Compounds > leuconicine a
Page last updated: 2024-11-13

leuconicine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

leuconicine A: from extracts of the Malaysian plant Leuconotis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44626771
CHEMBL ID1087883
MeSH IDM0568336

Synonyms (2)

Synonym
leuconicine a
CHEMBL1087883
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID464196Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.1 ug/ml vincristine2009Journal of natural products, Dec, Volume: 72, Issue:12
Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis.
AID1064669Cytotoxicity against human KB cells overexpressing human MDR1 assessed as reduction in cell viability after 4 days by MTT assay2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID1329361Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1064666Inhibition of p-glycoprotein (unknown origin) overexpressed in human KBV20C cells assessed as potentiation of vincristine-induced cytotoxicity at 3 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID464432Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay2010Journal of natural products, Jan, Volume: 73, Issue:1
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.
AID1064668Cytotoxicity against human KBV20C cells overexpressing pgp assessed as reduction in cell viability after 4 days by MTT assay2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID464434Cytotoxic activity against human A549 cells after 48 hrs by MTT assay2010Journal of natural products, Jan, Volume: 73, Issue:1
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.
AID464195Cytotoxicity against vincristine-resistant human KB/VJ300 cells2009Journal of natural products, Dec, Volume: 72, Issue:12
Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis.
AID464435Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay2010Journal of natural products, Jan, Volume: 73, Issue:1
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.
AID1064661Inhibition of human MDR1 overexpressed in human KB cells assessed as potentiation of vincristine-induced cytotoxicity at 3 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay relative to verapamil2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID464194Cytotoxicity against vincristine-sensitive human KB cells2009Journal of natural products, Dec, Volume: 72, Issue:12
Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis.
AID1329362Antibacterial activity against Enterococcus faecalis ATCC 10541 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1064673Binding affinity to p-glycoprotein (unknown origin) by intrinsic tryptophan fluorescence quenching assay2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID1064667Inhibition of p-glycoprotein (unknown origin) overexpressed in human KBV20C cells assessed as potentiation of vincristine-induced cytotoxicity at 1 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID1064662Inhibition of human MDR1 overexpressed in human KB cells assessed as potentiation of vincristine-induced cytotoxicity at 1 uM incubated for 1 hr prior to vincristine challenge measured after 4 days by MTT assay relative to verapamil2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
AID1329364Antibacterial activity against Staphylococcus aureus ATCC 25922 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID464433Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay2010Journal of natural products, Jan, Volume: 73, Issue:1
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.
AID464197Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.121 uM vincristine2009Journal of natural products, Dec, Volume: 72, Issue:12
Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis.
AID1329365Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
AID1329363Antibacterial activity against Escherichia coli ATCC 11775 after 24 hrs by broth microdilution method2016Journal of natural products, 09-23, Volume: 79, Issue:9
Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.110aromatic ether;
nitrile;
polyether;
tertiary amino compound
griseofulvin
Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.		2.13101-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
raubasine
ajmalicine : A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure.		2.1310methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
vallesiachotamine
vallesiachotamine: antiproliferative, from the leaves of Palicourea rigida (Rubiaceae) collected in the Brazilian Cerrado; structure in first source		2.0510
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.13101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
iproniazid
rhazinal: from the stem extracts of a Malayan Kopsia teoi; displays potent and unusual anti-mitotic property; structure in first source		2.1310
leuconolam
leuconolam: structure given in first source		2.1310monoterpenoid indole alkaloid
leuconicine b
leuconicine B: from extracts of the Malaysian plant Leuconotis; structure in first source		3.1750
ConditionIndicatedRelationship StrengthStudiesTrials