cefotaxime and Epididymitis

Topics: Ampicillin; Anti-Bacterial Agents; Cefotaxime; Epididymitis; Escherichia coli Infections; Humans; Infant, Newborn; Male; Orchitis; Remission Induction; Scrotum; Suppuration

Topics: Adult; Amikacin; Anti-Bacterial Agents; Bacteremia; Cefotaxime; Drug Resistance, Microbial; Drug Therapy, Combination; Enterobacteriaceae; Enterobacteriaceae Infections; Epididymitis; Humans; Male; Microbial Sensitivity Tests; Opportunistic Infections; Orchitis; Paraplegia

Epididymitis, or epididymo-orchitis, and infected hydrocele are unusual in the neonatal period. It is critical to differentiate them rapidly from testicular torsion to salvage the affected testis and avoid unnecessary surgical exploration. Escherichia coli is an important gram-negative bacteria causing diverse neonatal infections and is also the common bacteria causing epididymo-orchitis from an ascending route. We report the case of a preterm infant affected with epididymo-orchitis and infected hydrocele caused by early-onset E. coli sepsis. We highlight the importance of sampling proper cultures and using suitable antibiotics after excluding testicular torsion in a neonate with an acute scrotum.

Topics: Acute Disease; Bacteremia; Cefotaxime; Diagnosis, Differential; Epididymitis; Escherichia coli Infections; Humans; Infant, Newborn; Infant, Premature; Male; Orchitis; Scrotum; Sepsis; Spermatic Cord Torsion; Testicular Hydrocele; Tomography, X-Ray Computed; Ultrasonography

The in vivo efficacy of ofloxacin was compared with those of cefotaxime and doxycycline in a rat model of epididymitis due to Escherichia coli. Treatment was started 24 h after infection and was continued for 7 days. Ofloxacin reduced the numbers of E. coli organisms in the epididymides significantly more than the other therapeutic regimens and cured the infection more frequently. Histopathological changes in the epididymides of ofloxacin-treated animals were significantly less severe than those observed in untreated animals. Doxycycline was less effective than ofloxacin but significantly reduced the titers of organisms in rat epididymides. In contrast, despite excellent in vitro activity, cefotaxime failed to reduce the magnitude of infection. The results of this study suggest that ofloxacin may be a very effective antimicrobial agent for the treatment of epididymitis due to E. coli.

Topics: Animals; Cefotaxime; Doxycycline; Epididymitis; Escherichia coli; Escherichia coli Infections; Male; Microbial Sensitivity Tests; Ofloxacin; Rats; Rats, Wistar

Seven patients (four men, three women) with gonococcal urethritis resistant to spectinomycin treatment were seen in May and June 1989 in the Department of Dermatology in Berlin (West), and strains of Neisseria gonorrhoeae (NG) resistant to spectinomycin were detected, cultured in vitro from these individuals. In five of the seven patients penicillin-resistant strains were found, including a penicillinase-producing strain in one case; the other two patients had penicillin-sensitive strains. In all cases the NG-populations detected were sensitive to cephalosporin and cipro(oxo)floxacin. In a 17-year-old young man with the PPNG strain severe gonococcal epididymitis developed after repeated infection that had been inadequately treated with spectinomycin. All seven patients mentioned sexual contact with individuals who lived in Southeast Asia or had their origins there; in at least four cases the contact persons came from Thailand. This is the first report on spectinomycin-resistant Neisseria gonorrhoeae infections (PPNG and non-PPNG) in the Federal Republic of Germany. The necessity for monitoring the results of penicillin and/or spectinomycin treatment of gonorrhoea are underlined for the dermatovenereologist, and some guidelines for therapy are given.

Topics: Adolescent; Adult; Cefotaxime; Ciprofloxacin; Epididymitis; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin Resistance; Spectinomycin; Urethritis

Two groups of rats were treated for epididymitis in an experimental study. The developing infection of E. coli was treated effectively by a single dose of cephalosporin in one group of rats. In the other group, where abscess formation had taken place, no effect of up to 9 days of treatment could be demonstrated, indicating the importance of early antibiotic treatment in bacterial epididymitis.

Topics: Abscess; Animals; Cefotaxime; Epididymitis; Escherichia coli Infections; Male; Rats; Time Factors

Topics: Bacteriuria; Cefotaxime; Epididymitis; Humans; Male; Postoperative Complications; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Sepsis; Urinary Tract Infections