Page last updated: 2024-10-26

diclofenac and Gout

diclofenac has been researched along with Gout in 28 studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Research Excerpts

ExcerptRelevanceReference
"Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode."9.41Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial. ( Cui, X; Geng, H; Jia, E; Jiang, Y; Li, B; Ma, W; Qiu, X; Wei, J; Xiao, M; Xiao, Y; Xie, J; Yao, X; Zhang, J; Zhang, Y; Zhong, L, 2021)
"A single dose of compound betamethasone may be better than diclofenac sodium for the treatment of acute gouty arthritis."9.19Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout. ( Fan, YC; Song, LJ; Yang, H; Zhang, JY; Zhang, YK, 2014)
"Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile."9.12Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007)
" Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis."8.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
"To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain."8.02Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021)
"A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1."7.69Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996)
"Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode."5.41Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial. ( Cui, X; Geng, H; Jia, E; Jiang, Y; Li, B; Ma, W; Qiu, X; Wei, J; Xiao, M; Xiao, Y; Xie, J; Yao, X; Zhang, J; Zhang, Y; Zhong, L, 2021)
"A single dose of compound betamethasone may be better than diclofenac sodium for the treatment of acute gouty arthritis."5.19Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout. ( Fan, YC; Song, LJ; Yang, H; Zhang, JY; Zhang, YK, 2014)
" Twenty-five patients with acute gout arthritis were randomized into two groups and treated over 5 days: group A, diclofenac 75 mg orally, twice a day; and group B, laser irradiation once a day."5.12Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results. ( Campana, V; Gavotto, A; Moya, M; Palma, J; Simes, J; Soriano, F; Soriano, M; Soriano, R; Spitale, L, 2006)
"Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile."5.12Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout. ( Derbot, J; Jung, T; Krammer, G; Kreiss, A; Litschig, S; Mysler, E; Tate, GA; Thurston, H; Willburger, RE, 2007)
" Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis."4.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
"Treatment of gout involves two basic approaches: reducing the serum uric acid mainly by xanthine oxidase inhibitors (XOIs) and alleviating the intensity of the accompanying acute arthritic inflammation using non-steroidal anti-inflammatory drugs (NSAIDs)."4.31Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs. ( Abdel Moneim, AE; Daabees, HG; Elagawany, M; Rashad, AY; Rostom, SAF; Shahin, M, 2023)
"To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain."4.02Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats. ( Ángeles-López, GE; Aviles-Herrera, J; Bustamante-Marquina, A; Déciga-Campos, M; González-Trujano, ME; Navarrete-Vázquez, G; Ventura-Martínez, R, 2021)
"The objective of the present work was to develop polymeric nanoparticles of uricase and aceclofenac (NSAID) and to incorporate them into gel, for delivering drugs to synovial joints, for effective treatment of Gout."3.81Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach. ( Dwivedi, H; Kymonil, KM; Saraf, SA; Tiwari, S, 2015)
"A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1."3.69Case report: diclofenac-induced rhabdomyolysis. ( Delrio, FG; Grob, D; Herzlich, B; Park, Y, 1996)
"Etodolac is a new nonsteroidal anti-inflammatory drug (NSAID)."2.67Clinical response to etodolac in the management of pain. ( Mizraji, M, 1990)
" All adverse events were recorded for safety assessment."2.53Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis. ( Liu, P; Ma, JL; Wang, J; Zhang, S; Zhang, W; Zhang, Y, 2016)
" Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol."1.34Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19906 (21.43)18.7374
1990's3 (10.71)18.2507
2000's9 (32.14)29.6817
2010's6 (21.43)24.3611
2020's4 (14.29)2.80

Authors

AuthorsStudies
Rashad, AY1
Daabees, HG1
Elagawany, M1
Shahin, M1
Abdel Moneim, AE1
Rostom, SAF1
Li, M1
Yu, C1
Zeng, X1
Jia, E1
Zhang, Y2
Ma, W1
Li, B1
Geng, H1
Zhong, L1
Yao, X1
Xie, J1
Xiao, Y1
Jiang, Y1
Qiu, X1
Xiao, M1
Cui, X1
Wei, J1
Zhang, J1
Ventura-Martínez, R1
Déciga-Campos, M1
Bustamante-Marquina, A1
Ángeles-López, GE1
Aviles-Herrera, J1
González-Trujano, ME1
Navarrete-Vázquez, G1
Suresh, E1
Zhang, YK1
Yang, H1
Zhang, JY1
Song, LJ1
Fan, YC1
Tiwari, S1
Dwivedi, H1
Kymonil, KM1
Saraf, SA1
Zhang, S1
Liu, P1
Zhang, W1
Ma, JL1
Wang, J1
Prillwitz, H1
Flatz, A1
von Elm, E1
Xiao, XY1
Wang, YF1
Xu, R1
Oaks, JL2
Gilbert, M2
Virani, MZ1
Watson, RT1
Meteyer, CU2
Rideout, BA2
Shivaprasad, HL2
Ahmed, S1
Chaudhry, MJ1
Arshad, M1
Mahmood, S1
Ali, A1
Khan, AA1
Proffitt, F1
Bagla, P1
Shultz, S1
Baral, HS1
Charman, S1
Cunningham, AA1
Das, D1
Ghalsasi, GR1
Goudar, MS1
Green, RE1
Jones, A1
Nighot, P1
Pain, DJ1
Prakash, V1
Wieckhorst, A1
Tiroke, A1
Lins, M1
Reinecke, A1
Herrmann, G1
Krüger, D1
Simon, R1
Soriano, F1
Campana, V1
Moya, M1
Gavotto, A1
Simes, J1
Soriano, M1
Soriano, R1
Spitale, L1
Palma, J1
Willburger, RE1
Mysler, E1
Derbot, J1
Jung, T1
Thurston, H1
Kreiss, A1
Litschig, S1
Krammer, G1
Tate, GA1
Al-Sharkawi, MS1
Brogden, RN1
Heel, RC1
Pakes, GE1
Speight, TM1
Avery, GS1
Delrio, FG1
Park, Y1
Herzlich, B1
Grob, D1
Lund-Olesen, K1
Gröbner, W1
Walter-Sack, I1
Nicoletti, B1
Mignemi, G1
Bach, GL1
Terruzzi, V1
Minoli, G1
Frank, O1
Mizraji, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain[NCT05175001]Phase 4100 participants (Anticipated)Interventional2021-05-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for diclofenac and Gout

ArticleYear
Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis.
    BMJ open, 2020, 09-10, Volume: 10, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Diclofenac; Etoricoxib; Gout; Humans

2020
Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis.
    Clinical rheumatology, 2016, Volume: 35, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Eto

2016
[Use of non-steroidal antirheumatic drugs in acute gout].
    Praxis, 2015, Aug-05, Volume: 104, Issue:16

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gout; Gout Suppressants; Humans;

2015
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
    Drugs, 1980, Volume: 20, Issue:1

    Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact

1980

Trials

8 trials available for diclofenac and Gout

ArticleYear
Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial.
    Rheumatology (Oxford, England), 2021, 09-01, Volume: 60, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Febuxostat; Female; Gout; Gout Suppressa

2021
Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of acute attacks of gout.
    International journal of clinical practice, 2014, Volume: 68, Issue:5

    Topics: Acute Disease; Administration, Oral; Betamethasone; Diclofenac; Female; Gout; Gout Suppressants; Hum

2014
[Stage-based treatment of integrative medicine on the quality of life in patients with gout].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2012, Volume: 32, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Benzbromarone; Diclofenac; Drugs, Chinese Herbal; Female; Gout; Huma

2012
Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results.
    Photomedicine and laser surgery, 2006, Volume: 24, Issue:2

    Topics: Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Calcium Pyrophosphate; Diclofenac; Dinopro

2006
Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:7

    Topics: Abdominal Pain; Acute Disease; Administration, Oral; Adult; Aged; Analysis of Variance; Argentina; D

2007
A multicentre study of diclofenac sodium slow-release (Voltaren Retard) in the treatment of rheumatic disorders in the Kingdom of Saudi Arabia.
    The Journal of international medical research, 1984, Volume: 12, Issue:4

    Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Delayed-Action Preparations; Diclofenac; Fem

1984
[The acute attack of gout. Comparative treatment with 2 non-steroidal antirheumatics].
    Die Medizinische Welt, 1979, Nov-09, Volume: 30, Issue:45

    Topics: Diclofenac; Drug Evaluation; Drug Tolerance; Female; Gout; Humans; Male; Middle Aged; Phenylacetates

1979
Clinical response to etodolac in the management of pain.
    European journal of rheumatology and inflammation, 1990, Volume: 10, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Bursitis; Diclofenac; Eto

1990

Other Studies

16 other studies available for diclofenac and Gout

ArticleYear
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs.
    Bioorganic chemistry, 2023, Volume: 135

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Esters; Febuxostat; G

2023
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.
    The Journal of pharmacy and pharmacology, 2021, Sep-07, Volume: 73, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis; Diclofenac; Dis

2021
Problem based review: The patient with acute monoarthritis.
    Acute medicine, 2013, Volume: 12, Issue:2

    Topics: Acute Disease; Adult; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2013
Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach.
    Drug delivery and translational research, 2015, Volume: 5, Issue:3

    Topics: Absorption, Physiological; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroid

2015
Diclofenac residues as the cause of vulture population decline in Pakistan.
    Nature, 2004, Feb-12, Volume: 427, Issue:6975

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autopsy; Bird Diseases; Cause of Death; Conservati

2004
Ecology. Circling in on a vulture killer.
    Science (New York, N.Y.), 2004, Oct-08, Volume: 306, Issue:5694

    Topics: Animals; Animals, Domestic; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Conservation of

2004
Diclofenac poisoning is widespread in declining vulture populations across the Indian subcontinent.
    Proceedings. Biological sciences, 2004, Dec-07, Volume: 271 Suppl 6

    Topics: Animals; Bird Diseases; Diclofenac; Environmental Exposure; Falconiformes; Gout; India; Poisoning; P

2004
[Acute coronary syndrome after diclofenac induced coronary spasm].
    Zeitschrift fur Kardiologie, 2005, Volume: 94, Issue:4

    Topics: Acute Disease; Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Coronary Disease; Di

2005
Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps bengalensis).
    Journal of wildlife diseases, 2005, Volume: 41, Issue:4

    Topics: Animals; Animals, Wild; Anti-Inflammatory Agents, Non-Steroidal; Bird Diseases; Cause of Death; Dicl

2005
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
    Prescrire international, 2007, Volume: 16, Issue:92

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical

2007
Case report: diclofenac-induced rhabdomyolysis.
    The American journal of the medical sciences, 1996, Volume: 312, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Creatinine; Diclofenac; Erythema Mu

1996
[Acute treatment of gout].
    Ugeskrift for laeger, 1998, Mar-02, Volume: 160, Issue:10

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Dextropropoxyphene; Diclofenac; Emergencies; G

1998
[Hyperuricemia and gout. Case report].
    Deutsche medizinische Wochenschrift (1946), 2002, Feb-01, Volume: 127, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diagnosis, Differential; Diclofenac; Follow-Up

2002
[Therapeutic efficacy and tolerance of a new drug, sodium diclofenac, in inflammatory and metabolic rheumatism].
    Minerva medica, 1978, Oct-13, Volume: 69, Issue:48

    Topics: Adult; Aged; Arthritis, Rheumatoid; Diclofenac; Drug Evaluation; Female; Gout; Humans; Male; Middle

1978
[Endoscopic evaluation of the gastric tolerance of sodium diclofenac in high doses].
    La Clinica terapeutica, 1978, Mar-15, Volume: 84, Issue:5

    Topics: Arthritis, Rheumatoid; Diclofenac; Female; Gastroscopy; Gout; Humans; Joint Diseases; Male; Middle A

1978
The treatment of acute gouty arthritis.
    Advances in experimental medicine and biology, 1977, Volume: 76B

    Topics: Acute Disease; Apazone; Diclofenac; Gout; Gout Suppressants; Humans; Phenylbutazone; Triazines

1977