Compounds > leuconolam
Page last updated: 2024-11-07

leuconolam

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

leuconolam: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14442600
CHEMBL ID73223
CHEBI ID141918
SCHEMBL ID20943634
MeSH IDM0172178

Synonyms (8)

Synonym
leuconolam
CHEMBL73223
CHEBI:141918
AKOS032961599
FS-9175
(12r,19s)-12-ethyl-19-hydroxy-8,16-diazatetracyclo[10.6.1.02,7.016,19]nonadeca-1(18),2,4,6-tetraene-9,17-dione
SCHEMBL20943634
(8ar,12as,14as)-8a-ethyl-7,8,8a,10,11,12a-hexahydro-12a-hydroxyindolizino[8,1-ef][1]benzazonine-6,13(5h,9h)-dione; (-)-leuconolam
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
monoterpenoid indole alkaloidA terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1329362Antibacterial activity against Enterococcus faecalis ATCC 10541 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1460817Antiparasitic activity against Leishmania donovani LV9 axenic intramacrophage amastigotes infected in mouse RAW264.7 cells incubated for 48 hrs by Sybr Green I dye based assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
AID1460815Antiparasitic activity against Leishmania donovani LV9 axenic intramacrophage amastigotes infected in mouse RAW264.7 cells assessed induction of parasite cell morphological alteration at 100 uM incubated for 72 hrs by microscopy2017Journal of natural products, 04-28, Volume: 80, Issue:4
Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
AID1329363Antibacterial activity against Escherichia coli ATCC 11775 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1460818Antiparasitic activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 24 hrs assay by liquid scintillation spectrometry2017Journal of natural products, 04-28, Volume: 80, Issue:4
Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
AID1460816Cytotoxic activity against human MRC5 cells incubated for 72 hrs by resazurin dye based spectrophotometry2017Journal of natural products, 04-28, Volume: 80, Issue:4
Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
AID1329364Antibacterial activity against Staphylococcus aureus ATCC 25922 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1329361Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1460819Antiparasitic activity against Leishmania donovani LV9 axenic amastigotes incubated for 72 hrs by resazurin dye based assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.
AID1329365Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.1510phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
chloroquine diphosphate
[no description available]		2.1510
griseofulvin
Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.		2.13101-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
raubasine
ajmalicine : A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure.		2.1310methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
rhazinicine
rhazinicine: structure in first source		2.0810
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.13101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
rhazinilam
rhazinilam: tetracyclic structure comprises phenyl-pyrrole bridged by a nine-membered lactam ring; novel alkaloid isolated from Aspidosperma quebrachoblanco leaves; possesses mild analgesic activity in mice; RN given refers to (8aR-(8aR*,14aR*))-isomer; structure		3.9330
iproniazid
rhazinal: from the stem extracts of a Malayan Kopsia teoi; displays potent and unusual anti-mitotic property; structure in first source		2.1310
leuconicine a
leuconicine A: from extracts of the Malaysian plant Leuconotis; structure in first source		2.1310
leuconicine b
leuconicine B: from extracts of the Malaysian plant Leuconotis; structure in first source		2.1310
leuconoxine
leuconoxine: from Leuconotis eugenefolia; structure in first source		4.1140alkaloidmetabolite
ConditionIndicatedRelationship StrengthStudiesTrials