cefotaxime and Adenoma

Ceftizoxime (CZX) was given in daily doses of 4 approximately 6 g by intravenous drip infusion to 30 patients with infection accompanying lung cancer to investigate the usefulness of the drug for infectious disease: The rate of effectiveness (marked and moderate) was 73.3% (22/30 patients). Of the 30 patients, 2 had drug fever; 1, arthralgia; and 1, eosinophilia. These side effects improved after the drug was withdrawn. CZX is a very useful antibiotic with high effectiveness and safety in immunocompromised patients with infection accompanying advanced lung cancer.

Topics: Adenoma; Adult; Aged; Bacterial Infections; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cefotaxime; Ceftizoxime; Female; Fever; Humans; Lung Neoplasms; Male; Middle Aged; Pneumonia; Pyelitis; Respiratory Tract Infections

20, 30 and 90 minutes after a single intravenous injection of 2 g of cefotiam prostatic tissue and serum samples were taken from 12 patients who underwent transabdominal prostatectomy for prostatic adenoma. Cefotiam was assayed by HPLC. Mean serum and prostatic concentrations were respectively 157 +/- 39 mg/ml and 42 +/- 23 mg/g at 20 mn, 77 +/- 52 mg/ml and 54 +/- 2 mg/g at 30 mn, 36 +/- 21 mg/ml and 16 +/- 18 mg/g at 90 mn. Elimination half-life of cefotiam was 1 h 39 mn for serum and 1 h 10 mn for prostatic tissue. These findings confirm the satisfactory diffusion of cefotiam within prostatic tissue, although saturation occurs after 30 mn. Treatment of prostatitis by cefotiam can be expected to give excellent results.

Topics: Adenoma; Aged; Bacterial Infections; Cefotaxime; Cefotiam; Chromatography, High Pressure Liquid; Half-Life; Humans; Kinetics; Male; Prostate; Prostatectomy; Prostatic Neoplasms; Prostatitis

Within the framework of perioperative prophylaxis against infections, serum and tissue concentrations were measured following an i. v. bolus injection of 2.0 g of cefotaxime in 25 patients with a prostatic adenoma. The mean serum concentrations were 64.9 microgram/ml, 56.6 microgram/ml, 45.2 microgram/ml, 18.2 microgram/ml and 19.9 microgram/ml 30, 60, 90, 120 and 150 minutes respectively following the injection. The corresponding concentrations in the prostatic adenoma tissue were 8.8 microgram/g, 15.3 microgram/g, 22.9 microgram/g, 4.3 microgram/g and 2.7 microgram/g respectively. The tissue concentrations in ten testes from six patients were measured in a similar way. The maximum concentration (5.4 microgram/g) was also found to occur 90 minutes after the injection. We found very different values, ranging from 0.3 microgram/g to 39.6 microgram/g, in eight kidneys as a result of greatly differing diagnoses and function. Average concentrations of 9.2 microgram/g to 0.8 microgram/g in the ureter, fatty tissue and muscle tissue were within the therapeutically effective range. The cefotaxime concentrations found in serum and tissue lead us to expect successful therapy when cefotaxime is used to treat bacterial infections with sensitive pathogens in the urogenital tract.

Topics: Adenoma; Aged; Cefotaxime; Cephalosporins; Genitalia, Male; Humans; Kidney; Male; Prostate; Prostatic Neoplasms; Testis; Tissue Distribution; Ureter; Urinary Tract