diclofenac and Gout
diclofenac has been researched along with Gout in 28 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode." | 9.41 | Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial. ( Cui, X; Geng, H; Jia, E; Jiang, Y; Li, B; Ma, W; Qiu, X; Wei, J; Xiao, M; Xiao, Y; Xie, J; Yao, X; Zhang, J; Zhang, Y; Zhong, L, 2021) |
| "A single dose of compound betamethasone may be better than diclofenac sodium for the treatment of acute gouty arthritis." | 9.19 | Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout. ( Fan, YC; Song, LJ; Yang, H; Zhang, JY; Zhang, YK, 2014) |
| "Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile." | 9.12 | Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 8.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| "A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1." | 7.69 | Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996) |
| "Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode." | 5.41 | Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial. ( Cui, X; Geng, H; Jia, E; Jiang, Y; Li, B; Ma, W; Qiu, X; Wei, J; Xiao, M; Xiao, Y; Xie, J; Yao, X; Zhang, J; Zhang, Y; Zhong, L, 2021) |
| "A single dose of compound betamethasone may be better than diclofenac sodium for the treatment of acute gouty arthritis." | 5.19 | Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout. ( Fan, YC; Song, LJ; Yang, H; Zhang, JY; Zhang, YK, 2014) |
| " Twenty-five patients with acute gout arthritis were randomized into two groups and treated over 5 days: group A, diclofenac 75 mg orally, twice a day; and group B, laser irradiation once a day." | 5.12 | Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results. ( Campana, V; Gavotto, A; Moya, M; Palma, J; Simes, J; Soriano, F; Soriano, M; Soriano, R; Spitale, L, 2006) |
| "Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile." | 5.12 | Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Treatment of gout involves two basic approaches: reducing the serum uric acid mainly by xanthine oxidase inhibitors (XOIs) and alleviating the intensity of the accompanying acute arthritic inflammation using non-steroidal anti-inflammatory drugs (NSAIDs)." | 4.31 | Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs. ( Abdel Moneim, AE; Daabees, HG; Elagawany, M; Rashad, AY; Rostom, SAF; Shahin, M, 2023) |
| "To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain." | 4.02 | Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021) |
| "The objective of the present work was to develop polymeric nanoparticles of uricase and aceclofenac (NSAID) and to incorporate them into gel, for delivering drugs to synovial joints, for effective treatment of Gout." | 3.81 | Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach. ( Dwivedi, H; Kymonil, KM; Saraf, SA; Tiwari, S, 2015) |
| "A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1." | 3.69 | Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996) |
| "Etodolac is a new nonsteroidal anti-inflammatory drug (NSAID)." | 2.67 | Clinical response to etodolac in the management of pain. ( Mizraji, M, 1990) |
| " All adverse events were recorded for safety assessment." | 2.53 | Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis. ( Liu, P; Ma, JL; Wang, J; Zhang, S; Zhang, W; Zhang, Y, 2016) |
| " Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol." | 1.34 | Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007) |
Research
Studies (28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Rashad, AY | 1 |
| Daabees, HG | 1 |
| Elagawany, M | 1 |
| Shahin, M | 1 |
| Abdel Moneim, AE | 1 |
| Rostom, SAF | 1 |
| Li, M | 1 |
| Yu, C | 1 |
| Zeng, X | 1 |
| Jia, E | 1 |
| Zhang, Y | 2 |
| Ma, W | 1 |
| Li, B | 1 |
| Geng, H | 1 |
| Zhong, L | 1 |
| Yao, X | 1 |
| Xie, J | 1 |
| Xiao, Y | 1 |
| Jiang, Y | 1 |
| Qiu, X | 1 |
| Xiao, M | 1 |
| Cui, X | 1 |
| Wei, J | 1 |
| Zhang, J | 1 |
| Ventura-Martínez, R | 1 |
| Déciga-Campos, M | 1 |
| Bustamante-Marquina, A | 1 |
| Ángeles-López, GE | 1 |
| Aviles-Herrera, J | 1 |
| González-Trujano, ME | 1 |
| Navarrete-Vázquez, G | 1 |
| Suresh, E | 1 |
| Zhang, YK | 1 |
| Yang, H | 1 |
| Zhang, JY | 1 |
| Song, LJ | 1 |
| Fan, YC | 1 |
| Tiwari, S | 1 |
| Dwivedi, H | 1 |
| Kymonil, KM | 1 |
| Saraf, SA | 1 |
| Zhang, S | 1 |
| Liu, P | 1 |
| Zhang, W | 1 |
| Ma, JL | 1 |
| Wang, J | 1 |
| Prillwitz, H | 1 |
| Flatz, A | 1 |
| von Elm, E | 1 |
| Xiao, XY | 1 |
| Wang, YF | 1 |
| Xu, R | 1 |
| Oaks, JL | 2 |
| Gilbert, M | 2 |
| Virani, MZ | 1 |
| Watson, RT | 1 |
| Meteyer, CU | 2 |
| Rideout, BA | 2 |
| Shivaprasad, HL | 2 |
| Ahmed, S | 1 |
| Chaudhry, MJ | 1 |
| Arshad, M | 1 |
| Mahmood, S | 1 |
| Ali, A | 1 |
| Khan, AA | 1 |
| Proffitt, F | 1 |
| Bagla, P | 1 |
| Shultz, S | 1 |
| Baral, HS | 1 |
| Charman, S | 1 |
| Cunningham, AA | 1 |
| Das, D | 1 |
| Ghalsasi, GR | 1 |
| Goudar, MS | 1 |
| Green, RE | 1 |
| Jones, A | 1 |
| Nighot, P | 1 |
| Pain, DJ | 1 |
| Prakash, V | 1 |
| Wieckhorst, A | 1 |
| Tiroke, A | 1 |
| Lins, M | 1 |
| Reinecke, A | 1 |
| Herrmann, G | 1 |
| Krüger, D | 1 |
| Simon, R | 1 |
| Soriano, F | 1 |
| Campana, V | 1 |
| Moya, M | 1 |
| Gavotto, A | 1 |
| Simes, J | 1 |
| Soriano, M | 1 |
| Soriano, R | 1 |
| Spitale, L | 1 |
| Palma, J | 1 |
| Willburger, RE | 1 |
| Mysler, E | 1 |
| Derbot, J | 1 |
| Jung, T | 1 |
| Thurston, H | 1 |
| Kreiss, A | 1 |
| Litschig, S | 1 |
| Krammer, G | 1 |
| Tate, GA | 1 |
| Al-Sharkawi, MS | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Pakes, GE | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Delrio, FG | 1 |
| Park, Y | 1 |
| Herzlich, B | 1 |
| Grob, D | 1 |
| Lund-Olesen, K | 1 |
| Gröbner, W | 1 |
| Walter-Sack, I | 1 |
| Nicoletti, B | 1 |
| Mignemi, G | 1 |
| Bach, GL | 1 |
| Terruzzi, V | 1 |
| Minoli, G | 1 |
| Frank, O | 1 |
| Mizraji, M | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain[NCT05175001] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
4 reviews available for diclofenac and Gout
| Article | Year |
|---|---|
Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Diclofenac; Etoricoxib; Gout; Humans | 2020 |
Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Eto | 2016 |
[Use of non-steroidal antirheumatic drugs in acute gout].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gout; Gout Suppressants; Humans; | 2015 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Trials
8 trials available for diclofenac and Gout
| Article | Year |
|---|---|
Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Febuxostat; Female; Gout; Gout Suppressa | 2021 |
Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout.
Topics: Acute Disease; Administration, Oral; Betamethasone; Diclofenac; Female; Gout; Gout Suppressants; Hum | 2014 |
[Stage-based treatment of integrative medicine on the quality of life in patients with gout].
Topics: Adult; Aged; Aged, 80 and over; Benzbromarone; Diclofenac; Drugs, Chinese Herbal; Female; Gout; Huma | 2012 |
Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results.
Topics: Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Calcium Pyrophosphate; Diclofenac; Dinopro | 2006 |
Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
Topics: Abdominal Pain; Acute Disease; Administration, Oral; Adult; Aged; Analysis of Variance; Argentina; D | 2007 |
A multicentre study of diclofenac sodium slow-release (Voltaren Retard) in the treatment of rheumatic disorders in the Kingdom of Saudi Arabia.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Delayed-Action Preparations; Diclofenac; Fem | 1984 |
[The acute attack of gout. Comparative treatment with 2 non-steroidal antirheumatics].
Topics: Diclofenac; Drug Evaluation; Drug Tolerance; Female; Gout; Humans; Male; Middle Aged; Phenylacetates | 1979 |
Clinical response to etodolac in the management of pain.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Bursitis; Diclofenac; Eto | 1990 |
Other Studies
16 other studies available for diclofenac and Gout
| Article | Year |
|---|---|
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Esters; Febuxostat; G | 2023 |
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis; Diclofenac; Dis | 2021 |
Problem based review: The patient with acute monoarthritis.
Topics: Acute Disease; Adult; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 2013 |
Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach.
Topics: Absorption, Physiological; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroid | 2015 |
Diclofenac residues as the cause of vulture population decline in Pakistan.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autopsy; Bird Diseases; Cause of Death; Conservati | 2004 |
Ecology. Circling in on a vulture killer.
Topics: Animals; Animals, Domestic; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Conservation of | 2004 |
Diclofenac poisoning is widespread in declining vulture populations across the Indian subcontinent.
Topics: Animals; Bird Diseases; Diclofenac; Environmental Exposure; Falconiformes; Gout; India; Poisoning; P | 2004 |
[Acute coronary syndrome after diclofenac induced coronary spasm].
Topics: Acute Disease; Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Coronary Disease; Di | 2005 |
Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps bengalensis).
Topics: Animals; Animals, Wild; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Cause of Death; Dicl | 2005 |
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical | 2007 |
Case report: diclofenac-induced rhabdomyolysis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Creatinine; Diclofenac; Erythema Mu | 1996 |
[Acute treatment of gout].
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Dextropropoxyphene; Diclofenac; Emergencies; G | 1998 |
[Hyperuricemia and gout. Case report].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diagnosis, Differential; Diclofenac; Follow-Up | 2002 |
[Therapeutic efficacy and tolerance of a new drug, sodium diclofenac, in inflammatory and metabolic rheumatism].
Topics: Adult; Aged; Arthritis, Rheumatoid; Diclofenac; Drug Evaluation; Female; Gout; Humans; Male; Middle | 1978 |
[Endoscopic evaluation of the gastric tolerance of sodium diclofenac in high doses].
Topics: Arthritis, Rheumatoid; Diclofenac; Female; Gastroscopy; Gout; Humans; Joint Diseases; Male; Middle A | 1978 |
The treatment of acute gouty arthritis.
Topics: Acute Disease; Apazone; Diclofenac; Gout; Gout Suppressants; Humans; Phenylbutazone; Triazines | 1977 |