Protein-arginine deiminase type-1

A protein-arginine deiminase type-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULC6]

EC 3.5.3.15;
Peptidylarginine deiminase I;
Protein-arginine deiminase type I

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
streptonigrin	Homo sapiens (human)	IC50	48.3000	1	1

This protein enables 2 target(s):

Target	Category	Definition
protein-arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]