Craniofacial Dysarthrosis

Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.

Synonym
Crouzon Syndrome
Crouzon's Disease
Dysostosis, Craniofacial
Craniofacial Dysostosis Syndrome
Craniofacial Dysostosis Type 1
Craniofacial Dysostosis, Type I
Craniofacial Dysostosis
Crouzon Disease
Crouzon Craniofacial Dysostosis
Craniofacial Dysarthrosis

Excerpt	Reference
"Crouzon syndrome is a craniofaciostenosis characterized by brachycephaly, ocular proptosis, and maxillary retrusion."	( Avantaggiato, A; Carinci, F; Curioni, C, 1994)
"Crouzon syndrome is an autosomal dominant disorder resulting in facial dysmorphism and craniosynostosis involving multiple cranial sutures."	( Argenta, LC; David, LR; Velotta, E; Weaver, RG; Wilson, JA, 2002)
"Crouzon syndrome is caused by mutations in fibroblast growth factor receptor 2 (FGFR2) leading to constitutive activation of receptors in the absence of ligand binding."	( Darvann, T; Morriss-Kay, G; Ornitz, DM; Perlyn, CA; Tenenbaum, M, 2006)
"Facial deformity in Crouzon syndrome is characterized by exophthalmos, exorbitism, mild hypertelorism, and maxillary hypoplasia with a Class III occlusion."	( Davis, C; Lauritzen, C, 2008)
"Crouzon syndrome is an autosomal dominant disorder characterized by cranial synostosis, hypertelorism, orbital proptosis, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism, without extremity involvement."	( David, LR; Glazier, SS; Kirman, CN; Railean, S; Sanger, C; Tran, B, 2011)
"Crouzon syndrome is a rare, autosomal dominant disease from a fibroblast growth factor receptor 2 gene mutation, characterized by premature craniosynostosis, hypertelorism, orbital proptosis, psittichorina, hypoplastic maxilla, and mandibular prognathism."	( Tan, KH; Tay, YC; Yeow, VK, 2013)
"Crouzon syndrome is an autosomal dominant craniosynostosis syndrome caused by mutation in the fibroblast growth factor receptor 2 (FGFR-2)."	( Ge, M; Ke, R; Lei, J; Mu, X; Tianyi, C; Yang, X, 2015)
"Crouzon syndrome is the most common form of craniosynostosis, and mutations in the fibroblast growth factor receptor 2 and 3 (FGFR2 and FGFR3) genes are implicated in its pathogenesis."	( Al-Shahwan, S; Alshamrani, AA, 2018)
"Crouzon syndrome is associated with severe respiratory impairment of the upper airway due in part to midfacial dysmorphology."	( Alonso, N; Alperovich, M; Forte, AJ; Hashim, PW; Lu, X; Persing, JA; Steinbacher, DM, 2019)
"Crouzon syndrome is a craniofacial malformation caused by premature fusion of fibrous sutures in infants."	( Chen, ZH; Fan, SS; Gu, S; Liu, TJ; Wang, XL; Wu, SH, 2021)

Excerpt	Reference
"A child with severe Crouzon's disease had a markedly retruded forehead with exorbitism, which was treated by radical forehead advancement."	( Losken, HW; Morris, WM; Uys, PB, 1989)
"The patient was a 7-year-old girl with Crouzon disease who was treated by frontofacial monobloc/Le Fort IV minus glabellar osteotomy with quadruple internal distraction devices."	( Akizuki, T; Watanabe, Y, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	258 (59.58)	23.3326
1990's	44 (10.16)	12.5806
2000's	47 (10.85)	18.1394
2010's	74 (17.09)	28.8240
2020's	10 (2.31)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
quinacrine	low	3	0
salicylic acid	low	7	0
cytosine	low	1	0
lactic acid	low	3	0
iodine	low	1	0
thymine	low	1	0
pd 173074	low	1	0
phenytoin	medium	1	1
valproic acid	medium	1	1
enflurane	low	1	0
erythrosine	low	1	0
fluorouracil	medium	1	1
gentamicin	low	1	0
2-propanol	low	19	0
meclizine	low	1	0
apnea	low	1	0
primidone	medium	2	1
procainamide	low	1	0
propranolol	low	1	0
sevoflurane	low	1	0
thalidomide	low	6	0
mitomycin	low	1	0
thymidine	low	2	0
thyroxine	low	1	0
alanine	low	1	0
serine	low	2	0
bromodeoxyuridine	low	2	0
tyrosine	low	4	0
phenylalanine	low	1	0
colchicine	low	1	0
asparagine	low	1	0
tryptophan	low	4	0
arginine	low	7	0
vinyl chloride	low	1	0
thiazoles	low	1	0
hydantoins	low	2	0
durapatite	low	1	0
vancomycin	low	1	0
trimethaphan	low	1	0
tantalum	low	1	0
titanium	medium	7	1
calcium sulfate	low	1	0
trolamine salicylate	low	2	0
titanium dioxide	low	1	0
phenyl acetate	low	1	0
triamcinolone	low	1	0
glutamic acid	low	1	0
substance p	low	1	0
propiconazole	medium	203	1
piperacillin	low	1	0
atracurium	low	1	0
remifentanil	low	1	0
efavirenz	low	1	0
thiazolyl blue	low	1	0
tomatidine	low	1	0
proline	low	3	0
aminopterin	low	1	0
atropine	low	1	0
glucosamine	low	1	0
inositol 3-phosphate	low	10	0
quinidine	low	1	0
meropenem	low	1	0
retinol	low	1	0
glycosides	low	1	0
thiopental	low	1	0
u 0126	low	1	0
cystine	low	1	0
vitamin k semiquinone radical	low	1	0
isotretinoin	low	1	0
phenylephrine hydrochloride	low	74	0
morphine	low	1	0
lead	low	2	0
cysteine	low	8	0
cefotaxime	low	1	0
losartan potassium	low	2	0
scopolamine hydrobromide	low	1	0
jaw	low	3	0
natriuretic peptide, c-type	low	1	0
ro13-9904	low	1	0
piperidines	low	1	0
chondroitin	low	3	0
tetracycline	low	1	0
salicylates	low	1	0
warfarin	low	1	0
transforming growth factor beta	low	3	0
bmn 111	low	1	0
edetic acid	low	1	0
tomatine	low	1	0
levoleucovorin	medium	1	1
guanine	low	1	0
trypan blue	low	1	0
eye	low	22	0

Protein Targets (1,040)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	22	0	0	22
GLI family zinc finger 3	21	0	0	21
AR protein	24	0	0	24
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
retinoid X nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	28	0	0	28
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	8	0	0	8
thyroid hormone receptor beta isoform a	11	0	0	11
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
lamin isoform A-delta10	14	0	0	14
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Glutamate receptor 2	11	2	1	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	24	0	0	24
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
glucocorticoid receptor [Homo sapiens]	21	0	0	21
estrogen-related nuclear receptor alpha	26	0	0	26
pregnane X nuclear receptor	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Bile salt export pump	0	24	0	24
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	11	0	0	11
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Carbonic anhydrase 1	0	2	0	8
Carbonic anhydrase 2	0	2	0	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	1	9
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
farnesoid X nuclear receptor	11	0	0	11
peroxisome proliferator activated receptor gamma	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
thyroid hormone receptor beta isoform 2	15	0	0	15
Dihydrofolate reductase	0	4	0	4
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	2
Cellular tumor antigen p53	15	0	0	15
5-hydroxytryptamine receptor 2C	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	2
thioredoxin reductase	17	0	0	17
ATAD5 protein, partial	11	0	0	11
Microtubule-associated protein tau	9	0	0	9
arylsulfatase A	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Bloom syndrome protein isoform 1	8	0	0	8
D(1A) dopamine receptor	4	0	0	4
neuropeptide S receptor isoform A	3	0	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	9	0	0	9
NFKB1 protein, partial	3	0	0	3
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	8	0	0	8
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	13	0	0	13
flap endonuclease 1	8	0	0	8
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	6	0	0	6
Cytochrome P450 3A4	0	6	1	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	5
Amino acid transporter	0	3	0	3
NPYLR7B	0	0	2	2
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
cystic fibrosis transmembrane conductance regulator	0	2	0	2
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	7	0	9
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
5-hydroxytryptamine receptor 4	0	6	0	6
Muscarinic acetylcholine receptor M2	0	9	2	14
Muscarinic acetylcholine receptor M4	0	8	1	11
Muscarinic acetylcholine receptor M1	0	7	1	10
Muscarinic acetylcholine receptor M3	0	6	1	9
Muscarinic acetylcholine receptor M4	0	6	1	9
Muscarinic acetylcholine receptor M5	0	6	1	9
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M2	0	7	2	12
Muscarinic acetylcholine receptor M1	0	9	2	14
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	2	12
Alpha-1D adrenergic receptor	0	6	1	8
5-hydroxytryptamine receptor 2C	0	6	1	7
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	4	0	0	5
5-hydroxytryptamine receptor 7	0	5	0	5
Reverse transcriptase/RNaseH	0	2	1	9
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	12	0	12
interleukin 8	4	0	0	4
pregnane X receptor	7	0	0	7
progesterone receptor	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
IDH1	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
cellular tumor antigen p53 isoform a	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	15	0	0	15
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	5	0	0	5
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Nuclear receptor ROR-gamma	4	0	0	4
Spike glycoprotein	9	1	2	12
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	1	4
Metallo-beta-lactamase VIM-11	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Albumin	0	1	5	6
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	3	0	5
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	1	0	2
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-b-lactamase	0	0	0	3
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	4
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	0	0	3
Solute carrier family 22 member 7	0	1	0	2
Proteasome subunit beta type-11	0	0	0	1
acetylcholinesterase	7	0	0	7
Fumarate hydratase	7	0	0	7
USP1 protein, partial	8	0	0	8
Thrombopoietin	3	0	0	3
Smad3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	9	0	0	9
NADPH oxidase 1	0	1	0	1
G	6	0	0	6
cytochrome P450 2D6	7	0	0	7
polyprotein	7	0	0	7
67.9K protein	8	0	0	8
Snq2p	0	0	0	2
caspase-3	3	0	0	3
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	9	0	0	9
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
mitogen-activated protein kinase 1	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	3	0	0	3
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	5	3	1	9
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Bile salt export pump	0	4	0	4
Potassium channel subfamily K member 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	1	1	2
Integrin beta-3	2	0	1	3
Cytochrome P450 1A2	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	5	0	5
ATP-dependent translocase ABCB1	0	7	1	11
Integrin alpha-IIb	2	0	1	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	6	3	10
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	2	2	4
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2C9	0	6	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	1	5
5-hydroxytryptamine receptor 2A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	3	1	9
Alpha-1B adrenergic receptor	0	7	1	8
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	6	1	8
Gamma-aminobutyric acid receptor subunit delta	5	3	1	9
Gamma-aminobutyric acid receptor subunit gamma-2	5	3	1	9
Alpha-2C adrenergic receptor	0	5	2	8
D	0	2	0	2
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	5	1	8
Alpha-2B adrenergic receptor	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	3	1	9
Gamma-aminobutyric acid receptor subunit alpha-3	5	3	1	9
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	3	1	5
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	1	4
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	5	3	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	5	3	1	9
Alpha-1D adrenergic receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	6	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	3	1	9
Gamma-aminobutyric acid receptor subunit gamma-3	5	3	1	9
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	5	3	1	9
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	2	1	3
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	5	2	8
D(3) dopamine receptor	0	4	0	5
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	5	2	8
Kappa-type opioid receptor	0	5	2	8
5-hydroxytryptamine receptor 2B	0	6	1	7
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	7	1	8
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	4	1	5
Cytochrome P450 2J2	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	2	1	4
Calmodulin	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	5	3	1	9
Gamma-aminobutyric acid receptor subunit beta-3	5	3	1	9
Gamma-aminobutyric acid receptor subunit beta-2	5	3	1	9
Aldehyde oxidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Aldehyde oxidase	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
GABA theta subunit	5	3	1	9
Inositol hexakisphosphate kinase 1	6	0	0	6
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
Angiotensin-converting enzyme 2	0	1	2	3
Gamma-aminobutyric acid receptor subunit epsilon	5	3	1	9
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Chain A, Beta-lactamase	7	0	0	7
Chain A, Ferritin light chain	7	0	0	7
Luciferase	8	0	0	8
endonuclease IV	3	0	0	3
PAX8	0	0	0	1
PPM1D protein	4	0	0	4
glucocerebrosidase	2	0	0	2
aryl hydrocarbon receptor	9	0	0	9
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	4
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Deoxycytidine kinase	0	0	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2B6	0	0	0	1
Acetylcholinesterase	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Protease	0	1	0	2
Fructose-1,6-bisphosphatase 1	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Reverse transcriptase	0	1	1	2
Cholesterol 24-hydroxylase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
thioredoxin glutathione reductase	4	0	0	4
hypothetical protein, conserved	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	7	0	0	7
Skn7p	0	0	0	1
EWS/FLI fusion protein	9	0	0	9
nonstructural protein 1	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	1	0	2
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
regulator of G-protein signaling 4	6	0	0	6
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	4	1	6
Chain A, Cruzipain	2	0	0	2
Parkin	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
serine/threonine-protein kinase PLK1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	3	1	4
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-2 adrenergic receptor	0	2	1	4
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
Chain A, Protein (fibroblast Growth Factor (fgf) Receptor 1)	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Insulin receptor	0	1	0	1
Fibroblast growth factor receptor 1	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Fibroblast growth factor receptor 2	0	1	0	1
Fibroblast growth factor receptor 4	0	1	0	1
Fibroblast growth factor receptor 3	0	1	1	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Tyrosine-protein kinase CSK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	2	0	2
Platelet-derived growth factor receptor beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	4
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Carbonic anhydrase 3	0	1	0	4
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	1	0	4
Carbonic anhydrase 6	0	1	0	4
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
SLC16A10 protein	0	0	0	3
Carbonic anhydrase 9	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	3
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	4
Phospholipase A-2-activating protein	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
dopamine D1 receptor	2	0	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
N	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Histidine-rich protein PFHRP-II	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Cholinesterase	0	3	0	3
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Cholinesterase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	2	0	2
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	2	1	3
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	2	0	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
procathepsin L isoform 1 preproprotein	0	1	0	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Myeloperoxidase	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (433)

Protein Targets (1,040)

Craniofacial Dysarthrosis

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (433)

Drugs Studied (114)

Protein Targets (1,040)