Cranial Airocele

Presence of air or gas within the intracranial cavity (e.g., epidural space, subdural space, intracerebral, etc.) which may result from traumatic injuries, fistulous tract formation, erosions of the skull from NEOPLASMS or infection, NEUROSURGICAL PROCEDURES, and other conditions.

Synonym
Cranial Pneumocyst
Pneumocephalus, Tension
Intracranial Gas
Pneumocephalus, Epidural
Pneumocephalus, Traumatic
Pneumocephalus
Pressure Pneumocephalus
Cranial Airocele

Excerpt	Reference
"Pneumocephalus is sometimes the only sign of intracranial involvement."	( Flanagan, JC; Waring, GO, 1975)
"One common cause of pneumocephalus is a craniotomy or craniectomy, and therefore, patients undergoing these neurosurgical procedures may be at increased risk for the development of tension pneumocephalus if N2O is used during a subsequent anesthetic."	( Reasoner, DK; Scamman, FL; Todd, MM; Warner, DS, 1994)
"Treatment of pneumocephalus is mostly managed surgically, especially in a tension pneumocaephalus when the pressure has to be alleviated."	( Doğru, H; Döner, F; Kalkan, E; Kerman, M; Yariktaş, M, 2003)
"Pneumocephalus is a well-known complication of surgical procedures performed with the patients placed in the sitting position."	( de la Rosa-Carrillo, VN; Hernández-Palazón, J; López, F; Martínez-Lage, JF; Poza, M; Tortosa, JA, 2003)
"Pneumocephalus is the presence of air within the intracranial vault."	( Arivazhagan, A; Devi, I; Dua, R; Garg, N, 2008)
"Postoperative pneumocephalus is common following craniospinal surgical intervention in the sitting position."	( Colen, CB; Ham, SD; Kattner, KA; Sood, S; Stevens, QE, 2007)
"Spontaneous tension pneumocephalus is a rare life-threatening condition which is often caused by a bone defect near the tegmen tympani."	( Bocchetti, A; D'Avanzo, R; Mirone, G; Moraci, A; Natale, M; Rotondo, M; Scuotto, A, 2009)
"Tension pneumocephalus is a life-threatening condition that requires rapid recognition and intervention."	( Monas, J; Peak, DA, 2010)
"Postoperative pneumocephalus is a common occurrence after endoscopic endonasal skull base surgery (ESBS)."	( Anand, VK; Banu, MA; Mascarenhas, L; Salek, AA; Schwartz, TH; Szentirmai, O, 2014)
"Postoperative pneumocephalus is much more common following extended approaches than following transsellar surgery."	( Anand, VK; Banu, MA; Mascarenhas, L; Salek, AA; Schwartz, TH; Szentirmai, O, 2014)
"Pneumocephalus is collection of gas or air within the cranial cavity, commonly associated with trauma, cranial surgery, air embolism, open meningomyelocele; and rarely as a result of central nervous system infections."	( Choudhary, S; Makwana, M; Soni, JP; Tripathi, N, 2016)
"Pneumocephalus is defined as air in the cranial cavity."	( Kiraz, HA; Lüleci, N; Özdemir, U; Toman, H, 2017)
"Pneumocephalus is usually induced by trauma, infections, tumors of the skull base, and surgical interventions."	( Ajlan, A; Alhabib, S; Alsanosi, A; Bedaiwi, R; Elwatidy, S; Jan, B; Khurayzi, T, 2022)
"Pneumocephalus is an uncommon pathology that typically follows head trauma, neurosurgery, or skull base tumors."	( Anderson, R; Beaumont, R; Carlson, JN, 2021)
"Iatrogenic pneumocephalus is also observed, including lumbar puncture."	( Uchino, A, 2021)
"Early diagnosis of pneumocephalus is crucial to avoid severe consequences."	( Cao, L; Dong, G; Liu, R; Sheng, Q; Tong, X; Zhao, Y, 2021)

Excerpt	Reference
"The authors reported a case of pneumocephalus induced by bromocriptine (Bc) treatment for a recurrent invasive prolactinoma."	( Fukushima, T; Kitahara, S; Takakura, K; Teramoto, A, 1983)
"Treatment of pneumocephalus is mostly managed surgically, especially in a tension pneumocaephalus when the pressure has to be alleviated."	( Doğru, H; Döner, F; Kalkan, E; Kerman, M; Yariktaş, M, 2003)
"The mean change in pneumocephalus volume was higher in patients in the treatment arm as compared to patients in the control arm (p = 0."	( Biertz, F; Ertl, P; Grosshennig, A; Hermann, EJ; Hong, B; Krauss, JK; Lanfermann, H; Lang, JM; Nakamura, M; Raab, P; Scheinichen, D, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	51 (31.68)	23.3326
1990's	14 (8.70)	12.5806
2000's	33 (20.50)	18.1394
2010's	46 (28.57)	28.8240
2020's	17 (10.56)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	16	0
formaldehyde	low	1	0
nitrous oxide	medium	25	1
urea	low	1	0
amiodarone	low	1	0
bupivacaine	low	4	0
cefuroxime	low	1	0
pentetic acid	low	1	0
fentanyl	medium	1	1
gentamicin	low	1	0
guaifenesin	low	1	0
halothane	low	1	0
lidocaine	low	3	0
isoflurane	low	1	0
apnea	low	1	0
propofol	medium	2	1
sevoflurane	low	1	0
sulfadiazine	low	2	0
sulfamethizole	low	1	0
temazepam	low	1	0
tetracaine	low	1	0
trimethoprim	low	1	0
prednisolone	low	1	0
lysine	low	1	0
levodopa	low	1	0
ampicillin	low	1	0
mannitol	low	1	0
perflutren	low	1	0
methylprednisolone	low	2	0
penicillanic acid	low	1	0
durapatite	low	2	0
vancomycin	low	4	0
enbucrilate	low	1	0
tantalum	low	1	0
technetium	low	1	0
titanium	low	1	0
gadolinium	low	2	0
ytterbium	low	1	0
magnesium sulfate	low	1	0
barium sulfate	low	1	0
ozone	low	2	0
trolamine salicylate	low	1	0
bromocriptine	low	1	0
triamcinolone	low	1	0
amikacin	low	1	0
propiconazole	low	28	0
piperacillin	low	1	0
cabergoline	low	4	0
trimethoprim sulfamethizole	low	1	0
cephalosporin c	low	1	0
voriconazole	low	1	0
tazobactam	low	1	0
technetium tc 99m pentetate	low	1	0
ropivacaine	low	1	0
meropenem	low	1	0
metrizamide	low	1	0
cocaine	low	2	0
phenylephrine hydrochloride	low	20	0
oxycodone	low	1	0
morphine	low	1	0
cefepime	low	1	0
cefotaxime	low	3	0
ergoline	low	3	0
trametinib	low	1	0
pituitrin	low	1	0
ro13-9904	medium	4	1
eye	low	1	0
pyrimidinones	low	1	0

Protein Targets (956)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	20	0	0	20
peripheral myelin protein 22	6	0	0	6
histone acetyltransferase KAT2A isoform 1	3	0	0	3
lamin isoform A-delta10	16	0	0	16
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	12
Bile salt export pump	0	21	0	21
Canalicular multispecific organic anion transporter 1	0	12	0	12
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
acetylcholinesterase	4	0	0	4
phosphopantetheinyl transferase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	13	0	0	13
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	4	0	0	4
USP1 protein, partial	5	0	0	5
NFKB1 protein, partial	3	0	0	3
PPM1D protein	3	0	0	3
SMAD family member 3	4	0	0	4
TDP1 protein	10	0	0	10
Thrombopoietin	1	0	0	1
AR protein	15	0	0	15
caspase 7, apoptosis-related cysteine protease	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	7	0	0	7
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	8	0	0	8
EWS/FLI fusion protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	12	0	0	12
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	14	0	0	14
G	7	0	0	7
cytochrome P450 2D6	2	0	0	2
polyprotein	4	0	0	4
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	5	0	0	5
caspase-3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
thyroid stimulating hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	4	0	0	4
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
D(1A) dopamine receptor	4	0	0	4
chromobox protein homolog 1	12	0	0	12
thyroid hormone receptor beta isoform a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	5	0	0	5
flap endonuclease 1	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	15	0	0	15
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	1	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	14	0	0	14
Integrin beta-3	1	0	0	1
Tyrosine-protein kinase Fyn	0	2	1	3
ATP-dependent translocase ABCB1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	5	2	7
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	5	1	6
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	5	1	6
Androgen receptor	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	5	1	1	7
Alpha-1B adrenergic receptor	0	3	0	3
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	1	7
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	4	0	4
D(4) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	1	7
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	2	0	2
Endothelin-1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	1	7
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	1	7
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	7	3	11
D(3) dopamine receptor	0	5	0	5
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	6	2	9
Kappa-type opioid receptor	0	6	2	9
5-hydroxytryptamine receptor 2B	0	7	1	8
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H2 receptor	3	0	0	3
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	4	0	4
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	1	7
Gamma-aminobutyric acid receptor subunit beta-3	5	1	1	7
Gamma-aminobutyric acid receptor subunit beta-2	5	1	1	7
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	3	0	3
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	4	0	4
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	5	1	1	7
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Sodium channel protein type 2 subunit alpha	0	2	0	2
Ataxin-2	8	0	0	8
Sigma non-opioid intracellular receptor 1	0	10	0	10
Gamma-aminobutyric acid receptor subunit epsilon	5	1	1	7
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	2	0	5
acid sphingomyelinase	1	0	0	1
GLS protein	5	0	0	5
GLI family zinc finger 3	14	0	0	14
apical membrane antigen 1, AMA1	2	0	0	2
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	6
Metallo-beta-lactamase type 2	0	0	1	6
Metallo-beta-lactamase VIM-11	0	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	1	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	2	0	0	2
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	0	6
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	2
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	5
Efflux transporter	0	0	0	1
Beta-lactamase	0	1	0	5
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	1	0	3
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	1	4
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	6
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	6
Histamine H3 receptor	0	0	0	4
Beta-lactamase class B VIM-2	0	0	1	7
Beta-lactamase VIM-1	0	0	0	5
thioredoxin reductase	7	0	0	7
Microtubule-associated protein tau	2	0	0	2
arylsulfatase A	5	0	0	5
Bloom syndrome protein isoform 1	7	0	0	7
neuropeptide S receptor isoform A	1	0	0	1
Genome polyprotein	0	1	1	2
dopamine D1 receptor	3	0	0	3
regulator of G-protein signaling 4	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
vitamin D3 receptor isoform VDRA	3	0	0	3
Cytochrome P450 3A4	0	5	1	6
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	0	3
D(4) dopamine receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
D(2) dopamine receptor	0	2	1	3
ATPase family AAA domain-containing protein 5	7	0	0	7
Potassium channel subfamily K member 3	0	4	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Histamine H3 receptor	0	1	0	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-19	0	0	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	5
Beta-lactamase SHV-1	0	2	0	6
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	5
Kappa-type opioid receptor	0	5	0	8
Beta-lactamase TEM	0	2	0	4
Beta-lactamase	0	1	0	2
B2 metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
BlaVIM-1	0	0	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Albumin	0	2	3	5
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	1	0	2
Beta-lactamase	0	1	0	3
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium-dependent serotonin transporter	0	4	0	5
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	3	0	3
Luciferase	2	0	0	2
Solute carrier family 22 member 1	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	4	1	6
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	3	2	7
Mu-type opioid receptor	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Glutamate receptor 2	4	0	0	4
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
snurportin-1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
Polyphenol oxidase 2	0	1	0	3
Carbonic anhydrase 12	0	1	0	2
Epidermal growth factor receptor	0	1	1	2
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	1	2
Carbonic anhydrase 3	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Tyrosinase	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	2	0	3
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
phosphoglycerate kinase	1	0	0	1
IDH1	4	0	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
activating transcription factor 6	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	3	0	0	3
aryl hydrocarbon receptor	3	0	0	3
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
nonstructural protein 1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Glucocorticoid receptor	0	6	1	12
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	2	5
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
endonuclease IV	2	0	0	2
GALC protein	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
glp-1 receptor, partial	4	0	0	4
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	5	0	5
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	3	0	3
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	2	0	0	2
pregnane X receptor	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Aurora kinase A	0	1	1	2
interleukin 8	2	0	0	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Beta-lactamase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	2
Cytochrome P450 2B6	0	2	0	2
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Translocator protein	0	1	0	1
cGMP-gated cation channel alpha-1	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	1	2
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Rab-like protein 3	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
67.9K protein	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (161)

Protein Targets (956)

Cranial Airocele

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (161)

Drugs Studied (78)

Protein Targets (956)