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glycine and Gout

glycine has been researched along with Gout in 48 studies

Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Research Excerpts

Excerpt	Relevance	Reference
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."	7.66	Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
"THE CONCEPT OF AN ABNORMALITY OF GLUTAMINE METABOLISM IN PRIMARY GOUT WAS FIRST PROPOSED ON THE BASIS OF ISOTOPE DATA: when [(15)N]glycine was administered to gouty subjects, there was disproportionately great enrichment of N-(3 + 9) of uric acid, which derive from the amide-N of glutamine."	7.65	The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. ( Sperling, O; Starmer, CF; Wyngaarden, JB, 1973)
"Adenine inhibited the de novo synthesis of purines in both normal and gouty man as shown by inhibition of the incorporation of glycine-(15)N into urinary uric acid without altering the incorporation of glycine-(15)N into urinary creatinine."	7.64	Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects. ( Klinenberg, JR; Miller, J; Seegmiller, JE; Watts, RW, 1968)
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."	3.66	Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
"In the majority of patients with gout and excessive uric acid production, underlying enzyme abnormalities have not been identified."	3.65	Patterns of phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in fibroblasts from patients with gout and purine overproduction. ( Becker, MA, 1976)
"THE CONCEPT OF AN ABNORMALITY OF GLUTAMINE METABOLISM IN PRIMARY GOUT WAS FIRST PROPOSED ON THE BASIS OF ISOTOPE DATA: when [(15)N]glycine was administered to gouty subjects, there was disproportionately great enrichment of N-(3 + 9) of uric acid, which derive from the amide-N of glutamine."	3.65	The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. ( Sperling, O; Starmer, CF; Wyngaarden, JB, 1973)
"Certain gouty subjects with excessive de novo purine synthesis are deficient in hypoxanthineguanine phosphoribosyltransferase (HG-PRTase [EC 2."	3.65	Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency. ( Sorensen, LB, 1970)

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
MULLER, AF	2
BAUER, W	1
BENEDICT, JD	3
YU, TF	9
BIEN, EJ	3
GUTMAN, AB	9
STETTEN, D	3
WASSERMAN, LR	1
LASTER, L	2
WYNGAARDEN, JB	4
SEEGMILLER, JE	7
LIDDLE, LV	1
BLACK, H	1
YALOW, RS	1
BERSON, SA	1
YU, FT	1
ADLER, M	1
JAVITT, NB	1
YUE, TF	1
ROSENTHAL, IM	1
GABALLAH, S	1
RAFELSON, ME	1
BISHOP, C	1
RAND, R	1
TALBOTT, JH	1
ROCHE, M	1
Jakovcic, S	1
Sorensen, LB	5
Benke, PJ	1
Roboz, J	2
Musil, J	1
Raivio, KO	1
Becker, 7A	1
Meyer, LJ	4
Greene, ML	2
Nuki, G	1
Mertz, DP	1
Becker, MA	4
Emmerson, BT	4
Gordon, RB	2
Johnson, LA	1
Krízek, V	1
Brosh, S	1
Boer, P	1
Kupfer, B	1
de Vries, A	1
Sperling, O	4
de Graciansky, P	1
Larrégue, M	1
Martinet, C	1
Wood, AW	1
Starmer, CF	2
Kostel, PJ	1
Starmer, F	1
Delbarre, F	1
Auscher, C	1
Amor, B	1
de Gery, A	1
Thompson, L	1
Chang, GN	1
Fam, A	1
Little, AH	1
Malkin, A	1
Steele, TH	1
Kogut, MD	1
Donnell, GN	1
Nyhan, WL	2
Sweetman, L	2
Glueck, CJ	1
Fujimoto, WY	1
Kaung, C	1
Klinenberg, JR	1
Miller, J	1
Watts, RW	1
Ball, GV	1
Diamond, HS	1
Friedland, M	1
Halberstam, D	1
Kaplan, D	1
James, JA	1
Teberg, AJ	1
Nelson, LG	1
Wyncaarden, JB	1

Reviews

3 reviews available for glycine and Gout

Article	Year
[Theory of pathogenesis in primary hyperuricamia]. Medizinische Klinik, 1975, Jul-11, Volume: 70, Issue:28-29 Topics: Adenosine Monophosphate; Adult; Child; Female; Glucosephosphates; Glycine; Gout; Humans; Kidney; Les	1975
[Inborn errors of metabolism and their significance in urology and nephrology]. Zeitschrift fur Urologie und Nephrologie, 1976, Volume: 69, Issue:5 Topics: Acidosis, Renal Tubular; Alkaptonuria; Cystinuria; Diabetes Insipidus; Female; Glycine; Gout; Humans	1976
Control of uric acid excretion. The New England journal of medicine, 1971, May-27, Volume: 284, Issue:21 Topics: Animals; Dogs; Glycine; Gout; Humans; Kidney; Kidney Diseases; Kidney Tubules; Pyrazinamide; Uric Ac	1971

Trials

1 trial available for glycine and Gout

Article	Year
Urate kinetics in hypoxanthine-guanine phosphoribosyltransferase deficiency: their significance for the understanding of gout. The Quarterly journal of medicine, 1976, Volume: 45, Issue:177 Topics: Adolescent; Adult; Arthritis; Clinical Trials as Topic; Creatinine; Female; Genetic Linkage; Glycine	1976

Other Studies

44 other studies available for glycine and Gout

Article	Year
Uric acid production in normal and gouty subjects, determined by N15 labeled glycine. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 82, Issue:1 Topics: Biochemical Phenomena; Body Fluids; Glycine; Gout; Humans; Uric Acid; Urine	1953
A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. The Journal of clinical investigation, 1953, Volume: 32, Issue:8 Topics: Diet; Glycine; Gout; Nitrogen; Uric Acid	1953
A simultaneous study of glycine-N15 incorporation into uric acid and heme, and of Fe59 utilization, in a case of gout associated with polycythemia secondary to congenital heart disease. The American journal of medicine, 1953, Volume: 15, Issue:6 Topics: Blood; Cardiovascular Abnormalities; Cardiovascular System; Glycine; Gout; Heart Diseases; Heme; Hum	1953
Uric acid production in a case of myeloid metaplasia associated with gouty arthritis, studied with N15 labeled glycine. The American journal of medicine, 1953, Volume: 15, Issue:6 Topics: Arthritis, Gouty; Glycine; Gout; Humans; Metaplasia; Primary Myelofibrosis; Research; Uric Acid	1953
Normal glycine-C14-incorporation into uric acid in primary gout. Metabolism: clinical and experimental, 1958, Volume: 7, Issue:4 Pt 1 Topics: Glycine; Gout; Humans; Hyperuricemia; Uric Acid	1958
Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout. Metabolism: clinical and experimental, 1958, Volume: 7, Issue:4 Pt 1 Topics: Glycine; Gout; Humans; Hyperuricemia; Uric Acid	1958
Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. The American journal of medicine, 1958, Volume: 25, Issue:6 Topics: Glycine; Gout; Humans; Uric Acid	1958
Intramolecular distribution of uric acid-N15 after administration of glycine-N15 and ammonium-N15 chloride to goury and non-goury subjects. The Journal of clinical investigation, 1962, Volume: 41 Topics: Ammonia; Ammonium Chloride; Glycine; Gout; Humans; Uric Acid	1962
AN ABNORMALITY OF GLUTAMINE METABOLISM IN PRIMARY GOUT. The American journal of medicine, 1963, Volume: 35 Topics: Ammonia; Creatine; Creatinine; Glutamine; Glycine; Gout; Humans; Hyperuricemia; Kidney; Metabolism;	1963
GOUT IN INFANCY MANIFESTED BY RENAL FAILURE. Pediatrics, 1964, Volume: 33 Topics: Acute Kidney Injury; Adolescent; Blood Cell Count; Child; Citrates; Genetics, Medical; Glycine; Gout	1964
Rate of conversion of isotopic glycine to uric acid in the normal and gouty human and how this is affected by vitamin E and folic acid. Metabolism: clinical and experimental, 1955, Volume: 4, Issue:2 Topics: Folic Acid; Glycine; Gout; Humans; Uric Acid; Vitamin E	1955
Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism: clinical and experimental, 1952, Volume: 1, Issue:1 Topics: Glycine; Gout; Humans; Male; Nitrogen; Uric Acid	1952
Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis. Arthritis and rheumatism, 1967, Volume: 10, Issue:2 Topics: Adolescent; Allopurinol; Body Height; Body Weight; Carbon Isotopes; Enzyme Therapy; Glucosephosphate	1967
Biochemical evidence for a distinct type of primary gout. Nature, 1967, Mar-18, Volume: 213, Issue:5081 Topics: Adolescent; Allopurinol; Azathioprine; Carbon; Carbon Isotopes; Enzymes; Glycine; Gout; Humans; Hypo	1967
Incorporation of 15N from glycine into uric acid in gout: a follow-up study. Advances in experimental medicine and biology, 1984, Volume: 165 Pt A Topics: Adult; Follow-Up Studies; Glycine; Gout; Humans; Male; Nitrogen Isotopes; Uric Acid	1984
Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. The American journal of medicine, 1981, Volume: 70, Issue:4 Topics: Adult; Aged; Aging; Follow-Up Studies; Glycine; Gout; Humans; Male; Middle Aged; Nitrogen; Nitrogen	1981
Physiological characteristics of various experimental models for the study of disorders in purine metabolism. Advances in experimental medicine and biology, 1977, Volume: 76B Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose;	1977
Stimulation of human purine synthesis de novo by fructose infusion. Metabolism: clinical and experimental, 1975, Volume: 24, Issue:7 Topics: Adolescent; Adult; Creatinine; Erythrocytes; Fructose; Glycine; Gout; Humans; Male; Middle Aged; Ost	1975
Patterns of phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in fibroblasts from patients with gout and purine overproduction. The Journal of clinical investigation, 1976, Volume: 57, Issue:2 Topics: Adenine Phosphoribosyltransferase; Adolescent; Adult; Cells, Cultured; Erythrocytes; Female; Fibrobl	1976
De novo synthesis of purine nucleotides in human peripheral blood leukocytes. Excessive activity of the pathway in hypoxanthine-guanine phosphoribosyltransferase deficiency. The Journal of clinical investigation, 1976, Volume: 58, Issue:2 Topics: Amidophosphoribosyltransferase; Enzyme Activation; Formates; Glycine; Gout; Heterozygote; Humans; Hy	1976
[Hyperuricemia and psoriasis]. Annales de dermatologie et de syphiligraphie, 1976, Volume: 103, Issue:5-6 Topics: Carbon Radioisotopes; Female; Glycine; Gout; Humans; Male; Metabolic Diseases; Psoriasis; Uric Acid	1976
Purine overproduction in man associated with increased phosphoribosylpyrophosphate synthetase activity. Science (New York, N.Y.), 1973, Mar-16, Volume: 179, Issue:4078 Topics: Adenosine Triphosphate; Carbon Isotopes; Erythrocytes; Female; Fibroblasts; Glycine; Gout; Humans; M	1973
The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. The Journal of clinical investigation, 1973, Volume: 52, Issue:10 Topics: Adenosine Triphosphate; Adolescent; Adult; Carbon Isotopes; Glutamine; Glycine; Gout; Guanine; Hippu	1973
Increased PP-ribose-P synthetase activity: a genetic abnormality leading to excessive purine production and gout. Advances in experimental medicine and biology, 1973, Volume: 41 Topics: Adenine; Carbon Radioisotopes; Cellulose; Creatinine; Electrophoresis; Enzyme Activation; Erythrocyt	1973
Hyperglutamatemia in primary gout. The American journal of medicine, 1973, Volume: 54, Issue:6 Topics: Adult; Aged; Alanine; Ammonia; Chromatography; Fasting; Glutamates; Glutamine; Glycine; Gout; Humans	1973
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity. The American journal of medicine, 1973, Volume: 55, Issue:2 Topics: Adolescent; Adult; Carbon Isotopes; Child; Erythrocytes; Female; Fibroblasts; Glycine; Gout; Guanine	1973
A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. Transactions of the American Clinical and Climatological Association, 1973, Volume: 84 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Benzoates; Carbon Isotopes; Diet; Glutamine	1973
Urate metabolism in heterozygotes for HGPRTase deficiency. Advances in experimental medicine and biology, 1973, Volume: 41 Topics: Adult; Aged; Body Weight; Carbon Radioisotopes; Creatinine; Erythrocytes; Glycine; Gout; Guanine Nuc	1973
Gout with adenine phosphoribosyl transferase deficiency. Advances in experimental medicine and biology, 1973, Volume: 41 Topics: Adenine; Allopurinol; Carbon Radioisotopes; Erythrocytes; Female; Glycine; Gout; Humans; Male; Pedig	1973
Adenine phosphoribosyltransferase deficiency in a female with gout. Advances in experimental medicine and biology, 1973, Volume: 41 Topics: Adenine; Adult; Carbon Radioisotopes; Creatinine; Erythrocytes; Female; Glycine; Gout; Humans; Pento	1973
The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis". Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Adolescent; Adult; Chromatography, Ion Exchange; Glutamine; Glycine; Gout; Guanine Nucleotides; Hipp	1974
Hyperglutamatemia in primary gout. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Administration, Oral; Alanine; Erythrocytes; Glutamates; Glutamine; Glycine; Gout; Humans; Male; Pub	1974
The uptake of glycine-14C into the adenine and guanine of DNA and insoluble RNA of human leucocytes. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Adenine; Autoanalysis; Carbon Radioisotopes; Chromatography, Paper; DNA; Female; Glycine; Gout; Guan	1974
The effect of weight reduction on urate metabolism. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Blood Pressure; Body Weight; Carbon Radioisotopes; Creatinine; Diet Therapy; Glycine; Gout; Humans;	1974
Suppression of the shunt pathway in primary gout by azathioprine. Proceedings of the National Academy of Sciences of the United States of America, 1966, Volume: 55, Issue:3 Topics: Adenine Nucleotides; Azathioprine; Blood; Enzyme Repression; Glycine; Gout; Guanine Nucleotides; Hum	1966
Disorder of purine metabolism due to partial deficiency of hypoxanthine-guanine phosphoribosyltransferase. A study of a family. The American journal of medicine, 1970, Volume: 48, Issue:2 Topics: Adolescent; Adult; Carbon Isotopes; Child; Child, Preschool; Female; Glucosyltransferases; Glutamina	1970
Benign symmetric lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia. The American journal of medicine, 1970, Volume: 48, Issue:2 Topics: Adult; Azathioprine; Blood Protein Electrophoresis; Carbon Isotopes; Female; Glucose Tolerance Test;	1970
Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency. The Journal of clinical investigation, 1970, Volume: 49, Issue:5 Topics: Adult; Allopurinol; Athetosis; Carbon Isotopes; Child; Chorea; Compulsive Behavior; Deficiency Disea	1970
Effect of glycine loading on plasma and urinary uric acid and amino acids in normal and gouty subjects. The American journal of medicine, 1970, Volume: 49, Issue:3 Topics: Adult; Aged; Amino Acids; Glycine; Gout; Humans; Hydrogen-Ion Concentration; Kidney; Male; Middle Ag	1970
Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects. The Journal of clinical investigation, 1968, Volume: 47, Issue:5 Topics: Adenine Nucleotides; Carbon Isotopes; Glycine; Gout; Humans; Nitrogen; Purines; Uric Acid	1968
Pathogenesis of hyperuricemia in saturnine gout. The New England journal of medicine, 1969, 05-29, Volume: 280, Issue:22 Topics: Adult; Alcoholic Beverages; Alcoholism; Carbon Isotopes; Creatinine; Diet; Food Contamination; Glyci	1969
Glycine-C-14 incorporation into nucleic acid purine by leucocytes obtained from normal and gouty subjects. Annals of the rheumatic diseases, 1969, Volume: 28, Issue:3 Topics: Adenine; Carbon Isotopes; Cyanides; Depression, Chemical; DNA; Female; Glycine; Gout; Guanine; Human	1969
A new disorder of purine metabolism with behavioral manifestations. The Journal of pediatrics, 1969, Volume: 74, Issue:1 Topics: Adenine; Allopurinol; Autistic Disorder; Carbon Isotopes; Child Behavior Disorders; Child, Preschool	1969
The overproduction of uric acid in primary gout. Arthritis and rheumatism, 1965, Volume: 8, Issue:5 Topics: Carbon Isotopes; Glycine; Gout; Humans; Nitrogen; Radioisotopes; Uric Acid	1965

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