CTX) into the cerebrospinal fluid (CSF) was monitored to evaluate the prophylactic efficacy of the drug against post-craniotomy infections. Doses ranged from 1 to 2 g were administered to patients with subarachnoid hemorrhage due to the rupture of cerebral aneurysm, traumatic cerebral contusion, or subdural edema accompanied by intracerebral hemorrhage, by intravenous drip infusion over a period of 30 or 60 minutes. CTX readily entered the CSF with concentrations exceeding MICs against the major pathogens occurring after craniotomy. CTX proved to be effective in the prevention of post-craniotomy infections in noninflammatory situations, especially after surgery in the case of cerebral traumas or subarachnoid hemorrhage. Topics: Adult; Aged; Bacterial Infections; Brain Injuries; Cefotaxime; Craniotomy; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Complications; Subarachnoid Hemorrhage	1985

Article

Year

[A study on transference of cefmenoxime into the cerebrospinal fluid].

The Japanese journal of antibiotics, 1985, Volume: 38, Issue:1

Two grams of cefmenoxime (CMX) was administered by one-shot intravenous injection to the patients in normal pressure hydrocephalus without meningitis, and the transference of CMX into the cerebrospinal fluid (CSF) from blood was investigated. After the injection of CMX, CSF and serum were serially taken, and the concentrations of CMX were measured by agar-well method using E. coli. The conclusions drawn from this study are summarized as follows: The concentrations of CMX in CSF were more slowly decreased than those in serum. The mean ratio of transference of CMX into CSF from the serum was 1.4%. After the intravenous injection of 2 g CMX, the mean maximum concentration of CMX in CSF was 0.36 microgram/ml, which exceeded 80% MIC (minimal inhibitory concentration) against several Gram-positive cocci and Gram-negative rods, and higher concentrations than the 80% MIC were kept over 4 hours in CSF. The efficacy of CMX may be kept by its injections less than 4 times a day.

Topics: Aged; Cefmenoxime; Cefotaxime; Female; Humans; Hydrocephalus, Normal Pressure; Injections, Intravenous; Male; Middle Aged; Subarachnoid Hemorrhage; Time Factors

1985

[Penetration of cefotaxime into human cerebrospinal fluid].

The Japanese journal of antibiotics, 1985, Volume: 38, Issue:6

The penetration of cefotaxime (CTX) into the cerebrospinal fluid (CSF) was monitored to evaluate the prophylactic efficacy of the drug against post-craniotomy infections. Doses ranged from 1 to 2 g were administered to patients with subarachnoid hemorrhage due to the rupture of cerebral aneurysm, traumatic cerebral contusion, or subdural edema accompanied by intracerebral hemorrhage, by intravenous drip infusion over a period of 30 or 60 minutes. CTX readily entered the CSF with concentrations exceeding MICs against the major pathogens occurring after craniotomy. CTX proved to be effective in the prevention of post-craniotomy infections in noninflammatory situations, especially after surgery in the case of cerebral traumas or subarachnoid hemorrhage.

Topics: Adult; Aged; Bacterial Infections; Brain Injuries; Cefotaxime; Craniotomy; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Complications; Subarachnoid Hemorrhage

1985