oxadiazoles and Gout

oxadiazoles has been researched along with Gout* in 1 studies

Other Studies

1 other study(ies) available for oxadiazoles and Gout

Article	Year
[Design, synthesis and biological evaluation of oxadiazole derivatives as xanthine oxidase inhibitors]. Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:6 Xanthine oxidase (XO) is an important target for the treatment of hyperuricemia and gout. Based on the two known non-purine xanthine oxidase inhibitors, febuxostat and topiroxostat, 14 oxadiazole derivatives have been designed and synthesized. These compounds have been evaluated against XO and five of them exhibited significant inhibitory activities at the concentrations below 10 μmol·L(-1). Topics: Drug Design; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Oxadiazoles; Xanthine Oxidase	2016

Article

Year

[Design, synthesis and biological evaluation of oxadiazole derivatives as xanthine oxidase inhibitors].

Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:6

Xanthine oxidase (XO) is an important target for the treatment of hyperuricemia and gout. Based on the two known non-purine xanthine oxidase inhibitors, febuxostat and topiroxostat, 14 oxadiazole derivatives have been designed and synthesized. These compounds have been evaluated against XO and five of them exhibited significant inhibitory activities at the concentrations below 10 μmol·L(-1).

Topics: Drug Design; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Oxadiazoles; Xanthine Oxidase

2016