A sentrin-specific protease 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC62]
EC 3.4.22.-;
Axam2;
SMT3-specific isopeptidase 2;
Smt3ip2;
Sentrin/SUMO-specific protease SENP2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| streptonigrin | Homo sapiens (human) | IC50 | 6.9000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| SUMO-specific endopeptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO. [GOC:mah] |
| deSUMOylase activity | molecular function | An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nuclear pore | cellular component | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. [ISBN:0198547684] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| protein transport | biological process | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| protein sumoylation | biological process | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250] |
| protein desumoylation | biological process | The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:jl, PMID:11265250] |
| regulation of Wnt signaling pathway | biological process | Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. [GOC:dph, GOC:mah, GOC:tb] |
| negative regulation of protein ubiquitination | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah] |
| positive regulation of protein ubiquitination | biological process | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah] |
| protein destabilization | biological process | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah] |
| fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators] |
| mRNA transport | biological process | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |