Page last updated: 2024-11-13
leuconicine a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
leuconicine A: from extracts of the Malaysian plant Leuconotis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 44626771 |
| CHEMBL ID | 1087883 |
| MeSH ID | M0568336 |
Synonyms (2)
| Synonym |
|---|
| leuconicine a |
| CHEMBL1087883 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (20)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID464196 | Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.1 ug/ml vincristine | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. |
| AID1064669 | Cytotoxicity against human KB cells overexpressing human MDR1 assessed as reduction in cell viability after 4 days by MTT assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID1329361 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID1064666 | Inhibition of p-glycoprotein (unknown origin) overexpressed in human KBV20C cells assessed as potentiation of vincristine-induced cytotoxicity at 3 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID464432 | Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID1064668 | Cytotoxicity against human KBV20C cells overexpressing pgp assessed as reduction in cell viability after 4 days by MTT assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID464434 | Cytotoxic activity against human A549 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID464195 | Cytotoxicity against vincristine-resistant human KB/VJ300 cells | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. |
| AID464435 | Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID1064661 | Inhibition of human MDR1 overexpressed in human KB cells assessed as potentiation of vincristine-induced cytotoxicity at 3 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay relative to verapamil | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID464194 | Cytotoxicity against vincristine-sensitive human KB cells | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. |
| AID1329362 | Antibacterial activity against Enterococcus faecalis ATCC 10541 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID1064673 | Binding affinity to p-glycoprotein (unknown origin) by intrinsic tryptophan fluorescence quenching assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID1064667 | Inhibition of p-glycoprotein (unknown origin) overexpressed in human KBV20C cells assessed as potentiation of vincristine-induced cytotoxicity at 1 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID1064662 | Inhibition of human MDR1 overexpressed in human KB cells assessed as potentiation of vincristine-induced cytotoxicity at 1 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay relative to verapamil | 2014 | Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3 | Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. |
| AID1329364 | Antibacterial activity against Staphylococcus aureus ATCC 25922 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID464433 | Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID464197 | Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.121 uM vincristine | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. |
| AID1329365 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID1329363 | Antibacterial activity against Escherichia coli ATCC 11775 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.84
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.84) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||