Angiomyolipoma

A benign tumor containing vascular, adipose, and muscle elements. It occurs most often in the kidney with smooth muscle elements (angiolipoleiomyoma) in association with tuberous sclerosis. (Dorland, 27th ed)

Synonym
Angiomyolipoma

Excerpt	Reference
"Angiomyolipomas are tumours of uncertain histogenesis, most often occurring in association with the kidney."	( Busam, KJ; Chen, YT; Coplan, K; Iversen, K; Jungbluth, AA; Old, LJ; Stockert, E; Williamson, B, 1999)
"Hepatic angiomyolipomas are rare and often mimic other liver tumors."	( Flemming, P; Galanski, M; Högemann, D; Kreipe, H, 2001)
"Renal angiomyolipomas are highly vascular tumors that occur sporadically, in women with pulmonary lymphangiomyomatosis (LAM), and in tuberous sclerosis complex (TSC)."	( Henske, EP; Karbowniczek, M; Yu, J, 2003)
"If angiomyolipomas are found incidentally in nephrectomy specimens together with other tumours, it is important to exclude tuberous sclerosis retrospectively."	( Lazarus, J; Pillay, K; Wainwright, HC, 2003)
"Although angiomyolipoma is usually a non-invasive tumor that does not metastasize, chirurgical intervention, especially in case of large or enlarging tumors, is recommended due to their capacity to cause haemorrhage and other significant clinical complications."	( Aul, C; Schroeder, M, 2005)
"Angiomyolipoma is a distinctive neoplasm composed of an intimate admixture of three components, viz."	( Chinoy, RF; Dave, B; Desai, SB; Kulkarni, B; Kulkarni, JN; Tongaonkar, HB, 2005)
"Renal angiomyolipoma is a tumor composed of varying amounts of fat, smooth muscle, and blood vessels."	( Magi-Galluzzi, C; Roma, AA; Zhou, M, 2007)
"Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females."	( Petrolla, AA; Xin, W, 2008)
"Angiomyolipomas are benign mesenchymal tumours of smooth muscle, blood vessels and fat which occur sporadically or associated with tuberous sclerosis and lymphangioleiomyomatosis (LAM), a rare cystic lung disease."	( Asprey, SL; Clements, D; Johnson, SR; McCulloch, TA; Morris, TA; Watson, SA, 2009)
"Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm."	( Hua, X; Li, R; Zhang, XH, 2010)
"Renal angiomyolipomas are a frequent manifestation of tuberous sclerosis and sporadic lymphangioleiomyomatosis (LAM)."	( Cox, JA; Cross, JJ; Davies, DM; de Vries, PJ; Doyle, T; Howe, CJ; Johnson, SR; Kingswood, JC; McCartney, DL; Pointon, K; Sampson, JR; Serra, AL; Tattersfield, AE; Watson, PC, 2011)
"Kidney angiomyolipomas are benign tumors composed of blood vessels, adipose tissue, and smooth muscle and are associated with spontaneous bleeding and potential life-threatening hemorrhage if >4 cm."	( Budde, K; Gaedeke, J, 2012)
"The kidney angiomyolipomas are usually very common in this disease and are usually asymptomatic unless complications arise."	( Bujalance-Cabrera, C; Caballero-Ballesteros, L; Redel-Montero, J; Requejo-Jiménez, A; Santos-Luna, F; Vaquero-Barrios, JM, 2012)
"Angiomyolipomas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin (mTOR), and are common in patients with tuberous sclerosis complex and sporadic lymphangioleiomyomatosis."	( Belousova, E; Bissler, JJ; Brakemeier, S; Budde, K; Chen, D; de Vries, PJ; Frost, M; Kingswood, JC; Lebwohl, D; Lincy, J; Nonomura, N; Radzikowska, E; Sahmoud, T; Sauter, M; Shah, G; Whittemore, VH; Zonnenberg, BA, 2013)
"Hepatic angiomyolipoma is a rare benign mesenchymal tumor."	( Arisaka, Y; Higuchi, T; Kumasaka, S; Nakajima, T; Tokue, A; Tsushima, Y, 2014)
"Adrenal angiomyolipoma is an extremely rare tumor, although computed tomography (CT) or magnetic resonance imaging findings of adrenal angiomyolipoma have been reported, there are no reports regarding integrated fluorine-18-fluorodeoxyglucose positron emission tomography and computed tomography ((18)F-FDG PET/CT) imaging."	( Cao, Y; Chen, J; Guan, L; Li, W; Pang, H, 2015)
"Angiomyolipoma is a benign mesenchymal tumor composed of variable amounts of smooth muscle, adipose tissue and thick-walled blood vessels, and usually named PEComas (perivascular epithelioid cell tumors)."	( Kao, SC; Kau, HC; Lin, CY; Liu, CJ; Tsai, CC; Yu, WK, 2016)
"LAM and angiomyolipoma are significantly associated, and may coexist in the lungs in rare cases."	( Feng, R; Shi, J; Sun, X; Xu, KF; Zhang, Y, 2016)
"Hepatic angiomyolipomas are a rare, benign group of mesenchymal tumors in the liver."	( Kubo, H; Nishi, Y; Okada, T; Takahashi, Y; Yamazaki, H; Yokomori, H, 2017)
"Renal angiomyolipomas are the most common renal mesenchymal tumors."	( Griffin, A, 2017)
"Renal angiomyolipoma is a frequent manifestation of Tuberous Sclerosis Complex (TSC), for which everolimus therapy has been recently established as a novel non-invasive therapeutic option."	( Álvarez-Ossorio Fernández, JL; Ledo Cepero, MJ; Ojeda Claro, AV; Ruiz Guerrero, E; Soto Delgado, M, 2021)
"Angiomyolipoma is a common benign tumor in the kidney."	( Guo, YH; Yang, MF, 2022)

Excerpt	Reference
"Epithelioid angiomyolipoma has malignant potential; however, no effective therapy has been established for advanced cases."	( Kamba, T; Kohno, J; Matsui, Y; Mikami, Y; Ogawa, O; Shibasaki, N; Sumiyoshi, S; Yamasaki, T; Yoshimura, K, 2013)
"Hepatic epithelioid angiomyolipoma has variable morphological features and characteristic immunohistochemical phenotype."	( Li, G; Wang, H; Xu, H; Zhang, X, 2014)

Excerpt	Reference
"Intriguingly, while pretreatment of angiomyolipoma cells with RAD001 attenuated CHOP and BiP induction, apoptotic markers cleaved PARP and caspase-3 and eukaryotic translation initiation factor 2α phosphorylation were increased, along with evidence of increased autophagy."	( Babcock, JT; Bissler, JJ; Dixon, BP; Hellmann, AR; Lu, L; Quilliam, LA; Siroky, BJ; Yin, H, 2012)
"ANG II treatment of angiomyolipoma cells in vitro resulted in an exaggerated intracellular Ca(2+) response and increased proliferation, which were blocked by the ANG II type 2 receptor antagonist valsartan."	( Bell, PD; Bissler, JJ; Bunni, M; Dillon, J; Dixon, BP; Hellmann, AR; Ramkumar, T; Reichert, RJ; Sampson, JR; Siroky, BJ; Tsuchihashi, Z; Yin, H, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	21 (6.56)	12.5806
2000's	75 (23.44)	18.1394
2010's	178 (55.63)	28.8240
2020's	46 (14.38)	9.53

Drug	Relationship Strength	Studies	Trials
creatine	low	2	0
dimethyl sulfoxide	low	1	0
iodine	low	2	0
niacinamide	low	1	0
pyridoxal phosphate	low	1	0
uric acid	low	1	0
xanthine	low	1	0
acetaminophen	low	1	0
amitriptyline	low	1	0
baclofen	low	1	0
candesartan	low	1	0
clonidine	low	1	0
pentetic acid	low	1	0
valproic acid	low	1	0
fluorouracil	low	1	0
gabexate	low	1	0
ibuprofen	low	1	0
iodixanol	low	1	0
iohexol	medium	11	1
iopromide	medium	6	1
losartan	low	1	0
nifedipine	low	1	0
tizanidine	low	1	0
prednisolone	low	1	0
spironolactone	low	1	0
prednisone	low	3	0
estrone	low	1	0
edetic acid	low	1	0
valine	low	1	0
perflutren	low	1	0
meglumine	low	2	0
quinazolines	low	1	0
perfluorobutane	low	2	0
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
sulfur hexafluoride	medium	10	1
fluorescein-5-isothiocyanate	low	1	0
enbucrilate	medium	3	2
platinum	low	1	0
tantalum	low	1	0
gadolinium	low	2	0
camptothecin	low	1	0
silver nitrate	low	1	0
phenyl acetate	low	2	0
chloroprene	low	1	0
technetium tc 99m mertiatide	low	2	0
valsartan	low	1	0
3-iodobenzylguanidine	low	1	0
iopamidol	low	3	0
iobitridol	low	1	0
fluorodeoxyglucose f18	low	16	0
mizoribine	low	1	0
tryptoline	low	1	0
imatinib mesylate	low	3	0
gefitinib	low	1	0
1,4,7-triazacyclononane-n,n',n''-triacetic acid	low	1	0
technetium tc 99m pentetate	low	1	0
angiotensin ii	low	1	0
sorafenib	low	1	0
leupeptins	low	1	0
carboplatin	low	1	0
glycogen	low	2	0
farnesol	low	1	0
tacrolimus	low	1	0
mycophenolic acid	low	1	0
carbon-11 acetate	low	1	0
dactinomycin	low	2	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
bromochloroacetic acid	low	9	0
isomethyleugenol	low	1	0
cannabidiol	low	1	0
iothalamate meglumine	low	1	0
tamoxifen	low	5	0
u 0126	low	1	0
sphingosine	low	1	0
sphingosine 1-phosphate	low	1	0
lysophosphatidic acid	low	1	0
cysteine	low	1	0
s-trans,trans-farnesylthiosalicylic acid	low	1	0
cefotaxime	low	1	0
gadolinium dtpa	low	26	0
shu 508	low	1	0
mart-1 antigen	low	32	0
homatropine methylbromide	low	3	0
indocyanine green	low	2	0
hes1 protein, human	low	1	0
meglumine ioxithalamate	low	1	0
salicylates	low	1	0
n,n'-bis(pyridoxal-5-phosphate)ethylenediamine-n,n'-diacetic acid	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	1	0
cyclin d1	low	2	0
gadoxetic acid disodium	low	8	0
technetium tc 99m dimercaptosuccinic acid	low	1	0
levoleucovorin	low	1	0
deoxyguanosine	low	2	0
hypoxanthine	low	1	0
dacarbazine	low	2	0
8-hydroxy-2'-deoxyguanosine	low	2	0

Protein Targets (1,384)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Beta-lactamase	0	2	0	2
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	8	0	0	8
GLS protein	7	0	0	7
Thrombopoietin	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
cytochrome P450 2D6 isoform 1	6	0	0	6
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	10	0	0	10
lethal factor (plasmid)	5	0	0	5
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	14	0	1	15
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
RAR-related orphan receptor gamma	19	0	0	19
ATAD5 protein, partial	9	0	0	9
Microtubule-associated protein tau	11	0	0	11
Smad3	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
thyroid stimulating hormone receptor	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
progesterone receptor	15	0	0	15
EWS/FLI fusion protein	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	18	0	0	18
estrogen-related nuclear receptor alpha	24	0	0	24
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator activated receptor gamma	18	0	0	18
aryl hydrocarbon receptor	10	0	0	10
chromobox protein homolog 1	10	0	0	10
thyroid hormone receptor beta isoform 2	16	0	0	16
peripheral myelin protein 22	16	0	0	16
cytochrome P450 3A4 isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	12	0	0	12
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Bile salt export pump	0	24	0	24
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	3	0	4
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	9	0	10
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	9	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	12	0	0	12
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	12	0	1	13
UDP-glucuronosyltransferase 1-6	0	0	0	2
Glutamate receptor 2	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	12	0	0	12
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	3
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	12	0	0	12
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	2	3	6
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	6	0	0	6
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	12	0	1	13
Gamma-aminobutyric acid receptor subunit beta-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-2	12	0	1	13
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	12	0	0	12
Canalicular multispecific organic anion transporter 1	0	17	0	17
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	12	0	0	12
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
USP1 protein, partial	18	0	0	18
NFKB1 protein, partial	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
cytochrome P450 2D6	8	0	0	8
arylsulfatase A	9	0	0	9
D(1A) dopamine receptor	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
muscarinic acetylcholine receptor M1	4	0	0	4
Solute carrier family 22 member 1	0	4	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	6	0	6
Albumin	0	0	2	2
High affinity nerve growth factor receptor	0	1	7	8
Aldo-keto reductase family 1 member B1	0	7	0	7
Muscarinic acetylcholine receptor M2	0	4	0	5
Muscarinic acetylcholine receptor M4	0	4	0	5
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	4	0	5
Alpha-2A adrenergic receptor	0	6	2	8
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	5
Angiotensin-converting enzyme	0	4	0	4
D(2) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	5	1	6
Alpha-2B adrenergic receptor	0	9	1	10
Alpha-2C adrenergic receptor	0	5	2	7
5-hydroxytryptamine receptor 1A	0	8	0	8
Muscarinic acetylcholine receptor M3	0	4	0	5
D(1A) dopamine receptor	0	5	0	5
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	3
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	6	1	7
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	8	0	8
5-hydroxytryptamine receptor 1B	0	6	0	6
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	7	1	8
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	4	0	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	9	0	9
Alpha-1A adrenergic receptor	0	8	1	9
Histamine H2 receptor	10	1	0	12
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	6	0	6
5-hydroxytryptamine receptor 7	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	2	0	2
Ataxin-2	14	0	0	14
Sigma non-opioid intracellular receptor 1	0	4	0	4
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
glucocerebrosidase	5	0	0	5
DNA polymerase kappa isoform 1	6	0	0	6
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	5	4	9
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	5	0	5
Type-1 angiotensin II receptor	0	8	4	16
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	5	0	5
phosphopantetheinyl transferase	8	0	0	8
GLI family zinc finger 3	17	0	0	17
AR protein	27	0	0	27
regulator of G-protein signaling 4	9	0	0	9
67.9K protein	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
activating transcription factor 6	13	0	0	13
Bloom syndrome protein isoform 1	9	0	0	9
lamin isoform A-delta10	16	0	0	16
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	6	0	0	6
PPM1D protein	7	0	0	7
polyprotein	6	0	0	6
vitamin D3 receptor isoform VDRA	11	0	0	11
survival motor neuron protein isoform d	10	0	0	10
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	13	0	0	13
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Aromatase	0	5	0	5
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
thyroid stimulating hormone receptor	5	0	0	5
Cellular tumor antigen p53	20	0	0	20
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Chain A, Ferritin light chain	9	0	0	9
Chain A, Cruzipain	5	0	0	5
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
TDP1 protein	24	0	0	24
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
huntingtin isoform 2	5	0	0	5
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
DNA polymerase iota isoform a (long)	9	0	0	9
nuclear receptor ROR-gamma isoform 1	11	0	0	11
geminin	22	0	0	22
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	1	6	7
Histone deacetylase 3	0	3	0	3
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Integrin beta-3	4	0	0	4
Integrin alpha-IIb	4	0	0	4
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	6
DNA topoisomerase 2-alpha	0	1	5	6
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	3	0	3
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	7	0	0	7
DNA topoisomerase 2-beta	0	0	5	6
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	3	0	3
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
acetylcholinesterase	10	0	0	10
glucocorticoid receptor [Homo sapiens]	22	0	0	22
pregnane X nuclear receptor	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Epidermal growth factor receptor	0	9	6	15
Receptor tyrosine-protein kinase erbB-2	0	4	3	7
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	6	0	6
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	7	0	7
Thromboxane-A synthase	0	3	0	3
Type-1 angiotensin II receptor	0	4	1	5
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Leukotriene B4 receptor 2	0	0	2	3
Acetylcholinesterase	0	2	0	2
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
Cytochrome P450 2A6	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 3A5	0	3	0	4
Cannabinoid receptor 1	0	1	0	2
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	1	1	2
Cytochrome P450 2C19	0	4	0	4
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	3	0	3
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	3	0	3
Cholinesterase	0	1	0	1
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
estrogen receptor 2 (ER beta)	11	0	0	11
G	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Inositol hexakisphosphate kinase 1	5	0	0	5
cytochrome P450 2C9, partial	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Albumin	0	1	2	3
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	1	0	2
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	1	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	3	0	3
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	3	0	0	3
Membrane primary amine oxidase	0	2	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
Alpha-1A adrenergic receptor	0	0	2	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Adenosine receptor A2b	0	1	1	2
Adenosine receptor A2a	0	4	1	5
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
D(2) dopamine receptor	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	4	0	4
Nischarin	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
interleukin 8	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
farnesoid X nuclear receptor	11	0	0	11
peroxisome proliferator-activated receptor delta	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	3	0	0	3
RAD51	0	1	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	7	0	0	7
Caspase-7	4	0	0	4
thyroid hormone receptor beta isoform a	5	0	0	5
caspase-3	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
ATP-dependent translocase ABCB1	0	6	2	10
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	1	0	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	2	5	7
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	13	0	0	13
Thymidine kinase, cytosolic	0	3	0	6
Deoxycytidine kinase	0	0	5	6
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	1	1	0	2
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
endonuclease IV	5	0	0	5
GALC protein	2	0	0	2
nonstructural protein 1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
hexokinase-4 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
glucokinase regulatory protein	1	0	0	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Rap guanine nucleotide exchange factor 3	2	0	0	2
Estrogen receptor	0	8	3	13
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Steryl-sulfatase	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Androgen receptor	0	7	0	8
Mu-type opioid receptor	0	0	1	1
Alpha-synuclein	4	1	0	5
Solute carrier organic anion transporter family member 1A1	0	2	0	2
TAR DNA-binding protein 43	3	0	0	3
Estrogen receptor beta	0	6	3	10
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	1	9
Bone morphogenetic protein receptor type-1B	0	0	5	5
Cell division cycle 7-related protein kinase	0	0	5	5
Serine/threonine-protein kinase PLK4	0	2	5	7
ATP-dependent RNA helicase DDX3X	0	0	5	5
Pyridoxal kinase	0	0	5	5
Citron Rho-interacting kinase	0	0	5	5
Aurora kinase A	0	2	5	7
Cyclin-G-associated kinase	0	1	5	6
Ephrin type-B receptor 6	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 3	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 2	0	1	5	6
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	5	5
Dynamin-like 120 kDa protein, mitochondrial	0	0	5	5
Eukaryotic translation initiation factor 5B	0	0	3	3
Rho-associated protein kinase 2	0	0	5	5
Serine/threonine-protein kinase ULK1	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	5	5
Ribosomal protein S6 kinase alpha-5	0	0	5	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	5	5
Ribosomal protein S6 kinase alpha-4	0	0	5	5
Serine/threonine-protein kinase 16	0	0	5	5
Serine/threonine-protein kinase 10	0	0	5	5
Serine/threonine-protein kinase D3	0	1	5	6
Structural maintenance of chromosomes protein 2	0	0	5	5
Mitogen-activated protein kinase kinase kinase 6	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	5	5
Serine/threonine-protein kinase LATS1	0	0	5	5
Serine/threonine-protein kinase PAK 4	0	2	5	7
Tyrosine-protein kinase ABL1	0	5	7	12
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	3	3
ADP/ATP translocase 2	0	0	5	5
Protein kinase C beta type	0	1	5	6
Insulin receptor	0	3	5	8
Tyrosine-protein kinase Lck	0	3	5	8
Tyrosine-protein kinase Fyn	0	1	5	6
Cyclin-dependent kinase 1	0	0	5	5
Glycogen phosphorylase, liver form	0	0	5	5
Tyrosine-protein kinase Fes/Fps	0	0	5	5
Adenine phosphoribosyltransferase	0	0	5	5
Tyrosine-protein kinase Yes	0	0	5	5
Tyrosine-protein kinase Lyn	0	0	5	5
Proto-oncogene tyrosine-protein kinase receptor Ret	0	4	5	9
Insulin-like growth factor 1 receptor	0	0	5	5
Signal recognition particle receptor subunit alpha	0	0	4	4
Cytochrome c1, heme protein, mitochondrial	0	0	5	5
Hepatocyte growth factor receptor	0	2	5	7
Tyrosine-protein kinase HCK	0	3	5	8
Platelet-derived growth factor receptor beta	0	4	5	9
Tyrosine-protein kinase Fgr	0	0	5	5
Serine/threonine-protein kinase A-Raf	0	1	5	6
Glycogen phosphorylase, brain form	0	0	5	5
Breakpoint cluster region protein	0	1	7	8
Serine/threonine-protein kinase pim-1	0	0	5	5
Fibroblast growth factor receptor 1	0	2	5	7
Cyclin-dependent kinase 4	0	1	5	6
ADP/ATP translocase 3	0	0	5	5
Inosine-5'-monophosphate dehydrogenase 2	0	2	5	7
Proto-oncogene tyrosine-protein kinase Src	0	3	5	8
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	5	5
Serine/threonine-protein kinase B-raf	0	5	6	11
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	5	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	5	5
Tyrosine-protein kinase Fer	0	0	5	5
Protein kinase C alpha type	0	1	5	6
cAMP-dependent protein kinase catalytic subunit alpha	0	0	5	5
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	5	5
Casein kinase II subunit alpha'	0	0	5	5
Ras-related protein Rab-6A	0	0	5	5
Ephrin type-A receptor 1	0	0	5	5
Multifunctional protein ADE2	0	0	5	5
cAMP-dependent protein kinase catalytic subunit gamma	0	0	4	4
cAMP-dependent protein kinase catalytic subunit beta	0	0	5	5
Ferrochelatase, mitochondrial	0	0	5	5
Ribosomal protein S6 kinase beta-1	0	0	5	5
Tyrosine-protein kinase JAK1	0	0	5	5
Cyclin-dependent kinase 2	0	2	5	7
Beta-adrenergic receptor kinase 1	0	0	5	5
Probable ATP-dependent RNA helicase DDX6	0	0	5	5
Mitogen-activated protein kinase 3	0	1	5	6
MAP/microtubule affinity-regulating kinase 3	0	0	5	5
Mitogen-activated protein kinase 1	0	1	5	6
Ephrin type-A receptor 2	0	0	5	5
Ephrin type-B receptor 2	0	0	5	5
Non-receptor tyrosine-protein kinase TYK2	0	0	5	5
UMP-CMP kinase	0	0	4	4
Phosphatidylethanolamine-binding protein 1	0	0	4	4
Wee1-like protein kinase	0	0	5	5
Heme oxygenase 2	0	0	5	5
S-adenosylmethionine synthase isoform type-2	0	0	5	5
DnaJ homolog subfamily A member 1	0	0	5	5
RAC-alpha serine/threonine-protein kinase	0	2	5	7
RAC-beta serine/threonine-protein kinase	0	0	5	5
Dual specificity protein kinase TTK	0	0	5	5
DNA replication licensing factor MCM4	0	0	5	5
Myosin-10	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 2	0	1	5	6
Receptor-type tyrosine-protein kinase FLT3	0	3	5	9
Bone morphogenetic protein receptor type-1A	0	0	5	5
Activin receptor type-1B	0	0	5	5
TGF-beta receptor type-1	0	0	5	5
TGF-beta receptor type-2	0	0	5	5
Electron transfer flavoprotein subunit beta	0	0	5	5
Tyrosine-protein kinase CSK	0	0	5	5
Glycine--tRNA ligase	0	0	5	5
Protein kinase C iota type	0	1	5	6
Exosome RNA helicase MTR4	0	0	5	5
Serine/threonine-protein kinase mTOR	0	6	5	11
Tyrosine-protein kinase Tec	0	0	5	5
Tyrosine-protein kinase ABL2	0	0	5	5
Tyrosine-protein kinase FRK	0	0	5	5
G protein-coupled receptor kinase 6	0	0	5	5
Tyrosine-protein kinase SYK	0	0	5	5
26S proteasome regulatory subunit 6B	0	0	5	5
Mitogen-activated protein kinase 8	0	0	5	5
Mitogen-activated protein kinase 9	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 3	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	5	5
Casein kinase I isoform alpha	0	3	5	8
Casein kinase I isoform delta	0	0	5	5
MAP kinase-activated protein kinase 2	0	0	5	5
Elongation factor Tu, mitochondrial	0	0	5	5
Choline-phosphate cytidylyltransferase A	0	0	3	3
Cysteine--tRNA ligase, cytoplasmic	0	0	5	5
Casein kinase I isoform epsilon	0	0	5	5
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	5	5
Dual specificity protein kinase CLK1	0	0	5	5
Dual specificity protein kinase CLK2	0	0	5	5
Dual specificity protein kinase CLK3	0	0	5	5
Glycogen synthase kinase-3 alpha	0	0	5	5
Glycogen synthase kinase-3 beta	0	1	5	6
Cyclin-dependent kinase 7	0	0	5	5
Cyclin-dependent kinase 9	0	0	5	5
Ras-related protein Rab-27A	0	0	5	5
Interleukin-1 receptor-associated kinase 1	0	0	5	5
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Ribosomal protein S6 kinase alpha-3	0	1	5	6
Serine/threonine-protein kinase Nek2	0	1	5	6
Serine/threonine-protein kinase Nek3	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 6	0	0	5	5
Serine/threonine-protein kinase PLK1	0	3	5	8
LIM domain kinase 1	0	0	5	5
LIM domain kinase 2	0	0	5	5
Mitogen-activated protein kinase 10	0	0	5	5
Tyrosine--tRNA ligase, cytoplasmic	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-1	0	0	5	5
Ephrin type-B receptor 3	0	0	5	5
Ephrin type-A receptor 5	0	0	5	5
Ephrin type-B receptor 4	0	3	5	8
Ephrin type-A receptor 4	0	0	5	5
Adenylate kinase 2, mitochondrial	0	0	5	5
Adenosine kinase	0	0	5	5
Ras-related protein Rab-10	0	0	5	5
Actin-related protein 3	0	0	5	5
Actin-related protein 2	0	0	5	5
GTP-binding nuclear protein Ran	0	0	5	5
Casein kinase I isoform gamma-2	0	0	5	5
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase 6	0	1	5	6
Cyclin-dependent-like kinase 5	0	0	5	5
Cyclin-dependent kinase 16	0	0	5	5
Cyclin-dependent kinase 17	0	0	5	5
ATP-dependent 6-phosphofructokinase, platelet type	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 1	0	2	5	7
Protein kinase C theta type	0	1	5	6
Activin receptor type-1	0	0	5	5
Macrophage-stimulating protein receptor	0	0	5	5
Focal adhesion kinase 1	0	1	5	6
Protein kinase C delta type	0	1	5	6
Tyrosine-protein kinase BTK	0	0	5	5
Activated CDC42 kinase 1	0	0	5	5
Epithelial discoidin domain-containing receptor 1	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	5	5
Serine/threonine-protein kinase 4	0	0	5	5
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	5	6
Dual specificity mitogen-activated protein kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase 7	0	0	5	5
Serine/threonine-protein kinase PAK 2	0	0	5	5
Serine/threonine-protein kinase 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 1	0	0	5	5
Integrin-linked protein kinase	0	0	5	5
Rho-associated protein kinase 1	0	0	5	5
Non-receptor tyrosine-protein kinase TNK1	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	5	5
Activin receptor type-2B	0	0	5	5
Bone morphogenetic protein receptor type-2	0	0	5	5
Protein-tyrosine kinase 6	0	0	5	5
cGMP-dependent protein kinase 1	0	0	5	5
Cyclin-dependent kinase 13	0	0	5	5
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	5	5
Protein-tyrosine kinase 2-beta	0	0	5	5
Maternal embryonic leucine zipper kinase	0	0	5	5
Structural maintenance of chromosomes protein 1A	0	0	5	5
Chromodomain-helicase-DNA-binding protein 4	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 1	0	0	5	5
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	5	5
Ribosomal protein S6 kinase alpha-1	0	1	5	6
Dual specificity testis-specific protein kinase 1	0	0	5	5
Myosin light chain kinase, smooth muscle	0	1	5	6
Mitogen-activated protein kinase 11	0	0	5	5
Serine/threonine-protein kinase STK11	0	0	5	5
Serine/threonine-protein kinase N1	0	0	5	5
Serine/threonine-protein kinase N2	0	0	5	5
Mitogen-activated protein kinase 14	0	2	5	7
Calcium/calmodulin-dependent protein kinase type IV	0	0	5	5
Mitogen-activated protein kinase kinase kinase 11	0	0	5	5
AP2-associated protein kinase 1	0	1	5	6
Myosin light chain kinase 3	0	0	5	5
Putative heat shock protein HSP 90-beta 2	0	0	5	5
Serine/threonine-protein kinase MRCK alpha	0	0	5	5
Serine/threonine-protein kinase MRCK gamma	0	0	5	5
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase N3	0	0	5	5
Serine/threonine-protein kinase ULK3	0	0	5	5
Uncharacterized protein FLJ45252	0	0	5	5
Acyl-CoA dehydrogenase family member 11	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	4	4
Serine/threonine-protein kinase MARK2	0	0	5	5
ATP-dependent RNA helicase DHX30	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	5	5
STE20-related kinase adapter protein alpha	0	0	5	5
Myosin-14	0	0	5	5
AarF domain-containing protein kinase 1	0	0	5	5
ATP-dependent RNA helicase DDX42	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	5	5
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	5	5
Mitogen-activated protein kinase 15	0	0	5	5
Serine/threonine-protein kinase Nek9	0	0	5	5
Serine/threonine-protein kinase Nek7	0	0	4	4
ATP-dependent RNA helicase DDX1	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	5	5
Aurora kinase B	0	1	5	6
MAP/microtubule affinity-regulating kinase 4	0	0	5	5
Serine/threonine-protein kinase Nek1	0	0	5	5
PAS domain-containing serine/threonine-protein kinase	0	0	5	5
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	5	5
EKC/KEOPS complex subunit TP53RK	0	0	5	5
Dual specificity testis-specific protein kinase 2	0	0	3	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase kinase kinase 3	0	0	5	5
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	5	5
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	5	5
Serine/threonine-protein kinase D2	0	0	5	5
NUAK family SNF1-like kinase 2	0	0	4	4
RNA cytidine acetyltransferase	0	0	5	5
Serine/threonine-protein kinase SIK2	0	0	5	5
STE20-like serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO3	0	0	5	5
dCTP pyrophosphatase 1	0	0	5	5
Dual specificity protein kinase CLK4	0	0	5	5
Casein kinase I isoform gamma-1	0	0	5	5
Phenylalanine--tRNA ligase beta subunit	0	0	5	5
BMP-2-inducible protein kinase	0	0	5	5
Obg-like ATPase 1	0	0	5	5
Midasin	0	0	5	5
Interleukin-1 receptor-associated kinase 4	0	0	5	5
Mitogen-activated protein kinase kinase kinase 20	0	0	5	5
Cyclin-dependent kinase 12	0	0	5	5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase 26	0	0	5	5
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	5	5
Serine/threonine-protein kinase NLK	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-2	0	0	5	5
Serine/threonine-protein kinase TBK1	0	1	5	6
Septin-9	0	0	5	5
Potassium voltage-gated channel subfamily D member 3	0	2	0	2
Ribosomal protein S6 kinase alpha-6	0	0	5	5
TRAF2 and NCK-interacting protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO2	0	0	5	5
Long-chain-fatty-acid--CoA ligase 5	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase SIK3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 2	0	0	5	5
Thyroid hormone receptor-associated protein 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 3	0	1	5	6
Serine/threonine-protein kinase MRCK beta	0	0	5	5
Interleukin-1 receptor-associated kinase 3	0	0	5	5
Casein kinase I isoform gamma-3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 4	0	0	5	5
heat shock protein beta-1	4	0	0	4
Neuraminidase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	10	0	0	10
glp-1 receptor, partial	4	0	0	4
Skn7p	0	0	0	1
pregnane X receptor	5	0	0	5
IDH1	7	0	0	7
flap endonuclease 1	3	0	0	3
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	1	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	2	0	2
Coagulation factor XII	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Serine protease hepsin	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Leukotriene C4 synthase	0	0	3	3
epidermal growth factor receptor isoform a precursor	1	1	0	2
tyrosine-protein kinase Yes	3	0	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	3	3	6
Serine/threonine-protein kinase 25	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	3	3
Serine/threonine-protein kinase RIO3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 7	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	3	3
Peripheral plasma membrane protein CASK	0	0	3	3
Serine/threonine-protein kinase DCLK1	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	3	3
Muscle, skeletal receptor tyrosine-protein kinase	0	0	3	3
Mitogen-activated protein kinase 13	0	0	3	3
3-phosphoinositide-dependent protein kinase 1	0	0	3	3
Mitogen-activated protein kinase kinase kinase 13	0	0	3	3
Death-associated protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 7	0	0	3	3
NUAK family SNF1-like kinase 1	0	1	3	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	3	3
Tyrosine-protein kinase JAK2	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	3	3
Serine/threonine-protein kinase PAK 3	0	0	3	3
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 17B	0	0	3	3
Cyclin-dependent kinase 14	0	0	3	3
Serine/threonine-protein kinase OSR1	0	0	3	3
Serine/threonine-protein kinase Chk2	0	1	3	4
RAF proto-oncogene serine/threonine-protein kinase	0	4	3	7
Cytochrome P450 2E1	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	2	3	5
Proto-oncogene tyrosine-protein kinase ROS	0	0	3	3
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	3	3
Uncharacterized serine/threonine-protein kinase SBK3	0	0	3	3
Cytochrome P450 2C8	0	1	0	2
Mast/stem cell growth factor receptor Kit	0	5	4	9
Myosin light chain kinase, smooth muscle	0	0	3	3
Insulin receptor-related protein	0	0	3	3
Platelet-derived growth factor receptor alpha	0	4	4	8
Vascular endothelial growth factor receptor 1	0	3	3	6
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	3	3
Serine/threonine-protein kinase MAK	0	0	3	3
Cyclin-dependent kinase 11B	0	0	3	3
Fibroblast growth factor receptor 2	0	0	3	3
Receptor tyrosine-protein kinase erbB-3	0	1	3	4
Fibroblast growth factor receptor 4	0	0	3	3
Fibroblast growth factor receptor 3	0	0	3	3
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C eta type	0	1	3	4
Cruzipain	0	1	0	1
Activin receptor type-2A	0	0	3	3
Ephrin type-A receptor 3	0	0	3	3
Ephrin type-A receptor 8	0	0	3	3
Leukocyte tyrosine kinase receptor	0	0	3	3
Tyrosine-protein kinase receptor UFO	0	1	3	4
Mitogen-activated protein kinase 4	0	0	3	3
G protein-coupled receptor kinase 4	0	0	3	3
Tyrosine-protein kinase receptor Tie-1	0	0	3	3
Vascular endothelial growth factor receptor 3	0	3	3	6
Vascular endothelial growth factor receptor 2	0	6	4	11
Serine/threonine-protein kinase receptor R3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	3	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	3	3	6
Megakaryocyte-associated tyrosine-protein kinase	0	0	3	3
Tyrosine-protein kinase TXK	0	0	3	3
Tyrosine-protein kinase ZAP-70	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	3	3	6
Cyclin-dependent kinase 8	0	1	3	4
Tyrosine-protein kinase Blk	0	0	3	3
Cytoplasmic tyrosine-protein kinase BMX	0	0	3	3
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	3	3
Serine/threonine-protein kinase Nek4	0	0	3	3
Tyrosine-protein kinase JAK3	0	1	3	4
Death-associated protein kinase 1	0	0	3	3
Mitogen-activated protein kinase 12	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	3	4
Ephrin type-B receptor 1	0	0	3	3
Beta-secretase 1	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	3	3
Serine/threonine-protein kinase SIK1	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 4	0	0	3	3
Cell division control protein 2 homolog	0	0	3	3
Calcium-dependent protein kinase 1	0	0	3	3
Tubulin alpha-1A chain	0	0	3	3
Casein kinase II subunit alpha	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	3	3
SRSF protein kinase 2	0	0	3	3
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Mitogen-activated protein kinase kinase kinase 9	0	0	3	3
Serine/threonine-protein kinase PknB	0	0	3	3
Cyclin-dependent kinase-like 1	0	0	3	3
Synaptic vesicular amine transporter	0	1	0	1
Protein kinase C epsilon type	0	1	3	4
Angiopoietin-1 receptor	0	2	3	5
Mitogen-activated protein kinase kinase kinase 10	0	0	3	3
Transcription factor p65	0	1	0	1
Protein kinase C zeta type	0	1	4	5
Tyrosine-protein kinase receptor TYRO3	0	0	3	3
Cyclin-dependent kinase 18	0	0	4	4
Tyrosine-protein kinase ITK/TSK	0	0	3	3
Myotonin-protein kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 12	0	0	3	3
Tyrosine-protein kinase Mer	0	1	4	5
Serine/threonine-protein kinase PAK 1	0	0	3	3
cGMP-dependent protein kinase 2	0	0	3	3
Serine/threonine-protein kinase PRP4 homolog	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 1	0	1	3	4
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	3	3
Calcium/calmodulin-dependent protein kinase type 1	0	0	3	3
Serine/threonine-protein kinase D1	0	1	3	4
Serine/threonine-protein kinase 38	0	0	3	3
Receptor tyrosine-protein kinase erbB-4	0	1	3	4
Ribosomal protein S6 kinase alpha-2	0	0	3	3
Rhodopsin kinase GRK1	0	0	3	3
NT-3 growth factor receptor	0	0	3	3
BDNF/NT-3 growth factors receptor	0	0	3	3
Mitogen-activated protein kinase 6	0	0	3	3
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	3	3
Uncharacterized aarF domain-containing protein kinase 5	0	0	3	3
Serine/threonine-protein kinase ULK3	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	3	3
Mitogen-activated protein kinase kinase kinase 19	0	0	3	3
Serine/threonine-protein kinase TNNI3K	0	1	3	4
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	3	4
Serine/threonine-protein kinase Nek5	0	0	3	3
Dual serine/threonine and tyrosine protein kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 15	0	0	3	3
Serine/threonine-protein kinase tousled-like 2	0	0	3	3
Serine/threonine-protein kinase 32C	0	0	3	3
Serine/threonine-protein kinase pim-3	0	0	3	3
Serine/threonine-protein kinase VRK2	0	0	3	3
Myosin light chain kinase family member 4	0	0	3	3
Homeodomain-interacting protein kinase 1	0	1	3	4
Calcium/calmodulin-dependent protein kinase type 1D	0	0	3	3
Cyclin-dependent kinase-like 3	0	0	3	3
MAP kinase-activated protein kinase 5	0	1	4	5
Serine/threonine-protein kinase BRSK2	0	0	3	3
Serine/threonine-protein kinase NIM1	0	0	3	3
Serine/threonine-protein kinase ULK2	0	0	3	3
Misshapen-like kinase 1	0	0	4	4
Serine/threonine-protein kinase DCLK2	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	3	3
Casein kinase I isoform alpha-like	0	0	3	3
Homeodomain-interacting protein kinase 4	0	1	3	4
Myosin-IIIa	0	0	3	3
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	3	3
Serine/threonine-protein kinase Nek11	0	0	3	3
Serine/threonine-protein kinase BRSK1	0	0	3	3
Serine/threonine-protein kinase 35	0	0	3	3
Rhodopsin kinase GRK7	0	0	3	3
Serine/threonine-protein kinase 32A	0	0	3	3
Myosin-IIIb	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	3	3
Cyclin-dependent kinase-like 2	0	0	3	3
Serine/threonine-protein kinase Sgk3	0	0	3	3
Atypical kinase COQ8B, mitochondrial	0	0	3	3
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Cyclin-dependent kinase 15	0	0	3	3
SRSF protein kinase 1	0	0	3	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	3	3
Serine/threonine-protein kinase RIO1	0	0	3	3
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase RIO2	0	0	3	3
Cyclin-dependent kinase 19	0	1	3	4
Transient receptor potential cation channel subfamily M member 6	0	0	3	3
Testis-specific serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase 33	0	0	3	3
Serine/threonine-protein kinase DCLK3	0	0	3	3
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	3	3
Homeodomain-interacting protein kinase 2	0	1	3	4
Tyrosine-protein kinase Srms	0	0	3	3
Homeodomain-interacting protein kinase 3	0	1	3	4
Serine/threonine-protein kinase PLK3	0	2	3	5
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	3	4
Serine/threonine-protein kinase Nek6	0	0	3	3
Serine/threonine-protein kinase PAK 6	0	1	3	4
SNF-related serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase LATS2	0	0	3	3
Serine/threonine-protein kinase 36	0	0	3	3
Isoleucine--tRNA ligase, mitochondrial	0	0	4	4
Serine/threonine-protein kinase 32B	0	0	3	3
Serine/threonine-protein kinase PLK2	0	2	3	5
Serine/threonine-protein kinase MARK1	0	0	3	3
Serine/threonine-protein kinase pim-2	0	0	3	3
Serine/threonine-protein kinase PAK 5	0	1	3	4
eIF-2-alpha kinase GCN2	0	0	3	3
Phosphatidylinositol 4-kinase beta	0	0	3	3
Serine/threonine-protein kinase 17A	0	0	3	3
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	3	3
Ephrin type-A receptor 6	0	0	3	3
Death-associated protein kinase 2	0	0	3	3
Serine/threonine-protein kinase tousled-like 1	0	0	3	3
ALK tyrosine kinase receptor	0	1	3	4
SRSF protein kinase 3	0	0	3	3
Serine/threonine-protein kinase ICK	0	0	4	4
Cyclin-dependent kinase 11A	0	0	3	3
Aurora kinase C	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	3	3
Serine/threonine-protein kinase 38-like	0	0	3	3
Microtubule-associated serine/threonine-protein kinase 1	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
Chain E, Fibrin beta chain	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
hypothetical protein, conserved	2	0	0	2
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	2	0	2
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	2	0	2
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Purine nucleoside phosphorylase	0	0	1	2
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	0	1
Cholinesterase	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	4
Acetylcholinesterase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
DNA repair protein RAD52 homolog isoform a	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Neprilysin	0	1	0	1
Thromboxane A2 receptor	0	1	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Squalene synthase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Platelet glycoprotein VI	0	1	2	4
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Lysophosphatidic acid receptor 6	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 1	0	0	2	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 5	0	0	1	1
Lysophosphatidic acid receptor 2	0	0	1	1
Lysophosphatidic acid receptor 3	0	0	1	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	3	1	4
Adenosine receptor A1	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	6	3	14
Progesterone receptor	0	5	1	7
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Mineralocorticoid receptor	0	4	1	6
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Protein-S-isoprenylcysteine O-methyltransferase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Protein-S-isoprenylcysteine O-methyltransferase	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Membrane-associated progesterone receptor component 1	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	2	0	2
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	2	0	2
Protein delta homolog 1	0	1	2	3
Serine/threonine-protein kinase ATR	0	0	2	2
MAP kinase-activated protein kinase 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Rab-like protein 3	0	0	2	2
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
acid sphingomyelinase	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	2	2
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	2	0	2
Estrogen receptor	0	0	2	3
Protein kinase C delta type	0	2	0	2
Protein kinase C epsilon type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Estrogen receptor beta	0	0	2	3
Protein kinase C eta type	0	2	0	2
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	2	0	2
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Translocator protein	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Cyclin-dependent kinase 10	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
Transmembrane protease serine 2	0	0	1	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Procathepsin L	0	0	1	1
Beta-1 adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Phospholipase D1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Malate dehydrogenase	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	2	0	2
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Ricin	0	1	0	1
Xanthine dehydrogenase/oxidase	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (320)

Protein Targets (1,384)

Angiomyolipoma

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (320)

Drugs Studied (119)

Protein Targets (1,384)