fluorouracil has been researched along with Anemia, Hypoplastic in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin." | 8.86 | Interaction between capecitabine and brivudin in a patient with breast cancer. ( Baena-Cañada, JM; García-Olmedo, O; Jiménez-Bárcenas, R; Martínez, MJ; Muriel-Cueto, P, 2010) |
| "A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin." | 4.86 | Interaction between capecitabine and brivudin in a patient with breast cancer. ( Baena-Cañada, JM; García-Olmedo, O; Jiménez-Bárcenas, R; Martínez, MJ; Muriel-Cueto, P, 2010) |
| "Bone marrow from aplastic anemia (AA) patients shows reduced numbers in long-term culture (LTC)-initiating cell (LTC-IC) assays." | 1.32 | Quiescent (5-fluorouracil-resistant) aplastic anemia hematopoietic cells in vitro. ( Draycott, GS; Foukaneli, T; Gibson, FM; Gordon-Smith, EC; Pocock, C; Rizzo, S; Rutherford, TR; Scopes, J, 2004) |
| "5-FU combined with busulfan could impair the hematopoietic stem cells and resulted in an irreversible aplastic anemia in rats, making a rat aplastic anemia model with hematopoietic stem cell failure." | 1.31 | [A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan]. ( Chu, J; Ding, S; Liu, A; Wang, S; Xu, S; Zhao, J, 2001) |
| " Administration of 250 IU/kg/day of IFN-gamma in combination with 10(3) U/kg/day of IL-3, which alone had no effect on platelet counts, diminished the nadir for platelet count and shortened the duration of thrombocytopenia." | 1.29 | IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow aplasia. ( Harashima, A; Izumi, N; Kurimoto, M; Namba, M; Nishida, Y; Ohta, T; Okuda, Y; Tahata, H; Tsuji-Takayama, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, M | 1 |
| Chase, J | 1 |
| Brinkmeier, M | 1 |
| Xu, J | 1 |
| Weinberg, DN | 1 |
| Schira, J | 1 |
| Friedman, A | 1 |
| Malek, S | 1 |
| Grembecka, J | 1 |
| Cierpicki, T | 1 |
| Dou, Y | 1 |
| Camper, SA | 1 |
| Maillard, I | 1 |
| Baena-Cañada, JM | 1 |
| Martínez, MJ | 1 |
| García-Olmedo, O | 1 |
| Jiménez-Bárcenas, R | 1 |
| Muriel-Cueto, P | 1 |
| Chu, JX | 1 |
| Zhao, JM | 1 |
| Ding, SL | 1 |
| Xu, SC | 1 |
| Liu, AR | 1 |
| Wang, SP | 1 |
| Rizzo, S | 1 |
| Scopes, J | 1 |
| Draycott, GS | 1 |
| Pocock, C | 1 |
| Foukaneli, T | 1 |
| Rutherford, TR | 1 |
| Gordon-Smith, EC | 1 |
| Gibson, FM | 1 |
| Beuzeboc, P | 1 |
| Pierga, JY | 1 |
| Lyonnet, DS | 1 |
| Couturier, J | 1 |
| Pouillart, P | 1 |
| Tsuji-Takayama, K | 1 |
| Harashima, A | 1 |
| Tahata, H | 1 |
| Izumi, N | 1 |
| Nishida, Y | 1 |
| Namba, M | 1 |
| Okuda, Y | 1 |
| Ohta, T | 1 |
| Kurimoto, M | 1 |
| Zhao, J | 1 |
| Chu, J | 1 |
| Ding, S | 1 |
| Xu, S | 1 |
| Liu, A | 1 |
| Wang, S | 1 |
| Lokich, JJ | 1 |
| Skarin, AT | 1 |
| Goldfinger, D | 1 |
| McGinniss, MH | 1 |
| Pivniuk, VM | 1 |
| Buklina, ZP | 1 |
| Ezerskaia, LIa | 1 |
| Brocard, H | 1 |
| Akoun, G | 1 |
2 reviews available for fluorouracil and Anemia, Hypoplastic
| Article | Year |
|---|---|
Interaction between capecitabine and brivudin in a patient with breast cancer.
Topics: Aged; Anemia, Aplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2010 |
[Severe 5-fluorouracil toxicity in a woman treated for breast cancer with concurrent osteogenesis imperfecta and dehydrogenase deficiency].
Topics: Anemia, Aplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; B | 1996 |
1 trial available for fluorouracil and Anemia, Hypoplastic
| Article | Year |
|---|---|
Combination therapy with 5-fluorouracil (5-FU; NSC-19893) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) for disseminated gastrointestinal carcinoma.
Topics: Adult; Aged; Anemia, Aplastic; Blood Cell Count; Carcinoma; Clinical Trials as Topic; Colonic Neopla | 1972 |
9 other studies available for fluorouracil and Anemia, Hypoplastic
| Article | Year |
|---|---|
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.
Topics: Anemia, Aplastic; Animals; Animals, Newborn; Bone Marrow Diseases; Bone Marrow Failure Disorders; Bo | 2015 |
[Activation of auto-mesenchymal stem cells of skeletal muscle by bone morphogenetic protein for rescuing bone marrow failure].
Topics: Anemia, Aplastic; Animals; Bone Morphogenetic Proteins; Busulfan; Cell Differentiation; Female; Fluo | 2002 |
Quiescent (5-fluorouracil-resistant) aplastic anemia hematopoietic cells in vitro.
Topics: Anemia, Aplastic; Bone Marrow Cells; Cell Culture Techniques; Cell Division; Drug Resistance; Fluoro | 2004 |
IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow aplasia.
Topics: Anemia, Aplastic; Animals; Drug Therapy, Combination; Fluorouracil; Infusion Pumps, Implantable; Int | 1996 |
[A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan].
Topics: Anemia, Aplastic; Animals; Blood Cell Count; Busulfan; Disease Models, Animal; Female; Fluorouracil; | 2001 |
[Delayed post-transfusional hemolysis, leukemoid syndrome, autoimmune hemolytic anemia. Coordinating Committee for the Specific Study of Anemias under the chairmanship of H. Rochant].
Topics: Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Colonic Neoplasms; Female; Flu | 1987 |
Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibodies; Antibody Formation; Blood Group Incompatibili | 1971 |
[Hematopoietic changes following use of fluorouracil in animals with toxic hepatitis].
Topics: Anemia, Aplastic; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; F | 1970 |
[The results of attack polychemotherapy in broncho-pleuro-pulmonary cancer. Phytohemagglutinin in the prevention and treatment of hematologic complications of antimitotics].
Topics: Anemia, Aplastic; Antibiotics, Antineoplastic; Antineoplastic Agents; Azirines; Bronchial Neoplasms; | 1968 |