cefotaxime and Pericarditis

Acute pericarditis is inflammation of the pericardium with or without pericardial effusion. In the pediatric population, most patients with acute pericarditis are diagnosed with idiopathic pericarditis. Herein, we present two children with idiopathic pericarditis who underwent immunological assessment of pericardial effusion for the first time. Both patients showed equally high levels of interleukin-6 in the pericardial effusion. However, they had different treatment responses, in accordance with the pericardial effusion and serum interleukin-10 concentrations. Our present cases suggest that interleukin-10 may be associated with the response to anti-inflammatory therapy in idiopathic acute pericarditis.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cefotaxime; Child, Preschool; Cytokines; Dobutamine; Dopamine; Humans; Infant; Interleukin-10; Interleukin-6; Male; Meropenem; Pericardial Effusion; Pericardial Fluid; Pericarditis; Prednisolone; Treatment Outcome

Involvement of the pericardium in meningococcal disease is a well-recognized but rare complication. Isolated meningococcal pericarditis is defined as purulent pericarditis without clinical evidence of meningococcemia. Neisseria meningitidis serotypes C, B, and W135 have been previously described to cause pericarditis. This is the 1st case report of isolated meningococcal myopericarditis due to N. meningitidis serotype Y.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Cefotaxime; Child, Preschool; Electrocardiography; Female; Humans; Infant; Male; Meningococcal Infections; Middle Aged; Neisseria meningitidis, Serogroup Y; Penicillin G; Pericarditis

Meningococcal disease due to Neisseria meningitidis of serogroup W135 (N. meningitidis W135) is increasing in France. Clinical and outcome data concerning these infections in children are scarce. We report five cases of children hospitalized between June 2000 and December 2002 for N. meningitidis W135 infection. Extra-meningeal septic and/or non-septic complications were frequent and a prolonged post meningococcal inflammatory syndrome was reported. In N. meningitidis W135 infections a careful clinical evaluation of potential extra-meningeal complications and a long term follow up of children are needed.

Topics: Anti-Bacterial Agents; Arthritis, Infectious; Cefotaxime; Child; Child, Preschool; Ciprofloxacin; Female; Follow-Up Studies; Fosfomycin; Humans; Infant; Male; Meningitis, Meningococcal; Meningococcal Infections; Neisseria meningitidis; Pericarditis; Time Factors; Treatment Outcome; Uveitis

The authors report a fatal case of acute bacterial myocarditis in a nonneutropenic child with acute lymphoblastic leukemia. She was admitted to the hospital with a urinary tract infection resulting from and remained persistently febrile despite resolution of the infection. On hospital day 4 signs of acute cardiac failure developed. Despite aggressive resuscitation measures, she died. Pathologic examination revealed the cause of death to be bacterial myocarditis. In addition, she was found to have a generalized decrease in her serum immunoglobulin levels. Acute bacterial myocarditis in patients with malignancy has been rarely reported. The rapid clinical deterioration and death in the patient in this report is particularly interesting.

Topics: Acute Disease; Agammaglobulinemia; Antineoplastic Combined Chemotherapy Protocols; Cefotaxime; Child; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Immunocompromised Host; Klebsiella Infections; Klebsiella pneumoniae; Myocarditis; Oxacillin; Pericarditis; Pleurisy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Shoulder Pain; Tobramycin; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections

Topics: Aged; Cardiac Tamponade; Cefotaxime; Ceftriaxone; Cephalosporins; Drug Resistance, Microbial; Female; Humans; Penicillin Resistance; Pericarditis; Streptococcus pneumoniae

Topics: Cardiac Tamponade; Cefotaxime; Humans; Infant; Male; Meningococcal Infections; Neisseria meningitidis; Pericardial Effusion; Pericarditis