xanthine has been researched along with Gout in 30 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, we aimed to investigate diurnal variations in serum levels of UA and plasma levels of xanthine, hypoxanthine, and xanthine oxidoreductase (XOR) activity, which were measured at 18:00, 6:00, and 12:00 in male patients with coronary artery disease." | 8.31 | Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease. ( Hiki, M; Ishiwata, S; Kasai, T; Kato, T; Kuwabara, M; Matsumoto, H; Murase, T; Murata, A; Naito, R; Nakamura, T; Sato, A; Shimizu, M; Shitara, J; Suda, S; Yatsu, S, 2023) |
| "To further explore the possibility of xanthine and hypoxanthine to be gout biomarkers as substitutes for uric acid." | 7.91 | Study on the diagnosis of gout with xanthine and hypoxanthine. ( Deng, B; Deng, M; Fei, X; Huang, Z; Wang, Y; Ye, L, 2019) |
| "X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency in an inherited disorder of purine metabolism is usually associated with the clinical manifestations of hyperuricemia." | 7.81 | Hyperuricemia and gout due to deficiency of hypoxanthine-guanine phosphoribosyltransferase in female carriers: New insight to differential diagnosis. ( Kostalova, E; Musalkova, D; Pavelka, K; Stiburkova, B; Vlaskova, H, 2015) |
| "Ten women with crystal-proved primary gout and normal serum creatinine levels (below 116 mmol/L) were studied while they were on a purine-restricted diet and taking no medications known to influence uric acid metabolism." | 7.69 | Purine metabolism in women with primary gout. ( de Miguel, E; Gil, AA; Mateos, FA; Miranda, ME; Pérez de Ayala, C; Puig, JG; Torres, RJ, 1994) |
| "The behavior of plasma and urine oxypurines (hypoxanthine and xanthine) and of uric acid has been studied in normal subjects and in gout patients." | 7.67 | [Analysis of uric acid and oxypurines in normal subjects and in gout patients]. ( Di Stefano, A; Leoncini, R; Marinello, E; Pizzichini, M; Porcelli, B; Taddeo, A, 1989) |
| "The clearance of uric acid, hypoxanthine and xanthine has been examined in gout patients and in normal subjects compared to creatinine, after a purine-free diet." | 7.67 | [Clearance of oxypurines in normal subjects and in gout patients subjected to a purine-free diet. Effects of allopurinol]. ( Di Stefano, A; Leoncini, R; Marinello, E; Pizzichini, M; Porcelli, B; Taddeo, A, 1989) |
| "The renal excretion of uric acid is usually diminished in primary gout with respect to increased serum urate levels." | 7.67 | Renal excretion of hypoxanthine and xanthine in primary gout. ( Jiménez, ML; Mateos, FA; Puig, JG; Ramos, TH, 1988) |
| " Thus, we aimed to investigate diurnal variations in serum levels of UA and plasma levels of xanthine, hypoxanthine, and xanthine oxidoreductase (XOR) activity, which were measured at 18:00, 6:00, and 12:00 in male patients with coronary artery disease." | 4.31 | Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease. ( Hiki, M; Ishiwata, S; Kasai, T; Kato, T; Kuwabara, M; Matsumoto, H; Murase, T; Murata, A; Naito, R; Nakamura, T; Sato, A; Shimizu, M; Shitara, J; Suda, S; Yatsu, S, 2023) |
| "Low-purine food is not only the focus of gout patients, but also the focus of contemporary green diet development." | 3.96 | Effect of allicin and its mechanism of action in purine removal in turbot. ( Li, J; Li, Q; Li, T; Ren, L; Song, M; Wang, D, 2020) |
| "To further explore the possibility of xanthine and hypoxanthine to be gout biomarkers as substitutes for uric acid." | 3.91 | Study on the diagnosis of gout with xanthine and hypoxanthine. ( Deng, B; Deng, M; Fei, X; Huang, Z; Wang, Y; Ye, L, 2019) |
| " Accordingly, the glycosuria- and/or hyperglycemia-induced decrease in the biological half-life of oxypurinol must be considered in the administration of allopurinol to gouty patients with uncontrolled diabetes mellitus." | 3.69 | Effect of glucose infusion on the renal transport of purine bases and oxypurinol. ( Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T, 1995) |
| "Ten women with crystal-proved primary gout and normal serum creatinine levels (below 116 mmol/L) were studied while they were on a purine-restricted diet and taking no medications known to influence uric acid metabolism." | 3.69 | Purine metabolism in women with primary gout. ( de Miguel, E; Gil, AA; Mateos, FA; Miranda, ME; Pérez de Ayala, C; Puig, JG; Torres, RJ, 1994) |
| "The behavior of plasma and urine oxypurines (hypoxanthine and xanthine) and of uric acid has been studied in normal subjects and in gout patients." | 3.67 | [Analysis of uric acid and oxypurines in normal subjects and in gout patients]. ( Di Stefano, A; Leoncini, R; Marinello, E; Pizzichini, M; Porcelli, B; Taddeo, A, 1989) |
| "The clearance of uric acid, hypoxanthine and xanthine has been examined in gout patients and in normal subjects compared to creatinine, after a purine-free diet." | 3.67 | [Clearance of oxypurines in normal subjects and in gout patients subjected to a purine-free diet. Effects of allopurinol]. ( Di Stefano, A; Leoncini, R; Marinello, E; Pizzichini, M; Porcelli, B; Taddeo, A, 1989) |
| "The renal excretion of uric acid is usually diminished in primary gout with respect to increased serum urate levels." | 3.67 | Renal excretion of hypoxanthine and xanthine in primary gout. ( Jiménez, ML; Mateos, FA; Puig, JG; Ramos, TH, 1988) |
| "The plasma concentrations of oxipurinol, the chief metabolite of allopurinol, were studied in 66 patients with gout in whom the dose of allopurinol varied between 100 and 400 mg per day." | 3.67 | Plasma oxipurinol concentrations during allopurinol therapy. ( Cross, M; Emmerson, BT; Gordon, RB; Thomson, DB, 1987) |
| "In addition, a single patient with von Gierke's disease showed a marked increase in the plasma activity of this enzyme, relative to that apparent in normal subjects." | 1.29 | Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography. ( Higashino, K; Hiroishi, K; Moriwaki, Y; Nasako, Y; Takahashi, S; Tsutsumi, Z; Yamakita, J; Yamamoto, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sabolová, M | 1 |
| Kulma, M | 1 |
| Petříčková, D | 1 |
| Kletečková, K | 1 |
| Kouřimská, L | 1 |
| Li, Y | 1 |
| Han, X | 1 |
| Tong, J | 1 |
| Wang, Y | 2 |
| Liu, X | 1 |
| Liao, Z | 1 |
| Jiang, M | 3 |
| Zhao, H | 1 |
| Jia, Q | 1 |
| Yang, Z | 1 |
| Wang, Q | 1 |
| Yang, H | 1 |
| Tang, X | 1 |
| Zhang, H | 3 |
| Cao, L | 2 |
| Zhang, G | 1 |
| Shimizu, M | 1 |
| Naito, R | 1 |
| Sato, A | 1 |
| Ishiwata, S | 1 |
| Yatsu, S | 1 |
| Shitara, J | 1 |
| Matsumoto, H | 1 |
| Murata, A | 1 |
| Kato, T | 1 |
| Suda, S | 1 |
| Hiki, M | 1 |
| Kuwabara, M | 1 |
| Murase, T | 1 |
| Nakamura, T | 1 |
| Kasai, T | 1 |
| Li, T | 1 |
| Ren, L | 1 |
| Wang, D | 1 |
| Song, M | 1 |
| Li, Q | 1 |
| Li, J | 1 |
| Kang, L | 1 |
| Liu, J | 2 |
| Jin, Y | 1 |
| Zhang, M | 2 |
| Hu, P | 2 |
| Deng, M | 1 |
| Deng, B | 1 |
| Ye, L | 1 |
| Fei, X | 1 |
| Huang, Z | 1 |
| Kostalova, E | 1 |
| Pavelka, K | 1 |
| Vlaskova, H | 1 |
| Musalkova, D | 1 |
| Stiburkova, B | 1 |
| Nishino, T | 1 |
| Okamoto, K | 1 |
| Xu, Y | 1 |
| Sun, W | 1 |
| Ruan, S | 1 |
| Dalbeth, N | 1 |
| Wong, S | 1 |
| Gamble, GD | 1 |
| Horne, A | 1 |
| Mason, B | 1 |
| Pool, B | 1 |
| Fairbanks, L | 1 |
| McQueen, FM | 1 |
| Cornish, J | 1 |
| Reid, IR | 1 |
| Palmano, K | 1 |
| Feng, J | 1 |
| Li, X | 1 |
| Yang, X | 1 |
| Zhang, C | 1 |
| Yuan, Y | 1 |
| Pu, J | 1 |
| Zhao, Y | 1 |
| Xie, Y | 1 |
| Yuan, H | 1 |
| Bu, Y | 1 |
| Liao, F | 1 |
| Liu, Y | 1 |
| Yu, P | 1 |
| Sun, X | 1 |
| Di, D | 1 |
| Yamamoto, T | 4 |
| Ka, T | 1 |
| Moriwaki, Y | 3 |
| Takahashi, S | 3 |
| Yamamoto, A | 1 |
| Tsutsumi, Z | 2 |
| Inokuchi, T | 1 |
| Mertz, DP | 1 |
| Boulieu, R | 1 |
| Bory, C | 1 |
| Baltassat, P | 1 |
| Gonnet, C | 1 |
| Porcelli, B | 3 |
| Vannoni, D | 1 |
| Leoncini, R | 3 |
| Pizzichini, M | 3 |
| Pagani, R | 1 |
| Marinello, E | 3 |
| Puig, JG | 4 |
| Mateos, FA | 4 |
| Miranda, ME | 2 |
| Torres, RJ | 2 |
| de Miguel, E | 2 |
| Pérez de Ayala, C | 2 |
| Gil, A | 1 |
| Suda, M | 1 |
| Higashino, K | 2 |
| Gil, AA | 1 |
| Komoriya, K | 1 |
| Osada, Y | 1 |
| Hasegawa, M | 1 |
| Horiuchi, H | 1 |
| Kondo, S | 1 |
| Couch, RC | 1 |
| Griffin, TB | 1 |
| Yamakita, J | 1 |
| Nasako, Y | 1 |
| Hiroishi, K | 1 |
| Gröbner, W | 1 |
| Walter-Sack, I | 1 |
| Miranda Carús, ME | 1 |
| Luz Picazo, M | 1 |
| López Jiménez, M | 1 |
| Ortíz Vázquez, J | 1 |
| Di Stefano, A | 2 |
| Taddeo, A | 2 |
| Jiménez, ML | 1 |
| Ramos, TH | 1 |
| Emmerson, BT | 2 |
| Hazelton, RA | 1 |
| Whyte, IM | 1 |
| Gordon, RB | 1 |
| Cross, M | 1 |
| Thomson, DB | 1 |
3 reviews available for xanthine and Gout
| Article | Year |
|---|---|
Analysis of Metabolites in Gout: A Systematic Review and Meta-Analysis.
Topics: Creatinine; Gout; Humans; Hypoxanthine; Uric Acid; Xanthine | 2023 |
Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.
Topics: Catalytic Domain; Coenzymes; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Metalloproteins; Molybd | 2015 |
[Effect of ethanol on uric acid level].
Topics: Acetaldehyde; Animals; Erythrocytes; Ethanol; Gout; Humans; Hyperuricemia; Purines; Pyrazinamide; Ur | 2003 |
2 trials available for xanthine and Gout
| Article | Year |
|---|---|
Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial.
Topics: Adult; Animals; Cross-Over Studies; Gout; Humans; Hypoxanthine; Male; Middle Aged; Milk; Purine Nucl | 2010 |
Free oxypurines in plasma and urine of gout patients before and after a purine-free diet.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Diet Therapy; Female; Gout; Humans; H | 1994 |
25 other studies available for xanthine and Gout
| Article | Year |
|---|---|
Changes in purine and uric acid content in edible insects during culinary processing.
Topics: Animals; Edible Insects; Gout; Gryllidae; Humans; Insecta; Purines; Uric Acid; Xanthine | 2023 |
A liquid chromatography-tandem mass spectrometry method for comprehensive determination of metabolites in the purine pathway of rat plasma and its application in anti-gout effects of Lycium ruthenicum Murr.
Topics: Animals; Arthritis, Gouty; Chromatography, High Pressure Liquid; Gout; Lycium; Purines; Rats; Tandem | 2023 |
Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease.
Topics: Coronary Artery Disease; Gout; Humans; Male; Uric Acid; Xanthine; Xanthine Dehydrogenase | 2023 |
Effect of allicin and its mechanism of action in purine removal in turbot.
Topics: Adsorption; Animals; Chromatography, High Pressure Liquid; Cooking; Disulfides; Flatfishes; Food Han | 2020 |
Improved ultra-high performance liquid chromatographic method for simultaneous determination of five gout-related metabolites in human serum.
Topics: Chromatography, High Pressure Liquid; Creatinine; Gout; Humans; Hypoxanthine; Inosine; Uric Acid; Xa | 2021 |
Study on the diagnosis of gout with xanthine and hypoxanthine.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Gout; Humans; Hyperuricemia; Hypoxant | 2019 |
Hyperuricemia and gout due to deficiency of hypoxanthine-guanine phosphoribosyltransferase in female carriers: New insight to differential diagnosis.
Topics: Adult; Child; Diagnosis, Differential; Female; Gout; Heterozygote; Humans; Hyperuricemia; Hypoxanthi | 2015 |
Hypercrosslinked strong cation-exchange polymers for selective extraction of serum purine metabolites associated with gout.
Topics: Cation Exchange Resins; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Gout; Humans; | 2016 |
A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia.
Topics: Animals; Bacillus; Gout; Half-Life; Hyperuricemia; Male; Polyethylene Glycols; Rabbits; Rats; Rats, | 2010 |
Metabolite target analysis of human urine combined with pattern recognition techniques for the study of symptomatic gout.
Topics: Animals; Chromatography, High Pressure Liquid; Gout; Guanosine; Humans; Hypoxanthine; Male; Mice; Ri | 2012 |
Effects of long-term beer ingestion on plasma concentrations and urinary excretion of purine bases.
Topics: Adult; Alcohol Drinking; Beer; Ethanol; Gout; Humans; Hypoxanthine; Kidney Concentrating Ability; Ma | 2005 |
[Current therapy: combined drug therapy of hyperuricemia, gout and alcohol induced fatty liver].
Topics: Allopurinol; Benzbromarone; Benzofurans; Drug Therapy, Combination; Fatty Liver, Alcoholic; Gout; Hu | 1983 |
High-performance liquid chromatographic determination of hypoxanthine and xanthine in biological fluids.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Erythrocytes; Gout; Humans; Hypoxanthine; Hypoxan | 1982 |
Purine metabolism in female patients with primary gout.
Topics: Adenine; Arthritis, Gouty; Creatinine; Female; Gout; Humans; Hypoxanthine; Hypoxanthines; Male; Puri | 1994 |
Effect of glucose infusion on the renal transport of purine bases and oxypurinol.
Topics: Adult; Allopurinol; Biological Transport, Active; Diabetes Complications; Diabetes Mellitus; Glucose | 1995 |
Purine metabolism in women with primary gout.
Topics: Aged; Creatinine; Female; Gout; Humans; Hypoxanthine; Hypoxanthines; Male; Middle Aged; Prospective | 1994 |
Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees.
Topics: Administration, Oral; Allopurinol; Animals; Dose-Response Relationship, Drug; Febuxostat; Female; Go | 1993 |
Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Ethanol; Glycogen Storage Disease Type I; Gout; Heparin; Hepat | 1996 |
[Hyperuricemia and gout--diagnosis].
Topics: Adenine; Adult; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Female; Go | 2002 |
Familial nephropathy and gout: which comes first?
Topics: Adult; Creatinine; Female; Gout; Humans; Hypoxanthine; Hypoxanthines; Kidney Diseases; Kidney Failur | 1991 |
[Analysis of uric acid and oxypurines in normal subjects and in gout patients].
Topics: Adult; Gout; Humans; Hypoxanthine; Hypoxanthines; Middle Aged; Uric Acid; Xanthine; Xanthines | 1989 |
[Clearance of oxypurines in normal subjects and in gout patients subjected to a purine-free diet. Effects of allopurinol].
Topics: Adult; Allopurinol; Creatinine; Diet; Gout; Humans; Hypoxanthine; Hypoxanthines; Middle Aged; Uric A | 1989 |
Renal excretion of hypoxanthine and xanthine in primary gout.
Topics: Adult; Aged; Female; Gout; Humans; Hypoxanthine; Hypoxanthines; Kidney; Male; Middle Aged; Uric Acid | 1988 |
Comparison of the urate lowering effects of allopurinol and diflunisal.
Topics: Allopurinol; Diflunisal; Gout; Humans; Osmolar Concentration; Salicylates; Uric Acid; Xanthine; Xant | 1987 |
Plasma oxipurinol concentrations during allopurinol therapy.
Topics: Allopurinol; Creatine; Gout; Humans; Hypoxanthine; Hypoxanthines; Kidney Function Tests; Oxypurinol; | 1987 |