cefotaxime and AIDS-Related-Opportunistic-Infections

Salmonella meningitis is an unusual complication of Salmonella sepsis and occurs mainly in children. A rare case of Salmonella typhimurium meningitis occurring in an adult HIV positive man who presented with a history of fever and diarrhoea is reported. On examination he was dehydrated, and had oral thrush, weakness of lower limbs and neck stiffness. A septic diagnostic screen was performed and he was commenced on empiric intravenous cefotaxime therapy for meningitis. S typhimurium was cultured from cerebrospinal fluid and blood culture specimens. It was non-lactose fermenting, oxidase negative, H(2)S positive and motile. Cefotaxime was continued for 14 days and the patient responded without neurological sequelae.

Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Cefotaxime; Humans; Male; Meningitis, Bacterial; Salmonella Infections; Salmonella typhimurium

Topics: Adult; AIDS-Related Opportunistic Infections; Ampicillin; Cefotaxime; Ciprofloxacin; Drug Therapy, Combination; Endocarditis, Bacterial; Gentamicins; Gram-Negative Bacterial Infections; Heart Valve Prosthesis; Humans; Male; Prosthesis-Related Infections

In AIDS patients, non-typhoid salmonella metastatic abscesses in lung and brain due to bacteremia have been described previously. Here we present a case in which a group B Salmonella, serotype Copenhagen, caused right parietal subdural empyema. The etiologic diagnosis was based on culture of pus obtained from the lesion. The patient was treated for bacterial meningitis and made a good recovery. He is at present reasonably well and is taking ciprofloxacin as prophylaxis against salmonella relapse.

Topics: Adult; AIDS-Related Opportunistic Infections; Brain; Brain Abscess; Cefotaxime; Chloramphenicol; Ciprofloxacin; Empyema, Subdural; Humans; Male; Meningitis, Bacterial; Salmonella; Salmonella Infections; Serotyping; Tomography, X-Ray Computed

The profound impairment of cellular immunity associated with HIV infection predisposes to salmonella infections with recurrent bacteremia as a well recognized opportunistic infection in patients with AIDS. However, salmonella meningitis is extremely rare in this group of patients and only 4 cases have been reported so far. We present 1 case of recurrent Salmonella enteritidis meningitis in an AIDS patient. The infection recurred despite prolonged antimicrobial therapy. Treatment of salmonella infections in AIDS patients may be very difficult and, in some cases, lifelong maintenance therapy may be required.

Topics: Adult; AIDS-Related Opportunistic Infections; Cefotaxime; Cerebrospinal Fluid; Humans; Male; Meningitis, Bacterial; Recurrence; Salmonella enteritidis; Salmonella Infections