cefotaxime and Renal-Insufficiency

Topics: Anti-Bacterial Agents; Cefotaxime; Ciprofloxacin; Humans; Ofloxacin; Peritonitis; Primary Prevention; Renal Insufficiency; Secondary Prevention

Pharmacokinetics of cefotaxime (50 mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0.75 mg/kg) was administered intravenously, once daily for five consecutive days to induce kidney damage. The pharmacokinetic variables were calculated in both cases. Kidney damage caused several changes in the determined variables. The C(max) and C(min) of cefotaxime observed at 0.50 and 5 h in normal goats were 24.91+/-1.51 and 1.22+/-0.07 micro g/ml, respectively, while the same in kidney damaged goats at 1 and 72 h were 75.00+/-0.45 and 3.10+/-0.09 micro g/ml, respectively. Renal damage condition significantly increased t1/2,ka (0.48+/-0.01 h), t1/2,ke (20.03+/-0.16 h), AUC (2440.10+/-24.26 micro g. h/ml) and significantly decreased Vdarea (0.59+/-0.007 L/kg), Vss (0.58+/-0.007 L/kg) and ClB (0.02+/-0.008 L/kg/h) values of cefotaxime compared to normal goats.

Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Cefotaxime; Female; Goat Diseases; Goats; Half-Life; Injections, Intramuscular; Renal Insufficiency; Uranyl Nitrate