felbamate has been researched along with Anemia, Hypoplastic in 17 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Felbamate has been approved for refractory partial seizures since the early nineties." | 5.42 | The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015) |
| "Felbamate is a novel anti-epileptic drug (AED) which has recently been associated with reports of aplastic anaemia and liver failure." | 5.08 | Felbamate as add-on therapy. ( Duncan, JS; Li, LM; Moriarty, J; Nashef, L; Sander, JW, 1996) |
| "Since 1993, eight new antiepileptic drugs (AEDs) have become available in the United States for the treatment of epilepsy: felbamate, gabapentin, lamotrigine, topiramate, tiagabine, levetiracetam, oxcarbazepine, and zonisamide." | 4.81 | Some common issues in the use of antiepileptic drugs. ( Asconapé, JJ, 2002) |
| " More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0." | 4.79 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| "This single center analysis retrospectively evaluated the safety and efficacy of felbamate in a cohort of children, adolescents, and adults with epilepsy." | 3.83 | Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience. ( Devinsky, O; Friedman, D; Kothare, SV; Shah, YD; Singh, K, 2016) |
| "Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported." | 2.40 | Evaluation of case reports of aplastic anemia among patients treated with felbamate. ( Anderson, T; Harmon, DC; Kaufman, DW; Kelly, JP; Shapiro, S, 1997) |
| "Felbamate (FBM) was the first of the new antiepileptic drugs (AEDs) approved in the United States in 1993 with broad-spectrum efficacy against partial and generalized seizures of various types, and indicated for use as adjunctive and monotherapy." | 2.40 | Felbamate. ( Pellock, JM, 1999) |
| "Felbamate has been approved for refractory partial seizures since the early nineties." | 1.42 | The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015) |
| "Laboratory studies revealed very severe aplastic anemia." | 1.29 | Aplastic anemia in a patient receiving felbamate for complex partial seizures. ( Macdonald, RL; Ogaily, MS; Pennell, PB, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (70.59) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thakkar, K | 1 |
| Billa, G | 1 |
| Rane, J | 1 |
| Chudasama, H | 1 |
| Goswami, S | 1 |
| Shah, R | 1 |
| Shah, YD | 1 |
| Singh, K | 1 |
| Friedman, D | 1 |
| Devinsky, O | 1 |
| Kothare, SV | 1 |
| Asconapé, JJ | 1 |
| Popović, M | 1 |
| Nierkens, S | 1 |
| Pieters, R | 1 |
| Uetrecht, J | 1 |
| Brodie, MJ | 2 |
| Pellock, JM | 3 |
| Schmidt, D | 1 |
| Krämer, G | 1 |
| Rayson, D | 1 |
| Kang, EM | 1 |
| Inwards, DJ | 1 |
| Pennell, PB | 1 |
| Ogaily, MS | 1 |
| Macdonald, RL | 1 |
| Nightingale, SL | 1 |
| Li, LM | 1 |
| Nashef, L | 1 |
| Moriarty, J | 1 |
| Duncan, JS | 1 |
| Sander, JW | 1 |
| Avanzini, G | 1 |
| Canger, R | 1 |
| Dalla Bernardina, B | 1 |
| Vigevano, F | 1 |
| Kaufman, DW | 1 |
| Kelly, JP | 1 |
| Anderson, T | 1 |
| Harmon, DC | 1 |
| Shapiro, S | 1 |
| Foletti, GB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Normalization of Sodium on Bone Markers in Patients With Epilepsy. A Randomized Single-blinded Placebo-controlled Trial.[NCT03371199] | 21 participants (Actual) | Interventional | 2017-12-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for felbamate and Anemia, Hypoplastic
| Article | Year |
|---|---|
Some common issues in the use of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Anticonvulsants; Body Weight; Cognition Disorders; Drug E | 2002 |
The new anticonvulsant drugs. Implications for avoidance of adverse effects.
Topics: Abnormalities, Drug-Induced; Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Inju | 1994 |
Evaluation of case reports of aplastic anemia among patients treated with felbamate.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anemia, Aplastic; Anticonvulsants; Causality; Confou | 1997 |
Felbamate.
Topics: Adult; Age Factors; Anemia, Aplastic; Anorexia; Anticonvulsants; Child; Drug Administration Schedule | 1999 |
2 trials available for felbamate and Anemia, Hypoplastic
| Article | Year |
|---|---|
Felbamate as add-on therapy.
Topics: Adult; Anemia, Aplastic; Anticonvulsants; Epilepsy; Felbamate; Follow-Up Studies; Humans; Liver Fail | 1996 |
Felbamate in therapy-resistant epilepsy: an Italian experience. Felbamate Italian Study Group.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Anticonvulsants; Child; Child, Preschool; Drug Resistance | 1996 |
11 other studies available for felbamate and Anemia, Hypoplastic
| Article | Year |
|---|---|
The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame?
Topics: Anemia, Aplastic; Anticonvulsants; Drug Resistant Epilepsy; Epilepsies, Partial; Felbamate; Humans; | 2015 |
Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience.
Topics: Adolescent; Adult; Age of Onset; Anemia, Aplastic; Anticonvulsants; Child; Cohort Studies; Drug Labe | 2016 |
Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions.
Topics: Aldehydes; Anemia, Aplastic; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Felba | 2004 |
Taming the brain storms: felbamate updated.
Topics: Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Approval; Drug Monit | 1995 |
27-year-old woman with pancytopenia.
Topics: Adult; Anemia, Aplastic; Anticonvulsants; Felbamate; Female; Humans; Pancytopenia; Phenylcarbamates; | 1995 |
Felbamate linked to aplastic anemia; warning issued on drug's use.
Topics: Anemia, Aplastic; Drug Labeling; Felbamate; Humans; Phenylcarbamates; Propylene Glycols | 1994 |
Aplastic anemia in a patient receiving felbamate for complex partial seizures.
Topics: Anemia, Aplastic; Anticonvulsants; Epilepsy, Complex Partial; Felbamate; Female; Humans; Middle Aged | 1995 |
From the Food and Drug Administration.
Topics: Administration, Oral; Anemia, Aplastic; Anticonvulsants; Dosage Forms; Drug and Narcotic Control; Dr | 1994 |
FDA recommends taking patients off Felbatol.
Topics: Anemia, Aplastic; Anticonvulsants; Felbamate; Humans; Phenylcarbamates; Product Surveillance, Postma | 1994 |
Felbamate: 1997 update.
Topics: Anemia, Aplastic; Anticonvulsants; Drug Approval; Epilepsy; Felbamate; Humans; Liver Failure; Phenyl | 1997 |
[Clinical utilization of new anti-epileptic agents].
Topics: Acetates; Amines; Anemia, Aplastic; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dru | 2000 |